Abstract:
:The purpose of this study was to compare extraction socket healing in 8 patients after implantation with either xenogenic bovine bone (n=5 sites), demineralized freeze-dried bone (DFDBA) (n=3 sites), autologous bone (n=3 sites), or human bone morphogenetic proteins in an osteocalcein/osteonectin carrier (hBMP/NCP) (n=2 sites). Three of the patients received 6 commercially pure micro screws which were fixed into extraction sockets, after which the sockets were implanted with either bovine bone (n=3 sites), DFDBA (n=2 sites) or intraoral autologous bone (n=1 site). Biopsies of the extraction sockets were taken from 3 to 6 months after treatment (average, 4.6 months). For comparison of healing between the implanted materials, histologic evaluation and bone scores were determined. Bone scores of 0 indicated an absence of new bone, with dead implanted bone particles entrapped within connective tissue, while a score of 3 indicated the entire field consisted of vital bone. Biopsies from bovine bone sockets revealed dead implanted particles surrounded by connective tissue. Isolated sections showed host bone in contact with the bovine bone particles. Bone scores ranged from 0 to 3. Biopsies from DFDBA-implanted sites revealed dead particles entrapped with dense connective tissue. The bone scores ranged from 0 to 1. Biopsies from sites implanted with hBMP/NCP revealed a combination of woven and lamellar bone with bone scores of 3. Five of the 6 micro screws were processed and evaluated. One screw was mobile at the time of removal and was not evaluated. Bone scores were used to compare new bone formation adjacent to the micro screws. Bone scores ranged from 0 to 2. A score of 0 indicated non-vital implant material in contact with host bone and connective tissue in contact with implant; 2 indicated vital bone in contact with the majority of the implant surface. Retrieved sockets with micro screws implanted with bovine bone (n=2) demonstrated a connective tissue interface between the screws and the surrounding tissues (bone score 0). The adjacent tissues showed dead bovine particles entrapped within fibrous tissue. Retrieved screws implanted with DFDBA (n=2) were surrounded by connective tissue, with dead bone particles enmeshed within fibrous tissue (bone score 0). The screw implanted with intra-oral autologous bone was primarily surrounded by vital bone with a connective tissue interface (bone score 1). Three implant threads were in contact with bone. The results of this study indicate that bovine bone, DFDBA, and intraoral autologous bone do not promote extraction socket healing. Sockets implanted with hBMP/NCP contained vital woven and lamellar bone. Xenogenic bovine bone and DFDBA did not contribute to bone to micro screw contacts and are not recommended for enhancement of vital bone to implant contacts. Intraoral autogenous bone also does not appear to significantly contribute to bone to implant contacts. Intraoral autologous bone, xenogenic bone, and DFDBA appear to interfere with normal extraction socket healing.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Becker W,Clokie C,Sennerby L,Urist MR,Becker BEdoi
10.1902/jop.1998.69.4.414subject
Has Abstractpub_date
1998-04-01 00:00:00pages
414-21issue
4eissn
0022-3492issn
1943-3670journal_volume
69pub_type
临床试验,杂志文章abstract::The purpose of this study was to quantify glycosaminoglycans (GAG) released into the gingival crevicular fluid (GCF) during health, gingivitis, and adult periodontitis. The investigation tested the hypothesis that increased amounts of GAG can be measured in GCF associated with gingivitis and adult periodontitis as com...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.3.186
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:The role played by the internal basal lamina (IBL) and hemidesmosomes between an implant and the peri-implant epithelium (PIE) in the adherence of the epithelium to the implant is controversial. This study used rat maxilla implantation models to clarify the ultrastructure of the PIE-implant interface. METHO...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.6.961
更新日期:2000-06-01 00:00:00
abstract::Plaque-induced inflammation has been documented from various aspects, but is still not well understood. In an effort to clarify the physicochemical properties of dental plaque and to isolate the active factor which give rise to inflammation, we studied a factor in plaque which may be a direct and local cause of gingiv...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.7.400
更新日期:1980-07-01 00:00:00
abstract::A retrospective study was conducted of 620 patients in a periodontal practice over the years 1960 to 1982. Various periodontal therapies were assessed by using careful office protocols, meticulous record-keeping and well-defined outcome criteria. Four treatment outcome categories were used: two representing satisfacto...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.5.253
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Crohn's disease is a chronic inflammatory bowel disease characterized by uncertainty in etiology and pathogenesis occasionally with manifestations in oral mucous membranes. This report reviews the literature on Crohn's disease and presents a patient with Crohn's disease on continuous anti-inflammatory and im...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.4.537
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:This study compared 6-month and 3-year outcomes for root coverage (RC) by coronally advanced flap (CAF) procedures in localized gingival recessions. METHODS:Two centers, that had participated in a 6-month multinational multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2017.160767
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Some studies have reported an association between gestational diabetes mellitus (GDM) and periodontitis. The aim of the present study is to analyze this potential association and the influence of risk variables associated with GDM. METHODS:This case-control study includes 360 women, 90 with GDM and 270 cont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120350
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Clinical attachment level (CAL) and bone height (radiographic or clinical) are two well-accepted endpoint measures for periodontal clinical trials; however, neither one has been shown to be more predictive of long-term success than the other. We propose using a composite endpoint analysis combining clinical ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050275
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic inflammation. Dendritic cells (DC) are key regulators of T cell fate, and biomaterials that recruit and prog...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0411
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Microscopic and immunocytochemical studies have demonstrated both similarities and differences between the gingival mucosa and the peri-implant mucosa restored around dental implants. METHODS:This study was performed on 10 samples of peri-implant mucosa from 10 patients who had undergone implant treatment 1...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.5.555
更新日期:2002-05-01 00:00:00
abstract::Chronic inflammatory illnesses such as diabetes, arthritis, and heart disease are now seen as problems that might have impacts on the periodontium, and reciprocal effects of periodontal diseases are being considered as factors potentially affecting the progression of these diseases. Successful management of the inflam...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2005.76.11-S.2168
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:The main aim of treatment for acute necrotizing periodontal disease is fast and effective reduction of anaerobic destructive microorganisms to avoid periodontal damage. The effect of adjunctive local oxygen therapy in the treatment of necrotizing periodontal disease was examined in this study. METHODS:Thirt...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2006.77.1.31
更新日期:2006-01-01 00:00:00
abstract::Patient plaque removal is a major component of periodontal therapy and should be continuously monitored during and following treatment. There do not appear to be studies which address plaque score changes achieved primarily by patient performance from the time of initial presentation to, during, and following active t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.6.343
更新日期:1990-06-01 00:00:00
abstract::The responses of four tooth/site groupings to periodontal therapy were evaluated. Eighty-two patients with periodontitis were treated in a split mouth design with coronal scaling, root planing, modified Widman surgery, and flap with osseous resectional surgery. Patients were evaluated prior to therapy, 4 weeks post-Ph...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1990.61.3.173
更新日期:1990-03-01 00:00:00
abstract::Interdental gingival tissues are designated inflamed on the basis of their color and bleeding after stimulation. Gingival bleeding was previously shown in histological studies to indicate the presence of inflammatory lesions. The present study was undertaken to determine associations between bleeding and visual signs ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.11.722
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:The polyamines spermidine, spermine, and putrescine are known to be deeply linked with growth processes, gene expression, and extracellular matrix synthesis. Their cellular content depends primarily on the activity of the enzyme ornithine decarboxylase. High levels of ornithine decarboxylase and polyamines h...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.3.443
更新日期:2005-03-01 00:00:00
abstract::Clinical and laboratory data were compared in 72 patients with localized periodontitis (LP) and 103 patients with generalized periodontitis (GP). Significantly more LP than GP cases had decreased neutrophil chemotaxis (CTX), and were seropositive for Actinobacillus actinomycetemcomitans (Aa). Significantly, more GP ca...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.10.557
更新日期:1989-10-01 00:00:00
abstract::A study was done in an attempt to develop a simple test for the severity of periodontal disease. Gingival fluid collected on filter paper was tested for protein content, and the resulting color was compared to standard color filters. Tissue was excised and prepared for histologic examination. The inflammatory cell inf...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.8.391
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been found to promote the osteoblastic differentiation of human periodontal ligament cells. Its effect depends on the delivery system used. In this study we examined the effect of rhBMP-2 on the proliferation and osteoblastic differentiation of hum...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.7.982
更新日期:2003-07-01 00:00:00
abstract::The ability to objectively assess periodontal disease activity can significantly affect periodontal therapy. Aspartate aminotransferase (AST) is released extracellularly upon tissue destruction which suggests its potential as a key index in a quantitative assay for evaluating periodontal disease activity. The purpose ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.8.733
更新日期:1996-08-01 00:00:00
abstract::The purpose of this histologic, histometric, and autoradiographic study was to examine the effect of citric acid conditioning and lyophilized autologous plasma (LAP) application on healing following periodontal flap surgery. Mucoperiosteal flaps were elevated in six rhesus monkeys using the modified Widman flap proced...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.11.770
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.6.591
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Dietary calcium has long been a candidate to modulate periodontal disease. Animal as well as human studies of calcium intake, bone mineral density, and tooth loss provide a rationale for hypothesizing that low dietary intake of calcium is a risk factor for periodontal disease. METHODS:We evaluated the role ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.7.1057
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Periodontal disease has been associated with cardiovascular disorders with an atherosclerotic background, and number of teeth (NT) has been suggested as a possible risk indicator for cardiovascular disease. The objective of this study is to investigate whether NT was related to the intima-media thickness (IM...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110100
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Recombinant human bone morphogenetic protein (rhBMP)-2 in a bioabsorbable collagen sponge (ACS) carrier supports significant bone formation. However, histomorphometric data on the augmentation of bone formation beyond the skeletal envelope are insufficient. Our objective was to evaluate the short-term effect...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070305
更新日期:2008-02-01 00:00:00
abstract::Periodontal disease is a common infection-induced inflammatory disease among individuals suffering from diabetes mellitus. The purpose of this study was to assess the effects of treatment of periodontal disease on the level of metabolic control of diabetes. A total of 113 Native Americans (81 females and 32 males) suf...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1997.68.8.713
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2016.160015
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0338
更新日期:2020-08-21 00:00:00
abstract:BACKGROUND:Platelet-derived growth factor (PDGF-BB) has been shown to enhance periodontal regeneration. Principles of guided tissue regeneration dictate that one of the goals of therapy is to modulate the wound healing processes to favor repopulation of the wound with cells derived from the periodontal ligament rather ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.331
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Arachidonate-5-lipoxygenase (5-LO) activity and increased leukotriene B4 (LTB4) production have been implicated in various inflammatory conditions. Increased production of leukotrienes has been associated with periodontal diseases; however, their relative contribution to tissue destruction is unknown. In thi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170210
更新日期:2017-12-05 00:00:00