Abstract:
:The purpose of this histologic, histometric, and autoradiographic study was to examine the effect of citric acid conditioning and lyophilized autologous plasma (LAP) application on healing following periodontal flap surgery. Mucoperiosteal flaps were elevated in six rhesus monkeys using the modified Widman flap procedure. A total of 24 quadrants were treated, each included the first and second premolar and first and second molar teeth. Cementum was removed from the exposed root surfaces, and reference notches were inscribed into the roots at the alveolar bone margin. Two treatment modalities were employed: (1) surgery plus citric acid conditioning, to serve as control and (2) surgery plus citric acid followed by LAP application (400 mg/ml saline). Flaps were returned to their preoperative positions and sutured. Animal sacrifices were scheduled to provide observations 3, 7, 14, 21, 28, and 45 days after surgery. Each monkey received an intravenous injection of tritiated thymidine, 1 microCi/gm of body weight, 1 hour before it was killed. Tissue specimens were processed for evaluation following standard procedures. Histologically, tissue sections were examined for: (1) proliferation and attachment of epithelium, (2) organization and maturation of periodontal fibers, (3) inflammatory cell types, (4) presence or absence of new cementum deposition, and (5) degree of vascularity of the tissues. For histometric evaluation, the radicular notches were used as reference points. The distances examined histometrically were: (1) from the root surface notch to the alveolar bone crest, (2) from the root surface notch to the apical extent of the junctional epithelium, and (3) from the free gingival margin to the apical extent of the junctional epithelium. For autoradiographic evaluation labeled cells were counted in five spatial compartments at 400 X magnification: (1) oral epithelium, (2) crevicular area, (3) supracrestal connective tissue, (4) coronal periodontal membrane, and (5) coronal bone marrow. For each the histometric and autoradiographic evaluation involved a total of 36 tissue sections per quadrant (9 sections per tooth). Tooth and quadrant means were obtained for each monkey. The plasma-treated and control quadrants were compared at each time point by the paired t test. N = 2 monkeys were used for each comparison. Histologic results showed that in teeth that were acid-conditioned after root planing, the epithelium often migrated apically reaching the radicular notch. Those teeth that were conditioned and subsequently treated with LAP demonstrated fiber attachment to the planed root surface and little or no epithelial downgrowth.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Nasjleti CE,Caffesse RG,Castelli WA,Smith BA,Lopatin DE,Kowalski CJdoi
10.1902/jop.1987.58.11.770subject
Has Abstractpub_date
1987-11-01 00:00:00pages
770-9issue
11eissn
0022-3492issn
1943-3670journal_volume
58pub_type
杂志文章abstract:BACKGROUND:The protease-induced cytotoxicity of P. gingivalis may partly result from alteration of the extracellular matrix and/or surface receptors that mediate interaction between the host cells and their matrix. While P. gingivalis-induced degradation of E-cadherin has been documented, there is no information on the...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.5.641
更新日期:2001-05-01 00:00:00
abstract::Previous studies indicated that connective tissue attachment to the root surface appeared to be dependent upon a chronologic healing sequence related to fibrin and collagen interactions. It was the purpose of the present study to try and substantiate this hypothesis by using histologic techniques designed to different...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.3.141
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:During the last decade, there have been great strides in the treatment of gingival recession defects, especially with subepithelial connective tissue graft and guided tissue regeneration (GTR) procedures. Gingival recession represents a significant concern for patients. It is necessary to choose the most app...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2000.72.9.1258
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic inflammation. Dendritic cells (DC) are key regulators of T cell fate, and biomaterials that recruit and prog...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0411
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigens (HLAs) are a basic precondition to induce the immune response to pathogens. Therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and HLAs to test their impact together with additional risk factors in multivariate analyses. METHODS:Eig...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110545
更新日期:2013-01-01 00:00:00
abstract::Increasingly, patients referred to periodontists have undergone some form of non-surgical periodontal treatment prior to their referral. As a result of this, there is an increased need to treat isolated, rather than generalized, periodontal defects. A surgical technique that utilizes small incisions and a limited acce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1547
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Pigmentations of the oral cavity are commonly noted in clinical practice and may have physiologic, non-physiologic, or pathologic etiologies. The most common non-physiologic localized pigmentation is the amalgam tattoo; another, less common, non-physiologic pigmentation is the graphite tattoo. Graphite tatto...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1572
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The purpose of this experimental study was to evaluate the collagen fiber distribution histologically after phenytoin, cyclosporin, or nifedipine therapy and to correlate it with collagen I and matrix metalloproteinase (MMP)-1 and -2 gene expression levels. METHODS:Gingival samples from the canine area were...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070267
更新日期:2008-01-01 00:00:00
abstract::The purposes of this study were to determine if: 1) an association exists between cigarette smoking and signs of periodontal disease after controlling for the confounding variables of age, sex, plaque, and calculus; 2) the prevalence of 5 bacteria commonly associated with periodontal disease differs between smokers an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.12.1225
更新日期:1993-12-01 00:00:00
abstract::Sjögren's syndrome is an autoimmune disease characterized by keratoconjunctivitis sicca and xerostomia. Rapid bacterial plaque accumulation occurs in Sjögren's syndrome patients due to decreases in salivary flow rate. The purpose of this study was to evaluate the periodontal status of patients with Sjögren's syndrome ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.5.571
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Areca quid chewers have a higher prevalence of periodontal disease than non-chewers. Little is known about the influence of areca quid on the immune system. This study was to determine the possible effects of the areca nut on phagocytic activity of human neutrophils. METHODS:Aqueous extracts of ripe areca n...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.3.373
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:The polyamines spermidine, spermine, and putrescine are known to be deeply linked with growth processes, gene expression, and extracellular matrix synthesis. Their cellular content depends primarily on the activity of the enzyme ornithine decarboxylase. High levels of ornithine decarboxylase and polyamines h...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.3.443
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) may play an important role in insulin resistance. In this study, we hypothesized that TNF-alpha produced due to periodontal inflammation synergistically affects insulin resistance as well as TNF-alpha produced from adipose tissues in insulin-resistant type 2 diabetes p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.6.774
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Bone augmentation or grafting is often required for placement of dental implants or surgical reconstruction of bony defects. Bioabsorbable magnesium implant was shown to promote osteogenesis in long bones. The objectives of this study were to determine osteogenic effects of pure magnesium (Mg) in rat mandibl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0162
更新日期:2020-08-26 00:00:00
abstract::A multitude of new procedures and materials are being tested for their ability to promote periodontal wound healing. This review provides an overview of the most well-accepted methods for evaluating periodontal wound healing procedures/materials. Topics discussed include appropriate patient selection, general principl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.12s.1085
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:The need for keratinized mucosa (KM) or immobile keratinized mucosa (i.e., attached mucosa [AM]) for the maintenance of osseointegrated endosseous dental implants has been controversial. The purpose of this study was to investigate the significance of KM in the maintenance of root-form dental implants with d...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050393
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Crohn's disease is a chronic inflammatory bowel disease characterized by uncertainty in etiology and pathogenesis occasionally with manifestations in oral mucous membranes. This report reviews the literature on Crohn's disease and presents a patient with Crohn's disease on continuous anti-inflammatory and im...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.4.537
更新日期:2003-04-01 00:00:00
abstract::A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.163
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:This study systematically evaluates the effect of occlusal overload (OV) on peri-implant tissue health in animal studies. METHODS:MEDLINE, EMBASE, and LILACS databases were searched for articles published up to and including January 2010. Studies that reported outcomes of non-splinted titanium dental implan...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2010.100176
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Little evidence is available regarding the effects of long-term periodontal infection on diabetes mellitus (DM) control. The aim of this retrospective cohort study is to evaluate influence of periodontal status on changes of glycated hemoglobin (HbA1c) levels of patients with type 2 DM (DMt2). METHODS:Eight...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160140
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Sinus membrane perforation is the most common complication of the sinus-augmentation procedure. Anatomic factors have been implicated in the risk of sinus membrane perforation (SMP) during sinus-lift surgery. However, there are no reports on the relationships among gingival phenotype (GP), residual ridge hei...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110110
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Langerhans-cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.1.143
更新日期:2005-01-01 00:00:00
abstract::Saliva and serum samples were collected from 36 individuals with selective immunoglobulin A deficiency (IgAd) and 23 patients with common variable immunodeficiency (CVI). The oral examination included registration of the teeth, Russell's periodontal index (PI), pocket formation, and salivary flow rate in both unstimul...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.12.984
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorh...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120616
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:This study compares the levels of cytokines and bone-related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better-controlled, and poorly controlled patients with type 2 diabetes and CP. METHODS:Thirty-seven patients with type 2 diabetes ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100643
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Neutrophils (PMNs) are critical components of the innate immune system and help to maintain oral health in the face of a constant bacterial challenge. However, along with protecting the periodontium from microbial invasion, these cells release potent lysosomal enzymes and oxygen radicals that can be destruct...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070107
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100496
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (in...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2008.070623
更新日期:2008-08-01 00:00:00
abstract::Based on the findings observed after the insertion of 33 blade implants in 23 patients, ages 31 to 74, for periods up to 60 months, the following conclusions can be made: (1) The blade implant is a technically feasible procedure which can be maintained in the mouth for period up to 5 years, although some degree of bon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.1.19
更新日期:1976-01-01 00:00:00
abstract::The purpose of this study was to evaluate the healing potential of deep, primarily 3wall intrabony defects which were treated by flap debridement and expanded polytetrafluoroethylene (ePTFE) membranes and followed for extended time periods. All of the treated defects were in the mandibular arch. Thirty-two patients we...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.11s.1138
更新日期:1993-11-01 00:00:00