Abstract:
BACKGROUND:Little evidence is available regarding the effects of long-term periodontal infection on diabetes mellitus (DM) control. The aim of this retrospective cohort study is to evaluate influence of periodontal status on changes of glycated hemoglobin (HbA1c) levels of patients with type 2 DM (DMt2). METHODS:Eighty patients (mean age: 56.0 ± 8.9 years) with DMt2 were included. Patients were non-smokers, aged ≥40 years, and using antidiabetic drugs. Demographics, health history, and HbA1c levels were retrieved from medical charts. Probing depth and clinical attachment loss (AL) were recorded. RESULTS:Patients were examined at two time points within a mean interval of 38.6 ± 6.6 months. Increase in HbA1c over time was statistically significant when severe periodontitis was diagnosed at baseline (2.32%, 95% confidence interval [CI]: 1.50% to 3.15%), in patients showing at least one tooth with ≥2 mm of AL progression (2.24%, 95% CI: 1.56% to 2.91%), in males (2.75%, 95% CI: 1.72% to 3.78%), and in those with HbA1c <6.5% at baseline (3.08%, 95% CI: 2.47% to 3.69%). After adjusting for baseline HbA1c, significant changes were still observed for severe periodontitis and progression of AL with increases of 0.85% and 0.9%, respectively. After adjusting for sex and HbA1c, AL progression was also statistically significant, with increases of 0.84%. CONCLUSIONS:Periodontitis progression was associated with increase in HbA1c in patients with DMt2. Identification of these risk factors suggests that periodontal treatment may improve glycemic control of patients with DMt2 by eliminating periodontal infection.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Costa KL,Taboza ZA,Angelino GB,Silveira VR,Montenegro R Jr,Haas AN,Rego ROdoi
10.1902/jop.2016.160140subject
Has Abstractpub_date
2017-01-01 00:00:00pages
17-25issue
1eissn
0022-3492issn
1943-3670journal_volume
88pub_type
杂志文章abstract::The purpose of this study was to evaluate the feasibility and reliability of using a home screening occult blood test to detect the presence of gingival inflammation. Fifty (50) healthy male and female subjects participated in this study. Pre- and post-stimulation saliva samples were obtained and tested for occult blo...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.1.52
更新日期:1995-01-01 00:00:00
abstract::Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that bacterial pneumonia will assume increasing importance in the coming ye...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.10s.1114
更新日期:1996-10-01 00:00:00
abstract::This study examined for 3 years the changes in periodontal status and the possible correlations with selected subgingival microbiota and diabetic conditions in a group of 16 insulin-dependent diabetes mellitus (IDDM, JD) patients as compared with their 16 healthy cohabiting siblings (HS). JD patients were monitored ev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.2.120
更新日期:1998-02-01 00:00:00
abstract::A 26-year-old hispanic male presented with a nonspecific gingival lesion initially presumed to be of infectious etiology. During continued follow-up over several weeks, the lesion evolved into one typical of desquamative gingivitis. Direct immunofluorescent testing and routine histopathology resulted in a diagnosis of...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.9.611
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute phase protein involved in inflammation-associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor ne...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0358
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Crestal bone thickness is a critical determinant of peri-implant tissue stability. This retrospective observational study sought to quantify the buccal bone thickness achieved adjacent to virtual dental implants following guided bone regeneration (GBR) surgery and evaluate the influence of patient- and proce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0304
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Prostaglandin E2 (PGE2) plays important roles in the pathogenesis of periodontal disease. Recent studies have revealed the existence of 2 isozymes of cyclooxygenase (COX), called COX-1 and COX-2. The purpose of the present study was to investigate the contribution of COX-1 and COX-2 to PGE2 production by hum...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.10.1575
更新日期:2000-10-01 00:00:00
abstract::We review the basic functions of neurotrophins and their receptors and discuss the expression and functions of neurotrophins and their specific receptors based on recent data using cultured cells from human periodontal tissues. Neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neu...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.1.76
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Of the many forms of periodontal disease, refractory periodontal diseases are the least characterized. They are defined as the continued degeneration of the periodontium despite adequate management. This has led to the suggestion that there may be a systemic component that is a contributing factor to the dev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050108
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis is one of the major microbial pathogens associated with chronic periodontitis. To eradicate such pathogens by periodontal therapy, it is essential to clarify the source of infection. Recent findings suggest that the genotype of the fimbriae is one of the important factors in infectio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.9.1355
更新日期:2003-09-01 00:00:00
abstract::Consistently successful regenerative therapy for furcation defects using membrane techniques remains a challenge for clinicians. The purpose of this study was to determine if the thickness of tissue used to cover the membrane influences postsurgery recession. Thirty-seven (37) moderate to advanced adult periodontitis ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.5.397
更新日期:1995-05-01 00:00:00
abstract::Explants of bovine gingival mucosa were cultured for four days on scaled and citric acid-conditioned root surfaces. Demineralization of the hard tissue with citric acid exposed the collagenous matrix of the root. Undemineralized islands were frequently seen among the collagen fibers of the treated roots. When cultured...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.2.95
更新日期:1988-02-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:Several anti-inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open-flap debridement surgery. METHODS:For this prospective, double-masked, crossover, placebo-controlle...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2010.100059
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Morning breath odor is an often-encountered complaint. This double-blind, crossover, randomized study aimed to examine the bad breath-inhibiting effect of 3 commercially available mouthrinses on morning halitosis during an experimental period of 12 days without mechanical plaque control. METHODS:Twelve medi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2000.72.9.1183
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The use of nanoparticles of graft materials may lead to breakthrough applications for periodontal regeneration. However, due to their small particle size, nanoparticles may be eliminated from periodontal defects by phagocytosis. In an attempt to improve nanoparticle retention in periodontal defects, the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120701
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11.1823
更新日期:2005-11-01 00:00:00
abstract::Demineralized bone matrix (DBM) is widely used in the repair of pathologies associated with skeletal defects and periodontal diseases. The present study was directed at establishing in vivo and in vitro models for a quantitative assessment of the osteoinductivity of DBM before clinical use. Athymic mice were used in a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.11.1076
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Aortic aneurysms affect an increasing number of elderly patients and cause considerable morbidity and mortality. The understanding of the mechanisms involved in the pathogenesis of aortic aneurysms is unclear and little is known about the role of microorganisms in the development of the condition. The aim of...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.4.590
更新日期:2005-04-01 00:00:00
abstract::This study investigated a possible association between bruxism and severity of periodontal disease. Subjects consisted of 51 patients (mean age 47.3 years) referred to the Department of Periodontology for treatment of moderate to severe periodontal disease (Perio-group) and 40 patients (mean age 48.9 years) referred t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.3.173
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential correlations between detached subgingival bacteria collected in gingival crevicular fluid (GCF) an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0295
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Periodontitis is associated with increased prevalence of cardiovascular morbidity and mortality; however, the nature of this association is unclear. There is a rationale that indicates that the presence of periodontal pockets which can harbor pathogenic microorganisms and evoke a host response could elicit a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.5.494
更新日期:2002-05-01 00:00:00
abstract::As more types of implants have become available, clinicians have been faced with the task of choosing a specific implant from a wide array of options for a given clinical situation, which has led to an ever-increasing need for clinical evidence to help clinicians choose an implant. This article highlights the need for...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090265
更新日期:2009-10-01 00:00:00
abstract::Extensive data collected over the past decade demonstrate clearly that diseaseactive and disease-inactive periodontal pockets exist, disease progression is infrequent and episodic, and most progression occurs in a small proportion of highly susceptible individuals. Furthermore, traditionally used diagnostic procedures...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.4s.356
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Gingiva is composed of attached and marginal (free) gingiva and interdental papilla. Increasing esthetic demands in dentistry have created a need to restore all parts of the gingiva. However, the interdental papilla has limited regeneration potential compared to other parts of the gingiva. It also is more su...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060165
更新日期:2007-02-01 00:00:00
abstract::This cross-sectional study examined the gingivitis occurring at puberty in a population of insulin-dependent juvenile diabetics. Seventy-seven children between the ages of 6 and 15 years were examined for gingivitis levels, stages of pubertal maturation and blood levels of glucose and glycosylated hemoglobin. Bacteria...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.12.714
更新日期:1983-12-01 00:00:00
abstract::Cemental tears have been described both in exposed and unexposed cementum. The phenomenon is believed to be elicited by overloading or acute trauma from occlusion. In this case report a patient, with a history of periodontal health, presented with an acute periodontal lesion on the distal aspect of a bridge abutment t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.3.220
更新日期:1992-03-01 00:00:00
abstract::The laser reflection method of remote measurement was used to register small tooth movements of upper central incisors from a group of subjects with healthy teeth and another group with periodontally involved teeth. The mobility of the healthy maxillary incisors over a period of 24 hours was well within normal limits....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.7.439
更新日期:1982-07-01 00:00:00
abstract::The effects of twice weekly topical applications of hydrogen peroxide on the buccal epithelium of Syrian hamsters were studied. Animals were treated either with hydrogen peroxide alone, with hydrogen peroxide and the carcinogen 9, 10-dimethyl-1,2-benzanthracene (DMBA), or with DMBA alone. In animals treated with 30% H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.11.685
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:The primary goal of periodontal therapy is the reduction or elimination of inflammation. Traditionally, this is accomplished through removal of subgingival tooth-borne accretions using non-surgical and/or surgical treatment modalities. Numerous studies indicated the difficulty in removing these accretions to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080190
更新日期:2008-11-01 00:00:00