Abstract:
BACKGROUND:The pathogenesis of epithelial thickening in gingival overgrowth remains obscure. Apoptosis plays an important role in maintaining tissue hemostasis. The aim of the present study was to investigate apoptosis via immunohistochemical analyses in cyclosporin A-induced gingival overgrowth tissue samples to determine whether these processes play a role in the pathogenesis of gingival overgrowth. METHODS:Gingival biopsies (one per person) were harvested from 22 renal transplant recipients (eight men and 14 women; mean age, 36.4 +/- 13.3 years) who had been diagnosed with cyclosporin A-induced gingival enlargement and from 12 systemically healthy persons (seven men and five women; mean age, 27.0 +/- 16.0 years) with plaque-induced gingivitis. Distributions of caspase-3 and apoptosis were determined immunologically. RESULTS:Significant differences were found with regard to caspase-3 levels and the extent of apoptosis between the cyclosporin A group and the control group. Plaque index, gingival index, and probing depths were significantly lower in the control group. CONCLUSION:The extent of keratinocyte apoptosis and decreased levels of caspase-3 may be an important factor affecting the gingiva of kidney transplant recipients with cyclosporin A-induced gingival overgrowth.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Bulut S,Ozdemir BHdoi
10.1902/jop.2007.070226subject
Has Abstractpub_date
2007-12-01 00:00:00pages
2364-8issue
12eissn
0022-3492issn
1943-3670journal_volume
78pub_type
杂志文章abstract:BACKGROUND:Cytokines play a key role in the pathogenesis of inflammatory diseases. An obvious question is whether patients with aggressive periodontitis, juvenile idiopathic arthritis, or rheumatoid arthritis share blood cytokine profiles distinguishing them from individuals free of disease. METHODS:The study populati...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.12.2276
更新日期:2005-12-01 00:00:00
abstract::A case is presented in which an unusual amount of intraoral calculus was seen in a 59-year-old woman. The deposits completely covered all surfaces of most teeth and extended over the facial and lingual gingivae. The relationship between certain chemical salivary parameters and heavy calculus formers is briefly describ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.6.326
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0338
更新日期:2020-08-21 00:00:00
abstract:BACKGROUND:Application of cone-beam computed tomography (CBCT) has grown exponentially across dentistry with a clear impact in implant dentistry. This review aims at providing the scientific context to understand if CBCT imaging should become the standard of care for patients requiring dental implants. METHODS:A liter...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2017.160548
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Sinus membrane perforation is the most common complication of the sinus-augmentation procedure. Anatomic factors have been implicated in the risk of sinus membrane perforation (SMP) during sinus-lift surgery. However, there are no reports on the relationships among gingival phenotype (GP), residual ridge hei...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110110
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is an inflammatory granulomatous systemic disease that rarely affects the oral cavity. Gingival involvement has been reported in only a very limited number of cases, occasionally as the first manifestation of the disease. This article reports a case of sarcoidosis affecting the gingiva and alveol...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070139
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Morning breath odor is an often-encountered complaint. This double-blind, crossover, randomized study aimed to examine the bad breath-inhibiting effect of 3 commercially available mouthrinses on morning halitosis during an experimental period of 12 days without mechanical plaque control. METHODS:Twelve medi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2000.72.9.1183
更新日期:2001-09-01 00:00:00
abstract::In an earlier report, we examined the relationship of patient-derived clinical and epidemiological variables to the risk for future clinical attachment loss (CAL) in chronic adult periodontitis. We determined that the extent of the patient's existing periodontal disease as measured by mean attachment loss (MAL) and th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.4.262
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Crohn's disease is a chronic inflammatory bowel disease characterized by uncertainty in etiology and pathogenesis occasionally with manifestations in oral mucous membranes. This report reviews the literature on Crohn's disease and presents a patient with Crohn's disease on continuous anti-inflammatory and im...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.4.537
更新日期:2003-04-01 00:00:00
abstract::Temporary splints to immobilize periodontally diseased teeth were made by fiber glass bonded and attached to the teeth with acid-etch technique with BIS-GMA resin. Twenty-one splints were made. Observation time ranged from 4 to 14 months. During the observation only one splint fractured and was repaired while the othe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.4.193
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Crestal bone thickness is a critical determinant of peri-implant tissue stability. This retrospective observational study sought to quantify the buccal bone thickness achieved adjacent to virtual dental implants following guided bone regeneration (GBR) surgery and evaluate the influence of patient- and proce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0304
更新日期:2019-06-01 00:00:00
abstract::Tooth gliding occurs frequently both in the opening (55.9%) and closing (60.5%) chewing strokes. The average glide length was 1 mm. Good occlusions could not be distinguished from poor occlusion on the basis of frequency and length of gliding contacts. The greater the component of lateral movement during the closing s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.6.331
更新日期:1976-06-01 00:00:00
abstract::This study clinically analyzed the efficacy of a connective tissue graft including the periosteum used as a barrier to enhance new attachment and osseous regeneration. Fifteen patients, with no systemic diseases, and adult periodontitis including 2 Class II furcation involvements in lower molars comprised the study gr...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1991.62.12.775
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Various surgical techniques have been proposed for treating gingival recession. This randomized clinical trial compared the coronally positioned flap (CPF) alone or in conjunction with a subepithelial connective tissue graft (SCTG) in the treatment of gingival recession. METHODS:Eleven non-smoking subjects ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2004.75.3.413
更新日期:2004-03-01 00:00:00
abstract::The purpose of this study was to evaluate the safety and clinical efficacy of controlled-release tetracycline-containing fibers in patients with refractory periodontitis versus the preceding classical treatment. One hundred twenty-one sites in 20 patients were followed from baseline to 6 months after fiber insertion. ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1997.68.4.353
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The subgingival microbiota as well as determination of markers such as associated pathogens is still in the focus of dental research. The aim of this controlled clinical trial was to determine clinical applicability of a newly developed chairside bacterial test (CST) for the most relevant periodontal pathoge...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0180
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Periodontal disease is a major complication of type 1 diabetes mellitus (T1DM). The aim of the present study is to investigate the relationship between glycated hemoglobin and circulating levels of interleukin (IL)-6, IL-8, and C-X-C motif chemokine ligand 5 (CXCL5) in non-smoking patients suffering from T1D...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2015.150149
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Pentraxins are acute-phase proteins that belong to a family of evolutionarily conserved proteins, and they are considered markers of inflammation. Pentraxin-3 (PTX3) is a prototype of the long pentraxin group. It is suggested to play an important role in innate resistance against pathogens, regulation of inf...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.120718
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS:We conducted a case-control study of 581 COPD...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110472
更新日期:2012-10-01 00:00:00
abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.1.21
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.110685
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The purpose of this prospective study was to compare the changes in periodontal somatosensory function and microcirculation in patients with periodontitis following initial treatment with scaling and root planing (SRP) with or without adjuvant laser therapy. METHODS:Twenty-four patients suffering from perio...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1002/JPER.19-0562
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:An experimental periodontal sensor probe (SP) equipped with an optical fiber for recording function was developed. The aim was to test the intraexaminer reproducibility of probing using the SP and to assess the consistency with the manual probe (MP). METHODS:The SP was assembled with an external sheath cove...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2011.110047
更新日期:2012-02-01 00:00:00
abstract::The aims of this paper are to briefly describe laser physics, the types of lasers currently available for use on soft tissues focusing primarily on CO2 and Nd:YAG laser energies, the histological effects of lasers on oral tissues, laser safety, the clinical applications of lasers on oral soft tissues, and future direc...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1993.64.7.589
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Controversy over the long-term clinical effectiveness of hydroxyapatite (HA)-coated dental implants still persists, despite numerous clinical studies documenting high survival rates. Concerns about the degradation of the coating over the years have been raised; it has been speculated that resorption of the H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060271
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Unsupervised clustering is a method used to identify heterogeneity among groups and homogeneity within a group of patients. Without a prespecified outcome entry, the resulting model deciphers patterns that may not be disclosed using traditional methods. This is the first time such clustering analysis is appl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0489
更新日期:2020-12-14 00:00:00
abstract::The sensitivity to tetracycline of 345 bacterial isolates from periodontal lesions was determined. Most species of bacteria, including those thought to be involved in the initiation and progress of destructive periodontal disease, were inhibited in vitro by tetracycline concentrations of 4 to 8 micrograms/ml. This con...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1981.52.10.613
更新日期:1981-10-01 00:00:00
abstract::Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermo...
journal_title:Journal of periodontology
pub_type: 社论
doi:10.1002/JPER.18-0553
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Peri-implantitis treatments are mainly based on protocols for teeth but have not shown favorable outcomes for implants. The potential role of titanium dissolution products in peri-implantitis necessitate the consideration of material properties in devising treatment protocols. We assessed implant cleaning in...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0186
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.6.867
更新日期:2005-06-01 00:00:00