Abstract:
BACKGROUND:The habit of chewing areca quid (AQ) has been implicated in oral pathogenesis, including periodontal disease. Little is understood about the roles of AQ in the cytokine secretion by immune cells. The study examined the effects of areca nut, the major ingredient of AQ, on the production of interleukin (IL)-6 and IL-8 by peripheral blood mononuclear cells (PBMC), the immunocompetent cells. The possible role of oxidative stress of areca nut was also examined. METHODS:Extracts of ripe areca nut (rANE) and tender areca nut (tANE) were examined for their cytotoxic effects on human PBMC using the trypan blue exclusion test. The production of IL-6 and IL-8 by ANE-treated PBMC was analyzed using enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. Effects of an antioxidant, pyrrolidine dithiocarbamate (PDTC), on ANE-induced cytokine secretion were also studied. RESULTS:At the experimental conditions, 20 micro g/ml rANE decreased cell viability significantly, whereas no significant effect of tANE (< or =80 micro g/ml) was observed. Both rANE (< or =20 micro g/ml) and tANE (< or =160 micro g/ml) significantly increased the secretion of IL-6 and IL-8 by PBMC in a dose- and time-dependent manner. The altered mRNA expression of IL-6 by rANE and tANE was also observed. Moreover, the stimulating effects of rANE on cytokine expression in PBMC could be attenuated by PDTC, suggesting that the oxidative stress of rANE may play a role. CONCLUSIONS:Markedly enhancing effects of ANE on PBMC-released inflammatory cytokines might cause a sustained cytokine-rich inflammatory milieu in oral cavity of AQ chewers. These excessive cytokines from ANE-treated immune cells may impair periodontal health.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Chang LY,Wan HC,Lai YL,Liu TY,Hung SLdoi
10.1902/jop.2006.060039subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1969-77issue
12eissn
0022-3492issn
1943-3670journal_volume
77pub_type
杂志文章abstract:BACKGROUND:Maintaining normal weight, engaging in the recommended level of exercise, and eating healthy food are known to improve general health. The impact of these behaviors on periodontal health is not well documented. This study is aimed at examining whether the increased number of these behaviors is associated wit...
journal_title:Journal of periodontology
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更新日期:1998-12-01 00:00:00
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1982.53.7.439
更新日期:1982-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2010.100176
更新日期:2010-10-01 00:00:00
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.6.567
更新日期:1999-06-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.12.805
更新日期:1988-12-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.77.1.103
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.1981.52.2.99
更新日期:1981-02-01 00:00:00
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更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1902/jop.2004.75.2.306
更新日期:2004-02-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0107
更新日期:2020-07-01 00:00:00
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journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.11s.51
更新日期:1985-11-01 00:00:00