Abstract:
BACKGROUND:Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects during the surgical treatment of patients with periodontitis. METHODS:Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1% ALN gel or placebo gel during periodontal surgeries. Full-mouth periodontal examination was performed at baseline and at 3 and 6 months after surgical treatment. Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were recorded as the clinical outcomes. Bone defects were evaluated by digital subtraction radiography (DSR) at baseline and 6 months post-treatment. Analyses were performed through Fisher, Kruskal-Wallis, and ANOVA tests and a generalized estimation equations method. RESULTS:Both ALN and placebo groups showed significant improvements in BOP, PD, and CAL after periodontal surgical procedures (P < 0.001). Intergroup analysis showed significantly better outcomes in the ALN group with higher PD reduction and clinical attachment gain. DSR showed positive effects on periodontal bone repair strongly associated in the ALN group (P < 0.001). CONCLUSION:Topical application of 1% ALN may be a promising and beneficial adjuvant for the treatment of intrabony defects during surgical periodontal therapy.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Carvalho Dutra B,Oliveira AMSD,Oliveira PAD,Miranda Cota LO,Silveira JO,Costa FOdoi
10.1002/JPER.19-0160subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1079-1087issue
10eissn
0022-3492issn
1943-3670journal_volume
90pub_type
杂志文章,随机对照试验abstract::Interproximal bony defects were treated with either porous hydroxyapatite (PHA) or decalcified freeze-dried bone allograft (DFDB) implants at two different clinical centers. Twelve paired defects in 12 patients were treated at each center. Six months post-surgically the defects were measured to assess changes from the...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1990.61.7.399
更新日期:1990-07-01 00:00:00
abstract::Some confusion exists in the literature whether correlations exist between gingivitis severity and plaque levels as measured by the corresponding indices. The results of a clinical trial and a re-analysis of literature data indicate that a strong statistical correlation exists between the Löe-Silness Gingival Index va...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.4.172
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Susceptibility to periodontal infections may, in part, be genetically determined. Porphyromonas gingivalis is a major periodontopathogen, and the immune response to this organism requires T-cell help. The aim of the present study was to examine the specific T-cell cytokine responses to P. gingivalis outer me...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.6.591
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:A wide selection of Interdental Oral Hygiene (IOH) aids is available to consumers. Recommendations for selection are, however, limited by the lack of direct comparisons in available studies. We aimed to assess the comparative efficacy of IOH aids using Bayesian Network Meta-Analysis (BNMA). METHODS:Two inde...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/JPER.17-0368
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140171
更新日期:2014-12-01 00:00:00
abstract::The purpose of this study was to clinically evaluate the effectiveness of polytetrafluoroethylene membranes in the healing of interproximal Class II furcation defects in maxillary molars using a surgical treatment technique based on the principles of guided tissue regeneration. Eight subjects with similar bilateral Cl...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1998.69.9.1020
更新日期:1998-09-01 00:00:00
abstract::This study was undertaken to provide histologic observations on the effectiveness of citric acid and tetracycline HCl root surface demineralization when used in conjunction with guided tissue regeneration (GTR) procedures. Eight beagle dogs with naturally-occurring periodontitis were initially treated with scaling and...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.11.1052
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Many studies have shown that periodontal disease can be successfully treated. However, there is limited documentation as to what happens when periodontal disease is left untreated. This study examined patients in a private practice who were diagnosed with periodontal disease and did not complete any treatmen...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.5.672
更新日期:2003-05-01 00:00:00
abstract::The oral hygiene, the gingival condition, pocket depth, and the incidence of caries on crowned teeth were studied during a period of 5 years in a group of patients (114) who had been treated with fixed dental prostheses. Prior to the prosthetic treatment, the patients received periodontal treatment. During the study, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1977.48.4.221
更新日期:1977-04-01 00:00:00
abstract::The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-inci...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.12.1231
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:A subcategory of chronic neutropenia is chronic benign neutropenia, which is characterized by a prolonged non-cyclic neutropenia as the sole abnormality, with no underlying disease to which the neutropenia can be attributed. Chronic neutropenia is defined as a low absolute neutrophil count for >6 months. In ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.060076
更新日期:2006-11-01 00:00:00
abstract::The purpose of this study was to determine which treatment of a large osseous defect adjacent to an endosseous dental implant would produce the greatest regeneration of bone and degree of osseointegration: barrier membrane therapy plus demineralized freeze-dried bone allograft (DFDBA), membrane therapy alone, or no tr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.10.933
更新日期:1997-10-01 00:00:00
abstract::Periodontitis is a chronic inflammatory disease of the soft and hard supporting tissues of the teeth and is a major cause of tooth loss in adults. The local host response to periodontopathic bacteria results in the release of inflammatory mediators and cytokines. Since cytokines are indicative of effector functions, w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.5.515
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The main aim of treatment for acute necrotizing periodontal disease is fast and effective reduction of anaerobic destructive microorganisms to avoid periodontal damage. The effect of adjunctive local oxygen therapy in the treatment of necrotizing periodontal disease was examined in this study. METHODS:Thirt...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2006.77.1.31
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Today, implants are placed using both non-submerged and submerged approaches, and in 1- and 2-piece configurations. Previous work has demonstrated that peri-implant crestal bone reactions differ radiographically under such conditions and are dependent on a rough/smooth implant border in 1-piece implants and ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.9.1412
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Microbial internal contamination of oral implants has been suggested as being responsible for inflammatory infiltration of peri-implant tissues at the fixture-abutment interface of 2-stage and 2-component implant systems; it is also considered as a potential source of pathogens. The present in vivo study eva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.12.1652
更新日期:2001-12-01 00:00:00
abstract::1. The subjective separation of the normal and the diseased periodontium for splinting purposes is artificial. With the exception of cases of secondary trauma from occlusion, the diseased periodontium should be treated in the same manner as the normal periodontium with regards to splinting. 2. Retionales for stabiliza...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1976.47.7.405
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Unsupervised clustering is a method used to identify heterogeneity among groups and homogeneity within a group of patients. Without a prespecified outcome entry, the resulting model deciphers patterns that may not be disclosed using traditional methods. This is the first time such clustering analysis is appl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0489
更新日期:2020-12-14 00:00:00
abstract::Clinical and laboratory data were compared in 72 patients with localized periodontitis (LP) and 103 patients with generalized periodontitis (GP). Significantly more LP than GP cases had decreased neutrophil chemotaxis (CTX), and were seropositive for Actinobacillus actinomycetemcomitans (Aa). Significantly, more GP ca...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.10.557
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The purpose of this clinical study was to evaluate the possible influence of testosterone hormone on common clinical measurements of periodontal disease in men with hypergonadotropic hypogonadism. METHODS:Twenty-four hypergonadotropic hypogonadal men (H) and 24 systemically healthy men (S) were divided into...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050286
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:There is a large amount of data on surgical root coverage procedures for the treatment of gingival recessions but no controlled clinical trials on the behavior of marginal gingiva following non-surgical therapy. The aim of our study was to compare in terms of root coverage two different modalities of root su...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.2.256
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to longitudinally evaluate, over a 3-year period, the reduction of gingival recession through use of a subepithelial free connective tissue graft placed under a coronally advanced partial-thickness pedicle flap. METHODS:Twenty-one buccal recession defects (mean 3.67 mm; range 3...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2002.73.12.1412
更新日期:2002-12-01 00:00:00
abstract::Three block sections of treated human intraosseous lesions within one individual are presented. These lesions were debrided, filled with autogenous grafts and at two sites the root was treated with citric acid. The treated sites were lightly root planed once a month and the blocks were removed 6 months after surgery. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.2.67
更新日期:1983-02-01 00:00:00
abstract::Fresh and frozen allogeneic iliac grafts were used in surgically prepared intraosseous defects. Four adult rhesus monkeys provided 19 specimens from 0 to 56 days postoperative. There were 8 specimens for each type of graft and 3 others used as controls. Histologic sections from each specimen were prepared and a descri...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.4.187
更新日期:1976-04-01 00:00:00
abstract::Formation of the junctional epithelium was studied by routine light microscopy in the molar teeth of commercially slaughtered pigs. It was found that the process whereby the reduced enamel epithelium (REE) contributed to the junctional epithelium formation corresponded largely with changes in man previously described ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.3.164
更新日期:1986-03-01 00:00:00
abstract::Temporary splints to immobilize periodontally diseased teeth were made by fiber glass bonded and attached to the teeth with acid-etch technique with BIS-GMA resin. Twenty-one splints were made. Observation time ranged from 4 to 14 months. During the observation only one splint fractured and was repaired while the othe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.4.193
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorh...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120616
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The great variability of periodontal and systemic responses to experimental periodontitis reflects the inherent pathogenic complexity of mice models and could limit the resulting interpretations and their extension to human diseases. This study compared the effect of Porphyromonas gingivalis (Pg) infection a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110540
更新日期:2013-03-01 00:00:00
abstract::Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this review, the common pathologic mechanisms of these two common chronic conditions are explored. Emerging evidence now suggests a strong relationship between the extent and severity of periodontal disease and RA. While this rela...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11-S.2066
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:β-glucuronidase (βG) is one of the enzymes involved in the destruction of non-collagenous components of the extracellular matrix. It is also considered an indicator or predictor of periodontal disease activity. The present study was conducted to determine the presence and the levels of βG activity in gingiva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.4.618
更新日期:2000-04-01 00:00:00