Abstract:
BACKGROUND:Bleeding indices are used as a screen for periodontal disease activity, a measure of disease prevalence, and a measure of effectiveness in clinical trials. Bleeding on probing (BOP) is widely interpreted as a sign of disease activity whereas its absence is interpreted as both a sign and predictor of health. Aspirin use has become increasingly common in the prevention of cerebrovascular and cardiovascular diseases. Because of its anti-platelet activity, aspirin is a non-disease factor that has the potential to affect the appearance of BOP. The hypothesis being tested is that short-term aspirin use in doses of 81 mg and 325 mg will increase the number of bleeding sites in a population with gingivitis. METHODS:Fifty-four subjects were screened initially, those subjects with 20% to 30% whole mouth BOP were randomly assigned to one of three arms: placebo group, 81 mg aspirin group, or 325 mg aspirin group. Before and after exposure to the respective regimens, clinical parameters were measured on all the teeth: the plaque index was recorded at four sites per tooth, and probing depth and BOP were evaluated at six sites per tooth using an automated pressure-sensitive probe. RESULTS:The data obtained in this clinical trial were analyzed utilizing a linear regression analysis to control for confounding variables. The primary measure of interest was BOP in patients clinically demonstrating naturally occurring gingivitis. The results of this study indicate that while controlling for age, gender, and plaque, "low dose" 81 mg and "regular dose" 325 mg of aspirin demonstrated a statistically significant 5.30 (P = 0.001) and 4.13 (P = 0.010) increase from baseline, respectively, in percent BOP. CONCLUSION:Failure to consider the effects of aspirin on BOP could impair proper diagnosis and treatment planning for clinicians and introduce a significant confounding variable in research situations.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Royzman D,Recio L,Badovinac RL,Fiorellini J,Goodson M,Howell H,Karimbux Ndoi
10.1902/jop.2004.75.5.679subject
Has Abstractpub_date
2004-05-01 00:00:00pages
679-84issue
5eissn
0022-3492issn
1943-3670journal_volume
75pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Various forms of stress behavior were documented and in patients with periodontitis their relationship with periodontal disease was investigated. METHODS:Eighty-nine patients with different forms of chronic periodontitis were included in this retrospective case-control study. They were all undergoing period...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.11.1343
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:The use of nanoparticles of graft materials may lead to breakthrough applications for periodontal regeneration. However, due to their small particle size, nanoparticles may be eliminated from periodontal defects by phagocytosis. In an attempt to improve nanoparticle retention in periodontal defects, the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2013.120701
更新日期:2013-12-01 00:00:00
abstract::The morphotypes of the subgingival microflora from 85 12 to 18-year-old Finnish adolescents with insulin-dependent diabetes mellitus (IDDM) were studied in Gram- and Rhodes-stained smears. A comparison was made with subgingival plaque samples from paired age- and sex-matched healthy controls. Significant differences w...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.9.526
更新日期:1989-09-01 00:00:00
abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1985.56.1.18
更新日期:1985-01-01 00:00:00
abstract::The Keyes technique came to national attention following a reference in The New York Times in the late 1970s. Several lay press articles and discussions on national television served to further focus the interest of patients, general dentists, and periodontists on this potential approach to periodontal therapy. Early ...
journal_title:Journal of periodontology
pub_type: 杂志文章,收录出版
doi:
更新日期:1998-08-01 00:00:00
abstract::The laser reflection method of remote measurement was used to register small tooth movements of upper central incisors from a group of subjects with healthy teeth and another group with periodontally involved teeth. The mobility of the healthy maxillary incisors over a period of 24 hours was well within normal limits....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.7.439
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assesses the long-term "biologic remodeling" of periodontal dimensions of teeth treated with free gingival grafts (FGGs) compared with adjacent/untreated teeth. METHODS:Seventy-four patients...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170010
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120490
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The objective of this study was to systematically review the diagnostic criteria, indications, and need for treatment of ankyloglossia (tongue-tie), as well as the various treatment options for patients in different age groups. METHODS:The MEDLINE databases and the Cochrane Library were searched according t...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2009.090086
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Aspartate aminotransferase (AST) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. Its levels are associated with the severity of experimental gingivitis and the loss of periodontal attachement. The aim of the present study was to investig...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.7.1151
更新日期:2000-07-01 00:00:00
abstract::Clinical and laboratory data were compared in 72 patients with localized periodontitis (LP) and 103 patients with generalized periodontitis (GP). Significantly more LP than GP cases had decreased neutrophil chemotaxis (CTX), and were seropositive for Actinobacillus actinomycetemcomitans (Aa). Significantly, more GP ca...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1989.60.10.557
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.10.1335
更新日期:2004-10-01 00:00:00
abstract::Greater cell attachment to demineralized dentin has been associated with subsequent development of a fiber attachment system. The purpose of this study was to evaluate tissue interactions to dentin demineralized with different concentrations of tetracycline solution. Dentin specimens were obtained from beneath root su...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1988.59.11.714
更新日期:1988-11-01 00:00:00
abstract::This investigation was conducted on seven individuals referred for treatment of moderate adult periodontitis. Twenty-eight sites with an average probing depth of 5.6 +/- 0.9 mm were evaluated. One tooth per jaw quadrant was randomly assigned to receive one of the following treatments: (I) no treatment, i.e., control; ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1988.59.5.301
更新日期:1988-05-01 00:00:00
abstract::The aim of this controlled clinical trial was to assess the effect on healing following tetracycline (TTC) conditioning and fibrin-fibronectin sealing system (FFSS) application in association with flap debridement surgery (FDS) in 11 patients under treatment for moderate to severe periodontitis. Selection criteria inc...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1996.67.7.688
更新日期:1996-07-01 00:00:00
abstract::Several different types of interactions are possible between a chemical, a mixture of chemicals, and associated extrinsic factors (i.e., mechanical irritation) in the oral mucosa. These interactions can be broadly classified as irritative or allergenic in nature. In each case, the pathology usually includes mucosal in...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1998.69.6.620
更新日期:1998-06-01 00:00:00
abstract::Despite the improvement in the patients' oral hygiene, there was no significant decrease in the frequency of bacteremia. There was no significant difference in bacteremia between brushing, flossing, or deplaquing either before or after initial periodontal preparation and plaque control in 21 healthy subjects. Utilizin...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1976.47.12.683
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Guided bone regeneration (GBR) using a non-absorbable barrier has provided clinicians the ability to place implants in sites compromised by insufficient bone, including immediate extraction sites. Recent evidence suggests that successful GBR outcomes may be possible using bioabsorbable polymer barriers. MET...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.2.250
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have inability to maintain the normal levels of protein metabolism products, blood pressure and hematocrit. Periodontal disease involves an inflammatory destructive process. Identification of opportunistic viruses is extremely important as they are associated with c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0583
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2008.070558
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100250
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Periopathogens and cariogenic species survive more than 48 hours on toothbrushes even under dry storage. This study examined a decontamination of toothbrushes by means of the bactericidal effect of different toothpastes or a special coating of the tufts. METHODS:Eight untreated periodontitis patients were p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.3.312
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein-Barr virus type-1 (EBV-1), seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was to evaluate the subgingival presence of HCMV and EBV in patients with aggress...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.11.1634
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:The interproximal dental papilla is considered an essential component of the anterior and posterior regions of the maxilla and mandible. The absence of this structure has esthetic and phonetical consequences and lateral food impaction problems occur with the implant-supported prosthesis. The aims of the pres...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.9.1242
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Mechanical periodontal therapy consists of a non-surgical course, followed by surgical treatment to eliminate or reduce remaining pathological pockets. Only if diligent mechanical therapy fails are additional measures considered. It has been documented that smoking interferes with the host defense mechanisms...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.10.1166
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS:Gingival biopsy samples collected from 14 subjects during a 28-day stent-induce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080645
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Several studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to investigate the association between the circulating proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, prostaglandin E(2), serotonin, rheumatoid ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070599
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160273
更新日期:2017-02-01 00:00:00
abstract::This investigation studied the changes in probing depths and subgingival microbial flora of clinically healthy and diseased sites before and after scaling and root planing. Thirty-six sites in 18 individuals were studied in two groups of patients, Group I (9 patients) had received no periodontal surgery, while group I...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.7.391
更新日期:1984-07-01 00:00:00
abstract::The American Academy of Periodontology has developed the following parameter on the treatment of chronic periodontitis with slight to moderate loss of periodontal supporting tissues. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their respo...
journal_title:Journal of periodontology
pub_type: 指南,杂志文章,实务指引
doi:10.1902/jop.2000.71.5-S.853
更新日期:2000-05-01 00:00:00