Abstract:
:The aim of this controlled clinical trial was to assess the effect on healing following tetracycline (TTC) conditioning and fibrin-fibronectin sealing system (FFSS) application in association with flap debridement surgery (FDS) in 11 patients under treatment for moderate to severe periodontitis. Selection criteria included the presence of two bilateral, homologous, non-molar, interproximal sites with probing depth > or = 5 mm. The areas bilateral to the trial sites were matched for number and type of the teeth, and similar periodontal involvement. After initial therapy, a split-mouth design was used in which one area was treated by flap debridement surgery alone (control), and the contralateral area was treated following surgery with a 4-minute burnishing application of 100 mg/ml TTC solution and FFSS (test). Fibrin glue was applied with a syringe on the demineralized root surfaces and surrounding bone margins. Healing by primary intention was encouraged by flap repositioning with interrupted sutures left in place for 14 days. A monthly maintenance recall program was followed. Patients were clinically evaluated at baseline and 6 months and the following measurements were taken: gingival index, plaque control record, clinical attachment level, probing depth, recession, bleeding on probing. Statistical evaluation indicated that both approaches resulted in significant probing depth reduction and clinical attachment gain. However, the differences in healing between the test and control groups were not clinically nor statistically significant. These results suggest there is no additional benefit with TTC demineralization and topical FFSS application in conjunction with flap debridement surgery.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Trombelli L,Scabbia A,Scapoli C,Calura Gdoi
10.1902/jop.1996.67.7.688subject
Has Abstractpub_date
1996-07-01 00:00:00pages
688-93issue
7eissn
0022-3492issn
1943-3670journal_volume
67pub_type
临床试验,杂志文章,随机对照试验abstract::The purpose of this study was to provide additional evidence that in the lesions of acute necrotizing ulcerative gingivitis (ANUG), spirochetes and other microorganisms are capable of invading the nonnecrotic lamina propria of affected gingivae. Biopsies from eight patients with pathognomonic signs of ANUG were obtain...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.11.671
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The possible association between oral infection and chronic inflammation and cardiovascular disease risk has been studied intensively. The present study is designed to determine the strength of association between edentulism and angina pectoris in Mexican adults aged 35 years and older. METHODS:Using the to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130186
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:A major challenge for dental implantology is to consistently obtain appropriate bone augmentation before implant placement. The aim of this study is to evaluate the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) associated with bone substitute materials beta-tricalcium phosphate (β-TCP), ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110674
更新日期:2013-03-01 00:00:00
abstract::The laser reflection method of remote measurement was used to register small tooth movements of upper central incisors from a group of subjects with healthy teeth and another group with periodontally involved teeth. The mobility of the healthy maxillary incisors over a period of 24 hours was well within normal limits....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.7.439
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Unsupervised clustering is a method used to identify heterogeneity among groups and homogeneity within a group of patients. Without a prespecified outcome entry, the resulting model deciphers patterns that may not be disclosed using traditional methods. This is the first time such clustering analysis is appl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0489
更新日期:2020-12-14 00:00:00
abstract::The literature related to smoking and periodontal disease is reviewed. The effects of smoking on oral hygiene, gingivitis, necrotizing gingivitis, periodontitis, bacteria and the host's response are presented. From this review it is apparent that while the relationship between smoking and periodontal disease needs fur...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1986.57.10.617
更新日期:1986-10-01 00:00:00
abstract::THIS INVESTIGATION was undertaken to determine the distribution pattern and readability level of 20 widely distributed printed items containing periodontal health education literature. Average annual distribution was obtained from distributors of the material. The Minnesota Interactive Readability Approximation Progra...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1983.54.9.538
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential correlations between detached subgingival bacteria collected in gingival crevicular fluid (GCF) an...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0295
更新日期:2020-07-31 00:00:00
abstract::A classical treatment for chronic adult periodontitis consists of four to six consecutive sessions of scaling and root planing at a 1- to 2-week interval. Such a so-called "quadrant or sextant therapy" might result in a reinfection of a previously disinfected area by bacteria from an untreated region. The purpose of t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1996.67.12.1251
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs. METHODS:Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0107
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Systemic bone loss has been proposed as a risk factor for periodontal disease; however, the relationship between these two diseases is still not clear. The objective of this study was to assess the relationship between systemic bone mineral density and periodontal disease, controlling for known confounders. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.9.1492
更新日期:2000-09-01 00:00:00
abstract::A study was conducted to evaluate the effects of repeated hand instrumentation on the marginal portion of a cast gold crown. Seven extracted periodontally diseased premolars were used. The finishing line of the preparation was placed on the root surface and then the crown was cast and cemented in the usual manner. One...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.1.41
更新日期:1998-01-01 00:00:00
abstract::The purpose of this study was to examine the effect of inflammatory cytokines on IFN-γ-induced HLA-DR expression on cultured human gingival fibroblasts by flow cytometry. Natural human IFN-γ, recombinant human interleukin-1β (rhIL-1β), and rh tumor necrosis factor-α (rhTNF-α) were used. IFN-γ-induced upregulation of H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.4.336
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to: 1) test hypotheses that behavioral factors, baseline clinical status, and incident tooth loss are significantly associated with attachment loss incidence (ALI) and 2) quantify the effect of incident tooth loss on conclusions made about ALI. METHODS:The Florida Dental Ca...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.7.1161
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Reduction of alveolar height and width after tooth extraction may present problems for implant placement, especially in the anterior maxilla where bone volume is important for biologic and esthetic reasons. Different graft materials have been proposed to minimize the reduction in ridge volume. The aim of thi...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2009.080400
更新日期:2009-02-01 00:00:00
abstract::Oral malodor was measured using a portable sulphide monitor in 2,672 individuals aged 18 to 64 years. In addition, dental (DMFT) and periodontal conditions (CPITN and attachment loss), dental plaque, and tongue coating status were assessed. Before clinical examination, subjects were interviewed about their oral health...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.8.679
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:The baseline periodontal examination is reported to be a painful dental procedure, but currently there are limited practical techniques to reduce this pain. The objective of this study is to evaluate the efficacy of an intrapocket anesthetic gel in the reduction of pain on periodontal probing in a group of u...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.110106
更新日期:2012-12-01 00:00:00
abstract::The American Academy of Periodontology has developed the following parameter on the treatment of "refractory" periodontitis. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their responsibility in treatment. Consequences of no treatment shoul...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.5-S.859
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase-8 (MMP-8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. METHODS:Twelve chronic periodontitis patients received ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.1.103
更新日期:2002-01-01 00:00:00
abstract::The placement of hydroxyapatite-coated dental implants in fresh extraction sockets was compared to placement in adjacent healed sites in 14 patients. Systematic sequential documentation was obtained regarding periodontal health, radiographic bone levels, and implant stability at the time of implant placement, at uncov...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.7.468
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate cli...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2017.170126
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Gaucher's disease (GD) is a lysosomal storage disease with a high incidence in Ashkenazi Jews. The disease is caused by an autosomally recessive inherited deficiency of the lysosomal enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside in macrophages. The lipid-laden macrophages, called...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2007.060341
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The specific advantage of administering systemic antibiotics during initial, non-surgical therapy or in the context of periodontal surgery is unclear. This study assesses the differential outcomes of periodontal therapy supplemented with amoxicillin-metronidazole during either the non-surgical or the surgica...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2014.140478
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Previous studies have focused on antibiotic resistance of Gram-negative bacteria before and after periodontal therapy. The purpose of this analysis is to assess changes in resistance patterns of the commensal Gram-positive microbiota. The viridans group streptococci (VGS) have been suggested to serve as rese...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.150494
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Chemically modified non-antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix metalloproteinase, MMP) activity and bone resorption in vivo and in vitro. METHODS:In the current study, suboptimal doses of CMT-8 (a non-antimicrobial chemically modif...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.8.1069
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to evaluate the safety, patient acceptance, and short-term microbiologic effect of a new air-polishing device in subjects in maintenance care with residual pockets > or =5 mm. METHODS:This was an examiner-masked, randomized, split-mouth clinical trial. A new disposable nozzle, a...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2009.090394
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:This study evaluated patients who had been treated with recombinant human bone morphogenetic protein-2 (rhBMP-2) loaded in an absorbable collagen sponge (ACS) in human extraction sites or in sites that required alveolar ridge augmentation. An earlier report on the same patients revealed that after 4 months, ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2000.71.8.1241
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:The aim of the present review is to systematically evaluate the effects of autogenous platelet concentrates on clinical outcomes of the surgical treatment of periodontal diseases. METHODS:MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched using a combination of specific se...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1902/jop.2010.100605
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:A novel injectable, fast setting calcium phosphate cement (CPC) is currently used in orthopedic therapy for bone fractures. This study evaluated the possibility of applying this cement to healing periodontal defects. METHODS:Fenestrations and 3-walled periodontal defects were surgically created on bilateral...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.9.1043
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Gingival thickness, keratinized tissue width, and bone morphotype are three important parameters used to categorize periodontal phenotypes. These elements all play an important role in the maintenance of periodontal health. The aim of this review is to explore the importance of converting thin phenotype into...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1002/JPER.19-0337
更新日期:2020-03-01 00:00:00