Abstract:
BACKGROUND:A major challenge for dental implantology is to consistently obtain appropriate bone augmentation before implant placement. The aim of this study is to evaluate the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) associated with bone substitute materials beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), and bovine bone mineral on vertical guided bone regeneration (GBR) in rabbit calvarium. METHODS:Four titanium cylinders were fixed to the calvarium of 22 rabbits. In group 1 (n = 10), three cylinders were randomly filled with one of the test materials, and one cylinder was filled with a blood clot (CL). In group 2 (n = 12), the cylinders were randomly assigned to the same materials and CL but with the addition of rhBMP-2. Bone labels were injected over the course of 13 weeks, and euthanasia was performed 14 weeks after surgery in both groups. RESULTS:The mean volume and area of tissue growth was greater in group 2 (with rhBMP-2) than in group 1 (without rhBMP-2), irrespective of the material used (P <0.001). The mean volume of tissue growth in the CL cylinder was smaller than that observed with all other materials (P <0.001) in both groups. The mean area of regenerated bone in the CL cylinder was smaller than that observed in the β-TCP cylinder (P = 0.028). The histologic study revealed more lamellar bone in the rhBMP-2 group, with a greater level of biodegradation of all the bone substitute materials tested. CONCLUSION:The use of rhBMP-2/absorbable collagen sponge (ACS) combined with all of the bone substitute materials tested resulted in a greater amount of bone formation than that produced with the bone substitute materials alone or rhBMP-2/(ACS) and CL using the rabbit calvarium GBR model.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Polo CI,Lima JL,De Lucca L,Piacezzi CB,Naclério-Homem Mda G,Arana-Chavez VE,Sendyk WRdoi
10.1902/jop.2012.110674subject
Has Abstractpub_date
2013-03-01 00:00:00pages
360-70issue
3eissn
0022-3492issn
1943-3670journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Systemic bone loss has been proposed as a risk factor for periodontal disease; however, the relationship between these two diseases is still not clear. The objective of this study was to assess the relationship between systemic bone mineral density and periodontal disease, controlling for known confounders. ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.9.1492
更新日期:2000-09-01 00:00:00
abstract::As more types of implants have become available, clinicians have been faced with the task of choosing a specific implant from a wide array of options for a given clinical situation, which has led to an ever-increasing need for clinical evidence to help clinicians choose an implant. This article highlights the need for...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090265
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS:We conducted a case-control study of 581 COPD...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110472
更新日期:2012-10-01 00:00:00
abstract::A previous multi-center study examining patients diagnosed as having at least four periodontally diseased teeth showed that when BANA (N-Benzoyl-DL-Arginine-Naphthylamide) hydrolysis by periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus was evaluated versus clinical ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.9.848
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Hyaluronic acid (HA) has shown anti-inflammatory effects in gingivitis therapy. The potential benefits of local subgingival application of HA adjunctive to scaling and root planing (SRP) were evaluated in this study. METHODS:Twenty patients with chronic periodontitis were included in this split-mouth study....
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2004.75.8.1114
更新日期:2004-08-01 00:00:00
abstract::The laser reflection method of remote measurement was used to register small tooth movements of upper central incisors from a group of subjects with healthy teeth and another group with periodontally involved teeth. The mobility of the healthy maxillary incisors over a period of 24 hours was well within normal limits....
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.7.439
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiologi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.6.646
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:This study evaluates the effects on clinical and biochemical parameters of Lactobacillus reuteri-containing probiotic supplementation adjunctive to initial periodontal therapy in patients with chronic periodontitis (CP). METHODS:Thirty patients with CP were included and divided into two groups. Every patien...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.140612
更新日期:2015-06-01 00:00:00
abstract::Recent evidence suggests that dental plaque is not a homogeneous bacterial mass but, on the contrary, specific bacterial morphotypes and species may be preferentially located within certain microenvironments. The aim of the present study was to develop combined gold immunolabeling and scanning electron microscopic (SE...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.5.249
更新日期:1990-05-01 00:00:00
abstract::Probing pain threshold (PPT) assessments were conducted in the facial and oral sulci of maxillary central incisors and first molars of 10 periodontally healthy adults. All subjects were systemically healthy, free of pain, and reported no current medication usage. A computer-linked electronic probe, modified to deliver...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.7.812
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Several recent studies have indicated that total antioxidant capacity (TAOC) of plasma seems to be compromised in chronic periodontitis (ChP). The aim of this study is to investigate plasma TAOC in patients with ChP and to assess the effects of vitamin C as an adjunct to non-surgical periodontal treatment. ...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2010.100173
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:There is limited information about two-part implants placed in subcrestal positions. The aim of this study is to retrospectively evaluate the 1-year outcome of implants placed non-submerged and in a subcrestal position. METHODS:Records of 50 consecutive partially edentulous patients restored with dental imp...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090317
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigens (HLAs) are a basic precondition to induce the immune response to pathogens. Therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and HLAs to test their impact together with additional risk factors in multivariate analyses. METHODS:Eig...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.110545
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:A disintegrin and metalloproteinase 28 (ADAM28) is considered to be the possible virulence gene for congenital hypoplasia of tooth root. Periodontal ligament stem cells (PDLSCs) are regarded as playing crucial roles in the developing process of the periodontium and are generally used in dental regenerative m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090703
更新日期:2010-06-01 00:00:00
abstract::Histiocytosis X, a reticuloendothelial disorder, includes the three clinical syndromes: Letterer-Siwe and Hand-Schuller-Christian diseases and eosinophilic granuloma of the bone. Twenty-eight cases of adult onset of histiocytosis X involving the head and neck region were found in the literature during the past 20 year...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1989.60.1.57
更新日期:1989-01-01 00:00:00
abstract::The responses of four tooth/site groupings to periodontal therapy were evaluated. Eighty-two patients with periodontitis were treated in a split mouth design with coronal scaling, root planing, modified Widman surgery, and flap with osseous resectional surgery. Patients were evaluated prior to therapy, 4 weeks post-Ph...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1990.61.3.173
更新日期:1990-03-01 00:00:00
abstract::We review the basic functions of neurotrophins and their receptors and discuss the expression and functions of neurotrophins and their specific receptors based on recent data using cultured cells from human periodontal tissues. Neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neu...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.1.76
更新日期:2003-01-01 00:00:00
abstract::Chlorhexidine in an alcohol vehicle with flavoring agents has been used as a mouthrinse to reduce plaque accumulation in periodontal surgery patients. The purpose of this study was to evaluate the effects of a chlorhexidine-containing mouthrinse on the early tensile wound strength of healing surgical wounds in the rat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.8.719
更新日期:1993-08-01 00:00:00
abstract::Proposing to place endosseous implants is an integral facet of dental treatment plans. Their insertion is usually associated with a low incidence of untoward events. However, despite careful planning, surgical complications can arise: infection, intraoral hemorrhage, wound dehiscence, postoperative pain, lack of prima...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2008.070067
更新日期:2008-08-01 00:00:00
abstract::A case is presented in which an unusual amount of intraoral calculus was seen in a 59-year-old woman. The deposits completely covered all surfaces of most teeth and extended over the facial and lingual gingivae. The relationship between certain chemical salivary parameters and heavy calculus formers is briefly describ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.6.326
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:Osteoblasts and periodontal ligament stem cells (PDLSCs) play an important role in maintaining physiologic function of periodontal tissues and participating in periodontal regeneration. Elucidation of interactions between osteoblasts and PDLSCs will aid understanding of periodontal regeneration mechanisms. T...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170016
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:This cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. METHODS:Samples from 97 implants/teeth (58 implants [19 hea...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.160751
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Titanium (Ti) dental implants have been widely used for prosthetic reconstruction of dentition. Unfortunately, peri-implantitis can result in failure of dental implant osseointegration. Lipopolysaccharide (LPS) acts as a chronic inflammatory stimulus and maintains peri-implant inflammation, worsening the pro...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140386
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assesses the long-term "biologic remodeling" of periodontal dimensions of teeth treated with free gingival grafts (FGGs) compared with adjacent/untreated teeth. METHODS:Seventy-four patients...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170010
更新日期:2017-07-01 00:00:00
abstract::This is a posthumous interview with Dr. Maynard K. Hine (MKH), the second editor of the Journal of Periodontology (from 1950 to 1970), as prepared by Dr. David C. Vandersall (DCV). Dr. Vandersall was a colleague of Dr. Hine while serving as associate clinical professor of periodontics at the Indiana University School ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.781
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1508
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Non-surgical and surgical periodontal treatment may cause volumetric changes in the gingival contour. Many techniques have been suggested to minimize soft tissue shrinkage; however, there is a lack of three-dimensional (3D) quantitative data comparing different treatment approaches. The aim of the present st...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080288
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Metastasis of a malignant tumor to the oral cavity is rare, but it can be the first manifestation of a primary tumor. METHODS:The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described. A 57-year-old woman showed a rapidly growing, painless...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070246
更新日期:2008-01-01 00:00:00
abstract::Ten mouse monoclonal antibodies were prepared against cultured bovine periodontal ligament cells to be used as reagents for the study of periodontal disease and wound healing. Using standard immunohistochemical methods, these antibodies were found to recognize cell surface antigens in formalin-fixed bovine periodontiu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.3.190
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and poor outcomes, including severe cardiovascular disease and renal osteodystrophy. With advances in medical treatment, patients with CKD are living longer and require oral care. The aim of this study is to determine the e...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090379
更新日期:2010-02-01 00:00:00