Effects of enamel matrix derivative on clinical and inflammatory outcomes in periodontal maintenance patients: Randomized controlled clinical trial.

Abstract:

BACKGROUND:Efficient methods to treat persistent pockets during periodontal maintenance therapy (PMT) require further investigation. The hypothesis of this randomized controlled clinical trial was that local application of enamel matrix derivative (EMD) added to papilla reflection/root preparation (PR/RP) could enhance clinical and inflammatory outcomes, primarily clinical attachment level (CAL). METHODS:Fifty PMT patients with generalized stage III-IV, grade B periodontitis presenting with a 6- to 9-mm interproximal PD were randomly allocated to (PR/RP+EMD; n = 24) and control (PR/RP+saline; n = 26) therapies by sex and smoking status. Roots were treated with reflection of interproximal papillae, root planing assisted with endoscope evaluation, and acid etching, followed by EMD or saline application. Probing depth (PD), CAL, plaque index (PI), and interproximal bone height were evaluated at baseline and 12-months post-therapy. Gingival crevicular fluid, bleeding on probing (BOP), and interleukin-1β were tested (ELISA) at baseline, 2 weeks, and 6 and 12 months. Groups were compared over time and between groups with Wilcoxon Rank Sum and t-tests. RESULTS:Both PR/RP+ EMD and PR/RP+S resulted in significant improvements in clinical outcomes (PD and CAL, BOP) from baseline to 12 months. No significant differences were found in clinical or inflammatory outcomes between the experimental and control groups. CONCLUSIONS:The addition of EMD to PR/RP does not significantly improve clinical or inflammatory outcomes compared with PR/RP alone during periodontal maintenance therapy.

journal_name

J Periodontol

authors

Jasa EE,Gradoville JM,Christiansen MM,Samson KK,Reinhardt RA,Payne JB,Killeen AC

doi

10.1002/JPER.19-0623

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1400-1408

issue

11

eissn

0022-3492

issn

1943-3670

journal_volume

91

pub_type

杂志文章
  • New attachment achieved by guided tissue regeneration in beagle dogs.

    abstract::This study tested the effects of using a Gore-Tex periodontal material on new connective tissue attachment in beagle dogs with natural periodontitis. Seven female beagle dogs with advanced periodontitis were selected and given thorough root debridement. Under general anesthesia four weeks later, mucoperiosteal flaps w...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.9.589

    authors: Caffesse RG,Smith BA,Castelli WA,Nasjleti CE

    更新日期:1988-09-01 00:00:00

  • Systematic errors in estimating prevalence and severity of periodontal disease.

    abstract::Partial-mouth scores are often used in epidemiologic studies to estimate the prevalence and severity of periodontal disease. Such estimates systematically underestimate the prevalence of disease, but the bias can be in either direction for disease severity. Three large data sets containing full-mouth examinations (mes...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.11.707

    authors: Kingman A,Morrison E,Löe H,Smith J

    更新日期:1988-11-01 00:00:00

  • Effects of two cetylpyridinium chloride-containing mouthwashes on bacterial plaque.

    abstract::The purpose of this single blind clinical study was to determine the effects of two commerical mouthwashes (one containing cetylpyridinium chloride and domiphen bromide and the other containing only cetlypridinium chloride) on existing plaque accumulations. A second purpose was to determine if a residual effect could ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1976.47.7.419

    authors: Barnes GP,Roberts DW,Katz RV,Woolridge ED Jr

    更新日期:1976-07-01 00:00:00

  • Interleukin-1β Gene Expression in Human Oral Polymorphonuclear Leukocytes.

    abstract::Oral polymorphonuclear leukocytes (pmn) were obtained from 10 adult donors in good oral health using a method employing repeated mouth rinse collection. Interleukin-1β (IL-1β) mRNA was detected in freshly obtained cells by blot hybridization of total cellular RNA with a biotin labeled cDNA probe. Supernates from oral ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.9.761

    authors: Hendley TM,Steed RB,Galbraith GMP

    更新日期:1995-09-01 00:00:00

  • Serum lipoprotein-associated phospholipase A₂ and C-reactive protein levels in association with periodontal disease and hyperlipidemia.

    abstract:BACKGROUND:The aim of this study is to evaluate the levels of serum lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and high-sensitivity C-reactive protein (hsCRP) in association with periodontal disease and hyperlipidemia. METHODS:A total of 123 subjects with hyperlipidemia and 68 systemically healthy controls ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100417

    authors: Fentoğlu O,Köroğlu BK,Kara Y,Doğan B,Yılmaz G,Sütçü R,Ay ZY,Tonguç MÖ,Orhan H,Tamer MN,Kırzıoğlu FY

    更新日期:2011-03-01 00:00:00

  • Periodontal surgery of vertical bony defects with or without synthetic bioabsorbable barriers. 12-month results.

    abstract::The aim of the present study was to clinically and radiographically compare guided tissue regeneration (GTR) therapy with bioabsorbable polyglactin 910 barriers and conventional periodontal surgery in intrabony defects. In 26 patients with advanced periodontitis, 29 teeth exhibiting interproximal intrabony defects wer...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1998.69.11.1210

    authors: Eickholz P,Lenhard M,Benn DK,Staehle HJ

    更新日期:1998-11-01 00:00:00

  • A placebo-controlled trial to evaluate an anesthetic gel when probing in patients with advanced periodontitis.

    abstract:BACKGROUND:The baseline periodontal examination is reported to be a painful dental procedure, but currently there are limited practical techniques to reduce this pain. The objective of this study is to evaluate the efficacy of an intrapocket anesthetic gel in the reduction of pain on periodontal probing in a group of u...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.110106

    authors: Winning L,Polyzois I,Nylund K,Kelly A,Claffey N

    更新日期:2012-12-01 00:00:00

  • Localized aggressive periodontitis in primary dentition: a case report.

    abstract:BACKGROUND:A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit. METHODS:Clinical, radiographic, histological, and microbi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.7.1060

    authors: Suzuki J,Okada M,Wang Y,Nii N,Miura K,Kozai K

    更新日期:2003-07-01 00:00:00

  • Comparison of Nd:YAG laser versus scaling and root planing in periodontal therapy.

    abstract:BACKGROUND:The Nd:YAG laser has recently been used in the treatment of periodontal disease. However, although a clinical reduction of probing depth and gingival inflammation to this new approach has been reported, it has not been fully evaluated. Interleukin-1 beta (IL- 1beta), a potent stimulator of bone resorption, h...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.11.1276

    authors: Liu CM,Hou LT,Wong MY,Lan WH

    更新日期:1999-11-01 00:00:00

  • One stage full- versus partial-mouth disinfection in the treatment of chronic adult or generalized early-onset periodontitis. II. Long-term impact on microbial load.

    abstract:BACKGROUND:Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiologi...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.6.646

    authors: Quirynen M,Mongardini C,Pauwels M,Bollen CM,Van Eldere J,van Steenberghe D

    更新日期:1999-06-01 00:00:00

  • Aspartate aminotransferase (AST) levels in human periodontium-derived cells.

    abstract::The ability to objectively assess periodontal disease activity can significantly affect periodontal therapy. Aspartate aminotransferase (AST) is released extracellularly upon tissue destruction which suggests its potential as a key index in a quantitative assay for evaluating periodontal disease activity. The purpose ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.8.733

    authors: Mizuho F,Mori H,Deguchi S,Ogawa Y,Hori T

    更新日期:1996-08-01 00:00:00

  • Experimental gingivitis in ODU plaque-susceptible rats. V. On the vascular permeability factor of dental plaque.

    abstract::Plaque-induced inflammation has been documented from various aspects, but is still not well understood. In an effort to clarify the physicochemical properties of dental plaque and to isolate the active factor which give rise to inflammation, we studied a factor in plaque which may be a direct and local cause of gingiv...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.7.400

    authors: Matsuda K,Yamanaka Y,Shen CT,Mori M

    更新日期:1980-07-01 00:00:00

  • Collagen formation at the tooth-cell interface: comparative ultrastructural study on the effect of partial demineralization of cementum with dentin.

    abstract::In order to compare the effect of partial demineralization with root planing and partial demineralization of cementum with that of dentin on healing, the ultrastructural morphology of the interface between the layer of human periodontal ligament-derived, fibroblast-like cells (HPF) and the treated root surface was stu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.4.267

    authors: Higashi T,Onzuka T,Satoh G,Yoshino H,Okamoto H

    更新日期:1995-04-01 00:00:00

  • Analysis of consecutively placed loaded root-form and plate-form implants in adult Macaca mulatta monkeys.

    abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.12.1322

    authors: Fritz ME,Braswell LD,Koth D,Jeffcoat M,Reddy M,Brogan D,Cotsonis G,Winter M,Lemons JE

    更新日期:1996-12-01 00:00:00

  • Hepatitis. A review of the disease and its significance to dentistry.

    abstract::The report is a review of the literature related to hepatitis B and its implications for dental practitioners. Hepatitis B represents a serious health risk among dentists and simple preventive measures can greatly reduce the risk of transmission or contraction of the disease. Certain positive findings in a healthy his...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1980.51.3.162

    authors: Withers JA

    更新日期:1980-03-01 00:00:00

  • The relationship between bone mineral density and periodontitis in postmenopausal women.

    abstract:BACKGROUND:Systemic bone loss has been proposed as a risk factor for periodontal disease; however, the relationship between these two diseases is still not clear. The objective of this study was to assess the relationship between systemic bone mineral density and periodontal disease, controlling for known confounders. ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.9.1492

    authors: Tezal M,Wactawski-Wende J,Grossi SG,Ho AW,Dunford R,Genco RJ

    更新日期:2000-09-01 00:00:00

  • Relationship between transmission of Porphyromonas gingivalis and fimA type in spouses.

    abstract:BACKGROUND:Porphyromonas gingivalis is one of the major microbial pathogens associated with chronic periodontitis. To eradicate such pathogens by periodontal therapy, it is essential to clarify the source of infection. Recent findings suggest that the genotype of the fimbriae is one of the important factors in infectio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.9.1355

    authors: Asano H,Ishihara K,Nakagawa T,Yamada S,Okuda K

    更新日期:2003-09-01 00:00:00

  • Xenogenous Collagen Matrix and/or Enamel Matrix Derivative for Treatment of Localized Gingival Recessions: A Randomized Clinical Trial. Part I: Clinical Outcomes.

    abstract:BACKGROUND:Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double-masked, dual-center, randomized clinical trial is to evaluate cli...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2017.170126

    authors: Sangiorgio JPM,Neves FLDS,Rocha Dos Santos M,França-Grohmann IL,Casarin RCV,Casati MZ,Santamaria MP,Sallum EA

    更新日期:2017-12-01 00:00:00

  • Prevalence, location, and patency of accessory canals in the furcation region of permanent molars.

    abstract::One hundred and two extracted permanent molars were debrided in 3% H2O2, sealed at the apex, and placed in a vacuum chamber. Safranin dye was introduced into the teeth that were placed in a vacuum of 525 mm of Hg. Observations were made of the external root surface to determine any staining due to patent accessory can...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.1.21

    authors: Gutmann JL

    更新日期:1978-01-01 00:00:00

  • Effect of citric acid and lyophilized autologous plasma on healing following periodontal flap surgery in monkeys.

    abstract::The purpose of this histologic, histometric, and autoradiographic study was to examine the effect of citric acid conditioning and lyophilized autologous plasma (LAP) application on healing following periodontal flap surgery. Mucoperiosteal flaps were elevated in six rhesus monkeys using the modified Widman flap proced...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.11.770

    authors: Nasjleti CE,Caffesse RG,Castelli WA,Smith BA,Lopatin DE,Kowalski CJ

    更新日期:1987-11-01 00:00:00

  • Severe Periodontitis and Risk for Poor Glycemic Control in Patients with Non-Insulin-Dependent Diabetes Mellitus.

    abstract::This study tested the hypothesis that severe periodontitis in persons with non-insulin-dependent diabetes mellitus (NIDDM) increases the risk of poor glycemic control. Data from the longitudinal study of residents of the Gila River Indian Community were analyzed for dentate subjects aged 18 to 67, comprising all those...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.10s.1085

    authors: Taylor GW,Burt BA,Becker MP,Genco RJ,Shlossman M,Knowler WC,Pettitt DJ

    更新日期:1996-10-01 00:00:00

  • Prospective study of the impact of peri-implant soft tissue properties on patient-reported and clinically assessed outcomes.

    abstract:BACKGROUND:It has been proposed that the presence of a zone of keratinized mucosa (KM) around implants is associated with less discomfort during brushing and improved esthetic outcomes. Therefore, mucogingival procedures have been recommended for patients with discomfort during brushing, and to enhance esthetic results...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.18-0031

    authors: Bonino F,Steffensen B,Natto Z,Hur Y,Holtzman LP,Weber HP

    更新日期:2018-09-01 00:00:00

  • Biochemical and clinical factors influencing oral malodor in periodontal patients.

    abstract::The amounts of volatile sulfur compounds (VSC) and methyl mercaptan/hydrogen sulfide ratio in mouth air from patients with periodontal involvement were 8 times greater than those of control subjects. Our studies demonstrated that, in patients with periodontal disease: 1) the concentration of disulfide, which is conver...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1992.63.9.783

    authors: Yaegaki K,Sanada K

    更新日期:1992-09-01 00:00:00

  • Age-dependent distribution of periodontitis in two countries: Findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012.

    abstract:OBJECTIVE:We used epidemiologic data of clinical periodontal status from two population-based samples in two countries, United States and Germany, to examine 1) the impact of age on the relative contribution of recession and pocketing on the distribution of clinical attachment loss, and 2) whether it is feasible to def...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.17-0670

    authors: Billings M,Holtfreter B,Papapanou PN,Mitnik GL,Kocher T,Dye BA

    更新日期:2018-06-01 00:00:00

  • 1-Tetradecanol complex: therapeutic actions in experimental periodontitis.

    abstract:BACKGROUND:The present study was planned to investigate the therapeutic actions of 1-tetradecanol complex (1-TDC), a novel monounsaturated fatty acid mixture, in established periodontitis in rabbits. METHODS:Periodontitis was initiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.090002

    authors: Hasturk H,Goguet-Surmenian E,Blackwood A,Andry C,Kantarci A

    更新日期:2009-07-01 00:00:00

  • The effect of smoking and periodontal treatment on salivary composition in patients with established periodontitis.

    abstract:BACKGROUND:The purpose of this study was to evaluate the effect of smoking on the periodontal status and the salivary composition in subjects with established periodontitis before and after periodontal therapy. METHODS:Our study group included 26 healthy subjects, 12 smokers and 14 non-smokers with established periodo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.10.1240

    authors: Zuabi O,Machtei EE,Ben-Aryeh H,Ardekian L,Peled M,Laufer D

    更新日期:1999-10-01 00:00:00

  • Vertical ridge augmentation using an equine bone and collagen block infused with recombinant human platelet-derived growth factor-BB: a randomized single-masked histologic study in non-human primates.

    abstract:BACKGROUND:This study tests the effectiveness of hydroxyapatite and collagen bone blocks of equine origin (eHAC), infused with recombinant human platelet-derived growth factor-BB (rhPDGF-BB), to augment localized posterior mandibular defects in non-human primates (Papio hamadryas). METHODS:Bilateral critical-sized def...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.110478

    authors: Nevins M,Al Hezaimi K,Schupbach P,Karimbux N,Kim DM

    更新日期:2012-07-01 00:00:00

  • A histochemical investigation of the bone formation process by guided bone regeneration in rat jaws. Effect of PTFE membrane application periods on newly formed bone.

    abstract:BACKGROUND:Guided bone regeneration (GBR) has been widely utilized for the promotion of bone augmentation in bone loss areas. However, little information has been available regarding chronological changes in newly formed bone and alterations in the nature of newly formed bone after removal of a barrier membrane. The pr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.3.341

    authors: Ohnishi H,Fujii N,Futami T,Taguchi N,Kusakari H,Maeda T

    更新日期:2000-03-01 00:00:00

  • Human periodontal ligament cell responses to recombinant human bone morphogenetic protein-2 with and without bone allografts.

    abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been found to promote the osteoblastic differentiation of human periodontal ligament cells. Its effect depends on the delivery system used. In this study we examined the effect of rhBMP-2 on the proliferation and osteoblastic differentiation of hum...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2003.74.7.982

    authors: Markopoulou CE,Vrotsos IA,Vavouraki HN,Dereka XE,Mantzavinos ZS

    更新日期:2003-07-01 00:00:00

  • Current status of lasers in soft tissue dental surgery.

    abstract::The aims of this paper are to briefly describe laser physics, the types of lasers currently available for use on soft tissues focusing primarily on CO2 and Nd:YAG laser energies, the histological effects of lasers on oral tissues, laser safety, the clinical applications of lasers on oral soft tissues, and future direc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1993.64.7.589

    authors: Pick RM,Colvard MD

    更新日期:1993-07-01 00:00:00