Abstract:
BACKGROUND:T and B lymphocytes play important roles in periodontitis. Smoking is considered a risk factor for periodontitis and may exert its negative effects through leukocytes. Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+ and CD8+ subpopulations, B (CD19+) cells, and T-cell proliferative capacity in periodontitis. METHODS:Lymphocyte immunophenotyping for T cells, their CD4+ and CD8+ subsets, and B cells was performed on peripheral blood from 76 periodontitis patients and 36 controls. Proliferative capacity of T cells was determined in whole-blood lymphocyte culture assays after mitogenic stimulation. RESULTS:Total T cells, CD4+ and CD8+ subpopulations, and responsiveness to specific T-cell stimuli did not differ between patients and controls; in addition, B cells were not significantly elevated in periodontitis patients. However, more periodontal breakdown in smoking patients was associated with higher numbers of CD3+ T cells, as well as with CD4+ and CD8+ T-cell subsets, and increased T-cell proliferation. Numbers of B cells were not affected by smoking. CONCLUSIONS:The increased numbers of T-cells and elevated T-cell responsiveness in patients who smoke may be one of several explanations why smoking is a risk factor for periodontitis. The mechanism of how T-cell function contributes to increase the severity of periodontal breakdown in smoking periodontitis patients needs to be investigated further.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Loos BG,Roos MT,Schellekens PT,van der Velden U,Miedema Fdoi
10.1902/jop.2004.75.4.557subject
Has Abstractpub_date
2004-04-01 00:00:00pages
557-64issue
4eissn
0022-3492issn
1943-3670journal_volume
75pub_type
杂志文章abstract::We review the basic functions of neurotrophins and their receptors and discuss the expression and functions of neurotrophins and their specific receptors based on recent data using cultured cells from human periodontal tissues. Neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neu...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2003.74.1.76
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Periodontal wound healing has been accelerated by different low-level laser therapy (LLLT) protocols. However, just a few studies have evaluated use of this therapy adjunctive to periodontal plastic surgery procedures. The present study shows 2-year results of a connective tissue graft (CTG) associated with ...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2016.160391
更新日期:2017-04-01 00:00:00
abstract::The secretion of prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6) by adherent mononuclear cells (AMNC) from 28 patients with early-onset periodontitis was studied. The early onset-periodontitis patients consisted of 12 patients with localized ju...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.2.139
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:It has been suggested that cyclosporine A (CsA) induces gingival enlargement by promoting an increase in the gingival extracellular matrix (ECM). Nonetheless, the variable occurrence of CsA-induced gingival enlargement in patients receiving this medication indicates a multifactorial pathogenesis. Clinical ob...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120224
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs. METHODS:In eight beagle dogs, a critical-size...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120380
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Titanium dental material can become corroded because of electrochemical interaction in the oral environment. The corrosion process may result in surface modification. It was hypothesized that a titanium surface modified by corrosion may enhance the attachment of periodontal pathogens. This study evaluates th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130595
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Behçet's disease is a multisystem disorder of unknown etiology, affecting predominantly the oral mucosa, skin, and eyes. Recurrent and painful episodes of oral ulcerations interfere with regular oral hygiene leading to rapid bacterial plaque accumulation. The aims of this study were to evaluate the periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1449
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:T cell cytokine profiles in the spleens and anti-Porphyromonas gingivalis antibodies in the sera of P. gingivalis-immunized BALB/c (H-2d), CBA/CaH (H-2k), C57BL6 (H-2b), and DBA/2J (H-2d, C5 deficient) mice were examined. METHODS:Mice were immunized either by intraperitoneal injections of P. gingivalis oute...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.7.1130
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The specific advantage of administering systemic antibiotics during initial, non-surgical therapy or in the context of periodontal surgery is unclear. This study assesses the differential outcomes of periodontal therapy supplemented with amoxicillin-metronidazole during either the non-surgical or the surgica...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2014.140478
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Alveolar ridge augmentation procedures are often needed prior to implant placement or prosthetic rehabilitation. The purpose of this study was to develop a quantitative method to assess the clinical outcome of such procedures. METHODS:Two volumetric methods, based on the volume difference between the pre- a...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.3.302
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The protease-induced cytotoxicity of P. gingivalis may partly result from alteration of the extracellular matrix and/or surface receptors that mediate interaction between the host cells and their matrix. While P. gingivalis-induced degradation of E-cadherin has been documented, there is no information on the...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.5.641
更新日期:2001-05-01 00:00:00
abstract::The authors review patient-reported outcome (PRO) metrics for dentistry, and in particular, periodontics. The PRO commentary for periodontics includes a review of split-mouth, randomized, controlled clinical trial results that specifically tracked pain at different sites over time after intervention and provided guide...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2014.130693
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The primary goal of periodontal therapy is the reduction or elimination of inflammation. Traditionally, this is accomplished through removal of subgingival tooth-borne accretions using non-surgical and/or surgical treatment modalities. Numerous studies indicated the difficulty in removing these accretions to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080190
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to perform alveolar ridge augmentation by distraction osteogenesis (DO) and to enhance bone regeneration through the use of recombinant human bone morphogenetic protein-2 (rhBMP-2), followed by implant placement. METHODS:Alveolar segmental osteotomy was performed in the mandibl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.11.1524
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS:Gingival biopsy samples collected from 14 subjects during a 28-day stent-induce...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080645
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma (PRP) has been promoted as a surgical adjunct to enhance hard and soft tissue wound healing. Although anecdotally reported to be of value, the results of controlled studies examining the added effects of PRP on surgical procedures have been mixed. The purpose of this study was to test th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080626
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:A wide selection of Interdental Oral Hygiene (IOH) aids is available to consumers. Recommendations for selection are, however, limited by the lack of direct comparisons in available studies. We aimed to assess the comparative efficacy of IOH aids using Bayesian Network Meta-Analysis (BNMA). METHODS:Two inde...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/JPER.17-0368
更新日期:2018-05-01 00:00:00
abstract::Fourteen defects were treated with flap debridement procedures using the Prichard principle of epithelial exclusion. Six defects were considered to be medium in width (3-4 mm), seven defects were wide (greater than 4 mm), and one defect was narrow (1-2 mm). The parameters studied were changes in gingival and plaque sc...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.5.277
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:This case report describes a 22-year-old female who was referred with a radiolucent lesion between her mandibular right molars. The original radiographic image suggested an odontogenic cyst. METHODS:The surgical enucleation and osteotomy of the residual cavity were performed with a piezoelectric knife. Hist...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060417
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Bacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory cytokines. The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060321
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on t...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140171
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (GCF) and serum cytokines, and pregnancy outcomes. METHODS:A clinical trial was conducted on 120 community-dwelling, 16- to 35-year-old pregna...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2014.140248
更新日期:2014-12-01 00:00:00
abstract::The purpose of this study was to examine the effect of inflammatory cytokines on IFN-γ-induced HLA-DR expression on cultured human gingival fibroblasts by flow cytometry. Natural human IFN-γ, recombinant human interleukin-1β (rhIL-1β), and rh tumor necrosis factor-α (rhTNF-α) were used. IFN-γ-induced upregulation of H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.4.336
更新日期:1994-04-01 00:00:00
abstract::Oral malodor was measured using a portable sulphide monitor in 2,672 individuals aged 18 to 64 years. In addition, dental (DMFT) and periodontal conditions (CPITN and attachment loss), dental plaque, and tongue coating status were assessed. Before clinical examination, subjects were interviewed about their oral health...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.8.679
更新日期:1995-08-01 00:00:00
abstract::The purpose of this study was to evaluate the safety and clinical efficacy of controlled-release tetracycline-containing fibers in patients with refractory periodontitis versus the preceding classical treatment. One hundred twenty-one sites in 20 patients were followed from baseline to 6 months after fiber insertion. ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1997.68.4.353
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The aim of this clinical trial was to compare the outcome of non-surgical treatment of interproximal and non-interproximal Class II furcation involvements. METHODS:Thirty-eight patients presenting at least one Class II furcation involvement that bled on probing with a probing depth (PD) > or = 5 mm were rec...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2007.060312
更新日期:2007-02-01 00:00:00
abstract::This paper briefly reviews the historical relationship between oral medicine and periodontics. The reasons for including structured clinical oral medicine in a postdoctoral program in periodontics are discussed. Problems and solutions to such an integrated program are outlined. Guidelines for broadening the base of th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.426
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the colonization, immunoglobulin (Ig) G response, and alveolar bone loss in Aggregatibacter actinomycetemcomitans (Aa)-inoculated Fawn Hooded Hypertensive (FHH), Dahl Salt-Sensitive (DSS), and Brown Norway (BN) rats. METHODS:Each rat strain was divided into wild-type Aa-i...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100250
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Sinus membrane perforation is the most common complication of the sinus-augmentation procedure. Anatomic factors have been implicated in the risk of sinus membrane perforation (SMP) during sinus-lift surgery. However, there are no reports on the relationships among gingival phenotype (GP), residual ridge hei...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110110
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate effects of strontium ranelate (SR) on alveolar bone loss (ABL) in rats with experimental periodontitis. METHODS:Forty Wistar rats were randomly divided into five groups: 1) control (n = 8); 2) ligated (n = 8); 3) 300 mg/kg SR (SR300, n = 8); 4) 625 mg/kg SR (SR625, n ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160227
更新日期:2017-02-01 00:00:00