Enhancement of bone formation by bone morphogenetic protein-2 during alveolar distraction: an experimental study in sheep.

Abstract:

BACKGROUND:The purpose of this study was to perform alveolar ridge augmentation by distraction osteogenesis (DO) and to enhance bone regeneration through the use of recombinant human bone morphogenetic protein-2 (rhBMP-2), followed by implant placement. METHODS:Alveolar segmental osteotomy was performed in the mandible of 10 sheep followed by placement of 1.5 mm alveolar distraction devices. The study group was injected on the fifth day of distraction with a single dose of 10 microg rhBMP-2. Only distraction was performed in the control group. RESULTS:A mean alveolar augmentation of 12 mm was achieved. After 12 weeks of consolidation, the distraction devices were removed and biopsies were taken for histological and immunohistochemical characterization and morphometry of the newly formed bone. Titanium threaded cylindrical implants were then placed in the newly augmented bone. Radiological evaluation showed lifting of the transport segment and integration of the implants within both the transport segment and the regenerated bone. The histological study demonstrated that the association of DO and BMP resulted in increased trabecular bone size and volume (32.2%+/-0.95% versus 18.6%+/-0.71%; P <1 x 10(-17) after 24 days of lengthening and 63.8%+/-1.89% versus 42.5%+/-1.33%; P<1 x 10(-15) after 12 weeks of consolidation) and increased numbers of proliferating cell nuclear antigen stained cells (0.7+/-0.04 versus 0.47+/-0.04; P<1 x 10(-10)) compared with the DO only group. CONCLUSIONS:Alveolar distraction augments atrophic alveolar ridge and creates new bone that permits implant placement. rhBMP-2 enhances bone quality and may shorten the consolidation period of distraction allowing for earlier implant placement.

journal_name

J Periodontol

authors

Rachmiel A,Aizenbud D,Peled M

doi

10.1902/jop.2004.75.11.1524

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1524-31

issue

11

eissn

0022-3492

issn

1943-3670

journal_volume

75

pub_type

杂志文章
  • Magnesium-enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months.

    abstract:BACKGROUND:Reduction of alveolar height and width after tooth extraction may present problems for implant placement, especially in the anterior maxilla where bone volume is important for biologic and esthetic reasons. Different graft materials have been proposed to minimize the reduction in ridge volume. The aim of thi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2009.080400

    authors: Crespi R,Capparè P,Gherlone E

    更新日期:2009-02-01 00:00:00

  • Periodontal microcirculatory abnormalities in patients with systemic sclerosis.

    abstract:BACKGROUND:The aim of this study was to observe the differences in periodontal microcirculation between healthy patients and patients with systemic sclerosis (SSc). METHODS:Fifteen healthy patients and 15 patients with SSc were examined. Periodontal capillaroscopy was used to investigate the characteristics of microci...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1991

    authors: Scardina GA,Pizzigatti ME,Messina P

    更新日期:2005-11-01 00:00:00

  • Rapid loss of alveolar bone associated with nonprecious alloy crowns in two patients with nickel hypersensitivity.

    abstract::In recent years there has been a dramatic increase in the use of nonprecious alloy and porcelain crowns in clinical dentistry. The alloy in these restorations frequently contains a high percentage (greater than 70%) of nickel. Most cases of metal hypersensitivity are related to nickel, and clinical manifestations of t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.7.486

    authors: Lamster IB,Kalfus DI,Steigerwald PJ,Chasens AI

    更新日期:1987-07-01 00:00:00

  • Bilateral subpontic osseous hyperplasia. A case report.

    abstract::A case of osseous hyperplasia under the pontics of fixed partial dentures in right and left mandibular first molar regions is presented. Radiographs showed hemispherical radio-opacities on the alveolar ridges. Histologic examination revealed the lesions were composed of a dense mass of mature bone with well-developed ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1988.59.5.311

    authors: Takeda Y,Itagaki M,Ishibashi K

    更新日期:1988-05-01 00:00:00

  • Detection of Actinobacillus actinomycetemcomitans but not bacteria of the red complex in aortic aneurysms by multiplex polymerase chain reaction.

    abstract:BACKGROUND:Aortic aneurysms affect an increasing number of elderly patients and cause considerable morbidity and mortality. The understanding of the mechanisms involved in the pathogenesis of aortic aneurysms is unclear and little is known about the role of microorganisms in the development of the condition. The aim of...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.4.590

    authors: Marques da Silva R,Caugant DA,Lingaas PS,Geiran O,Tronstad L,Olsen I

    更新日期:2005-04-01 00:00:00

  • A Novel Rat Model of Polymicrobial Peri-Implantitis: A Preliminary Study.

    abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160273

    authors: Koutouzis T,Eastman C,Chukkapalli S,Larjava H,Kesavalu L

    更新日期:2017-02-01 00:00:00

  • Inter-implant bone height changes in anterior maxillary immediate and non-immediate adjacent dental implants.

    abstract:BACKGROUND:The purpose of this study was to evaluate inter-implant bone crest height changes between immediate and non-immediate dental implants placed in the anterior maxillary region. METHODS:A retrospective study was conducted on consecutively treated patients requiring at least two adjacent implants in the anterio...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.060443

    authors: Kupershmidt I,Levin L,Schwartz-Arad D

    更新日期:2007-06-01 00:00:00

  • Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: a randomized clinical trial.

    abstract:BACKGROUND:In the treatment of periodontal intrabony defects, the benefits of adding platelet-rich plasma (PRP) to a bone replacement grafting material have not been tested. The purpose of this study was to compare the clinical outcomes obtained by the combination of PRP and a bovine derived xenograft (BDX) to those ob...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2004.75.12.1668

    authors: Hanna R,Trejo PM,Weltman RL

    更新日期:2004-12-01 00:00:00

  • Application of the theory of planned behavior to nurse practitioners' understanding of the periodontal disease-systemic link.

    abstract:BACKGROUND:Mounting evidence supports a connection between periodontal disease and coronary heart disease, ischemic stroke, and diabetes. This theoretically grounded study examines the knowledge, attitudes, and screening and referral behaviors of primary care nurse practitioners (NPs) in relation to the periodontal dis...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2010.100259

    authors: Ward AS,Cobb CM,Kelly PJ,Walker MP,Williams KB

    更新日期:2010-12-01 00:00:00

  • Association between respiratory disease in hospitalized patients and periodontal disease: a cross-sectional study.

    abstract:BACKGROUND:Recent research indicated that periodontal infection may worsen systemic diseases, including pulmonary disease. Respiratory infections, such as pneumonia and the exacerbation of chronic obstructive pulmonary disease, involve the aspiration of bacteria from the oropharynx into the lower respiratory tract. ME...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100582

    authors: Sharma N,Shamsuddin H

    更新日期:2011-08-01 00:00:00

  • Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation.

    abstract::Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. The rationale for use of DFDBA includes the fact that proteins capable of inducing new bone; i.e., bone morphogenetic proteins, can be isolated from bone grafts. Commercial bone banks have provided DFDBA to the dental p...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.9.918

    authors: Schwartz Z,Mellonig JT,Carnes DL Jr,de la Fontaine J,Cochran DL,Dean DD,Boyan BD

    更新日期:1996-09-01 00:00:00

  • Immediate loading of dental implants placed in severely resorbed edentulous maxillae reconstructed with Le Fort I osteotomy and interpositional bone grafting.

    abstract:BACKGROUND:Reconstruction and rehabilitation of atrophic maxillae with bone grafts is a lengthy and demanding procedure. This study reports the immediate loading of 50 implants placed on six extremely atrophied edentulous maxillae reconstructed with Le Fort I osteotomy and iliac bone grafting. METHODS:Six patients, ag...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.110460

    authors: Pieri F,Lizio G,Bianchi A,Corinaldesi G,Marchetti C

    更新日期:2012-08-01 00:00:00

  • Identification of Actinobacillus actinomycetemcomitans by gold immunolabeling and scanning electron microscopy.

    abstract::Recent evidence suggests that dental plaque is not a homogeneous bacterial mass but, on the contrary, specific bacterial morphotypes and species may be preferentially located within certain microenvironments. The aim of the present study was to develop combined gold immunolabeling and scanning electron microscopic (SE...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1990.61.5.249

    authors: Carrassi A,Soligo D,Vogel G,Lambertenghi-Deliliers G,Zambon JJ

    更新日期:1990-05-01 00:00:00

  • Bone sialoprotein gene transfer to periodontal ligament cells may not be sufficient to promote mineralization in vitro or in vivo.

    abstract:BACKGROUND:To improve regenerative therapies, it is important to understand the cells and factors modulating periodontal tissues. Our group has focused on bone sialoprotein (BSP), a mineralized tissue-selective protein considered to be involved in the initiation of cementogenesis and osteogenesis. In this study, we exa...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050057

    authors: Hakki SS,Wang D,Franceschi RT,Somerman MJ

    更新日期:2006-02-01 00:00:00

  • Periodontal emotional stress syndrome.

    abstract::Eleven cases are presented which demonstrated severe periodontal bone loss especially in the posterior segments of the mouth in a group of young men, ages 22 to 32, unexplained by other local etiologic factors. The only common denominator in all cases was severe emotional stress associated with active duty in Viet Nam...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1976.47.2.67

    authors: De Marco TJ

    更新日期:1976-02-01 00:00:00

  • Clinical and laboratory studies of a family with a high prevalence of juvenile periodontitis.

    abstract::The form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis (JP). The disease has been the object of intense study because from its analysis may come insights into understanding other, more common, forms of periodontitis. We recently had th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1985.56.10.602

    authors: Page RC,Vandesteen GE,Ebersole JL,Williams BL,Dixon IL,Altman LC

    更新日期:1985-10-01 00:00:00

  • Effect of implant cleaning on titanium particle dissolution and cytocompatibility.

    abstract:BACKGROUND:Peri-implantitis treatments are mainly based on protocols for teeth but have not shown favorable outcomes for implants. The potential role of titanium dissolution products in peri-implantitis necessitate the consideration of material properties in devising treatment protocols. We assessed implant cleaning in...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0186

    authors: Kotsakis GA,Black R,Kum J,Berbel L,Sadr A,Karoussis I,Simopoulou M,Daubert D

    更新日期:2020-08-26 00:00:00

  • Efficacy of preprocedural mouth rinsing in reducing aerosol contamination produced by ultrasonic scaler: a pilot study.

    abstract:BACKGROUND:The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2013.120616

    authors: Gupta G,Mitra D,Ashok KP,Gupta A,Soni S,Ahmed S,Arya A

    更新日期:2014-04-01 00:00:00

  • A rapid chairside test for the severity of periodontal disease using gingival fluid.

    abstract::A study was done in an attempt to develop a simple test for the severity of periodontal disease. Gingival fluid collected on filter paper was tested for protein content, and the resulting color was compared to standard color filters. Tissue was excised and prepared for histologic examination. The inflammatory cell inf...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.8.391

    authors: Dombrowski JC,Schacterle GR,Livne JK,White DK

    更新日期:1978-08-01 00:00:00

  • Calprotectin and lactoferrin levels in the gingival crevicular fluid of children.

    abstract::The purpose of this study was to determine the levels of calprotectin and lactoferrin, 2 microbiostatic proteins, in the gingival crevicular fluid (GCF) of normal children. The children represented a population, primarily underprivileged, seeking care at a regional dental health care center. GCF was collected from Ram...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1998.69.8.879

    authors: Miyasaki KT,Voganatsi A,Huynh T,Marcus M,Underwood S

    更新日期:1998-08-01 00:00:00

  • Update on the changing numbers and distribution of periodontists.

    abstract::A review of the 2006 and past American Dental Association (ADA) studies on the distribution of dentists provides information on the evolving number of periodontists. Despite an overall increase in the number of periodontists, major differences continue in practitioner/population ratios in different geographic areas. A...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2009.080592

    authors: Waldman HB,Chaudhry RA

    更新日期:2009-05-01 00:00:00

  • Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature.

    abstract:BACKGROUND:Ossifying fibromyxoid tumors (OFTs) are uncommon soft tissue neoplasms. Only one case arising in the gingiva has been described. METHODS:A 21-year-old woman presented with a painless exophytic mass located in the right posterior mandibular gingiva, which was identified 6 months earlier. Radiographs showed i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2009.080535

    authors: Nonaka CF,Pacheco DF,Nunes RP,Freitas Rde A,Miguel MC

    更新日期:2009-04-01 00:00:00

  • Underestimation of periodontitis in NHANES surveys.

    abstract::The study design of national surveys of periodontal disease often uses partial-mouth examination protocols to rationalize the need for resources so that the collection of data from a large number of subjects can be achieved within the available means without significantly sacrificing precision and validity. Studies sh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100638

    authors: Albandar JM

    更新日期:2011-03-01 00:00:00

  • A chlorhexidine-containing methacrylic gel as a periodontal dressing.

    abstract::The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1975.46.8.465

    authors: Addy M,Douglas WH

    更新日期:1975-08-01 00:00:00

  • Early soft tissue healing around one-stage dental implants: clinical and microbiologic parameters.

    abstract:BACKGROUND:Despite the potential significance of early soft tissue healing to long-term outcomes, this aspect of one-stage dental implants has not been investigated. The purpose of this prospective study was to characterize clinical and microbiologic parameters of early soft tissue healing around dental implants placed...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070122

    authors: DeAngelo SJ,Kumar PS,Beck FM,Tatakis DN,Leblebicioglu B

    更新日期:2007-10-01 00:00:00

  • Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III.

    abstract:BACKGROUND:Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). METHODS:Data from 755 men (aged ≥ 30 years), including ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2015.140530

    authors: Steffens JP,Wang X,Starr JR,Spolidorio LC,Van Dyke TE,Kantarci A

    更新日期:2015-10-01 00:00:00

  • Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis.

    abstract:BACKGROUND:Hemagglutinin and outer membrane protein (OMP) are major virulence factors associated with colonization of Porphyromonas gingivalis in the gingival crevice. The genes for the 200-kDa antigenic protein (200-kDa AP) and 40-kDa OMP of P. gingivalis have been successfully cloned. Additionally, the 200-kDa AP gen...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050138

    authors: Kobayashi T,Kaneko S,Tahara T,Hayakawa M,Abiko Y,Yoshie H

    更新日期:2006-03-01 00:00:00

  • Immunohistochemical expression of extracellular matrix components of normal and healing periodontal tissues in the beagle dog.

    abstract::Periodontal regeneration requires formation of periodontal tissues lost due to periodontal disease. To better understand the formation of new periodontal tissues during periodontal repair and regeneration, immunohistochemical expression of extracellular matrix components of normal as well as healing periodontal tissue...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1995.66.7.579

    authors: Matsuura M,Herr Y,Han KY,Lin WL,Genco RJ,Cho MI

    更新日期:1995-07-01 00:00:00

  • A case report of unusual dental calculus formation.

    abstract::A case is presented in which an unusual amount of intraoral calculus was seen in a 59-year-old woman. The deposits completely covered all surfaces of most teeth and extended over the facial and lingual gingivae. The relationship between certain chemical salivary parameters and heavy calculus formers is briefly describ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.6.326

    authors: Moskow BS

    更新日期:1978-06-01 00:00:00

  • The sutureless free gingival graft.

    abstract::A technique designed to utilize the autogenous free gingival graft without the use of sutures was demonstrated. Necessary objectives were maintained but achieved without unnecessarily piercing the graft, and in less time. The only variance in results would be due to the underlying physical properties of the recipient ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1979.50.2.75

    authors: Hoexter DL

    更新日期:1979-02-01 00:00:00