Abstract:
BACKGROUND:The present study was conducted to determine the possible effect of naproxen sodium on clinical status and the enzymatic profile of gingival crevicular fluid (GCF) when given as adjunct to periodontal treatment. METHODS:A total of 34 subjects with chronic periodontitis were selected and divided into two groups to receive either naproxen sodium or placebo. At baseline, GCF samples were obtained and probing depths (PD), gingival index (GI), plaque index (PI), and gingival bleeding index (GBI) scores were recorded. In the non-steroidal anti-inflammatory drug (NSAID) group, patients were treated with a protocol consisting of baseline periodontal treatment (scaling, root planing) and naproxen sodium (275 mg) administration daily for 6 weeks. In the placebo group, patients received the same treatment except placebo was given instead of naproxen sodium. At the end of the experimental period, clinical recordings and GCF sampling were repeated. Myeloperoxidase (MPO) and elastase-like enzyme activity (ELA) levels were determined in GCF samples by a spectrophotometric method. GCF enzymatic content was calculated both as total enzyme activity and enzyme concentration. RESULTS:All of the clinical parameters, except mean GBI, were significantly lower in the experimental group (P <0.05). At baseline and at the end of the experimental period, there were no significant differences between the NSAID and placebo groups regarding GCF MPO and ELA levels in either mode of data presentation (P <0.05). However, in the NSAID group, mean ELA concentration (P = 0.002) and mean total ELA (P = 0.003) presented significant decreases with treatment. Also, with treatment, a general reduction in MPO levels was seen; however, this difference was not significant. Although constant and stable correlations between GCF enzyme levels and clinical parameters could not be found, positive and strong correlations were observed between total enzyme activity and enzyme concentrations. CONCLUSION:Based on the positive clinical effect and the ELA profile of GCF, it can be suggested that NSAIDs given as an adjunct to baseline periodontal treatment could be beneficial in the outcome of treatment.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Aras H,Cağlayan F,Güncü GN,Berberoğlu A,Kilinç Kdoi
10.1902/jop.2007.060412subject
Has Abstractpub_date
2007-05-01 00:00:00pages
868-73issue
5eissn
0022-3492issn
1943-3670journal_volume
78pub_type
杂志文章,随机对照试验abstract::Periodontal pockets of 11 subjects were irrigated once with either 1.64% SnF2 or saline applied by syringe. Changes on the total anaerobic colony forming units (CFU) and black pigmented bacteroides (BPBs) of the irrigated pockets were assessed for 31 days. The results showed little change of the CFUs by either single ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.6.330
更新日期:1985-06-01 00:00:00
abstract::The literature related to smoking and periodontal disease is reviewed. The effects of smoking on oral hygiene, gingivitis, necrotizing gingivitis, periodontitis, bacteria and the host's response are presented. From this review it is apparent that while the relationship between smoking and periodontal disease needs fur...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1986.57.10.617
更新日期:1986-10-01 00:00:00
abstract::A small laser doppler probe with an outside diameter comparable to a conventional periodontal probe (0.5 mm) was developed. The objectives of this investigation were to determine if intrasulcular laser doppler readings (LDR): 1) are reproducible; 2) can detect vascular changes associated with trauma from probe placeme...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.3.171
更新日期:1995-03-01 00:00:00
abstract::There are few studies that provide information on the natural history of calculus formation. The purpose of this study is to evaluate the relationship between pre-scaling baseline calculus scores, the time since the last prophylaxis before baseline, and scores 8 weeks after scaling in a group of presumed heavy calculu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.8.750
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Increased collagenolytic activity, characteristic of uncontrolled diabetes, may compromise collagen membrane (CM) survival. Tetracycline (TCN) possesses anticollagenolytic properties and delays CM degradation in healthy animals. This study evaluates the degradation of TCN--immersed and -non-immersed CMs in r...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120188
更新日期:2013-04-01 00:00:00
abstract::A randomized double-blind crossover design study using 25 patients requiring bilateral gingival flap surgery was completed. The effect of rinsing postsurgically three times daily with an antimicrobial mouthrinse or physiological saline on dental plaque formation, gingival inflammation, bleeding, wound healing, and pat...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1989.60.1.31
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:To determine the level of perceived pain after different types of periodontal/oral surgical procedures, and the differences in patients' selection of pain management, over the counter (OTC) versus opioid, based on procedure type. METHODS:Patients undergoing surgical procedures were asked to complete a pain ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0315
更新日期:2020-11-05 00:00:00
abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.4.550
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140077
更新日期:2014-09-01 00:00:00
abstract::This review defines terms such as accuracy, validity, and reliability, which are used to describe the quality of methods for taking x-rays and for analyzing digital images. Values for these parameters are described for techniques of taking standardized x-rays such as ear-rod fixation and fixation by use of teeth with ...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2000.71.3.497
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Recently, brain-derived neurotrophic factor (BDNF)/high molecular weight hyaluronic acid (HMW-HA) complex with flap surgery has been shown to promote periodontal tissue regeneration. The objective of this study was to evaluate the effects of local subgingival application of BDNF/HMW-HA complex adjunctive to ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0070
更新日期:2019-01-01 00:00:00
abstract::The secretion of prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6) by adherent mononuclear cells (AMNC) from 28 patients with early-onset periodontitis was studied. The early onset-periodontitis patients consisted of 12 patients with localized ju...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.2.139
更新日期:1994-02-01 00:00:00
abstract::This study showed histopathological findings of the extracellular matrix in healthy, inflamed, and hyperplastic human gingiva with immunohistochemical techniques. The distribution of collagen types V and VI, as well as of glycoprotein fibronectin, shows that they are extracellular matrix structural components which di...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.2.110
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiologi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.6.646
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:One endpoint of periodontal therapy is to regenerate the structure lost due to periodontal disease. In the periodontium, gingival epithelium is regenerated by oral epithelium. Underlying connective tissue, periodontal ligament, bone, and cementum are derived from connective tissue. Primitive connective tissu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.12.2194
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Most dental implants are positioned using a drilling surgery technique. However, dentistry recently experienced the implementation of piezoelectric surgery. This technique was introduced to overcome some of the limitations involving rotating instruments in bone surgery. This study used biomolecular and histo...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060285
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the total antioxidant capacity, superoxide dismutase and glutathione peroxidase activities, and malondialdehyde levels in serum, saliva, and gingival crevicular fluid (GCF) in preeclamptic and normotensive pregnant women with and without periodontal disease. METHODS:...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060469
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1508
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The purpose of this clinical study is to evaluate the radiographic bone remodeling, survival rate, and soft tissue health surrounding a variable-thread tapered implant immediately placed in extraction sites. METHODS:Sixty implants were placed in 55 patients at six centers according to a predetermined protoc...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1902/jop.2013.120638
更新日期:2014-03-01 00:00:00
abstract::In order to increase our understanding of the immunologic aspects of periodontal disease, three groups of extracted human teeth were evaluated for the presence of antibody on the cementum surface. Antibody was demonstrated by direct immunofluorescence using monospecific antibody with human alpha , gamma and upsilon ch...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.168
更新日期:1982-03-01 00:00:00
abstract::Ultrasonic scalers may be operated at different power settings which may influence the final therapeutic result. The displacement amplitude of the scaling tip may affect scaling efficiency or the degree of root surface damage. This investigation aimed to determine whether there was any difference in periodontal healin...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1995.66.9.756
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:The number of immunocompromised patients is increasing as a consequence of successful organ transplantation. Placing dental implants in these patients has been questioned because of their increased risk for infections. The 10-year follow-up data of a 71-year-old liver transplant recipient with long-term immu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2004.75.6.909
更新日期:2004-06-01 00:00:00
abstract::Plaque-induced inflammation has been documented from various aspects, but is still not well understood. In an effort to clarify the physicochemical properties of dental plaque and to isolate the active factor which give rise to inflammation, we studied a factor in plaque which may be a direct and local cause of gingiv...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.7.400
更新日期:1980-07-01 00:00:00
abstract::One hundred mandibles of South African Negroes were examined for the presence of intrabony defects, and the distance between the cemento-enamel junction and alveolar bone crest was measured along the buccal and lingual surface of roots associated with interdental craters. Two-hundred thirty-one intrabony defects were ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1984.55.3.149
更新日期:1984-03-01 00:00:00
abstract::This study examined histologic and histometric responses to 2 bioabsorbable membranes made from a synthetic copolymer of glycolide and lactide. They were tested for their biocompatibility, resorption characteristics, and ability to support periodontal regeneration. Expanded polytetrafluoroethylene (ePTFE) was used as ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.6.583
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to determine whether sex dimorphism exists in the expression of inflammatory and apoptotic mediators in gingiva obtained from normal and diseased sites of periodontal disease. METHODS:Gingival papillae were obtained from individuals (56 males and 62 females) who required extract...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130718
更新日期:2014-11-01 00:00:00
abstract:SCOPE:These Guidelines apply to products used to promote the regeneration of periodontal tissues lost due to periodontal diseases or other causes. Periodontal regeneration is defined histologically as regeneration of the tooth's supporting tissues, including alveolar bone, periodontal ligament, and cementum over a prev...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.9.1081
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis is one of the major microbial pathogens associated with chronic periodontitis. To eradicate such pathogens by periodontal therapy, it is essential to clarify the source of infection. Recent findings suggest that the genotype of the fimbriae is one of the important factors in infectio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2003.74.9.1355
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Cicatricial pemphigoid (benign mucous membrane pemphigoid) is an autoimmune vesiculobullous disease that affects mucosal tissues of adults and rarely presents in children. Only 9 cases in the English literature have reported cicatricial pemphigoid in children, primarily as oral mucosal lesions. This paper pr...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2002.73.6.657
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:This study evaluates the influence of platelet-rich plasma derived from bone marrow aspirate (PRP-BMA) on the healing of periodontal fenestration defects in rats. METHODS:Periodontal fenestration defects were surgically created in the mandibles of 40 rats. The animals were randomly divided into two groups, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140083
更新日期:2014-12-01 00:00:00