Abstract:
:Serial histological sections of gingiva obtained from each of six advanced adult periodontitis, two localized juvenile periodontitis and two periodontally healthy patients were used for specific identification of bacteria within the oral epithelium and adjacent connective tissue. Healthy gingival biopsies served as controls. Sections from patients and control biopsies were Gram-stained and also screened with antibacterial sera associated with the peroxidase immunocytochemical technique for specific bacterial identification. The "Pop-off" electron microscopic technique was also used to further demonstrate the bacterial nature of peroxidase-stained material. In addition, the possible correlation between bacteria and areas of possible reduced keratinization was investigated. The results showed that sections of orthokeratinized healthy gingiva did not contain bacteria. Gram-stained sections from diseased sites contained large numbers of bacteria in the oral epithelium and adjacent connective tissue. Bacteroides gingivalis and to a lesser extent Capnocytophaga gingivalis were found in periodontitis, and Actinobacillus actinomycetemcomitans was found in juvenile periodontitis when the immunoperoxidase technique was used. The bacterial nature of peroxidase-stained material was confirmed by the "pop-off" technique. In the disease biopsies, bacterial presence was correlated with areas of reduced amounts of keratin suggesting that the oral epithelium may be a portal of entry for bacteria into gingival tissues.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Saglie FR,Smith CT,Newman MG,Carranza FA Jr,Pertuiset JH,Cheng L,Auil E,Nisengard RJdoi
10.1902/jop.1986.57.8.492subject
Has Abstractpub_date
1986-08-01 00:00:00pages
492-500issue
8eissn
0022-3492issn
1943-3670journal_volume
57pub_type
杂志文章abstract:BACKGROUND:The aim of the present study was to evaluate the effect of strict supragingival plaque control on the subgingival microbiota in smokers and never-smokers. Research into the impact of supragingival plaque control on the number of subgingival bacteria has resulted in contradictory findings. Real-time polymeras...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2008.070558
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The biologic safety profile of oral health care products is often assumed on the basis of simplistic test models such as monolayer cell culture systems. We developed and characterized a tissue-engineered human oral mucosal model, which was proven to represent a potentially more informative and more clinicall...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.080610
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Titanium dental material can become corroded because of electrochemical interaction in the oral environment. The corrosion process may result in surface modification. It was hypothesized that a titanium surface modified by corrosion may enhance the attachment of periodontal pathogens. This study evaluates th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130595
更新日期:2014-09-01 00:00:00
abstract::Periodontitis is an inflammatory disease caused by microbial infection in the subgingival region. Risk factors associated with the development and progression of this disease are numerous, multifactorial, complex, and often not well defined across individuals and population groups. The focus of this paper is to provid...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1994.65.5s.539
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), a capnophilic facultative anaerobe, is associated with localized aggressive periodontitis and endocarditis. When grown in broth, the cells begin to die rapidly after overnight growth. The cells also often lose viability ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100590
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Controversy over the long-term clinical effectiveness of hydroxyapatite (HA)-coated dental implants still persists, despite numerous clinical studies documenting high survival rates. Concerns about the degradation of the coating over the years have been raised; it has been speculated that resorption of the H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060271
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:This study compared 6-month and 3-year outcomes for root coverage (RC) by coronally advanced flap (CAF) procedures in localized gingival recessions. METHODS:Two centers, that had participated in a 6-month multinational multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2017.160767
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute phase protein involved in inflammation-associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor ne...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0358
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:This preliminary in vitro study, presented at the General Session of the International and American Association for Dental Research in 2010 (Barcelona, Spain), evaluates whether three-dimensional (3D) optical scanning and subsequent superimposing procedures could be used for reproducible volumetric evaluatio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110143
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to peri...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.100733
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The aim of the present study is to assess the osteogenic differentiation of rat bone marrow stromal cells (RBMCs) in β-tricalcium phosphate (β-TCP) blocks containing extracellular matrix (ECM) produced by human alveolar bone periosteal cells (HABPCs). METHODS:HABPCs were cultured in β-TCP blocks for 1 week ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120490
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobio...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080139
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.090741
更新日期:2010-08-01 00:00:00
abstract::Wounds were prepared in the oral cavity of 15 rabbits and five dogs, and an enzyme-solubilized calfskin collagen was placed over the surgery sites on one side. The contralateral sides acted as controls. Results indicated that the membrane was biologically acceptable to the oral mucosa of rabbits and dogs. Th collagen ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.5.250
更新日期:1979-05-01 00:00:00
abstract::In order to increase our understanding of the immunologic aspects of periodontal disease, three groups of extracted human teeth were evaluated for the presence of antibody on the cementum surface. Antibody was demonstrated by direct immunofluorescence using monospecific antibody with human alpha , gamma and upsilon ch...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.3.168
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0721
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:Efficient methods to treat persistent pockets during periodontal maintenance therapy (PMT) require further investigation. The hypothesis of this randomized controlled clinical trial was that local application of enamel matrix derivative (EMD) added to papilla reflection/root preparation (PR/RP) could enhance...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0623
更新日期:2020-11-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00
abstract::Twelve gingival samples removed from 6 human volunteers were sectioned in small pieces, parts of which served as uncultured pieces. The remaining pieces were organ cultured for 5 hours in control, compound 48/80, and antihuman IgE media. Uncultured tissues, cultured tissues, and cultured spent media were analyzed spec...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.3.171
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Periodontitis patients harboring Actinobacillus actinmycetemcomitans (Aa) are prime candidates for systemic antibiotic therapy. Besides tetracycline and the combination of metronidazole and amoxicillin the fluoroquinolones are also believed to have antibacterial activity against Aa. The aim of the present st...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2000.71.2.202
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase-8 (MMP-8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. METHODS:Twelve chronic periodontitis patients received ...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.1.103
更新日期:2002-01-01 00:00:00
abstract::THE MORBIDITY and incidence of bacteremia in periodontal surgery with or without cephalexin prophylaxis were assessed in adults on the basis of clinical evaluations and blood cultures. Cephalexin reduced the incidence of polymicrobic bacteremias. There was no correlation between objective signs of tissue healing and a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1982.53.5.319
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Chédiak-Higashi syndrome (CHS) is a rare immunodeficient disorder. Patients with CHS are prone to severe periodontitis. To date, limited improvement following periodontal therapy has been reported. Thus, successful clinical outcomes in patients with CHS are of interest. METHODS:A 12-year-old girl was referr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070440
更新日期:2008-07-01 00:00:00
abstract::The authors review patient-reported outcome (PRO) metrics for dentistry, and in particular, periodontics. The PRO commentary for periodontics includes a review of split-mouth, randomized, controlled clinical trial results that specifically tracked pain at different sites over time after intervention and provided guide...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2014.130693
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Sinus membrane perforation is the most common complication of the sinus-augmentation procedure. Anatomic factors have been implicated in the risk of sinus membrane perforation (SMP) during sinus-lift surgery. However, there are no reports on the relationships among gingival phenotype (GP), residual ridge hei...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110110
更新日期:2012-04-01 00:00:00
abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.4.163
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Through the use of optimal surveillance measures and standard case definitions, it is now possible to more accurately determine population-average risk profiles for severe (SP) and non-severe periodontitis (NSP) in adults (aged 30 years and older) in the United States. METHODS:Data from the 2009 to 2012 Nat...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160013
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Behçet's disease is a multisystem disorder of unknown etiology, affecting predominantly the oral mucosa, skin, and eyes. Recurrent and painful episodes of oral ulcerations interfere with regular oral hygiene leading to rapid bacterial plaque accumulation. The aims of this study were to evaluate the periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.12.1449
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The main aim of treatment for acute necrotizing periodontal disease is fast and effective reduction of anaerobic destructive microorganisms to avoid periodontal damage. The effect of adjunctive local oxygen therapy in the treatment of necrotizing periodontal disease was examined in this study. METHODS:Thirt...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2006.77.1.31
更新日期:2006-01-01 00:00:00
abstract::The purpose of this study was to evaluate the feasibility and reliability of using a home screening occult blood test to detect the presence of gingival inflammation. Fifty (50) healthy male and female subjects participated in this study. Pre- and post-stimulation saliva samples were obtained and tested for occult blo...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.1995.66.1.52
更新日期:1995-01-01 00:00:00