Monoclonal antibodies against integrin subunits alpha6 and beta1 inhibit migration of gingival epithelium in organ culture.

Abstract:

BACKGROUND:The main problem in the posterior instrumental treatment of periodontitis is the re-epithelization of the periodontal defects, leading to the formation of an unphysiological, long junctional epithelium inhibiting the regeneration of periodontal attachment. A precondition for the re-epithelization is the interaction between epithelial cells and their extracellular matrix mediated by integrins. Integrins are cellular adhesion molecules (CAM), binding to different structures of the extracellular matrix, e.g., collagen, laminin, or fibronectin. METHODS:Biopsy specimens of marginal gingiva, composed of epithelium and subepithelial connective tissue, were cultivated on microporous membranes in tissue culture plates. The culture medium was supplemented with monoclonal antibodies directed against human integrin subunits. The period of cultivation was 6 days and the medium was replaced daily. After cultivation, the tissue development was analyzed by histological and immunohistochemical methods. RESULTS:We found that the combination of antibodies directed against the integrin subunits alpha6 and beta1 inhibited the migration of epithelium completely in 9 out of 10 cultures, whereas control cultures containing none or only irrelevant antibodies demonstrated connective tissues completely covered by epithelium. CONCLUSIONS:Influencing the regeneration of periodontal tissue on a molecular basis by using antibodies directed against integrin subunits may be of future interest in postsurgical treatment of periodontal diseases.

journal_name

J Periodontol

authors

Gräber HG,Wilharm J,Conrads G

doi

10.1902/jop.1999.70.4.388

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

388-93

issue

4

eissn

0022-3492

issn

1943-3670

journal_volume

70

pub_type

杂志文章
  • Early-onset periodontitis associated with Weary-Kindler syndrome: a case report.

    abstract::Weary-Kindler syndrome is a rare and poorly understood genetic disorder that has manifestations of both epidermolysis bullosa and poikiloderma congenitale. There are approximately 70 cases documented in the past 40 years but no cases appear in the dental literature, although dental findings have been discussed superfi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.10.1004

    authors: Wiebe CB,Silver JG,Larjava HS

    更新日期:1996-10-01 00:00:00

  • Twenty-year results after connective tissue grafts and guided tissue regeneration for root coverage.

    abstract:BACKGROUND:Evaluation of clinical long-term results 20 years after connective tissue grafting (CTG) or guided tissue regeneration (GTR) using bioabsorbable barriers for root coverage therapy. METHODS:Initially, 15 patients with 38 Miller Class I and II recession defects underwent CTG or GTR according to random assignm...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0203

    authors: Petsos H,Eickholz P,Ratka-Krüger P,Neukranz E,Nickles K

    更新日期:2020-03-01 00:00:00

  • EDTA gel root conditioning: lack of effect on clinical and radiographic outcomes of intrabony defect treatment with enamel matrix derivative.

    abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.77.1.103

    authors: Parashis AO,Tsiklakis K,Tatakis DN

    更新日期:2006-01-01 00:00:00

  • Laser irradiation of bone: III. Long-term healing following treatment by CO2 and Nd:YAG lasers.

    abstract:BACKGROUND:Relative few reports exist concerning healing of laser created osteotomies over an extended period of time. The purpose of this study was to evaluate long-term healing, from 21 to 63 days, of osteotomy defects in the rat tibia created with the Nd:YAG and CO2 in the presence of a surface cooling spray of air/...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.2.174

    authors: McDavid VG,Cobb CM,Rapley JW,Glaros AG,Spencer P

    更新日期:2001-02-01 00:00:00

  • Analysis of Subgingival Plaque Ability to Stimulate Toll-Like Receptor 2 and 4.

    abstract:BACKGROUND:It has been shown that toll-like receptor (TLR) 2- and TLR4-stimulating abilities of supragingival plaque (SPP) are associated with periodontal conditions. It is hypothesized that SPP might affect the periodontium through its influence on subgingival plaque (SBP). This study investigates relationships betwee...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.150573

    authors: Ziauddin SM,Montenegro Raudales JL,Sato K,Yoshioka H,Ozaki Y,Kaneko T,Yoshimura A,Hara Y

    更新日期:2016-09-01 00:00:00

  • Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration. A review.

    abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1985.56.1.18

    authors: Barnett ML

    更新日期:1985-01-01 00:00:00

  • Periodontally diseased vs. normal roots as evaluated by scanning electron microscopy and electron probe analysis.

    abstract::A scanning electron microscope and electron probe study was carried out to compare root structure from deep within periodontal pockets with roots exhibiting no periodontal disease. To eliminate the possibility of extraneous ion introduction or deletion, no attempt was made to subject the roots to fixation, embedding, ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.9.634

    authors: Barton NS,Van Swol RL

    更新日期:1987-09-01 00:00:00

  • Relationship between self-reported bruxism and periodontal status: Findings from a cross-sectional study.

    abstract:BACKGROUND:Several studies seek to prove the relationship between bruxism and periodontal status although it remains unclear and debatable. We aimed to assess the association between self-reported (SR) bruxism with the periodontal status in a large scale survey. MATERIAL AND METHODS:A total of 1064 individuals from th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.19-0364

    authors: Botelho J,Machado V,Proença L,Rua J,Martins L,Alves R,Cavacas MA,Manfredini D,Mendes JJ

    更新日期:2019-12-18 00:00:00

  • Periodontal and microbiological changes associated with the placement of orthodontic appliances. A review.

    abstract::This review examines specific aspects of orthodontic treatment and periodontal health, namely the effects of orthodontic banded attachments on periodontal disease and more specifically the microflora found around the gingival margins. This review highlights critical developments in orthodontic techniques and microbiol...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1996.67.2.78

    authors: Atack NE,Sandy JR,Addy M

    更新日期:1996-02-01 00:00:00

  • A critical review of the biologic rationale for guided tissue regeneration.

    abstract::This review discusses the rationale for using guided tissue regeneration therapy. The review not only attempts to clarify the concept of selective tissue regeneration using non-resorbable and resorbable barriers, but to discuss differences in healing events after treatment with the two types of barriers together with ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析

    doi:10.1902/jop.1991.62.3.171

    authors: Minabe M

    更新日期:1991-03-01 00:00:00

  • Epidermolysis bullosa acquisita: clinical manifestations, microscopic findings, and surgical periodontal therapy. A case report.

    abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.4.550

    authors: Hakki SS,Celenligil-Nazliel H,Karaduman A,Usubütün A,Ertoy D,Ayhan A,Ruacan S

    更新日期:2001-04-01 00:00:00

  • Evaluation of the titanium Ti-6Al-7Nb alloy with and without plasma-sprayed hydroxyapatite coating on growth and viability of cultured osteoblast-like cells.

    abstract:BACKGROUND:Osseointegrated dental implants are currently recognized as a standard treatment method in dentistry. Titanium (Ti) and its alloys are the metals of choice for endosseous parts of currently available dental implants. Ti-6Al-4V is the most used Ti alloy, however; an improved version, Ti-6Al-7Nb, has been rece...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2002.73.8.900

    authors: de Lavos-Valereto IC,Deboni MC,Azambuja N Jr,Marques MM

    更新日期:2002-08-01 00:00:00

  • The Use of Cone-Beam Computed Tomography in Management of Patients Requiring Dental Implants: An American Academy of Periodontology Best Evidence Review.

    abstract:BACKGROUND:Application of cone-beam computed tomography (CBCT) has grown exponentially across dentistry with a clear impact in implant dentistry. This review aims at providing the scientific context to understand if CBCT imaging should become the standard of care for patients requiring dental implants. METHODS:A liter...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2017.160548

    authors: Rios HF,Borgnakke WS,Benavides E

    更新日期:2017-10-01 00:00:00

  • Cervical enamel projections and associated pouch-like opening in mandibular furcations.

    abstract:BACKGROUND:Cervical enamel projections (CEPs) have been listed among the tooth-associated risk factors that could lead to isolated furcation defects around molar teeth. This is more likely when Grade III CEPs are present. However, the histologic aspects of the CEP interface with regard to the presence or absence of cem...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110088

    authors: Blanchard SB,Derderian GM,Averitt TR,John V,Newell DH

    更新日期:2012-02-01 00:00:00

  • Analysis of consecutively placed loaded root-form and plate-form implants in adult Macaca mulatta monkeys.

    abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.12.1322

    authors: Fritz ME,Braswell LD,Koth D,Jeffcoat M,Reddy M,Brogan D,Cotsonis G,Winter M,Lemons JE

    更新日期:1996-12-01 00:00:00

  • Treatment of aggressive periodontitis by osseointegrated dental implants. A case report.

    abstract:BACKGROUND:Generalized aggressive periodontitis is described as a clinical entity affecting both deciduous and permanent dentition with extensive alveolar bone loss, mobility, and exfoliation of all or many teeth. Controversy exists on dental implant use to restore missing dentition in younger patients. METHODS:This c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.3.411

    authors: Yalçin S,Yalçin F,Günay Y,Bellaz B,Onal S,Firatli E

    更新日期:2001-03-01 00:00:00

  • Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature.

    abstract:BACKGROUND:Ossifying fibromyxoid tumors (OFTs) are uncommon soft tissue neoplasms. Only one case arising in the gingiva has been described. METHODS:A 21-year-old woman presented with a painless exophytic mass located in the right posterior mandibular gingiva, which was identified 6 months earlier. Radiographs showed i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2009.080535

    authors: Nonaka CF,Pacheco DF,Nunes RP,Freitas Rde A,Miguel MC

    更新日期:2009-04-01 00:00:00

  • The association between osteopenia and periodontal attachment loss in older women.

    abstract:BACKGROUND:Recent research suggests that osteopenia may be a predisposing factor for periodontal tissue destruction. If so, then a relationship should exist between measures of systemic bone mineral density and periodontal tissue destruction. The purpose of the present cross-sectional study was to evaluate the associat...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.9.982

    authors: Weyant RJ,Pearlstein ME,Churak AP,Forrest K,Famili P,Cauley JA

    更新日期:1999-09-01 00:00:00

  • The effects of incubation length and temperature on the specificity and sensitivity of the BANA (N-benzoyl-DL-arginine-naphthylamide) test.

    abstract::A previous multi-center study examining patients diagnosed as having at least four periodontally diseased teeth showed that when BANA (N-Benzoyl-DL-Arginine-Naphthylamide) hydrolysis by periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus was evaluated versus clinical ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1993.64.9.848

    authors: Amalfitano J,De Filippo AB,Bretz WA,Loesche WJ

    更新日期:1993-09-01 00:00:00

  • Preemptive dexamethasone and etoricoxib for pain and discomfort prevention after periodontal surgery: a double-masked, crossover, controlled clinical trial.

    abstract:BACKGROUND:Several anti-inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open-flap debridement surgery. METHODS:For this prospective, double-masked, crossover, placebo-controlle...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2010.100059

    authors: Steffens JP,Santos FA,Sartori R,Pilatti GL

    更新日期:2010-08-01 00:00:00

  • Ossification of a collagen membrane cross-linked by sugar: a human case series.

    abstract:BACKGROUND:Collagen membranes cross-linked by glycation (GLYM) for guided bone regeneration (GBR) and guided tissue regeneration (GTR) are used extensively with proven safety and efficacy. Complete GLYM ossification, when placed in contact with bone, was described in a canine jaw model, suggesting that GLYM may serve a...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070421

    authors: Zubery Y,Nir E,Goldlust A

    更新日期:2008-06-01 00:00:00

  • Effect of periodontal therapy on patients maintained for 15 years or longer. A retrospective study.

    abstract::A retrospective study of tooth loss in 211 patients who were treated for periodontal disease in private practice and maintained for 15 to 34 years on 3- to 6-month recall schedules is reported. The average age of the patients was 42 years, and the average length of time in maintenance was 22 years. On the basis of res...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1986.57.6.347

    authors: Goldman MJ,Ross IF,Goteiner D

    更新日期:1986-06-01 00:00:00

  • Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study.

    abstract:BACKGROUND:Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication-related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (μCT) imag...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0547

    authors: Kniha K,Bock A,Peters F,Magnuska ZA,Gremse F,Möhlhenrich SC,Hölzle F,Modabber A

    更新日期:2020-11-30 00:00:00

  • Periodontal status and bruxism. A comparative study of patients with periodontal disease and occlusal parafunctions.

    abstract::This study investigated a possible association between bruxism and severity of periodontal disease. Subjects consisted of 51 patients (mean age 47.3 years) referred to the Department of Periodontology for treatment of moderate to severe periodontal disease (Perio-group) and 40 patients (mean age 48.9 years) referred t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.3.173

    authors: Hanamura H,Houston F,Rylander H,Carlsson GE,Haraldson T,Nyman S

    更新日期:1987-03-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A 15-year report.

    abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.9.589

    authors: Smithloff M,Fritz ME

    更新日期:1987-09-01 00:00:00

  • Using a Delphi panel to survey criteria for successful periodontal therapy in anterior teeth.

    abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.9.1508

    authors: Lightfoot WS,Hefti A,Mariotti A

    更新日期:2005-09-01 00:00:00

  • Sarcoidosis affecting the periodontium: a long-term follow-up case.

    abstract:BACKGROUND:Clinical manifestations of sarcoidosis affecting the periodontium could mimic aggressive periodontitis. This case report documents the occurrence of sarcoidosis affecting the periodontium, including its clinical features, diagnosis, treatment, and 6-year follow-up. METHODS:An individual with a history of pu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070117

    authors: Moretti AJ,Fiocchi MF,Flaitz CM

    更新日期:2007-11-01 00:00:00

  • Histologic and histomorphometric findings from retrieved, immediately occlusally loaded implants in humans.

    abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11.1823

    authors: Romanos GE,Testori T,Degidi M,Piattelli A

    更新日期:2005-11-01 00:00:00

  • Histologic evaluation of the effects of intrasulcular toothbrushing on human sulcular epithelium.

    abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1978.49.4.163

    authors: Fry HR,App GR

    更新日期:1978-04-01 00:00:00

  • Genetic Control of the Immune Response in Pathogenesis.

    abstract:BACKGROUND:Epidemiological studies have suggested that there is a genetic component to susceptibility to chronic periodontitis. Studies in humans and in animal models have suggested that some of the important components may be polymorphisms in key immunological genes. METHODS:This paper summarizes previously published...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.11-S.2042

    authors: Baker PJ

    更新日期:2005-11-01 00:00:00