Abstract:
BACKGROUND:The main problem in the posterior instrumental treatment of periodontitis is the re-epithelization of the periodontal defects, leading to the formation of an unphysiological, long junctional epithelium inhibiting the regeneration of periodontal attachment. A precondition for the re-epithelization is the interaction between epithelial cells and their extracellular matrix mediated by integrins. Integrins are cellular adhesion molecules (CAM), binding to different structures of the extracellular matrix, e.g., collagen, laminin, or fibronectin. METHODS:Biopsy specimens of marginal gingiva, composed of epithelium and subepithelial connective tissue, were cultivated on microporous membranes in tissue culture plates. The culture medium was supplemented with monoclonal antibodies directed against human integrin subunits. The period of cultivation was 6 days and the medium was replaced daily. After cultivation, the tissue development was analyzed by histological and immunohistochemical methods. RESULTS:We found that the combination of antibodies directed against the integrin subunits alpha6 and beta1 inhibited the migration of epithelium completely in 9 out of 10 cultures, whereas control cultures containing none or only irrelevant antibodies demonstrated connective tissues completely covered by epithelium. CONCLUSIONS:Influencing the regeneration of periodontal tissue on a molecular basis by using antibodies directed against integrin subunits may be of future interest in postsurgical treatment of periodontal diseases.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Gräber HG,Wilharm J,Conrads Gdoi
10.1902/jop.1999.70.4.388subject
Has Abstractpub_date
1999-04-01 00:00:00pages
388-93issue
4eissn
0022-3492issn
1943-3670journal_volume
70pub_type
杂志文章abstract::Weary-Kindler syndrome is a rare and poorly understood genetic disorder that has manifestations of both epidermolysis bullosa and poikiloderma congenitale. There are approximately 70 cases documented in the past 40 years but no cases appear in the dental literature, although dental findings have been discussed superfi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.10.1004
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Evaluation of clinical long-term results 20 years after connective tissue grafting (CTG) or guided tissue regeneration (GTR) using bioabsorbable barriers for root coverage therapy. METHODS:Initially, 15 patients with 38 Miller Class I and II recession defects underwent CTG or GTR according to random assignm...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0203
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.77.1.103
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Relative few reports exist concerning healing of laser created osteotomies over an extended period of time. The purpose of this study was to evaluate long-term healing, from 21 to 63 days, of osteotomy defects in the rat tibia created with the Nd:YAG and CO2 in the presence of a surface cooling spray of air/...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.2.174
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:It has been shown that toll-like receptor (TLR) 2- and TLR4-stimulating abilities of supragingival plaque (SPP) are associated with periodontal conditions. It is hypothesized that SPP might affect the periodontium through its influence on subgingival plaque (SBP). This study investigates relationships betwee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150573
更新日期:2016-09-01 00:00:00
abstract::The use of antibiotics in periodontal therapy has received increasing attention in recent years. Although generally safe, certain antibiotics, including tetracycline and ampicillin, have been shown to interact indirectly with oral contraceptives, with a resultant decrease in oral contraceptive efficacy. This paper rev...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1985.56.1.18
更新日期:1985-01-01 00:00:00
abstract::A scanning electron microscope and electron probe study was carried out to compare root structure from deep within periodontal pockets with roots exhibiting no periodontal disease. To eliminate the possibility of extraneous ion introduction or deletion, no attempt was made to subject the roots to fixation, embedding, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.9.634
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Several studies seek to prove the relationship between bruxism and periodontal status although it remains unclear and debatable. We aimed to assess the association between self-reported (SR) bruxism with the periodontal status in a large scale survey. MATERIAL AND METHODS:A total of 1064 individuals from th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0364
更新日期:2019-12-18 00:00:00
abstract::This review examines specific aspects of orthodontic treatment and periodontal health, namely the effects of orthodontic banded attachments on periodontal disease and more specifically the microflora found around the gingival margins. This review highlights critical developments in orthodontic techniques and microbiol...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.1996.67.2.78
更新日期:1996-02-01 00:00:00
abstract::This review discusses the rationale for using guided tissue regeneration therapy. The review not only attempts to clarify the concept of selective tissue regeneration using non-resorbable and resorbable barriers, but to discuss differences in healing events after treatment with the two types of barriers together with ...
journal_title:Journal of periodontology
pub_type: 杂志文章,meta分析
doi:10.1902/jop.1991.62.3.171
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Epidermolysis bullosa acquisita (EBA) is an uncommon, acquired, chronic subepidermal bullous disease. This report describes a case of EBA with gingival involvement. A 43-year-old woman with EBA was referred to our clinic for periodontal therapy because of gingival tenderness and bleeding. She has been on cyc...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.4.550
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Osseointegrated dental implants are currently recognized as a standard treatment method in dentistry. Titanium (Ti) and its alloys are the metals of choice for endosseous parts of currently available dental implants. Ti-6Al-4V is the most used Ti alloy, however; an improved version, Ti-6Al-7Nb, has been rece...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.8.900
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Application of cone-beam computed tomography (CBCT) has grown exponentially across dentistry with a clear impact in implant dentistry. This review aims at providing the scientific context to understand if CBCT imaging should become the standard of care for patients requiring dental implants. METHODS:A liter...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2017.160548
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Cervical enamel projections (CEPs) have been listed among the tooth-associated risk factors that could lead to isolated furcation defects around molar teeth. This is more likely when Grade III CEPs are present. However, the histologic aspects of the CEP interface with regard to the presence or absence of cem...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110088
更新日期:2012-02-01 00:00:00
abstract::The present paper describes 36 consecutively treated non-human primates (Macaca mulatta) as part of a balanced block design study to examine osseointegration in root- and plate-form implants prepared by atraumatic preparation of bone. Clinical measurements around selected teeth and digital radiology were utilized to m...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.12.1322
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Generalized aggressive periodontitis is described as a clinical entity affecting both deciduous and permanent dentition with extensive alveolar bone loss, mobility, and exfoliation of all or many teeth. Controversy exists on dental implant use to restore missing dentition in younger patients. METHODS:This c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.411
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Ossifying fibromyxoid tumors (OFTs) are uncommon soft tissue neoplasms. Only one case arising in the gingiva has been described. METHODS:A 21-year-old woman presented with a painless exophytic mass located in the right posterior mandibular gingiva, which was identified 6 months earlier. Radiographs showed i...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2009.080535
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Recent research suggests that osteopenia may be a predisposing factor for periodontal tissue destruction. If so, then a relationship should exist between measures of systemic bone mineral density and periodontal tissue destruction. The purpose of the present cross-sectional study was to evaluate the associat...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.9.982
更新日期:1999-09-01 00:00:00
abstract::A previous multi-center study examining patients diagnosed as having at least four periodontally diseased teeth showed that when BANA (N-Benzoyl-DL-Arginine-Naphthylamide) hydrolysis by periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus was evaluated versus clinical ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.9.848
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Several anti-inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open-flap debridement surgery. METHODS:For this prospective, double-masked, crossover, placebo-controlle...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2010.100059
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Collagen membranes cross-linked by glycation (GLYM) for guided bone regeneration (GBR) and guided tissue regeneration (GTR) are used extensively with proven safety and efficacy. Complete GLYM ossification, when placed in contact with bone, was described in a canine jaw model, suggesting that GLYM may serve a...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070421
更新日期:2008-06-01 00:00:00
abstract::A retrospective study of tooth loss in 211 patients who were treated for periodontal disease in private practice and maintained for 15 to 34 years on 3- to 6-month recall schedules is reported. The average age of the patients was 42 years, and the average length of time in maintenance was 22 years. On the basis of res...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.6.347
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication-related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (μCT) imag...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0547
更新日期:2020-11-30 00:00:00
abstract::This study investigated a possible association between bruxism and severity of periodontal disease. Subjects consisted of 51 patients (mean age 47.3 years) referred to the Department of Periodontology for treatment of moderate to severe periodontal disease (Perio-group) and 40 patients (mean age 48.9 years) referred t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.3.173
更新日期:1987-03-01 00:00:00
abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.9.589
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1508
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Clinical manifestations of sarcoidosis affecting the periodontium could mimic aggressive periodontitis. This case report documents the occurrence of sarcoidosis affecting the periodontium, including its clinical features, diagnosis, treatment, and 6-year follow-up. METHODS:An individual with a history of pu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.070117
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The immediate loading treatment concept can be successfully used in implant dentistry. Bone cells migrate onto the implant surface and establish a stable anchorage on the titanium surface. When implants are loaded immediately after surgery, there is a high long-term success rate of the implant-supported reco...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11.1823
更新日期:2005-11-01 00:00:00
abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.4.163
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Epidemiological studies have suggested that there is a genetic component to susceptibility to chronic periodontitis. Studies in humans and in animal models have suggested that some of the important components may be polymorphisms in key immunological genes. METHODS:This paper summarizes previously published...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.11-S.2042
更新日期:2005-11-01 00:00:00