Genetic Control of the Immune Response in Pathogenesis.

Abstract:

BACKGROUND:Epidemiological studies have suggested that there is a genetic component to susceptibility to chronic periodontitis. Studies in humans and in animal models have suggested that some of the important components may be polymorphisms in key immunological genes. METHODS:This paper summarizes previously published data from a mouse model in which alveolar bone loss is induced by oral infection with Porphyromonas gingivalis. Mice of different inbred immune-normal strains were used, as well as the F1 heterozygotes from crosses between strains. In addition, tissue expression of an array of immunological genes was measured in the gingiva and spleen of these mice by quantitative reverse transcription-polymerase chain reaction (QPCR). RESULTS:Not all strains of mice are susceptible to bone loss. Intercross experiments demonstrate that susceptibility is an inherited trait. A subset of immunological genes tested showed differential basal expression in the gingiva or spleens (or both). Tumor necrosis factor and osteoprotegerin mRNAs are more highly expressed in the gingiva and interleukin-1 mRNA is more highly expressed in both the gingiva and the spleens of susceptible mice than resistant mice. In the resistant mice, interleukin-15 mRNA in the gingiva and Selp mRNA in the spleen are present at higher levels. In the resistant mice no genes changed expression after P. gingivalis infection, while mRNA for interleukin-1, osteoprotegerin, and STAT6 all increased in the susceptible mice. CONCLUSIONS:Susceptibility and resistance are heritable traits. Strain differences in basal mRNA expression correlate with differences in susceptibility. Genes that change expression in response to infection also correlate with differences in susceptibility.

journal_name

J Periodontol

authors

Baker PJ

doi

10.1902/jop.2005.76.11-S.2042

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

2042-2046

eissn

0022-3492

issn

1943-3670

journal_volume

76 Suppl 11S

pub_type

杂志文章
  • Early-onset periodontitis associated with Weary-Kindler syndrome: a case report.

    abstract::Weary-Kindler syndrome is a rare and poorly understood genetic disorder that has manifestations of both epidermolysis bullosa and poikiloderma congenitale. There are approximately 70 cases documented in the past 40 years but no cases appear in the dental literature, although dental findings have been discussed superfi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1996.67.10.1004

    authors: Wiebe CB,Silver JG,Larjava HS

    更新日期:1996-10-01 00:00:00

  • Periodontitis in patients with coronary artery disease: an 8-year follow-up.

    abstract:BACKGROUND:This study examines whether preceding assessment of periodontal status in patients with established coronary artery disease (CAD) can predict future CAD endpoints (myocardial infarction, new revascularization procedure, or CAD-related death) during 8-year follow-up and whether the changes in periodontal stat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.120730

    authors: Johansson CS,Ravald N,Pagonis C,Richter A

    更新日期:2014-03-01 00:00:00

  • The potential role of bone morphogenetic proteins in periodontal reconstruction.

    abstract::Growth factors and cytokines are currently under investigation as potential therapeutics for the site-specific regeneration of alveolar bone. Many of these factors, including TGF-beta, PDGF, IGF-I, IGF-II, and FGF influence bone growth and resorption, and as such may be useful in the regeneration process. However, the...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1995.66.6.506

    authors: Wozney JM

    更新日期:1995-06-01 00:00:00

  • Association between periodontitis and blood lipid levels in a Korean population.

    abstract:BACKGROUND:Hyperlipidemia is a known risk factor for cardiovascular diseases. A common biologic mechanism between systemic diseases, such as cardiovascular diseases, and periodontal diseases has been suggested. The aim of this study is to examine the association between blood lipid profile and periodontitis. METHODS:T...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.170111

    authors: Lee S,Im A,Burm E,Ha M

    更新日期:2018-01-01 00:00:00

  • Association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females.

    abstract:BACKGROUND:Previous findings of an association between 25-hydroxyvitamin D [25(OH)D] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin D. To the best of the authors' knowledge, no study has investigated the association between 25(OH)D and pathogenic oral bacter...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2013.130518

    authors: Sahli MW,Wactawski-Wende J,Ram PK,LaMonte MJ,Hovey KM,Genco RJ,Andrews CA,Millen AE

    更新日期:2014-07-01 00:00:00

  • Current understanding of the role of microscopic monitoring, baking soda, and hydrogen peroxide in the treatment of periodontal disease. Committee on Research, Science and Therapy. The American Academy of Periodontology.

    abstract::The Keyes technique came to national attention following a reference in The New York Times in the late 1970s. Several lay press articles and discussions on national television served to further focus the interest of patients, general dentists, and periodontists on this potential approach to periodontal therapy. Early ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,收录出版

    doi:

    authors:

    更新日期:1998-08-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A 15-year report.

    abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.9.589

    authors: Smithloff M,Fritz ME

    更新日期:1987-09-01 00:00:00

  • Comparison of analgesic and anti-inflammatory efficacy of selective and non-selective cyclooxygenase-2 inhibitors in dental implant surgery.

    abstract:BACKGROUND:The analgesic and anti-inflammatory efficacy of tenoxicam and meloxicam were evaluated in this double-masked, randomized, prospective study by analyzing pain scores and the need for rescue-analgesic agents following dental implant surgery. METHODS:One hundred patients, in whom 241 dental implants were place...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2007.070192

    authors: Karabuda ZC,Bolukbasi N,Aral A,Basegmez-Zeren C,Ozdemir T

    更新日期:2007-12-01 00:00:00

  • Clinical recommendations for avoiding and managing surgical complications associated with implant dentistry: a review.

    abstract::Proposing to place endosseous implants is an integral facet of dental treatment plans. Their insertion is usually associated with a low incidence of untoward events. However, despite careful planning, surgical complications can arise: infection, intraoral hemorrhage, wound dehiscence, postoperative pain, lack of prima...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2008.070067

    authors: Greenstein G,Cavallaro J,Romanos G,Tarnow D

    更新日期:2008-08-01 00:00:00

  • Laser-assisted regenerative surgical therapy for peri-implantitis: A randomized controlled clinical trial.

    abstract:BACKGROUND:Different surgical approaches have been proposed to treat peri-implantitis defects with limited effectiveness and predictability. Laser has been proposed as an effective tool to assist in bacterial decontamination and modulating peri-implant tissue inflammation. The aim of this pilot clinical trial was to ev...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0040

    authors: Wang CW,Ashnagar S,Gianflippo RD,Arnett M,Kinney J,Wang HL

    更新日期:2020-08-06 00:00:00

  • The influence of genetic variation on the splenic T cell cytokine and specific serum antibody responses to Porphyromonas gingivalis in mice.

    abstract:BACKGROUND:T cell cytokine profiles in the spleens and anti-Porphyromonas gingivalis antibodies in the sera of P. gingivalis-immunized BALB/c (H-2d), CBA/CaH (H-2k), C57BL6 (H-2b), and DBA/2J (H-2d, C5 deficient) mice were examined. METHODS:Mice were immunized either by intraperitoneal injections of P. gingivalis oute...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2000.71.7.1130

    authors: Gemmell E,Winning TA,Grieco DA,Bird PS,Seymour GJ

    更新日期:2000-07-01 00:00:00

  • Standardization of relative centrifugal forces in studies related to platelet-rich fibrin.

    abstract::Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermo...

    journal_title:Journal of periodontology

    pub_type: 社论

    doi:10.1002/JPER.18-0553

    authors: Miron RJ,Pinto NR,Quirynen M,Ghanaati S

    更新日期:2019-08-01 00:00:00

  • Langerhans-cell histiocytosis: a clinical case without bone involvement.

    abstract:BACKGROUND:Langerhans-cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.1.143

    authors: Manfredi M,Corradi D,Vescovi P

    更新日期:2005-01-01 00:00:00

  • Experimental gingivitis in ODU plaque-susceptible rats. V. On the vascular permeability factor of dental plaque.

    abstract::Plaque-induced inflammation has been documented from various aspects, but is still not well understood. In an effort to clarify the physicochemical properties of dental plaque and to isolate the active factor which give rise to inflammation, we studied a factor in plaque which may be a direct and local cause of gingiv...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1980.51.7.400

    authors: Matsuda K,Yamanaka Y,Shen CT,Mori M

    更新日期:1980-07-01 00:00:00

  • Periodontal status in men with hypergonadotropic hypogonadism: effects of testosterone deficiency.

    abstract:BACKGROUND:The purpose of this clinical study was to evaluate the possible influence of testosterone hormone on common clinical measurements of periodontal disease in men with hypergonadotropic hypogonadism. METHODS:Twenty-four hypergonadotropic hypogonadal men (H) and 24 systemically healthy men (S) were divided into...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050286

    authors: Daltaban O,Saygun I,Bolu E

    更新日期:2006-07-01 00:00:00

  • Bacterial invasion in experimental gingivitis in man.

    abstract::Gingival biopsies of the mesial papilla area of the first molar were obtained from each patient at 0-, 14- and 21-day intervals during plaque formation. The biopsies were fixed, serially sectioned, and Gram-stained. The incidence and distribution of the bacteria-like structures were studied by microscopy. In all the s...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.12.837

    authors: Saglie FR,Pertuiset JH,Rezende MT,Sabet MS,Raoufi D,Carranza FA Jr

    更新日期:1987-12-01 00:00:00

  • Smoker's melanosis. A case report.

    abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1991.62.8.524

    authors: Brown FH,Houston GD

    更新日期:1991-08-01 00:00:00

  • In vivo determination of radiographic projection errors produced by a novel filmholder and an x-ray beam manipulator.

    abstract::Subtraction radiography requires radiographs made with identical projection geometry. The purpose of the present investigation was to develop and evaluate a new in vivo method to measure angular radiographic projection error. This included the development of a system for accurate control of the x-ray beam angulation r...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1991.62.11.674

    authors: Zappa U,Simona C,Graf H,van Aken J

    更新日期:1991-11-01 00:00:00

  • Commentary: A Translational Medicine Approach to Tooth Transplantation.

    abstract::The autogenous tooth transplantation approach to replace missing teeth has been in use for a long time. Different surgical techniques have been developed to improve prognosis and longevity of transplanted teeth with complete root formation. Many factors reportedly affected short- and long-term success of the procedure...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.160820

    authors: Prato GP,Zuccati G,Clauser C

    更新日期:2017-06-01 00:00:00

  • Influence of Apico-Coronal Implant Placement on Post-Surgical Crestal Bone Loss in Humans.

    abstract:BACKGROUND:Contradictory results exist regarding influence of apico-coronal implant placement on crestal bone levels. METHODS:Complete charts of patients ≥18 years old with one or more dental implants were included. Demographic, medical, surgical, and prosthetic information was recorded. Implant bone levels were evalu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2017.160802

    authors: Ercoli C,Jammal G,Buyers M,Tsigarida AA,Chochlidakis KM,Feng C,Caton J

    更新日期:2017-08-01 00:00:00

  • A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases.

    abstract::TEN PATIENTS WHO REQUIRED two or more anterior teeth extractions were utilized in this study. Extraction procedures were carried out with a full thickness surgical flap approach. After flap reflection, teeth were removed with a minimum of trauma to the surrounding bone. Following extraction silicone-based impression t...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1997.68.6.563

    authors: Lekovic V,Kenney EB,Weinlaender M,Han T,Klokkevold P,Nedic M,Orsini M

    更新日期:1997-06-01 00:00:00

  • The gene expression profile in refractory periodontitis patients.

    abstract:BACKGROUND:There are no specific bacterial profiles or diagnostic tests capable of identifying refractory periodontitis patients before a treatment regimen is initiated. Therefore, in this high-risk cohort of patients who do not respond appropriately, host factors that might be partly under genetic control may play a c...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050254

    authors: Kim DM,Ramoni MF,Nevins M,Fiorellini JP

    更新日期:2006-06-01 00:00:00

  • The rotation flap for covering denuded root surfaces - a closed wound technique.

    abstract::A rotation flap for covering denuded single root surfaces with attached gingiva has been described and illustrated. This was performed utilizing a closed wound technique. The single flap provided attached gingiva coverage for a moderate area while a double flap provided coverage for a larger area. Although more attach...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1977.48.1.41

    authors: Patur B

    更新日期:1977-01-01 00:00:00

  • A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.

    abstract:BACKGROUND:Chemically modified non-antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix metalloproteinase, MMP) activity and bone resorption in vivo and in vitro. METHODS:In the current study, suboptimal doses of CMT-8 (a non-antimicrobial chemically modif...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.8.1069

    authors: Llavaneras A,Ramamurthy NS,Heikkilä P,Teronen O,Salo T,Rifkin BR,Ryan ME,Golub LM,Sorsa T

    更新日期:2001-08-01 00:00:00

  • Underestimation of periodontitis in NHANES surveys.

    abstract::The study design of national surveys of periodontal disease often uses partial-mouth examination protocols to rationalize the need for resources so that the collection of data from a large number of subjects can be achieved within the available means without significantly sacrificing precision and validity. Studies sh...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100638

    authors: Albandar JM

    更新日期:2011-03-01 00:00:00

  • Efficacy of varying concentrations of subgingivally delivered metformin in the treatment of chronic periodontitis: a randomized controlled clinical trial.

    abstract:BACKGROUND:Metformin (MF), a second-generation biguanide, is a commonly used oral antidiabetic drug that has been shown recently to stimulate osteoblasts and reduce alveolar bone loss. The present study aims to explore the efficacy of 0.5%, 1%, and 1.5% MF gel as a local drug delivery system in adjunct to scaling and r...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2012.120025

    authors: Pradeep AR,Rao NS,Naik SB,Kumari M

    更新日期:2013-02-01 00:00:00

  • Long-term efficacy of subantimicrobial-dose doxycycline as an adjunctive treatment to scaling and root planing: a systematic review and meta-analysis.

    abstract:BACKGROUND:Subantimicrobial-dose doxycycline (SDD) is widely used as an adjunctive treatment to scaling and root planing (SRP), but its long-term effectiveness remains controversial. The purpose of this systematic review was to assess the actual evidence of the effectiveness of SRP + SDD compared to SRP + placebo in th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1902/jop.2011.110026

    authors: Sgolastra F,Petrucci A,Gatto R,Giannoni M,Monaco A

    更新日期:2011-11-01 00:00:00

  • The effect of smoking and periodontal treatment on salivary composition in patients with established periodontitis.

    abstract:BACKGROUND:The purpose of this study was to evaluate the effect of smoking on the periodontal status and the salivary composition in subjects with established periodontitis before and after periodontal therapy. METHODS:Our study group included 26 healthy subjects, 12 smokers and 14 non-smokers with established periodo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1999.70.10.1240

    authors: Zuabi O,Machtei EE,Ben-Aryeh H,Ardekian L,Peled M,Laufer D

    更新日期:1999-10-01 00:00:00

  • Implants in regenerated bone in a primate model.

    abstract:BACKGROUND:Earlier publications from our laboratory described the use of guided bone regeneration to fill large bone voids in the mandible created through en bloc resection in primates. The present report describes placement of implants into the regenerated bone with subsequent prostheses construction and loading. MET...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.6.703

    authors: Fritz ME,Jeffcoat MK,Reddy M,Koth D,Braswell LD,Malmquist J,Lemons J

    更新日期:2001-06-01 00:00:00

  • Progression of periodontitis in a sample of regular and irregular compliers under maintenance therapy: a 3-year follow-up study.

    abstract:BACKGROUND:To our knowledge, prospective studies (matched for sex, smoking, and diabetes) that investigated the influence of compliance in the progression of periodontitis and tooth loss in periodontal maintenance therapy (PMT) programs were not previously reported. METHODS:A total of 58 regular complier (RC) and 58 e...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.100664

    authors: Oliveira Costa F,Miranda Cota LO,Pereira Lages EJ,Medeiros Lorentz TC,Soares Dutra Oliveira AM,Dutra Oliveira PA,Costa JE

    更新日期:2011-09-01 00:00:00