Abstract：
BACKGROUND:Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital roles in the progression of bone loss in periodontitis. In this study, the expression of RANKL and OPG mRNA and the relationship between these factors and periodontopathic bacteria in periodontal tissue were studied. METHODS:Gingival tissue and subgingival plaque samples were collected from 15 patients with chronic periodontitis and 15 periodontally healthy subjects. RNA was extracted from the tissue and subjected to reverse transcription-polymerase chain reaction (RT-PCR) using primers specific for RANKL or OPG. Beta-actin was amplified as a control to ensure equal loading. The intensity of RT-PCR products was analyzed by a densitometer in proportion to the intensity of beta-actin. The numbers of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were determined by quantitative real-time PCR. RESULTS:Our results showed increased levels of RANKL mRNA in chronic periodontitis tissues. The RANKL/OPG expression ratio was significantly higher in the periodontitis group compared to the healthy control group (P = 0.001). Interestingly, the expression of RANKL (r = 0.64; P <0.001), but not OPG (r = -0.24; P = 0.20), was significantly correlated with increased numbers of P. gingivalis. A. actinomycetemcomitans was detected in only 6.7% of all sites. CONCLUSIONS:Chronic periodontitis was associated with RANKL mRNA upregulation and increased RANKL/OPG mRNA expression ratio. In addition, our data showed for the first time to our knowledge an association between upregulated RANKL levels and the number of P. gingivalis in clinically obtained periodontal tissues.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Wara-aswapati N,Surarit R,Chayasadom A,Boch JA,Pitiphat Wdoi
10.1902/jop.2007.060398subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1062-9issue
6eissn
0022-3492issn
1943-3670journal_volume
78pub_type
杂志文章abstract：:The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-inci...
journal_title：Journal of periodontology
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pub_type： 临床试验,杂志文章
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pub_type： 临床试验,杂志文章
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更新日期：2020-10-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of periodontology
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journal_title：Journal of periodontology
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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pub_type： 杂志文章
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