Abstract:
BACKGROUND:Metastases to the oral mucosa are rare, representing less than 1% of the tumors at this site. Most of these metastatic neoplasms originate in the lungs, kidneys, and liver. METHODS:The clinicopathologic features of an occult hepatocellular carcinoma, metastatic to the oral mucosa, are reported. The patient, a 70-year-old male, complained of 3 distinct polypoid, reddish lesions of the antero-inferior alveolar crest and both the right and left postero-superior attached gingiva, without bone involvement. The lesions were excised, with the clinical diagnosis of multiple vascular tumors, formalin-fixed, paraffin-embedded, cut and stained with hematoxylin and eosin. Consecutive sections were immunostained for alpha-1-antichymotrypsin, CEA, cytokeratins, EMA, hepatocyte antigen, PSA, S-100 protein, and thyroglobulin, using the alkaline phosphatase/anti-alkaline phosphatase technique. RESULTS:The morphologic features of the lesions were consistent with the diagnosis of carcinoma with trabecular and glandular patterns and bile secretion; furthermore, immunohistochemical reactivity for alpha-1-antichymotrypsin, cytokeratins, CEA, EMA, and hepatocyte antigen was demonstrated and the hepatic origin of the tumor was postulated. Ultrasonography demonstrated a liver mass, which was biopsied and treated by chemoembolization. While no further complications occurred in the oral mucosa, the patient died 8 months after the diagnosis for widespread diffusion of the tumor to the lungs and brain. CONCLUSIONS:This case emphasizes the need to include metastatic tumors in the differential diagnosis of atypical neoplasms of the oral mucosa and to evaluate the opportunity of surgical treatment in order to preserve the functions of the mouth, even if the prognosis of the primary tumors remains unfavorable.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Maiorano E,Piattelli A,Favia Gdoi
10.1902/jop.2000.71.4.641subject
Has Abstractpub_date
2000-04-01 00:00:00pages
641-5issue
4eissn
0022-3492issn
1943-3670journal_volume
71pub_type
杂志文章abstract:BACKGROUND:Proper formation of cementum, a mineralized tissue lining the tooth root surface, is required for development of a functional periodontal ligament. Further, the presence of healthy cementum is considered to be an important criterion for predictable restoration of periodontal tissues lost as a consequence of ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.1.63
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic width applied to subjects with severe, generalized, chronic periodontit...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.080066
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:A 22-year-old African American female was referred for augmentation of keratinized gingiva around implants at the right and left maxillary second premolar sites. Presurgical evaluation revealed generalized melanosis of the buccal gingiva and a lack of keratinized tissue around implants at sites #4 and #13. N...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090289
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Recent research suggests that osteopenia may be a predisposing factor for periodontal tissue destruction. If so, then a relationship should exist between measures of systemic bone mineral density and periodontal tissue destruction. The purpose of the present cross-sectional study was to evaluate the associat...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1999.70.9.982
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:In an attempt to evaluate the influence of cyclosporin A (CsA) on fibroblast metabolism, the phospholipase C beta1, (PLC beta1) nuclear expression was evaluated in fibroblasts from heart transplantation patients treated with CsA who exhibited gingival overgrowth (GO) and from controls. METHODS:PLC beta1 was...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.11.1722
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Cytokines play a key role in the pathogenesis of inflammatory diseases. An obvious question is whether patients with aggressive periodontitis, juvenile idiopathic arthritis, or rheumatoid arthritis share blood cytokine profiles distinguishing them from individuals free of disease. METHODS:The study populati...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.12.2276
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Generalized aggressive periodontitis is described as a clinical entity affecting both deciduous and permanent dentition with extensive alveolar bone loss, mobility, and exfoliation of all or many teeth. Controversy exists on dental implant use to restore missing dentition in younger patients. METHODS:This c...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.3.411
更新日期:2001-03-01 00:00:00
abstract::To quantify patient perceptions of periodontal therapy, we administered a self-report questionnaire employing a visual analog scale (VAS) to 162 patients following surgical and non-surgical treatments. The questionnaire tested for variables of pain, sensitivity, swelling, function, altered appearance, comparison of po...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.10.990
更新日期:1993-10-01 00:00:00
abstract::During the acute phase of periodontal disease, as many as 60% of the cells of the junctional epithelium may be accounted for by polymorphonuclear cells (PMNs). It is generally accepted that these cells play a dominant role in the destruction of connective tissue by virtue of the proteinases they release and the free o...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.7.422
更新日期:1986-07-01 00:00:00
abstract::This review defines terms such as accuracy, validity, and reliability, which are used to describe the quality of methods for taking x-rays and for analyzing digital images. Values for these parameters are described for techniques of taking standardized x-rays such as ear-rod fixation and fixation by use of teeth with ...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2000.71.3.497
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:It is estimated that approximately 85% of all halitosis cases have their origin within the mouth; of these, 50% are caused by tongue residues. Previous studies have established that hydrogen sulfide and mercaptans are the primary components of halitosis. Thus, tongue cleaning gains importance as a means of h...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章
doi:10.1902/jop.2004.75.7.1009
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Controversy over the long-term clinical effectiveness of hydroxyapatite (HA)-coated dental implants still persists, despite numerous clinical studies documenting high survival rates. Concerns about the degradation of the coating over the years have been raised; it has been speculated that resorption of the H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060271
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The possible association between oral infection and chronic inflammation and cardiovascular disease risk has been studied intensively. The present study is designed to determine the strength of association between edentulism and angina pectoris in Mexican adults aged 35 years and older. METHODS:Using the to...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130186
更新日期:2014-03-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:The polyamines spermidine, spermine, and putrescine are known to be deeply linked with growth processes, gene expression, and extracellular matrix synthesis. Their cellular content depends primarily on the activity of the enzyme ornithine decarboxylase. High levels of ornithine decarboxylase and polyamines h...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.3.443
更新日期:2005-03-01 00:00:00
abstract::Specific risk indicators associated with either susceptibility or resistance to severe forms of periodontal disease were evaluated in a cross-section of 1,426 subjects, 25 to 74 years of age, mostly metropolitan dwellers, residing in Erie County, New York, and surrounding areas. The study sample exhibited a wide range...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.3.260
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome is becoming a common disorder worldwide. Studies have shown a relationship between metabolic syndrome and periodontal disease, although information on the relationship is limited. METHODS:We analyzed 1,070 Japanese people aged 40, 50, 60, and 70 years who participated in health and period...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090218
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160273
更新日期:2017-02-01 00:00:00
abstract::This study examined histologic and histometric responses to 2 bioabsorbable membranes made from a synthetic copolymer of glycolide and lactide. They were tested for their biocompatibility, resorption characteristics, and ability to support periodontal regeneration. Expanded polytetrafluoroethylene (ePTFE) was used as ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.6.583
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of boric acid irrigation as an adjunct to scaling and root planing (SRP) on clinical and microbiologic parameters and compare this method with chlorhexidine irrigation and SRP alone in patients with chronic p...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2012.120467
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identif...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2002.73.11.1273
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:A J-shaped relationship of body mass index (BMI) with severe periodontitis has been reported. However, it is unknown for other anthropometric indexes in young adults. METHODS:A cross-sectional study examined the relationships in 325 military men and women, aged 20 to 45 years in Taiwan. Anthropometric index...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0275
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Periodontitis is a polymicrobial, chronic inflammatory disease leading to loss of tooth-supporting structures. The bacteremia, endotoxemia, and systemic low-grade inflammation associate periodontitis with systemic illnesses such as diabetes mellitus and coronary artery disease. Periodontal pathogens have bee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.18-0466
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Periodontists have found the gingival autograft to be an effective and predictable technique to increase the amount of attached gingiva around teeth, but this technique requires the surgeon to harvest donor tissue from a remote surgical site. The present study seeks to evaluate the safety and effectiveness o...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.6.867
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Infection and inflammation induce epigenetic changes that alter gene expression. In periodontal disease, inflammation, and microbial dysbiosis occur, which can lead to compromised barrier function of the gingival epithelia. Here, we tested the hypotheses that infection of cultured human gingival epithelial (...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.20-0262
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Recombinant human bone morphogenetic protein (rhBMP)-2 in a bioabsorbable collagen sponge (ACS) carrier supports significant bone formation. However, histomorphometric data on the augmentation of bone formation beyond the skeletal envelope are insufficient. Our objective was to evaluate the short-term effect...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070305
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Most studies comparing prevalence of periodontal disease and risk factors by using partial protocols were performed in adult populations, with several studies being conducted in clinical settings. The aim of this study is to assess the accuracy of partial protocols in estimating the prevalence of periodontal...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2011.110250
更新日期:2012-03-01 00:00:00
abstract::A multitude of new procedures and materials are being tested for their ability to promote periodontal wound healing. This review provides an overview of the most well-accepted methods for evaluating periodontal wound healing procedures/materials. Topics discussed include appropriate patient selection, general principl...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1992.63.12s.1085
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Bad breath is often caused by periodontitis and/or tongue coating. This study followed the impact of initial periodontal therapy on several halitosis-related outcome variables over a 6-month period. Organoleptic ratings are often uncomfortable for the patient and have several disadvantages. They are, for ins...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2005.76.5.705
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate effects of strontium ranelate (SR) on alveolar bone loss (ABL) in rats with experimental periodontitis. METHODS:Forty Wistar rats were randomly divided into five groups: 1) control (n = 8); 2) ligated (n = 8); 3) 300 mg/kg SR (SR300, n = 8); 4) 625 mg/kg SR (SR625, n ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.160227
更新日期:2017-02-01 00:00:00