New porcine microRNA genes found by homology search.

Abstract:

:MicroRNAs (miRNAs) repress target genes at the post-transcriptional level and play important roles in development and cell lineage decisions. In vertebrates, however, both the targets of miRNAs and their expression profiles during development are poorly understood. Thus far, 326 human miRNAs, 249 mouse miRNAs, and 195 rat miRNAs have been identified. Even though the pig is a promising animal model in regenerative biology, as well as in livestock production, only 54 pig miRNAs have been identified. Here, we report the identification of 58 new pig miRNAs. We conducted a homology search using either human or mouse miRNAs genes queried against the pig genome. The new pig miRNAs consist of 23 miRNAs showing homology to mouse, 21 showing homology to human, and 16 showing homology to both human and mouse. The expression profile of 6 miRNAs were analyzed by Northern blot analysis isolated from porcine tissues: ovary, heart, kidney, liver, and pancreas.

journal_name

Genome

journal_title

Genome

authors

Kim HJ,Cui XS,Kim EJ,Kim WJ,Kim NH

doi

10.1139/g06-120

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

1283-6

issue

10

eissn

0831-2796

issn

1480-3321

pii

g06-120

journal_volume

49

pub_type

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