SCN organization reconsidered.

Abstract:

:The SCN has long had organizational schemas imposed on it. In most, the SCN is dichotomized, with one region typically associated with the presence of vasopressin cells and the other associated with cells containing vasoactive intestinal polypeptide and certain afferent terminal fields. If assumed to be accurate, the schemas that have been intended to simplify and conceptually organize the known anatomy may actually interfere with the understanding of how various cell types and input pathways contribute to circadian rhythm regulation. This review describes inadequacies of existing schemas and notes several practical difficulties that undermine their usefulness. These include "static" versus "dynamic" anatomy, generalizations about SCN organization in relation to the plane or level of section, and the concept of differential density, all of which contribute to a view in which the SCN is substantially more complex than typically depicted in oversimplified line drawings. The need for accurate topographical description is emphasized.

journal_name

J Biol Rhythms

authors

Morin LP

doi

10.1177/0748730406296749

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

3-13

issue

1

eissn

0748-7304

issn

1552-4531

pii

22/1/3

journal_volume

22

pub_type

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