Abstract:
:Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocytes are highly sensitive to vasoactive intestinal polypeptide (VIP), a neuropeptide released by neurons and important for the coordination of daily cycling, the authors hypothesized that VIP entrains circadian rhythms in astrocytes. They used astrocyte cultures derived from knock-in mice containing a bioluminescent reporter of PERIOD2 (PER2) protein, to assess the effects of VIP on the rhythmic properties of astrocytes. VIP induced a dose-dependent increase in the peak-to-trough amplitude of the ensemble rhythms of PER2 expression with maximal effects near 100 nM VIP and threshold values between 0.1 and 1 nM. VIP also induced dose- and phase-dependent shifts in PER2 rhythms and daily VIP administration entrained bioluminescence rhythms of astrocytes to a predicted phase angle. This is the first demonstration that a neuropeptide can entrain glial cells to a phase predicted by a phase-response curve. The authors conclude that VIP potently entrains astrocytes in vitro and is a candidate for coordinating daily rhythms among glia in the brain.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Marpegan L,Krall TJ,Herzog EDdoi
10.1177/0748730409332042subject
Has Abstractpub_date
2009-04-01 00:00:00pages
135-43issue
2eissn
0748-7304issn
1552-4531pii
24/2/135journal_volume
24pub_type
杂志文章abstract::Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730411420242
更新日期:2011-12-01 00:00:00
abstract::Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This pres...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730406291329
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abstract::The hematologic system performs a number of essential functions, including oxygen transport, the execution of the immune response against tumor cells and invading pathogens, and hemostasis (blood clotting). These roles are performed by erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (p...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
doi:10.1177/0748730415592729
更新日期:2015-10-01 00:00:00
abstract::In mammals, the suprachiasmatic nucleus (SCN) is the central pacemaker organizing circadian rhythms of behavior and physiology. At the cellular level, the mammalian clock consists of autoregulatory feedback loops involving a set of "clock genes," including the Cryptochrome (Cry) genes, Cry1 and Cry2. Experimental evid...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730412461246
更新日期:2012-12-01 00:00:00
abstract::Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873099129000524
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abstract::We investigated the extent to which photoperiodic fluctuations synchronize annual thyroid and gonadal rhythmicity in edible dormice. The effects of different daylength manipulations (LD 4:20, LD 6:18, LD 18:6, LD 20:4) were examined during the two critical ascending and regressive phases of the annual plasma testoster...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/074873049100600405
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abstract::Access to electric light might have shifted the ancestral timing and duration of human sleep. To test this hypothesis, we studied two communities of the historically hunter-gatherer indigenous Toba/Qom in the Argentinean Chaco. These communities share the same ethnic and sociocultural background, but one has free acce...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
doi:10.1177/0748730415590702
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abstract::A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
abstract::The synchronizing stimulus, its transduction site, and the afferent pathways responsible for feeding entrainment remain unknown. In fish, the role of the diet in the development of feeding anticipatory activity (FAA) is not well understood and fundamental questions on the mechanisms of feeding entrainment, such as the...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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abstract::Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...
journal_title:Journal of biological rhythms
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract::Numerous studies have used the classic van der Pol oscillator, which contains a cubic nonlinearity, to model the effect of light on the human circadian pacemaker. Jewett and Kronauer demonstrated that Aschoff's rule could be incorporated into van der Pol type models and used a van der Pol type oscillator with higher o...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
abstract::Siberian hamsters (Phodopus sungorus) exhibit changes in immune function following adaptation to short photoperiods, including a marked attenuation of energetically expensive thermoregulatory and behavioral responses to gram-negative bacterial infections. Whether this seasonal attenuation of the immune response is idi...
journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
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更新日期:1991-04-01 00:00:00
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journal_title:Journal of biological rhythms
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journal_title:Journal of biological rhythms
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更新日期:1998-12-01 00:00:00
abstract::The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...
journal_title:Journal of biological rhythms
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-02-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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journal_title:Journal of biological rhythms
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journal_title:Journal of biological rhythms
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journal_title:Journal of biological rhythms
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journal_title:Journal of biological rhythms
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journal_title:Journal of biological rhythms
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更新日期:2006-02-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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abstract::Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of rese...
journal_title:Journal of biological rhythms
pub_type: 杂志文章,评审
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Journal of biological rhythms
pub_type: 杂志文章
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