Abstract：
:Plasma levels of gamma-aminobutyric acid (GABA) were determined in 34 clinically symptomatic patients with diagnosis of affective disorder and in 20 normal controls. Lowest levels were found in patients with familial pure depressive disease and in depression spectrum disease, while levels of patients with sporadic depressive disease, though significantly lower than control, were not as low. Plasma GABA levels in secondary depression and in bipolar depression were similar to control. Bipolar manic patients had plasma GABA levels that were significantly higher than control values.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Petty F,Schlesser MAdoi
10.1016/0165-0327(81)90003-3subject
Has Abstractpub_date
1981-12-01 00:00:00pages
339-43issue
4eissn
0165-0327issn
1573-2517pii
0165-0327(81)90003-3journal_volume
3pub_type
杂志文章abstract：:Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor f...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90115-z
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Self-generated thoughts (SGTs), such as during mind wandering, occupy much of our waking life. Individuals with Major Depressive Disorder (MDD) are less in the "here and now" and prone to rumination. Few studies have looked at SGTs in depression using experience sampling methods and no study has so far inves...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.03.005
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in e...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2012.02.017
更新日期：2012-07-01 00:00:00
abstract：:Theory of Mind (ToM) deficits interfere in social cognitive functioning in schizophrenia (SCZ) and are increasingly recognized to do so in bipolar disorder (BD), however their clinical and neurobiological correlates remain unclear. This study represents the first direct comparison of subjects with SCZ (N = 26), BD (N ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.12.094
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:Suicide is a major public health problem and depression is among the most important risk factors for suicide. Treatment of depression might prevent suicide. To study this hypothesis further we conducted an ecological study. METHODS:An ecological study using sales data for antidepressants and numbers of suic...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.12.002
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Depression is a common disorder in both men and women, and the recurrence rate is high. The aim of this study was to identify risk factors for recurrence in depression in the Lundby Study. METHODS:The Lundby Study is a community-based longitudinal study with focus on mental health. The study started in 1947...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.11.038
更新日期：2018-03-01 00:00:00
abstract：:The clinical features of 104 patients admitted to a mother and baby unit over a 5-year period with RDC diagnoses of depression or schizoaffective depression were studied by self-ratings, measurements of non-verbal behaviour from standardised videotaped interviews, and observer ratings based on multiple information sou...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(88)90006-7
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to find the sociodemographic and clinical characteristics of major depressive episode (MDE) with (MDE-HPS+) and without a history of psychotic symptoms (MDE-HPS) in the general population. METHODS:The Mental Health in the General Population survey interviewed 38,694 individuals in ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.04.048
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Telephone-administered psychotherapy (tCBT) and internet-based treatments (iCBT) may overcome barriers to mental health treatment. TCBT has demonstrated efficacy similar to traditional psychotherapy, however, few studies have compared iCBT to efficacious interventions. This exploratory study examined the non...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.11.093
更新日期：2021-02-15 00:00:00
abstract：BACKGROUND:Various associations between monthly Google search volumes (MGSVs) and monthly suicide rates (MSRs) have been reported. However, these studies often analyzed a limited number of search terms using suboptimal statistical methods. While controlling for spurious associations, this study examined a wide array of...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.014
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Emerging evidence implicates the gut microbiota in central nervous system functioning via its effects on inflammation, the hypothalamic-pituitary axis, and/or neurotransmission. Our understanding of the cellular underpinnings of the brain-gut relationship is based almost exclusively on animal models with som...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.12.020
更新日期：2020-03-01 00:00:00
abstract：:Background: To evaluate the effectiveness of quetiapine extended release once daily in bipolar depression. Methods: Double-blind, placebo-controlled study in acutely depressed adults with bipolar I or II disorder, with or without rapid cycling.Patients were randomized to 8 weeks of quetiapine extended release(XR) 300 ...
journal_title：Journal of affective disorders
pub_type： 更正并重新发布的文章,杂志文章
doi：10.1016/j.jad.2014.07.007
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:The relationship between anxiety and impulsivity is controversial and not well explored. In a previous study we compared impulsivity, measured by different rating tools, in patients with anxiety disorders vs. healthy controls. In the same sample we now explore the influence of comorbid soft bipolar spectrum d...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.04.033
更新日期：2011-10-01 00:00:00
abstract：:Using single photon emission computerized tomography (SPECT) with a 99mTc-HMPAO perfusion technique, we studied the regional cerebral blood flow (rCBF) of 42 drug-free inpatients suffering from Major Depression' (n = 21) or dysthymia with the super-imposed diagnosis of a major depressive episode (n = 21). The patients...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90013-a
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Although some authors have recently investigated the co-occurrence of anxiety and bipolar disorders, the topic remains insufficiently studied. Defining the prevalence and predictors of BD-OCD comorbidity has important nosological, clinical and therapeutic implications. METHODS:A systematic review and meta-a...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2015.06.005
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA an...
journal_title：Journal of affective disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jad.2009.09.001
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Characteristic of the cardinal symptom of anhedonia, people with clinical depression report lower levels of anticipatory pleasure. However, the psychological mechanisms underlying these deficits are poorly understood. This is the first study to assess whether, and to what extent, phenomenological characteris...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.09.039
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Schizoaffective disorder is viewed as a heterogeneous diagnosis among psychotic illnesses. Different diagnostic systems differ in their definition with DSM (-IIIR, -IV, and -V) providing a narrower definition than RDC and ICD-10. It is unclear whether this difference is reflected in patient samples diagnosed...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2013.12.001
更新日期：2014-03-01 00:00:00
abstract：:104 patients in a cardiology clinic with atypical or non-anginal chest pain were studied through a structured clinical interview. 43 without coronary artery disease fit diagnostic criteria for panic disorder. 19 (44%) of this group reported a lifetime prevalence of major depression, nine (21%) current and ten (23%) pa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(87)90073-5
更新日期：1987-07-01 00:00:00
abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample in...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.02.077
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Antenatal depressive and anxiety symptoms are common and may persist over time after delivery, with negative consequences on the mothers and their children. Evidence on the efficacy of psychological and pharmacological interventions during pregnancy aimed at preventing post-partum depression is controversial...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2018.12.028
更新日期：2019-03-01 00:00:00
abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine, and therefore is of significant interest as a candidate gene in studies of affective disorders. We have carried out the linkage study between the susceptibility gene for affective disorder and tetranucleotide polymor...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(95)00004-7
更新日期：1995-05-17 00:00:00
abstract：BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.03.001
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and whit...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.10.021
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Studies examining the way in which cognitive impairment is associated with depression have produced inconsistent findings. Different severity of depressed mood across studies may account for such conflicting reports. However, inconsistent results have also been reported in relation to the specific associatio...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.jad.2009.04.022
更新日期：2009-12-01 00:00:00
abstract：:The nature and structure of posttraumatic stress disorder (PTSD) has been the subject of much interest in recent times. This research has been represented by two streams, the first representing a substantive body of work which focuses specifically on the factor structure of PTSD and the second exploring PTSD's relatio...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.02.011
更新日期：2011-07-01 00:00:00
abstract：:Platelet serotonin uptake was measured in 45 patients (12 males, 33 females) with panic attacks and 21 controls (9 males, 12 females). Higher Vmax values were obtained in the patient group than in the controls (100.2 +/- 11.5 vs. 34.9 +/- 3.8 pmol/10(8) platelets/min; P less than 0.0005) while the affinity constant Km...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(86)90062-5
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:Previous studies showed that the insulin resistance (IR) could be related to depression. However, this association is still equivocal in the general population. Herein, we aimed to investigate the association between IR and depressive symptoms in a large sample in South Korea. METHODS:A cross-sectional stud...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.10.027
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:Increasing gender equality remains an imperative for countries and organisations worldwide, and is associated with the improved life outcomes of men and women. Unlike many health and wellbeing indicators, death by suicide is more common among men, but suicidal behaviours are more common among women. Understa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.07.105
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that depression is more prevalent in vascular dementia than Alzheimer's disease (AD). Subjects for these studies were either psychiatry or neurology patients, raising the issue of whether factors leading to treatment might have introduced sampling bias. METHODS:Data for the prese...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00070-6
更新日期：1999-01-01 00:00:00
