Combined therapy of somatostatin analogues and dopamine agonists in the treatment of pituitary tumours.

abstract：OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Ha...

journal_title：European journal of endocrinology

authors： Ramos RB,Wiltgen D,Spritzer PM

更新日期：2013-10-01 00:00:00

abstract：:The GH/IGF1 axis may play an important role in cognitive function. This theory is supported by the finding that both GH and IGF1 receptors are located in several brain areas such as the hippocampus, a brain area that is known to play an essential role in cognitive processes, especially memory and learning. However, th...

journal_title：European journal of endocrinology

authors： van Nieuwpoort IC,Drent ML

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

journal_title：European journal of endocrinology

authors： Grossman A,Johannsson G,Quinkler M,Zelissen P

更新日期：2013-10-21 00:00:00

abstract：CONTEXT:It is unknown whether the metabolic effects of the removal of an adrenal incidentaloma (AI) can be predicted by the assessment of cortisol hypersecretion before surgery. OBJECTIVE:To evaluate the accuracy of several criteria of hypothalamic-pituitary-adrenal axis activity in predicting the metabolic outcome af...

journal_title：European journal of endocrinology

authors： Eller-Vainicher C,Morelli V,Salcuni AS,Battista C,Torlontano M,Coletti F,Iorio L,Cairoli E,Beck-Peccoz P,Arosio M,Ambrosi B,Scillitani A,Chiodini I

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancr...

journal_title：European journal of endocrinology

authors： Pasquali D,Circelli L,Faggiano A,Pancione M,Renzullo A,Elisei R,Romei C,Accardo G,Coppola VR,De Palma M,Ferolla P,Grimaldi F,Colao A,Colantuoni V

更新日期：2011-03-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...

journal_title：European journal of endocrinology

authors： Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...

journal_title：European journal of endocrinology

authors： Rosato R,Lindenbergh-Kortleve D,Neck Jv,Drop S,Jahn G

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To assess the value of the diagnostic whole body (131)I scan after thyroidectomy and (131)I ablation. DESIGN:Retrospective analysis of all patients with differentiated thyroid cancer treated in one centre between 1990 and 2000. RESULTS:A total of 153 consecutive patients who underwent diagnostic scanning fo...

journal_title：European journal of endocrinology

authors： Taylor H,Hyer S,Vini L,Pratt B,Cook G,Harmer C

更新日期：2004-05-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：:The human growth hormone variant (GH-V) gene is expressed during pregnancy in the syncytiotrophoblast and, as shown recently, in the normal human testis. In addition to the classical transcript encoding for the 22 K major form, intron D-retaining processed mRNAs (GH-V2) have also been described in both tissues. In the...

journal_title：European journal of endocrinology

authors： Untergasser G,Hermann M,Rumpold H,Berger P

更新日期：1998-10-01 00:00:00

abstract：:In vitro studies indicate a physiological role for insulin-like growth factor I (IGF-I) in paracrine regulation of testicular function and recent clinical studies suggest a potential role for growth hormone (GH) and/or IGF-I in the treatment of hypogonadotrophic states in males. This study aimed to examine the effects...

journal_title：European journal of endocrinology

authors： Crawford BA,Handelsman DJ

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID). DESIGN:A longitudinal population-based study (DanThyr). METHODS:...

journal_title：European journal of endocrinology

authors： Krejbjerg A,Bjergved L,Pedersen IB,Carlé A,Jørgensen T,Perrild H,Ovesen L,Rasmussen LB,Knudsen N,Laurberg P

更新日期：2014-03-08 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Makorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic-pituitary-gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen ...

journal_title：European journal of endocrinology

authors： Varimo T,Dunkel L,Vaaralahti K,Miettinen PJ,Hero M,Raivio T

更新日期：2016-06-01 00:00:00

abstract：:Autoimmune thyroid disease is the archetype for organ-specific autoimmune disorders. Progress in treating these disorders lies in improvements of our understanding of the predisposing factors responsible, the mechanisms responsible for progression of disease, and the interaction between thyroid antigens and the immune...

journal_title：European journal of endocrinology

authors： Weetman AP

更新日期：2003-01-01 00:00:00

abstract：AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...

journal_title：European journal of endocrinology

authors： Turner HE,Adams CB,Wass JA

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:In inflammatory bowel diseases, increased serum interleukin (IL)-6 levels are associated with high serum insulin-like growth factor-binding protein 2 (IGFBP-2) levels, and cytokines modify the insulin-like growth factor (IGF)/IGFBP system in models in vitro. In cystic fibrosis (CF) the IGF/IGFBP system has no...

journal_title：European journal of endocrinology

authors： Street ME,Ziveri MA,Spaggiari C,Viani I,Volta C,Grzincich GL,Virdis R,Bernasconi S

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare physical activity and biochemical markers with bone mineral acquisition in rhythmic gymnasts and ballet dancers. METHODS:Weight, height, body mass index, nutritional intake, bone age and menstrual histories were analyzed in nine rhythmic gymnasts, twelve ballet dancers and fourteen con...

journal_title：European journal of endocrinology

authors： Muñoz MT,de la Piedra C,Barrios V,Garrido G,Argente J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Apelin is a novel adipokine acting on APJ receptor, regulated by insulin and tumor necrosis factor-alpha (TNF-alpha) in adipose tissue (AT). Plasma apelin levels are increased in obese hyperinsulinemic subjects. The aim was to investigate whether the hypocaloric diet associated with weight loss modifies the e...

journal_title：European journal of endocrinology

authors： Castan-Laurell I,Vítkova M,Daviaud D,Dray C,Kováciková M,Kovacova Z,Hejnova J,Stich V,Valet P

更新日期：2008-06-01 00:00:00

abstract：:There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...

journal_title：European journal of endocrinology

authors： Schafroth U,Godang K,Ueland T,Bollerslev J

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have shown that more than 50% of patients with congestive heart failure (CHF) have decreased bone mineral density (BMD). There is limited knowledge about the longitudinal changes of BMD and how to treat bone loss in patients with CHF. METHODS:The present study was a prospective, long...

journal_title：European journal of endocrinology

authors： Frost RJ,Sonne C,Wehr U,Stempfle HU

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

journal_title：European journal of endocrinology

authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

journal_title：European journal of endocrinology

authors： Holováčová D,Kužma M,Killinger Z,Payer J

更新日期：2016-10-01 00:00:00

abstract：:The rat prostate, a classical androgen-target tissue, contains both known isozymes of steroid 5alpha-reductase. i.e. type I and type II. So far, the role of the type I isozyme has been proposed as catabolic. The abundant expression of type I 5alpha-reductase in an androgen-target tissue is therefore puzzling. Assessme...

journal_title：European journal of endocrinology

authors： Span PN,Sweep CG,Benraad TJ,Smals A

更新日期：1996-03-01 00:00:00

abstract：:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS ...

journal_title：European journal of endocrinology

authors： Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii M

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been suggested as a diagnostic marker of malignancy. The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results o...

journal_title：European journal of endocrinology

authors： Cetani F,Ambrogini E,Viacava P,Pardi E,Fanelli G,Naccarato AG,Borsari S,Lemmi M,Berti P,Miccoli P,Pinchera A,Marcocci C

更新日期：2007-05-01 00:00:00

abstract：:Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...

journal_title：European journal of endocrinology

authors： Gasco V,Prodam F,Grottoli S,Marzullo P,Longobardi S,Ghigo E,Aimaretti G

更新日期：2013-02-20 00:00:00

abstract：:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

journal_title：European journal of endocrinology

authors： Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

更新日期：1994-11-01 00:00:00