Abstract:
:The synthesis of tooth development biology with human studies focusing on inherited conditions that specifically interfere with tooth development is improving our understanding of normal and pathological tooth formation. The type of inherited dental malformations observed in a given kindred relate to when, during odontogenesis, the defective gene is critically expressed. Information about the protein encoded by the defective gene and the resulting dental phenotype helps us understand the major processes underway at different stages during tooth development. Genes affecting early tooth development (PAX9, MSX1, and AXIN2) are associated with familial tooth agenesis or oligodontia. Genes expressed by odontoblasts (COL1A1, COL1A2, and DSPP), and ameloblasts (AMELX, ENAM, MMP20, and KLK4) during the crown formation stage, are associated with dentinogenesis imperfecta, dentin dysplasia, and amelogenesis imperfecta. Late genes expressed during root formation (ALPL and DLX3) are associated with cementum agenesis (hypophosphatasia) and taurodontism. Understanding the relationships between normal tooth development and the dental pathologies associated with inherited diseases improves our ability to diagnose and treat patients suffering the manifestations of inherited dental disorders.
journal_name
Orthod Craniofac Resjournal_title
Orthodontics & craniofacial researchauthors
Hu JC,Simmer JPdoi
10.1111/j.1601-6343.2007.00384.xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
45-52issue
2eissn
1601-6335issn
1601-6343pii
OCR384journal_volume
10pub_type
杂志文章,评审abstract:OBJECTIVES:The purpose of our study was to determine morphological changes and bone mineral density (BMD) differences in the adult mandible of offspring exposed to high calcium, low phosphorus diets in utero until weaning age. MATERIALS AND METHODS:Time-mated FVB wild-type mice were fed normal or experimental diet dur...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12269
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:To assess the effects of a modified alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol in combination with facemask (FM) in Class III growing patients. SETTING AND SAMPLE POPULATION:Thirty one Class III patients (17 males, 14 females) were treated with a modified Alt-RAMEC/FM protocol...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12051
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To determine the levels of the receptor activator of NFkB ligand (RANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement. A second objective was to investigate the effect of compression force on RANKL and OPG production from human periodontal ligament (hPDL) ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2006.00340.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:To detect changes in mandibular growth between a historical group (HG) from the American Association of Orthodontics Foundation Craniofacial Growth Legacy Collection (AAOF Legacy) and a contemporary group (CG) of normodivergent or hypodivergent Class II untreated subjects. SETTING AND SAMPLE POPULATION:The ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12321
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:An investigation to determine the changing facial appearance of identical twins. DESIGN:Clinical study. MATERIALS AND METHODS:Two Minolta Vivid 900 3D optical laser scanners were placed as a stereo pair to capture the soft tissues of a pair of identical twins. Each scan took approximately 2.5 s. The scanned...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2005.00320.x
更新日期:2005-05-01 00:00:00
abstract:UNLABELLED:AUTHOR: Shen G Objective -This review was compiled to explore the role of type X collagen in growth, development and remodeling of articular cartilage by elucidating the linkage between the synthesis of this protein and the phenotypic changes in chondrogenesis and the onset of endochondral ossification. DES...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2004.00308.x
更新日期:2005-02-01 00:00:00
abstract::Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and lik...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/ocr.12171
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To compare the predicted tooth width measurements of permanent canine and premolars from Tanaka-Johnston regression equations and Moyers probability tables with the in situ measurements in a sample of Peruvian adolescents. DESIGN:Cross-sectional. SETTING AND SAMPLE POPULATION:Trujillo, Peru; 248 dental cas...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0544.2003.03251.x
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:This study sought to investigate the three-dimensional (3D) changes in anteroposterior, vertical and mediolateral positions and orientations of the mandibular condyle as well as joint space parameters following maxillary first premolar extraction and incisor retraction in skeletal Class II patients. SETTING...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12141
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To investigate the 3D morphological variations in 169 temporomandibular ioint (TMJ) condyles, using novel imaging statistical modeling approaches. SETTING AND SAMPLE POPULATION:The Department of Orthodontics and Pediatric Dentistry at the University of Michigan. Cone beam CT scans were acquired from 69 subj...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12070
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To develop a questionnaire to assess the psychosocial aspects which orthognathic patients considered important regarding their dento-facial deformity. SETTING AND SAMPLE POPULATION:A multicentre, prospective, questionnaire development and validation study based in the UK. MATERIAL AND METHODS:Questionnaire...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12061
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:To explore centre-level variation in otitis media with effusion (OME), hearing loss and treatments in children in Cleft Care UK (CCUK) and to examine the association between OME, hearing loss and developmental outcomes at 5 and 7 years. SETTING AND SAMPLE POPULATION:Two hundred and sixty-eight 5-year-old Br...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12184
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To explore asymmetry values of antimeric deciduous tooth crown dimensions in three types of twins: monozygotic (MZ), dizygotic same-sex (DZ) and opposite-sex (OS) vs. single-born controls. SETTING AND SAMPLE POPULATION:Mesiodistal and labio-lingual crown dimensions of second deciduous molars and mesiodistal...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12122
更新日期:2016-08-01 00:00:00
abstract:OBJECTS:Isolated cleft palate (CPO) is the rarest form of oral clefting affecting 1-25 per 10 000 newborns worldwide. There is increasing evidence for the different pathogenetic backgrounds of CPO and cleft lip with or without cleft palate. The role of environmental factors in the origin of non-syndromic and syndromic ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12361
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To measure skull thickness in a group of subjects with skeletal Class II and a group with skeletal Class III malocclusion and compare these results with a group with Class I occlusion. SETTING AND SAMPLE POPULATION:Department of Orthodontics, School of Dentistry, University of Copenhagen. The Class II group...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2008.00434.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare three-dimensional airway changes resulting from mandibular advancement surgery and mandibular advancement surgery with constriction. SETTING AND SAMPLE POPULATION:The University of Michigan School of Dentistry and Medical Center. A total of 42 patients undergoing mandibu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12292
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To experimentally determine the effects of increased surgical trauma on the rates of tooth movement and apical root resorption. Two surgical techniques for rapid protraction of multi-rooted teeth in foxhound dogs immediately following premolar extraction were compared. METHODS:Split-mouth design to randomly as...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2010.01494.x
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:This paper describes the use of adult facial template in gender-specific facial analysis. SUBJECTS AND METHODS:Eighty adults, mean age 24.5, were selected for the study. Laser-scanned images of the subjects were obtained under a reproducible and controlled environment with two Minolta Vivid 900 (Osaka, Japan) ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2006.00359.x
更新日期:2006-02-01 00:00:00
abstract::The mental health of children, adolescents, and adults with orofacial clefts has been studied extensively. Outcomes of interest have included parental adaptation, parent-child attachment, child development, intellectual and academic outcomes, behavioral adaptation, and quality of life. The literature sheds light on me...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2007.00394.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:While some eruption disorders occur as part of a medical syndrome, primary failure of eruption (PFE) - defined as a localized failure of secondary tooth eruption - exists without systemic involvement. Recent studies support that heredity may play an important role in the pathogenesis of PFE. The objective of...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2009.01440.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Literature is poor of data about the occlusion in children affected by neurofibromatosis type 1 (NF1). This case-control study investigated the occlusal traits in a group of children with NF1. SETTING AND SAMPLE POPULATION:A hundred and fifteen children with NF1 were enrolled; non-NF1 controls were sequenti...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12108
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To clarify the correlation between variations in maximum occlusal force and the maxillofacial skeletal pattern in subjects with malocclusion using a compact device. DESIGN:Three hundred and fifty patients (150 males 200 females) with malocclusion were included. The male and female subjects were divided into ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2007.00405.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that there are no gender differences in the outcomes of patients with class II malocclusion treated with the headgear-activator Teuscher appliance (HATA). DESIGN:Retrospective, longitudinal SETTING AND SAMPLE POPULATION:Puerto Rico and Scotland, UK. Thirty-one patients requiring corr...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0854.2003.c245.x
更新日期:2003-05-01 00:00:00
abstract::This essay briefly considers some underlying concerns about the direction of clinical research in orthodontics. The field is viewed from a personal perspective as things are now, as they are becoming, and as I believe they should be. ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2004.00292.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the accuracy of three-dimensional stereophotogrammetry by comparing values obtained from direct anthropometry and the 3dMDface system. To achieve a more comprehensive evaluation of the reliability of 3dMD, both linear and surface measurements were examined. SETTING AND SAMPLE POPULATION:UCLA Sec...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12178
更新日期:2017-06-01 00:00:00
abstract::In cranial sutural samples derived from five children with premature cranial suture fusion we have performed immunostaining for the urokinase plasminogen activator (uPA) and urokinase receptor (uPAR). We have found a strong reactivity for cell- or matrix-bound uPA and uPAR in the sutural connective tissue and associat...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0544.2002.50101.x
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of lithium on alveolar bone formation during orthodontic retention in rats. MATERIALS AND METHODS:After 2 weeks of orthodontic tooth movement (OTM), 42 8-week-old male Wistar rats were randomly divided into two orthodontic retention groups: one without (control) and the other with L...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12190
更新日期:2017-08-01 00:00:00
abstract::The skin and the oral mucosa act as a barrier against the external environment. Loss of this barrier function causes dehydration and a high risk of infection. For the treatment of extensive skin wounds such as in severe burns, autologous skin for transplantation is often not available in sufficient amounts. Reconstruc...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2009.01475.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:This investigation evaluates the evidence of case-based reasoning (CBR) in providing additional information on the prediction of future Class III craniofacial growth. SETTINGS AND SAMPLE POPULATION:The craniofacial characteristics of 104 untreated Class III subjects (7-17 years of age), monitored with two la...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12466
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVE:To compare the concentration of nickel, chromium and cobalt in oral mucosa cells of patients with and without fixed orthodontic appliances. MATERIALS AND METHODS:A total of 60 patients were included in this study. The control group consisted of 30 patients without any type of fixed orthodontic appliances or ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2008.00414.x
更新日期:2008-02-01 00:00:00