Immunolocalization of urokinase and its receptor in prematurely fused cranial sutures of infants.

Abstract:

:In cranial sutural samples derived from five children with premature cranial suture fusion we have performed immunostaining for the urokinase plasminogen activator (uPA) and urokinase receptor (uPAR). We have found a strong reactivity for cell- or matrix-bound uPA and uPAR in the sutural connective tissue and associated with the osteoblasts and osteocytes lining the calvarial bone. The sutural tissue itself showed a banding with different intensity of urokinase and uPAR staining concerning connective tissue. It is proposed that the components of the plasminogen activating system are involved in tissue turnover of sutural tissue and in sutural growth.

journal_name

Orthod Craniofac Res

authors

Zeitler P,Pahnke J,Collmann H

doi

10.1034/j.1600-0544.2002.50101.x

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

22-8

issue

1

eissn

1601-6335

issn

1601-6343

journal_volume

5

pub_type

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