Zoledronic acid and alendronate sodium and the implications in orthodontic movement.

Abstract:

OBJECTIVE:To evaluate orthodontic tooth movement (OTM) in rats treated with two types of bisphosphonates (BPs), alendronate sodium (A) and zoledronic acid (Z). DESIGN:In all, 15 male Wistar rats were randomly divided into three groups. Group OTM+A: orthodontic tooth movement and subcutaneous administration of alendronate sodium (2.5 mg/kg); Group OTM+Z: orthodontic tooth movement and subcutaneous administration of zoledronic acid (0.02 mg/kg), and Group OTM: orthodontic tooth movement and subcutaneous injection of saline. The BPs were administered once a day during 25 days before OTM started and during 10 days of OTM. The left upper first molar was moved with a stainless-steel closed coil spring which delivered an initial force of 0.4N. OTM was measured with a digital caliper comparing the moved and the contralateral side. The histomorphometric analysis counted the number of osteoclasts, inflammatory cells, blood vessels and fibroblasts (n/104  m2 ) in periodontal ligament (PDL) of the distobuccal root. RESULTS:A reduction of 58.3% of OTM was found in Group OTM+A and 99.6% in Group OTM+Z, when compared with Group OTM. There was a significant decrease of osteoclasts and inflammatory cells in BP-treated groups. Blood vessels and fibroblastic cells decreased mainly in Group OTM+Z. CONCLUSION:Alendronate sodium and zoledronic acid have similar effects on the periodontal tissue during orthodontic treatment in rats. Especially, zoledronic acid can affect orthodontic tooth movement.

journal_name

Orthod Craniofac Res

authors

Franzoni JS,Soares FMP,Zaniboni E,Vedovello Filho M,Santamaria MP,Dos Santos GMT,Esquisatto MAM,Felonato M,Mendonca FAS,Franzini CM,Santamaria M Jr

doi

10.1111/ocr.12192

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

164-169

issue

3

eissn

1601-6335

issn

1601-6343

journal_volume

20

pub_type

杂志文章
  • Accuracy of volumetric measurement of teeth in vivo based on cone beam computer tomography.

    abstract:OBJECTIVES:to evaluate the accuracy of cone beam computed tomography (CBCT) for volumetric measurement of teeth, using micro-computed tomography (Micro-CT) as the reference standard. SETTING AND SAMPLE POPULATION:The Department of Orthodontics at Sichuan University. The sample consisted of 27 maxillary and mandibular ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2011.01525.x

    authors: Wang Y,He S,Yu L,Li J,Chen S

    更新日期:2011-11-01 00:00:00

  • Fundamentals of image acquisition and processing in the digital era.

    abstract:OBJECTIVES:To review the historic context for digital imaging in dentistry and to outline the fundamental issues related to digital imaging modalities. CONTEXT:Digital dental X-ray images can be achieved by scanning analog film radiographs (secondary capture), with photostimulable phosphors, or using solid-state detec...

    journal_title:Orthodontics & craniofacial research

    pub_type: 历史文章,杂志文章

    doi:10.1034/j.1600-0544.2003.231.x

    authors: Farman AG

    更新日期:2003-01-01 00:00:00

  • Prognostic approach to Class III malocclusion through case-based reasoning.

    abstract:OBJECTIVE:This investigation evaluates the evidence of case-based reasoning (CBR) in providing additional information on the prediction of future Class III craniofacial growth. SETTINGS AND SAMPLE POPULATION:The craniofacial characteristics of 104 untreated Class III subjects (7-17 years of age), monitored with two la...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12466

    authors: Auconi P,Ottaviani E,Barelli E,Giuntini V,McNamara JA,Franchi L

    更新日期:2021-01-08 00:00:00

  • Effects of different orthodontic retention protocols on the periodontal health of mandibular incisors.

    abstract:OBJECTIVES:To test the following two hypotheses: 1) different types of retainers result in distinct levels of biomarkers in gingival crevicular fluid (GCF) and 2) the retainer bonded to all mandibular anterior teeth induces more detrimental outcomes to the periodontium. SETTING AND SAMPLE POPULATION:The Department of ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12129

    authors: Rody WJ Jr,Elmaraghy S,McNeight AM,Chamberlain CA,Antal D,Dolce C,Wheeler TT,McGorray SP,Shaddox LM

    更新日期:2016-11-01 00:00:00

  • The effect of chewing gum on the impact, pain and breakages associated with fixed orthodontic appliances: a randomized clinical trial.

    abstract:OBJECTIVES:To determine whether the use of chewing gum reduced the impact and pain of fixed orthodontic appliances. SETTING AND SAMPLE POPULATION:The Orthodontic Department of the Charles Clifford Dental Hospital, Sheffield, UK. Fifty-seven patients aged 18 years or younger and who were about to start fixed orthodonti...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-6343.2012.01546.x

    authors: Benson PE,Razi RM,Al-Bloushi RJ

    更新日期:2012-08-01 00:00:00

  • Effect of ovariectomy on maxilla and mandible dimensions of female rats.

    abstract:OBJECTIVE:The role of oestrogen in craniofacial growth still remains unclear. Therefore, the present study aimed to assess the effect of oestrogen deficiency on maxilla and mandible dimensions. SETTING AND SAMPLE POPULATION:The study was conducted at the Department of Pediatric Dentistry at the School of Dentistry of ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12376

    authors: Omori MA,Marañón-Vásquez GA,Romualdo PC,Martins Neto EC,Stuani MBS,Matsumoto MAN,Nelson-Filho P,Proff P,León JE,Kirschneck C,Küchler EC

    更新日期:2020-08-01 00:00:00

  • Skin and oral mucosa equivalents: construction and performance.

    abstract::The skin and the oral mucosa act as a barrier against the external environment. Loss of this barrier function causes dehydration and a high risk of infection. For the treatment of extensive skin wounds such as in severe burns, autologous skin for transplantation is often not available in sufficient amounts. Reconstruc...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-6343.2009.01475.x

    authors: Liu J,Bian Z,Kuijpers-Jagtman AM,Von den Hoff JW

    更新日期:2010-02-01 00:00:00

  • Primary tooth size asymmetry in twins and singletons.

    abstract:OBJECTIVES:To explore asymmetry values of antimeric deciduous tooth crown dimensions in three types of twins: monozygotic (MZ), dizygotic same-sex (DZ) and opposite-sex (OS) vs. single-born controls. SETTING AND SAMPLE POPULATION:Mesiodistal and labio-lingual crown dimensions of second deciduous molars and mesiodistal...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12122

    authors: Heikkinen T,Harila V,Ollikkala A,Alvesalo L

    更新日期:2016-08-01 00:00:00

  • Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats.

    abstract:OBJECTIVE:To investigate the effects of diabetes on orthodontic tooth movement and orthodontically induced root resorption in rats. SETTING AND SAMPLE POPULATION:Twenty-three 10-week-old male Sprague-Dawley rats divided into control (n = 7), diabetes (n = 9), and diabetes + insulin (n = 7) groups. MATERIALS AND METHO...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12117

    authors: Arita K,Hotokezaka H,Hashimoto M,Nakano-Tajima T,Kurohama T,Kondo T,Darendeliler MA,Yoshida N

    更新日期:2016-05-01 00:00:00

  • Comparison of treatment effects of different maxillary protraction methods in skeletal class III patients.

    abstract:OBJECTIVE:The aim of this study was to compare treatment outcomes with different maxillary protraction methods in patients with skeletal Class III malocclusion resulting from maxillary retrognathia. SETTING AND SAMPLE POPULATION:A total of 55 individuals consisting of 29 females and 26 males with a mean age of 11.4 ± ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12389

    authors: Buyukcavus MH,Kale B,Aydemir B

    更新日期:2020-11-01 00:00:00

  • Change in maximum occlusal force in association with maxillofacial growth.

    abstract:OBJECTIVE:To clarify the correlation between variations in maximum occlusal force and the maxillofacial skeletal pattern in subjects with malocclusion using a compact device. DESIGN:Three hundred and fifty patients (150 males 200 females) with malocclusion were included. The male and female subjects were divided into ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2007.00405.x

    authors: Usui T,Uematsu S,Kanegae H,Morimoto T,Kurihara S

    更新日期:2007-11-01 00:00:00

  • Skull thickness in patients with skeletal Class II and Class III malocclusions.

    abstract:OBJECTIVES:To measure skull thickness in a group of subjects with skeletal Class II and a group with skeletal Class III malocclusion and compare these results with a group with Class I occlusion. SETTING AND SAMPLE POPULATION:Department of Orthodontics, School of Dentistry, University of Copenhagen. The Class II group...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2008.00434.x

    authors: Arntsen T,Kjaer I,Sonnesen L

    更新日期:2008-11-01 00:00:00

  • Evaluation of three-dimensional root surface changes and resorption following rapid maxillary expansion: a cone beam computed tomography investigation.

    abstract:OBJECTIVES:To evaluate root surface changes and resorption following toothborne rapid maxillary expansion (RME) using cone beam computed tomography (CBCT). SETTING AND SAMPLE POPULATION:The Department of Orthodontics at The University of Texas Health Science Center. Twenty-four consecutively treated patients (mean age...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12069

    authors: Akyalcin S,Alexander SP,Silva RM,English JD

    更新日期:2015-04-01 00:00:00

  • Dietary consistency and the midline sutures in growing pigs.

    abstract:OBJECTIVES:The purpose of this study was to investigate the effects of reduced masticatory function on midline suture growth and morphology in growing pigs. SETTING AND SAMPLE POPULATION:The sample was 20 pigs separated into two dietary groups and raised at the Department of Anthropology, Harvard University. Midline s...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2010.01483.x

    authors: Burn AK,Herring SW,Hubbard R,Zink K,Rafferty K,Lieberman DE

    更新日期:2010-05-01 00:00:00

  • A prospective longitudinal controlled assessment of pain experience and oral health-related quality of life in adolescents undergoing fixed appliance treatment.

    abstract:OBJECTIVE:To compare subjective pain experience and oral health-related quality of life (OH-QoL) in treated and untreated subjects over the first 3 months of fixed appliance therapy. SETTING AND SAMPLE POPULATION:The Department of Orthodontics, School of Medicine and Dentistry. One hundred and twenty-four subjects age...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12044

    authors: Johal A,Fleming PS,Al Jawad FA

    更新日期:2014-08-01 00:00:00

  • A developmental approach to mental health for children and adolescents with orofacial clefts.

    abstract::The mental health of children, adolescents, and adults with orofacial clefts has been studied extensively. Outcomes of interest have included parental adaptation, parent-child attachment, child development, intellectual and academic outcomes, behavioral adaptation, and quality of life. The literature sheds light on me...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-6343.2007.00394.x

    authors: Collett BR,Speltz ML

    更新日期:2007-08-01 00:00:00

  • Osteoglophonic dysplasia: dental and orthodontic implications.

    abstract:AIMS AND OBJECTIVES:Documentation of dental and orthodontic implications of osteoglophonic dysplasia (OGD). SETTINGS AND PARTICIPANTS:Case report describing oral and dental manifestations of a female with OGD, aged 39 years, who was first documented three decades ago. RESULTS:This rare genetic disorder manifests with...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2006.00369.x

    authors: Roberts TS,Stephen L,Beighton P

    更新日期:2006-08-01 00:00:00

  • Taking stock: a critical perspective on contemporary orthodontics.

    abstract::This essay briefly considers some underlying concerns about the direction of clinical research in orthodontics. The field is viewed from a personal perspective as things are now, as they are becoming, and as I believe they should be. ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2004.00292.x

    authors: Baumrind S

    更新日期:2004-08-01 00:00:00

  • Incidence and severity of root resorption in orthodontically moved premolars in dogs.

    abstract:OBJECTIVES:To study treatment-related factors for external root resorption during orthodontic tooth movement. DESIGN:An experimental animal study. SETTING AND SAMPLE POPULATION:Department of Orthodontics and Oral Biology, University Medical Centre Nijmegen, The Netherlands. Twenty-four young adult beagle dogs. EXPER...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2004.00283.x

    authors: Maltha JC,van Leeuwen EJ,Dijkman GE,Kuijpers-Jagtman AM

    更新日期:2004-05-01 00:00:00

  • The effect of antimicrobial agents on bond strength of orthodontic adhesives: a meta-analysis of in vitro studies.

    abstract::Antimicrobial orthodontic adhesives aim to reduce white spot lesions' incidence in orthodontic patients, but they should not jeopardizing its properties. Systematic review and meta-analysis were performed to answer the question whether the association of antimicrobial agents with orthodontic adhesives compromises its ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ocr.12100

    authors: Altmann AS,Collares FM,Leitune VC,Samuel SM

    更新日期:2016-02-01 00:00:00

  • Development of dento-maxillofacial cone beam X-ray computed tomography system.

    abstract::We have developed a cone beam X-ray computed tomography (CT) system to make more accurate three-dimensional (3-D) images for diagnosis of dento-maxillofacial region. The developed system has sufficient spatial resolution, resolution of 3-D images and image distortion for diagnosis of dentomaxillofacial region. ...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1034/j.1600-0544.2003.249.x

    authors: Yamamoto K,Ueno K,Seo K,Shinohara D

    更新日期:2003-01-01 00:00:00

  • Lithium enhances alveolar bone formation during orthodontic retention in rats.

    abstract:OBJECTIVE:To investigate the effect of lithium on alveolar bone formation during orthodontic retention in rats. MATERIALS AND METHODS:After 2 weeks of orthodontic tooth movement (OTM), 42 8-week-old male Wistar rats were randomly divided into two orthodontic retention groups: one without (control) and the other with L...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12190

    authors: Pan J,He S,Yin X,Li Y,Zhou C,Zou S

    更新日期:2017-08-01 00:00:00

  • Prediction of mesiodistal canine and premolar tooth width in a sample of Peruvian adolescents.

    abstract:OBJECTIVES:To compare the predicted tooth width measurements of permanent canine and premolars from Tanaka-Johnston regression equations and Moyers probability tables with the in situ measurements in a sample of Peruvian adolescents. DESIGN:Cross-sectional. SETTING AND SAMPLE POPULATION:Trujillo, Peru; 248 dental cas...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1034/j.1600-0544.2003.03251.x

    authors: Flores-Mir C,Bernabé E,Camus C,Carhuayo MA,Major PW

    更新日期:2003-08-01 00:00:00

  • Current concepts in periodontal bioengineering.

    abstract::Repair of tooth supporting alveolar bone defects caused by periodontal and peri-implant tissue destruction is a major goal of reconstructive therapy. Oral and craniofacial tissue engineering has been achieved with limited success by the utilization of a variety of approaches such as cell-occlusive barrier membranes, b...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-6343.2005.00352.x

    authors: Taba M Jr,Jin Q,Sugai JV,Giannobile WV

    更新日期:2005-11-01 00:00:00

  • Examination of rare genetic variants in dental enamel genes: The potential role of next-generation sequencing in primary dental care.

    abstract:OBJECTIVES:To examine the potential role of next-generation sequencing (NGS) and genetic testing to guide preventive care in dental enamel disorders using publicly available databases to access the frequency of deleterious alleles in AMTN, AMLEX and ENAM, associated with amelogenesis imperfecta (AI). SETTING AND SAMPL...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12266

    authors: Farrow E,Rengasamy Venugopalan S,Thiffault I,Saunders C

    更新日期:2019-05-01 00:00:00

  • Occlusal traits in children with neurofibromatosis type 1.

    abstract:OBJECTIVES:Literature is poor of data about the occlusion in children affected by neurofibromatosis type 1 (NF1). This case-control study investigated the occlusal traits in a group of children with NF1. SETTING AND SAMPLE POPULATION:A hundred and fifteen children with NF1 were enrolled; non-NF1 controls were sequenti...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12108

    authors: Bardellini E,Tonni I,Micheli R,Molinaro A,Amadori F,Flocchini P,Piana G,Majorana A

    更新日期:2016-02-01 00:00:00

  • Forces and moments generated by aligner-type appliances for orthodontic tooth movement: A systematic review and meta-analysis.

    abstract::The aim of this review was to systematically appraise the evidence on aligner mechanics and forces and moments generated across difference types of aligners. In vitro- laboratory studies for model simulated tooth movement with aligners. Database searches within Medline via Pubmed, Cochrane Central Register of Controll...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ocr.12333

    authors: Iliadi A,Koletsi D,Eliades T

    更新日期:2019-11-01 00:00:00

  • Three-dimensional skeletal mandibular changes associated with Herbst appliance treatment.

    abstract:OBJECTIVES:Three-dimensional evaluation of skeletal mandibular changes following Herbst appliance treatment. SETTING AND SAMPLE POPULATION:Retrospective case-control study, based on a sample size calculation. Twenty-five pubertal patients treated with Herbst appliance (HAG), and 25 matched Class II patients who receiv...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/ocr.12154

    authors: Souki BQ,Vilefort PLC,Oliveira DD,Andrade I Jr,Ruellas AC,Yatabe MS,Nguyen T,Franchi L,McNamara JA Jr,Cevidanes LHS

    更新日期:2017-05-01 00:00:00

  • The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage.

    abstract:UNLABELLED:AUTHOR: Shen G Objective -This review was compiled to explore the role of type X collagen in growth, development and remodeling of articular cartilage by elucidating the linkage between the synthesis of this protein and the phenotypic changes in chondrogenesis and the onset of endochondral ossification. DES...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-6343.2004.00308.x

    authors: Shen G

    更新日期:2005-02-01 00:00:00

  • Effects of increased surgical trauma on rates of tooth movement and apical root resorption in foxhound dogs.

    abstract:PURPOSE:To experimentally determine the effects of increased surgical trauma on the rates of tooth movement and apical root resorption. Two surgical techniques for rapid protraction of multi-rooted teeth in foxhound dogs immediately following premolar extraction were compared. METHODS:Split-mouth design to randomly as...

    journal_title:Orthodontics & craniofacial research

    pub_type: 杂志文章

    doi:10.1111/j.1601-6343.2010.01494.x

    authors: Cohen G,Campbell PM,Rossouw PE,Buschang PH

    更新日期:2010-08-01 00:00:00