Abstract:
OBJECTS:Isolated cleft palate (CPO) is the rarest form of oral clefting affecting 1-25 per 10 000 newborns worldwide. There is increasing evidence for the different pathogenetic backgrounds of CPO and cleft lip with or without cleft palate. The role of environmental factors in the origin of non-syndromic and syndromic CPO is unclear in most patients. The aim of this study was to estimate possible maternal risk factors in the origin of CPO. SETTING AND SAMPLE POPULATION:The Hungarian Case-Control Surveillance of Congenital Abnormalities contains data of 32 345 birth defect cases and 57 231 control newborns. The study samples included 751 cases with isolated CPO, 1196 matched controls and 57 231 population controls. MATERIAL AND METHODS:Maternal diseases during pregnancy in cases and population controls were compared, and adjusted ORs with 95% CI were calculated in a multivariable unconditional logistic regression model. RESULTS:Beyond the well-known robust female excess (58.9%)-maternal smoking (OR with 95% CI: 2.34, 1.94-2.81) medically recorded maternal anaemia, threatened abortion and excessive vomiting in pregnancy were associated with a higher risk for CPO in the offspring. An elevated risk was found in Graves' disease (OR: 4.30, 1.74-10.62), epilepsy (OR: 4.64, 2.44-8.82), migraine (OR: 2.82, 1.18-6.76) and essential hypertension (OR: 2.33, 1.32-4.10). Among acute diseases common cold (OR: 4.94, 3.48-7.03), acute respiratory infections (OR: 4.20, 1.49-11.82), influenza (OR: 2.95, 1.75-4.95), pulpitis (OR: 7.85, 2.80-22.03), cholecystitis (OR: 3.15, 1.16-8.60), acute urinary tract infections (OR: 4.08, 2.22-7.49) and pelvic inflammatory diseases (OR: 3.93, 1.62-9.53) during pregnancy also were associated with an increased risk for developing CPO. CONCLUSION:The findings of this study suggest that maternal diseases and lifestyle factors during the first trimester play a significant role in the development of isolated cleft palate.
journal_name
Orthod Craniofac Resjournal_title
Orthodontics & craniofacial researchauthors
Ács L,Bányai D,Nemes B,Nagy K,Ács N,Bánhidy F,Rózsa Ndoi
10.1111/ocr.12361subject
Has Abstractpub_date
2020-05-01 00:00:00pages
174-180issue
2eissn
1601-6335issn
1601-6343journal_volume
23pub_type
杂志文章abstract:OBJECTIVES:Three-dimensional evaluation of skeletal mandibular changes following Herbst appliance treatment. SETTING AND SAMPLE POPULATION:Retrospective case-control study, based on a sample size calculation. Twenty-five pubertal patients treated with Herbst appliance (HAG), and 25 matched Class II patients who receiv...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12154
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To assess total Streptococci (TS) counts and biofilm mass over tooth-tissue-borne palatal expander (TTBPE), as well as the effect of chlorhexidine (CHX) mouth rinse on these variables. DESIGN:A cross-sectional study design employed clinical procedures and laboratorial techniques. SETTING AND SAMPLE POPULAT...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-6343.2007.00418.x
更新日期:2008-08-01 00:00:00
abstract::The synthesis of tooth development biology with human studies focusing on inherited conditions that specifically interfere with tooth development is improving our understanding of normal and pathological tooth formation. The type of inherited dental malformations observed in a given kindred relate to when, during odon...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2007.00384.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To examine the potential role of next-generation sequencing (NGS) and genetic testing to guide preventive care in dental enamel disorders using publicly available databases to access the frequency of deleterious alleles in AMTN, AMLEX and ENAM, associated with amelogenesis imperfecta (AI). SETTING AND SAMPL...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12266
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Concurrent maxillary and mandibular expansion is a treatment option for patients with maxillary and mandibular transverse constriction. These patients do not present with crossbite but require expansion due to narrow arches and associated crowding, dark buccal corridors and decreased anterior arch contour. Th...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12359
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To compare the concentration of nickel, chromium and cobalt in oral mucosa cells of patients with and without fixed orthodontic appliances. MATERIALS AND METHODS:A total of 60 patients were included in this study. The control group consisted of 30 patients without any type of fixed orthodontic appliances or ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2008.00414.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare treatment outcomes with different maxillary protraction methods in patients with skeletal Class III malocclusion resulting from maxillary retrognathia. SETTING AND SAMPLE POPULATION:A total of 55 individuals consisting of 29 females and 26 males with a mean age of 11.4 ± ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12389
更新日期:2020-11-01 00:00:00
abstract::This essay briefly considers some underlying concerns about the direction of clinical research in orthodontics. The field is viewed from a personal perspective as things are now, as they are becoming, and as I believe they should be. ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2004.00292.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:To introduce a new, fast, reliable, and free from software-related bias method to predict three-dimensionally the root position and angulation during and after orthodontic treatment. The final goal is to keep to a minimum the use of ionizing radiation by eliminating the necessity of multiple radiation exposu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12252
更新日期:2019-02-01 00:00:00
abstract::The skin and the oral mucosa act as a barrier against the external environment. Loss of this barrier function causes dehydration and a high risk of infection. For the treatment of extensive skin wounds such as in severe burns, autologous skin for transplantation is often not available in sufficient amounts. Reconstruc...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2009.01475.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:To test the following two hypotheses: 1) different types of retainers result in distinct levels of biomarkers in gingival crevicular fluid (GCF) and 2) the retainer bonded to all mandibular anterior teeth induces more detrimental outcomes to the periodontium. SETTING AND SAMPLE POPULATION:The Department of ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12129
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:An investigation to determine the changing facial appearance of identical twins. DESIGN:Clinical study. MATERIALS AND METHODS:Two Minolta Vivid 900 3D optical laser scanners were placed as a stereo pair to capture the soft tissues of a pair of identical twins. Each scan took approximately 2.5 s. The scanned...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2005.00320.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:Bone repair strategies continue to be developed for alternatives to autografting, allogeneic implants of banked bone, and other bone substitutes. Efforts have included the delivery of potent growth and/or differentiation factors and the use of gene therapy. For bone regeneration, gene therapy is the delivery...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2005.00332.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:Basic research concerning craniofacial development presently runs along two pathways, namely the molecular and the morphometric. This gap needs to be bridged. DESIGN:Using histological serial sections of human fetuses computer-aided three-dimensional reconstructions were made (Software Analysis, SIS) with s...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0544.2003.240.x
更新日期:2003-01-01 00:00:00
abstract::Repair of tooth supporting alveolar bone defects caused by periodontal and peri-implant tissue destruction is a major goal of reconstructive therapy. Oral and craniofacial tissue engineering has been achieved with limited success by the utilization of a variety of approaches such as cell-occlusive barrier membranes, b...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2005.00352.x
更新日期:2005-11-01 00:00:00
abstract::The mental health of children, adolescents, and adults with orofacial clefts has been studied extensively. Outcomes of interest have included parental adaptation, parent-child attachment, child development, intellectual and academic outcomes, behavioral adaptation, and quality of life. The literature sheds light on me...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2007.00394.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the reliability of a new technique for measuring 3D-scanned orthodontic cast models with cross-section planes using teledent, a new software, developed at Technion - for the purpose of this research. EXPERIMENTAL VARIABLE:Thirty orthodontic plaster models were divided into three equal groups acc...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2007.00417.x
更新日期:2008-05-01 00:00:00
abstract::Antimicrobial orthodontic adhesives aim to reduce white spot lesions' incidence in orthodontic patients, but they should not jeopardizing its properties. Systematic review and meta-analysis were performed to answer the question whether the association of antimicrobial agents with orthodontic adhesives compromises its ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ocr.12100
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Functional appliances lead, in different degrees, to loss of anchorage in the lower arch. By anchoring them to the mandibular bone, any dental side effects may be avoided and the skeletal effect enhanced. Stability of bone-borne fixation would be affected by forces created by the pull of the masticatory mu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12004
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:The aim of this qualitative study was to explore and describe adolescents' experiences of treatment with removable functional appliances. SETTING AND SAMPLE POPULATION:Public Dental Service, Gothenburg, Sweden. MATERIAL AND METHODS:Individual interviews focusing on adolescents' experiences of using a remov...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ocr.12093
更新日期:2015-08-01 00:00:00
abstract::Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and lik...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/ocr.12171
更新日期:2017-06-01 00:00:00
abstract:UNLABELLED:AUTHOR: Shen G Objective -This review was compiled to explore the role of type X collagen in growth, development and remodeling of articular cartilage by elucidating the linkage between the synthesis of this protein and the phenotypic changes in chondrogenesis and the onset of endochondral ossification. DES...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2004.00308.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:Literature is poor of data about the occlusion in children affected by neurofibromatosis type 1 (NF1). This case-control study investigated the occlusal traits in a group of children with NF1. SETTING AND SAMPLE POPULATION:A hundred and fifteen children with NF1 were enrolled; non-NF1 controls were sequenti...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12108
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The role of oestrogen in craniofacial growth still remains unclear. Therefore, the present study aimed to assess the effect of oestrogen deficiency on maxilla and mandible dimensions. SETTING AND SAMPLE POPULATION:The study was conducted at the Department of Pediatric Dentistry at the School of Dentistry of ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12376
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the stability of Natural Head Position (NHP) over time using the 3dMDface System. SETTING AND SAMPLE POPULATION:This was an experimental study. Three-dimensional facial images of 40 students were captured on two different occasions, with an interval of at least two weeks. ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12344
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:This investigation evaluates the evidence of case-based reasoning (CBR) in providing additional information on the prediction of future Class III craniofacial growth. SETTINGS AND SAMPLE POPULATION:The craniofacial characteristics of 104 untreated Class III subjects (7-17 years of age), monitored with two la...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12466
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:To evaluate cephalometrically craniofacial morphology in children with operated sagittal synostosis and to compare the findings with age- and sex-matched controls. SETTING AND SAMPLE POPULATION:Forty-two children (37 boys) with operated primary sagittal synostosis were compared retrospectively with age- and...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12056
更新日期:2015-02-01 00:00:00
abstract::We have developed a cone beam X-ray computed tomography (CT) system to make more accurate three-dimensional (3-D) images for diagnosis of dento-maxillofacial region. The developed system has sufficient spatial resolution, resolution of 3-D images and image distortion for diagnosis of dentomaxillofacial region. ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0544.2003.249.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To evaluate whether changes in the concentration of different biomarkers in the gingival crevicular fluid (GCF) can be used to detect the root resorption process in adult or adolescent patients undergoing treatment with a fixed appliance, in comparison with untreated subjects or treated patients not showing ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12329
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the effects of reduced masticatory function on midline suture growth and morphology in growing pigs. SETTING AND SAMPLE POPULATION:The sample was 20 pigs separated into two dietary groups and raised at the Department of Anthropology, Harvard University. Midline s...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2010.01483.x
更新日期:2010-05-01 00:00:00