Abstract:
:"Triad" asthmatics often have sinus disease, nasal polyps, and obstructive airways disease. This presentation is reminiscent of the symptoms of persons afflicted with various forms of ciliary dyskinesia. Therefore, we examined tissues from seven "triad" asthmatic patients for ciliary structural or functional abnormalities. Transmission and scanning electron microscopy revealed no specific abnormalities. Cultures of nasal epithelia were maintained for up to 20 weeks. They showed normal ciliary activity which was not influenced by perfusing the tissue with medium containing aspirin. In contrast, control tissue from a patient with situs inversus and sinusitis showed the expected structural and functional ciliary abnormalities. In culture, the ciliary function of tissue from this patient could be partly restored by perfusion with ATP or ATPase.
journal_name
Chestjournal_title
Chestauthors
Lewis FH,Beals TF,Carey TE,Baker SR,Mathews KPdoi
10.1378/chest.83.3.487subject
Has Abstractpub_date
1983-03-01 00:00:00pages
487-90issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)39988-3journal_volume
83pub_type
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