Inhibition of active transport and macromolecular synthesis by pyocin 103 in Neisseria gonorrhoeae.

Abstract:

:The mechanism of inhibition of Neisseria gonorrhoeae by pyocin 103 was examined. Pyocin 103 decreases the viability of N. gonorrhoeae immediately after its addition to logarithmically growing cells by single-hit kinetics. This inhibition was paralleled by an immediate cessation of protein synthesis, RNA synthesis, and active transport. From the data presented, it is likely that pyocin kills N. gonorrhoeae in the same manner that it kills Pseudomonas aeruginosa, i.e., by interfering with energy metabolism.

journal_name

Sex Transm Dis

authors

Stein DC,Clark VL,Young FE

doi

10.1097/00007435-198301000-00002

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

7-13

issue

1

eissn

0148-5717

issn

1537-4521

journal_volume

10

pub_type

杂志文章
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    authors: Lau JT,Yeung NC,Mui LW,Tsui HY,Gu J

    更新日期:2011-09-01 00:00:00

  • Risk-based human immunodeficiency virus (HIV) testing fails to detect the majority of HIV-infected persons in medical care Settings.

    abstract:OBJECTIVES:To evaluate opportunities for earlier human immunodeficiency virus (HIV) diagnosis within a comprehensive public health care system. STUDY DESIGN:Retrospective review of newly diagnosed HIV-infected patients between September 2001 and December 2003. RESULTS:One hundred twenty of 348 (34%) newly diagnosed H...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000194617.91454.3f

    authors: Jenkins TC,Gardner EM,Thrun MW,Cohn DL,Burman WJ

    更新日期:2006-05-01 00:00:00

  • Evaluation of interviewing techniques to enhance recall of sexual and drug injection partners.

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    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-200111000-00010

    authors: Brewer DD,Garrett SB

    更新日期:2001-11-01 00:00:00

  • Alcohol Use and Associations With Biological Markers and Self-Reported Indicators of Unprotected Sex in Human Immunodeficiency Virus-Positive Female Sex Workers in Mombasa, Kenya.

    abstract:BACKGROUND:Studies of alcohol use and sexual behavior in African populations have primarily been cross-sectional, used nonvalidated measures of alcohol use, or relied on self-reported sexual risk endpoints. Few have focused on human immunodeficiency virus (HIV)-positive women. METHODS:Longitudinal data were collected ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000502

    authors: White D,Wilson KS,Masese LN,Wanje G,Jaoko W,Mandaliya K,Richardson BA,Kinuthia J,Simoni JM,McClelland RS

    更新日期:2016-10-01 00:00:00

  • Genital ulcer disease treatment policies and access to acyclovir in eight sub-Saharan African countries.

    abstract:BACKGROUND:Herpes simplex virus-2, the most common cause of genital ulcer disease (GUD) globally, is a cofactor in human immunodeficiency virus type-1 (HIV-1) acquisition and transmission. Current World Health Organization guidelines for sexually transmitted infections recommend acyclovir as first-line syndromic treatm...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181e212e5

    authors: Corbell C,Stergachis A,Ndowa F,Ndase P,Barnes L,Celum C

    更新日期:2010-08-01 00:00:00

  • Epidemic Lymphogranuloma venereum during epidemics of crack cocaine use and HIV infection in the Bahamas.

    abstract:BACKGROUND:Since the early 1980s, the Bahamas has experienced sequential epidemics of freebase/crack cocaine use, genital ulcer-inguinal adenopathy disease (GUD), and heterosexual HIV infection. GOAL:To prospectively define the etiology of GUD in patients at the Princess Margaret Hospital during outbreaks of crack coc...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200205000-00001

    authors: Bauwens JE,Orlander H,Gomez MP,Lampe M,Morse S,Stamm WE,Cone R,Ashley R,Swenson P,Holmes KK

    更新日期:2002-05-01 00:00:00

  • Persistent nongonococcal urethritis associated with a minocycline-resistant strain of Ureaplasma urealyticum: a case report.

    abstract::Culture of urethral specimens from a 21-year-old man with nongonococcal urethritis yielded both Chlamydia trachomatis and a minocycline-resistant strain of Ureaplasma urealyticum. In such situations, the causal agent of the urethritis is frequently considered to be C. trachomatis. However, the etiology of this case wa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Magalhães M

    更新日期:1983-07-01 00:00:00

  • The role of mycoplasmas in the upper genital tract of women.

    abstract::Mycoplasma hominis is isolated from the cervix of 10-20% of healthy, fertile women. In contrast, the organism is recovered from the lower genital tract of 50-70% of women with pelvic inflammatory disease. Moreover, a significant antibody response to M. hominis is found in one-fourth of all patients with clinical and/o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Møller BR

    更新日期:1983-10-01 00:00:00

  • Syphilitic hepatitis treated with doxycycline in an HIV-infected patient and review of the literature.

    abstract::An HIV-infected male patient who had sex with men and with a penicillin allergy presented with liver dysfunction due to secondary syphilis and was successfully treated with doxycycline. This case highlights that syphilitic hepatitis may be overlooked in this particular population, and health care providers should be a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/OLQ.0000000000000143

    authors: Bork JT,Macharia T,Choi J,Gilliam BL,Buchwald UK

    更新日期:2014-08-01 00:00:00

  • Douching practices among women at high risk of HIV infection in the United States: implications for microbicide testing and use.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200207000-00008

    authors: Koblin BA,Mayer K,Mwatha A,Brown-Peterside P,Holt R,Marmor M,Smith C,Chiasson MA

    更新日期:2002-07-01 00:00:00

  • The high-risk sexual practices of crack-smoking sex workers recruited from the streets of three American cities. The Multicenter Crack Cocaine and HIV Infection Study Team.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199804000-00002

    authors: Jones DL,Irwin KL,Inciardi J,Bowser B,Schilling R,Word C,Evans P,Faruque S,McCoy HV,Edlin BR

    更新日期:1998-04-01 00:00:00

  • Measured versus self-reported compliance with doxycycline therapy for chlamydia-associated syndromes: high therapeutic success rates despite poor compliance.

    abstract:OBJECTIVE:To compare self-reported doxycycline compliance in men and women attending an STD clinic with indications for Chlamydia trachomatis treatment to compliance measured using microprocessor-containing medication vials to count each time and date medication vials were opened. A secondary objective was to correlate...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199905000-00006

    authors: Bachmann LH,Stephens J,Richey CM,Hook EW 3rd

    更新日期:1999-05-01 00:00:00

  • Evidence-based planning of a randomized controlled trial on diaphragm use for prevention of sexually transmitted infections.

    abstract:OBJECTIVES:We conducted formative research to evaluate the acceptability and feasibility of continuous diaphragm use among low-income women highly exposed to sexually transmitted infections (STIs) in Madagascar. GOAL:To identify potential obstacles to researching the effectiveness of diaphragm use for STI prevention i...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31815abaa2

    authors: Behets FM,Van Damme K,Turner AN,Rabenja NL,Ravelomanana NL,Raharinivo MS,Zeller KA,Rennie SM,Swezey TA

    更新日期:2008-03-01 00:00:00

  • A Comparison of U.S. Clinical Laboratory Chlamydia and Gonorrhea Testing Practices Prior to and Following the 2014 CDC Testing Recommendations.

    abstract:BACKGROUND:Adherence to recommended laboratory testing practices is crucial for sexually transmitted infection (STI) prevention and control. The objective of this paper is to compare Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) testing practices of US clinical laboratories in 2013 prior to the updated 2014...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001299

    authors: Davis A,Gaynor A

    更新日期:2020-09-18 00:00:00

  • Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation.

    abstract:BACKGROUND:Clinical studies demonstrate increased prevalence of human papillomavirus (HPV)-associated disease in HIV-infected individuals and an increased risk of HIV acquisition in HPV-infected individuals. The mechanisms underlying this synergy are not defined. We hypothesize that women with cervical intraepithelial ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318255aeef

    authors: Mhatre M,McAndrew T,Carpenter C,Burk RD,Einstein MH,Herold BC

    更新日期:2012-08-01 00:00:00

  • Hepatitis C seroprevalence and risk behaviors in patients attending sexually transmitted disease clinics.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is a major global problem, transmitted primarily by percutaneous exposure to contaminated blood. GOAL:The goal of the study was to determine the seroprevalence of and risk factors for HCV among patients attending two urban STD clinics in Alberta. STUDY DESIGN:Anonymous unlinked sero...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200301000-00008

    authors: Romanowski B,Preiksaitis J,Campbell P,Fenton J

    更新日期:2003-01-01 00:00:00

  • Measuring the in vitro susceptibility of Trichomonas vaginalis to metronidazole: a disk broth method.

    abstract::Strains of Trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. A serial twofold dilution method that measured minimal inhibitory concentrations (MICs) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trop...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198007000-00005

    authors: Smith RF,Di Domenico A

    更新日期:1980-07-01 00:00:00

  • Sexually transmitted disease clinic clients at risk for subsequent gonorrhea and chlamydia infections: possible 'core' transmitters.

    abstract:BACKGROUND:From an sexually transmitted disease (STD) intervention perspective, developing a practical way to identify persons in core transmitter groups has been difficult. However, persons who have repeated STD infections may be in such groups. GOAL:To evaluate a self-administered risk assessment approach that would...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200007000-00008

    authors: Gunn RA,Fitzgerald S,Aral SO

    更新日期:2000-07-01 00:00:00

  • The Estimated Lifetime Medical Cost of Chlamydia, Gonorrhea, and Trichomoniasis in the United States, 2018.

    abstract:BACKGROUND:The purpose of this study was to provide updated estimates of the average lifetime medical cost per infection for chlamydia, gonorrhea, and trichomoniasis. METHODS:We adapted a published decision tree model that allowed for 7 possible outcomes of infection: (1) symptomatic infection, treated, no sequelae; (...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001357

    authors: Kumar S,Chesson H,Spicknall IH,Kreisel K,Gift TL

    更新日期:2021-01-23 00:00:00

  • Partner referral by patients with gonorrhea and chlamydial infection. Case-finding observations.

    abstract:OBJECTIVE:To evaluate the outcomes of a partner referral program at the sexually transmitted disease (STD) clinic in Amsterdam that encourages gonorrhea and chlamydia patients to refer their own partners to medical examination. STUDY DESIGN:355 patients with a confirmed infection cooperated in partner referral and gav...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199707000-00005

    authors: van de Laar MJ,Termorshuizen F,van den Hoek A

    更新日期:1997-07-01 00:00:00

  • Scale-free networks and sexually transmitted diseases: a description of observed patterns of sexual contacts in Britain and Zimbabwe.

    abstract:BACKGROUND:Sexually transmitted infections spread through a network of contacts created by the formation of sexual partnerships. In physics, networks have been characterized as "scale-free" if they follow a power law with an exponent between 2 and 3. OBJECTIVE:The objective of this study was to test statistically whet...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200406000-00012

    authors: Schneeberger A,Mercer CH,Gregson SA,Ferguson NM,Nyamukapa CA,Anderson RM,Johnson AM,Garnett GP

    更新日期:2004-06-01 00:00:00

  • Characteristics of Women and Their Male Sex Partners Predict Bacterial Vaginosis Among a Prospective Cohort of Kenyan Women With Nonoptimal Vaginal Microbiota.

    abstract:BACKGROUND:Up to 50% of women with nonoptimal vaginal microbial community state type (CST) have bacterial vaginosis (BV). Little is known about what distinguishes women with and without BV diagnosis within nonoptimal CST. We identified features of women and their male sex partners associated with BV among women with no...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

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    authors: Mehta SD,Agingu W,Nordgren RK,Green SJ,Bhaumik DK,Bailey RC,Otieno F

    更新日期:2020-12-01 00:00:00

  • No Pathogen-Specific Sign or Symptom Predicts the Etiology of Monomicrobial Nongonococcal Urethritis in Men.

    abstract::Identifying pathogen-specific signs or symptoms of nongonococcal urethritis could improve syndromic management accuracy. We evaluated nongonococcal urethritis signs and symptoms in 220 men with single-pathogen infections (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, or Ureaplasma urealyticum) o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001158

    authors: Jordan SJ,Toh E,Williams JA,Fortenberry LJ,LaPradd M,Ryan JD,Nelson DE,Batteiger TA

    更新日期:2020-05-01 00:00:00

  • An Illustration of Errors in Using the P Value to Indicate Clinical Significance or Epidemiological Importance of a Study Finding.

    abstract::We conducted a simulation study to illustrate that P values can suggest but not confirm statistical significance; and they may not indicate epidemiological significance (importance). We recommend that researchers consider reporting effect sizes as P values in conjunction with confidence intervals or point estimates wi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000635

    authors: Kang J,Hong J,Esie P,Bernstein KT,Aral S

    更新日期:2017-08-01 00:00:00

  • Sexually transmitted disease syndromes in rural South Africa. Results from health facility surveillance.

    abstract:BACKGROUND AND OBJECTIVE:Surveillance for sexually transmitted diseases (STD) is important for priority setting, service development, and evaluating interventions. GOAL:To conduct health facility-based surveillance for STDs to inform design of a control program and to provide baseline measures for evaluation of interv...

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    pub_type: 杂志文章

    doi:10.1097/00007435-199801000-00005

    authors: Wilkinson D,Connolly AM,Harrison A,Lurie M,Karim SS

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  • Effect of highly active antiretroviral therapy on incidence of early syphilis in HIV-infected patients.

    abstract:OBJECTIVES:To evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. STUDY DESIGN:Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (prima...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

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    更新日期:2008-03-01 00:00:00

  • Concurrency, sex partner risk, and high-risk human papillomavirus infection among African American, Asian, and Hispanic women.

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    authors: Marrazzo JM,Ellen JM,Kent C,Gaydos C,Chapin J,Dunne EF,Rietmeijer CA

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    pub_type: 杂志文章

    doi:10.1097/00007435-197701000-00004

    authors: Walzer PD,Armstrong D

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    pub_type: 杂志文章

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    更新日期:1978-10-01 00:00:00