Abstract:
BACKGROUND:Clinical studies demonstrate increased prevalence of human papillomavirus (HPV)-associated disease in HIV-infected individuals and an increased risk of HIV acquisition in HPV-infected individuals. The mechanisms underlying this synergy are not defined. We hypothesize that women with cervical intraepithelial neoplasia (CIN) will exhibit changes in soluble mucosal immunity that may promote HPV persistence and facilitate HIV infection. METHODS:The concentrations of immune mediators and endogenous anti-Escherichia coli activity in genital tract secretions collected by cervicovaginal lavage were compared in HIV-negative women with high-risk HPV-positive (HRHPV+) CIN-3 (n = 37), HRHPV+ CIN-1 (n = 12), or PAP-negative control subjects (n = 57). RESULTS:Compared with control subjects, women with CIN-3 or CIN-1 displayed significantly higher levels of proinflammatory cytokines including interleukin (IL)-1α, IL-1β, and IL-8 (P < 0.002) and significantly lower levels of anti-inflammatory mediators and antimicrobial peptides, including IL-1 receptor antagonist, secretory leukocyte protease inhibitor (P < 0.01), and human β defensins 2 and 3 (P < 0.02). There was no significant difference in endogenous anti-E. coli activity after controlling for age and sample storage time. CONCLUSION:HRHPV+ CIN is characterized by changes in soluble mucosal immunity that could contribute to HPV persistence. The observed mucosal inflammation suggests a mechanism that may also contribute to the epidemiologic link between persistent HPV and HIV.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Mhatre M,McAndrew T,Carpenter C,Burk RD,Einstein MH,Herold BCdoi
10.1097/OLQ.0b013e318255aeefsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
591-7issue
8eissn
0148-5717issn
1537-4521pii
00007435-201208000-00004journal_volume
39pub_type
杂志文章abstract:BACKGROUND:Efforts to identify and link human immunodeficiency virus-infected persons to medical care are the first steps to achieving viral suppression. In the United States, the goals are to link 85% of newly diagnosed persons to medical care in 30 days or less and for 80% to become virally suppressed by 2020. Among ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000776
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The past 10 years' wave of syphilis epidemics has challenged syphilis control programs. Although apparently connected to drugs-for-sex trading of crack cocaine, the genesis and resolution of these epidemics is poorly understood. GOALS OF THE STUDY:The goals of this study were to develop a mat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199601000-00008
更新日期:1996-01-01 00:00:00
abstract::Three cases of endocarditis caused by Neisseria gonorrhoeae involving the aortic, mitral an tricuspid valves are reported. Two cases in young women, following syndromes suggestive of gonococcal arthritis, presented as acute endocarditis and were fatal. The male patient experienced a subacute course, and the diagnosis ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-197707000-00002
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:In the District of Columbia (DC), Neisseria gonorrhoeae (gonorrhea) infections accounted for more than 25% of 9321 incident sexually transmitted infections reported in 2011; untreated infections can lead to reproductive complications and a higher risk for HIV transmission. In DC, limited capacity to measure ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000304
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) is a major global problem, transmitted primarily by percutaneous exposure to contaminated blood. GOAL:The goal of the study was to determine the seroprevalence of and risk factors for HCV among patients attending two urban STD clinics in Alberta. STUDY DESIGN:Anonymous unlinked sero...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200301000-00008
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Sexual behavior changes are widely cited as contributing factors to sexually transmitted disease trends. We explore a rarely examined aspect of behavior trends in an open cohort--the relative impact of individuals' changing reported behavior versus new responses due to a changing respondent base. METHODS:...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318214e42e
更新日期:2011-08-01 00:00:00
abstract::Identifying pathogen-specific signs or symptoms of nongonococcal urethritis could improve syndromic management accuracy. We evaluated nongonococcal urethritis signs and symptoms in 220 men with single-pathogen infections (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, or Ureaplasma urealyticum) o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001158
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To evaluate opportunities for earlier human immunodeficiency virus (HIV) diagnosis within a comprehensive public health care system. STUDY DESIGN:Retrospective review of newly diagnosed HIV-infected patients between September 2001 and December 2003. RESULTS:One hundred twenty of 348 (34%) newly diagnosed H...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000194617.91454.3f
更新日期:2006-05-01 00:00:00
abstract::Between 1988 and 1991, 64 homosexual men and 43 bisexual men were screened for human immunodeficiency virus (HIV) in Southern Taiwan; 5 of them were found to carry HIV antibodies. According to a self-administered questionnaire completed before screening, the average age of the men in the study group was 27 years, and ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:The impact of length of enrollment in a health plan on eligibility of women under the Healthcare Effectiveness Data and Information Set (HEDIS) chlamydia screening measure is not fully understood. We assessed the representativeness of the measure among the proportion of women aged 15 to 24 years with a gap in...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000338
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Public health authorities want to evaluate their sexually transmitted disease (STD) surveillance systems to promote the most effective use of health resources. GOAL:The goal of this study was to estimate the sensitivity of national laboratory reports of in Switzerland (the proportion of cases detected by na...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200211000-00016
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:The use of new technologies, such as mobile phones and internet, has increased dramatically in recent years. Text messages offer a novel method of sexual health promotion to young people who are the greatest users of new technology and are also at high risk of sexually transmitted infections (STIs). METHODS...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181f68d7b
更新日期:2011-04-01 00:00:00
abstract::Given the many options available, selecting an HIV test for a particular clinical or research setting can be daunting. Making an informed decision requires an assessment of the likelihood of acute infection in the test population and an understanding of key aspects of the tests themselves. The ability of individual te...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000719
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To compare self-reported doxycycline compliance in men and women attending an STD clinic with indications for Chlamydia trachomatis treatment to compliance measured using microprocessor-containing medication vials to count each time and date medication vials were opened. A secondary objective was to correlate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199905000-00006
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including i...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000772
更新日期:2018-06-01 00:00:00
abstract::Among 413 Nigerian men who have sex with men and transgender women, retrospective testing for Mycoplasma genitalium revealed mostly asymptomatic infections of the anorectum (prevalence, 36.8%; incidence, 18.4 cases/100 person-years) and urogenital tract (12.4%, 4.0 cases/100 person-years). Risk factors included HIV an...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001105
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Enzyme-linked immunosorbent assay (ELISA) is the most popular method used by blood banks in China to screen for antibodies to Treponema pallidum (TP). However, this method produces a high percentage of false-positive reactions.The current study aimed to propose a more effective procedure for screening anti-T...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31819db594
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Sexually transmitted disease (STD) clinics often serve a population that has low medical care utilization. The objective of this study was to determine the susceptibility of an STD clinic population to vaccine-preventable diseases. STUDY DESIGN:A cross-sectional study of immunization practices...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199808000-00001
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:At-risk sexual behaviors appear to have increased recently in France, possibly because of the reassuring efficacy of highly active antiretroviral treatments. The objective of this study was to assess the pattern of change. GOAL:The goal was to analyze trends in the incidence of male urethritis, a marker of ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200206000-00002
更新日期:2002-06-01 00:00:00
abstract::Female guinea pigs were inoculated intravaginally with guinea pig cytomegalovirus (GPCMV) propagated either in guinea pig embryo fibroblast cultures (GPEF) or salivary glands. The incidence of infection was higher with GPEF virus. Rare instances of isolation of GPCMV from cervical swabs 9-48 hr after inoculation was a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198901000-00009
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:High incidence and prevalence of sexually transmitted infection (STI) in blacks have been attributed to multiple factors. However, few articles have discussed spatial access to healthcare as a driver of disparities. The objective of this analysis was to evaluate the relationship between travel time to a heal...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318235b673
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:To examine the epidemiology of multiple infections in teenagers and their contacts. GOAL:To demonstrate a network approach to the prevalence of STDs/HIV. STUDY DESIGN:A community-based network study of ethnographically representative adolescents. RESULTS:Of the 512 interviewees, 90% of the boys and 80% of...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000258132.06764.a1
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Sexually transmitted infections spread through a network of contacts created by the formation of sexual partnerships. In physics, networks have been characterized as "scale-free" if they follow a power law with an exponent between 2 and 3. OBJECTIVE:The objective of this study was to test statistically whet...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200406000-00012
更新日期:2004-06-01 00:00:00
abstract::The implementation of express testing in an sexually transmitted infection (STI) clinic reduced the length of visit time compared with other visit types and increased the proportion of STIs diagnosed at clinic visits. Express testing did not impact the time to treatment for asymptomatic patients diagnosed as having an...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000363
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Adolescents and young adults comprise disproportionately high percentages of individuals living with human immunodeficiency virus (HIV) and those with undiagnosed HIV. Our objective was to determine factors associated with history of HIV testing and receipt of results among a sample of urban, high-risk, sexu...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318214bb70
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES/GOAL:We compared risk behaviors and HIV testing between recent (in the U.S. <5 years) and established (in the U.S. >5 years) Hispanic immigrant men (N = 410). STUDY:This study was a population-based, cross-sectional survey of HIV/sexually transmitted disease markers and risk behaviors in men age 18 to 35 ye...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000161185.06387.94
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Patients with sexually transmitted diseases (STDs) are at an increased risk of HIV infection and they must be targeted for increased condom use. GOAL:To identify predictors of condom use among patients with STDs. STUDY DESIGN:In a cross-sectional survey, an interview-administered questionnair...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199910000-00001
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) is a frequent cause of vaginal discharge that may be more common among women reporting sex with women (WSW). The objective of this study was to determine the prevalence of BV and predictors of infection among a sample of African American WSW. METHODS:African American WSW aged 18 yea...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000004
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Routine chlamydia screening is not readily available at all college campuses. OBJECTIVES:: To assess the prevalence of Chlamydia trachomatis among asymptomatic college students and to compare chlamydia positivity by selected demographic variables. METHODS:Analysis of demographical data collected on 789 stu...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181676697
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:: To estimate the effects of reproductive tract infections (RTIs) on HIV acquisition among Zimbabwean and Ugandan women. METHODS:: A multicenter prospective observational cohort study enrolled 4439 HIV-uninfected women aged 18 to 35 attending family planning clinics in Zimbabwe and Uganda. Participants were ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e3181a4f695
更新日期:2009-06-01 00:00:00