Response of guinea pigs to intravaginal inoculation with guinea pig cytomegalovirus.

Abstract:

:Female guinea pigs were inoculated intravaginally with guinea pig cytomegalovirus (GPCMV) propagated either in guinea pig embryo fibroblast cultures (GPEF) or salivary glands. The incidence of infection was higher with GPEF virus. Rare instances of isolation of GPCMV from cervical swabs 9-48 hr after inoculation was attributed to survival of inoculum in the genital tract. Neither immunofluorescence microscopy nor histopathologic examination showed evidence for active infection of genital tract tissue examined up to day 5 after inoculation. At necropsy on days 30-49, GPCMV was isolated from salivary glands and occasionally from pancreas and lymph nodes. Seroconversion following intravaginal inoculation was demonstrated by an enzyme-linked immunosorbent assay (ELISA) test, and titers were comparable to those after intraperitoneal or subcutaneous inoculation. However, titers of neutralizing antibody, determined by plaque-reduction assay, were significantly lower in the group inoculated intravaginally. These findings are relevant to consideration of cytomegalovirus as a sexually transmitted agent in humans.

journal_name

Sex Transm Dis

authors

Barron AL,Menna JH,Moses EB,Rank RG,Ryu H,White HJ

doi

10.1097/00007435-198901000-00009

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

41-6

issue

1

eissn

0148-5717

issn

1537-4521

journal_volume

16

pub_type

杂志文章
  • Etiology of acute pelvic inflammatory disease proven by laparoscopy.

    abstract:BACKGROUND:Only a few studies have investigated the etiology of acute pelvic inflammatory disease (PID) in laparoscopy-proven cases using pelvic samples for culture. Most of these studies were conducted in North America and Scandinavia. GOAL OF THE STUDY:To study the microbial etiology of laparoscopy-proven acute pelv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199305000-00008

    authors: Dan M,Samra Z,Katz A,Debby A,Gutman R,Zakut H

    更新日期:1993-05-01 00:00:00

  • Anal lymphogranuloma venereum infection screening with IgA anti-Chlamydia trachomatis-specific major outer membrane protein serology.

    abstract:BACKGROUND:Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differenti...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181e50671

    authors: de Vries HJ,Smelov V,Ouburg S,Pleijster J,Geskus RB,Speksnijder AG,Fennema JS,Morré SA

    更新日期:2010-12-01 00:00:00

  • Sexual transmission of hepatitis C virus from a patient with chronic disease to his sex partner after removal of an intrauterine device.

    abstract:BACKGROUND:Approximately 40% of patients infected with hepatitis C virus (HCV) have no history of blood transfusion or other high-risk practice. Other causes should be considered. GOAL:The goal was to describe sexual transmission of HCV from a chronic carrier to his female partner during unprotected vaginal intercours...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200305000-00015

    authors: Quer J,Murillo P,Esteban JI,Martell M,Esteban R,Guardia J

    更新日期:2003-05-01 00:00:00

  • Evaluation of the limulus amebocyte lysate assay for presumptive diagnosis of gonorrhea in men at a clinic for sexually transmitted diseases.

    abstract::Specimens of urethral exudate from 200 men with uncomplicated urethritis were tested for Neisseria gonorrhoeae by the limulus amebocyte lysate assay, culture on modified Thayer-Martin medium, and gram-stained smear. As compared with cultures, the sensitivity and specificity of the limulus assay were 94.8% and 89.3%, r...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198107000-00001

    authors: Chapel TA,Adcock M,Smith B,Barnes T,Goodman M

    更新日期:1981-07-01 00:00:00

  • Epidemiologic and prophylactic treatment of gonorrhea: a decision analysis review.

    abstract::This review of the treatment of patients exposed to gonorrhea uses decision analysis techniques to estimate and compare the probabilities of disease and treatment risks for epidemiologic treatment, for treatment contingent on results of gram stains and culture, and for treatment contingent on culture results alone. E...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-197904000-00022

    authors: Johnson RE

    更新日期:1979-04-01 00:00:00

  • Diagnosis of male Chlamydia trachomatis urethritis by polymerase chain reaction.

    abstract:BACKGROUND AND OBJECTIVES:A quick and highly sensitive diagnostic test would be valuable in the diagnosis of Chlamydia trachomatis. GOAL OF THIS STUDY:We compared a new polymerase chain reaction (PCR) technique to Chlamydiazyme (Abbott, North Chicago, IL) in the detection of male chlamydial urethritis, and evaluated t...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007435-199409000-00004

    authors: Wiesenfeld HC,Uhrin M,Dixon BW,Sweet RL

    更新日期:1994-09-01 00:00:00

  • Mycoplasma hominis in cervicitis and endometritis.

    abstract::The presence of serum IgG antibody to Mycoplasma hominis was studied by enzyme immunoassay in 150 women with suspected cervicitis at a clinic for sexually transmitted diseases. Positive levels of antibody were associated with gravidity and parity but not with age, method of birth control, or sexual behavior. Women fro...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Paavonen J,Miettinen A,Stevens CE,Kiviat N,Kuo CC,Stamm WE,Holmes KK

    更新日期:1983-10-01 00:00:00

  • Extragenital Testing for Neisseria gonorrhoeae and Chlamydia trachomatis in a Large HIV Clinic in the US South: Implementation and Epidemiology.

    abstract:BACKGROUND:Rectal and oral Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) infections are common among people with HIV, especially men who have sex with men (MSM); however, GC/CT testing rates remain low in many HIV clinics. We evaluated the real-world implementation and results of extragenital nucleic acid a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001349

    authors: Pottorff A,Duarte P,Chow J,Luque A,Nijhawan AE

    更新日期:2021-02-01 00:00:00

  • Diagnosis of gonorrhea by gram-stained smears and cultures in men and women: role of the urethral smear.

    abstract::A retrospective study of the diagnosis of gonorrhea by gram-stained smear and culture was made. Of 1,681 men with gonococcal urethritis, 1,437 (85.5%) were positive by both smear and culture; 151 (9%), by smear alone; and 93 (5.5%), by culture alone. Of 1,148 women with gonorrhea, 742 (64.6%) had infection in both the...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198507000-00008

    authors: Goh BT,Varia KB,Ayliffe PF,Lim FK

    更新日期:1985-07-01 00:00:00

  • Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis.

    abstract:BACKGROUND:Chronic nongonococcal urethritis (NGU) is a well-recognized clinical problem in genitourinary medicine clinics, but its etiology and optimal management are poorly understood. GOAL:The authors showed previously that antibody to chlamydial hsp60 is associated with urethritis 30 to 92 days after treatment of a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200302000-00007

    authors: Horner P,Thomas B,Gilroy C,Egger M,McClure M,Taylor-Robinson D

    更新日期:2003-02-01 00:00:00

  • Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199118020-00012

    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00

  • Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai.

    abstract:BACKGROUND:Azithromycin has been used to treat primary and secondary syphilis and as prophylaxis for sexual partners. We evaluated syphilis treatment failure in patients who received azithromycin therapy. METHODS:Patients who did not respond to azithromycin therapy were referred to Shanghai Skin Disease and sexually t...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181e2c753

    authors: Zhou P,Li K,Lu H,Qian Y,Gu X,Gong W,Tucker JD,Cohen MS

    更新日期:2010-11-01 00:00:00

  • Evaluation of opa-based real-time PCR for detection of Neisseria gonorrhoeae.

    abstract:OBJECTIVES:Detection of Neisseria gonorrhoeae by commercial and in-house-based assays has been hampered by false-positive and false-negative results. The current study describes a sensitive and specific real-time 5'-nuclease PCR assay targeting a 90-bp region of the multicopy opa gene. GOAL:To evaluate the sensitivity...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000154495.24519.bf

    authors: Tabrizi SN,Chen S,Tapsall J,Garland SM

    更新日期:2005-03-01 00:00:00

  • Persistent nongonococcal urethritis associated with a minocycline-resistant strain of Ureaplasma urealyticum: a case report.

    abstract::Culture of urethral specimens from a 21-year-old man with nongonococcal urethritis yielded both Chlamydia trachomatis and a minocycline-resistant strain of Ureaplasma urealyticum. In such situations, the causal agent of the urethritis is frequently considered to be C. trachomatis. However, the etiology of this case wa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Magalhães M

    更新日期:1983-07-01 00:00:00

  • Treponema pallidum pallidum Genotypes and Macrolide Resistance Status in Syphilitic Lesions among Patients at 2 Sexually Transmitted Infection Clinics in Lima, Peru.

    abstract::We report the circulating genotypes and the frequency of macrolide-resistance patterns among Treponema pallidum pallidum DNA isolated from syphilitic lesions from patients who attended 2 sexual health clinics in Lima, Peru. We implemented and used a molecular typing scheme to describe local T. pallidum pallidum strain...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000465

    authors: Flores JA,Vargas SK,Leon SR,Perez DG,Ramos LB,Chow J,Konda KA,Calvo GM,Salvatierra HJ,Klausner JD,Caceres CF

    更新日期:2016-07-01 00:00:00

  • Prevalence and Correlates of Genital Infections Among Newly Diagnosed Human Immunodeficiency Virus-Infected Adults Entering Human Immunodeficiency Virus Care in Windhoek, Namibia.

    abstract:BACKGROUND:Identifying and treating genital infections, including sexually transmitted infections (STI), among newly diagnosed human immunodeficiency virus (HIV)-infected individuals may benefit both public and individual health. We assessed prevalence of genital infections and their correlates among newly diagnosed HI...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000513

    authors: Djomand G,Schlefer M,Gutreuter S,Tobias S,Patel R,DeLuca N,Hood J,Sawadogo S,Chen C,Muadinohamba A,Lowrance DW,Bock N

    更新日期:2016-11-01 00:00:00

  • Benefits and Potential Harms of Human Immunodeficiency Virus Self-Testing Among Men Who Have Sex With Men in China: An Implementation Perspective.

    abstract:BACKGROUND:Human immunodeficiency virus self-testing (HIVST) holds great promise for reaching high-risk key populations who do not access facility-based services. We sought to characterize unsupervised HIVST implementation among men who have sex with men in China. METHODS:We conducted a nationwide online survey in Chi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000581

    authors: Qin Y,Tang W,Nowacki A,Mollan K,Reifeis SA,Hudgens MG,Wong NS,Li H,Tucker JD,Wei C

    更新日期:2017-04-01 00:00:00

  • Condom use to prevent incident STDs: the validity of self-reported condom use.

    abstract:BACKGROUND:Studies of sexual behavior and of interventions designed to reduce human immunodeficiency virus risk usually depend on self-report. Validation of self-reported condom use measures has not been previously reported in an urban population at high risk for sexually transmitted diseases and human immunodeficiency...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199501000-00003

    authors: Zenilman JM,Weisman CS,Rompalo AM,Ellish N,Upchurch DM,Hook EW 3rd,Celentano D

    更新日期:1995-01-01 00:00:00

  • Uptake of Home-Based Syphilis and Human Immunodeficiency Virus Testing Among Male Partners of Pregnant Women in Western Kenya.

    abstract:BACKGROUND:Few men are tested for syphilis or human immunodeficiency virus (HIV) during their partner's pregnancy, a high-risk period for HIV and syphilis transmission. Offering home-based rapid testing of syphilis to couples during pregnancy can support prevention efforts to reduce transmission of sexually transmitted...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/OLQ.0000000000000649

    authors: Mark J,Kinuthia J,Roxby AC,Krakowiak D,Osoti A,Richardson BA,Gone MA,Asila V,Parikh S,Farquhar C

    更新日期:2017-09-01 00:00:00

  • High-frequency of quinolone-resistant Neisseria gonorrhoeae in Austria with a common pattern of triple mutations in GyrA and ParC genes.

    abstract:OBJECTIVE:Quinolones have a broad spectrum of antimicrobial activity and are widely used for the treatment of uncomplicated Neisseria gonorrhoeae infections. A dramatic increase in the number of reported N. gonorrhoeae infections as well as quinolone-resistant isolates in Vienna prompted us to investigate the pattern o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000140019.18390.28

    authors: Uthman A,Heller-Vitouch C,Stary A,Bilina A,Kuchinka-Koch A,Söltz-Szöts J,Tschachler E

    更新日期:2004-10-01 00:00:00

  • Developing a predictive model to prioritize human immunodeficiency virus partner notification in North Carolina.

    abstract:BACKGROUND:Disease intervention specialists (DIS) in North Carolina have less time to conduct partner notification because of competing responsibilities while simultaneously facing increased case loads because of increased human immunodeficiency virus (HIV) testing. We developed a model to predict undiagnosed HIV infec...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318239da4e

    authors: Hoots BE,MacDonald PD,Hightow-Weidman LB,Leone PA,Miller WC

    更新日期:2012-01-01 00:00:00

  • The high-risk sexual practices of crack-smoking sex workers recruited from the streets of three American cities. The Multicenter Crack Cocaine and HIV Infection Study Team.

    abstract:BACKGROUND AND OBJECTIVES:Small ethnographic and clinic-based studies indicate that crack-smoking sex workers are at high risk for human immunodeficiency virus (HIV) and sexually transmitted diseases (STD). STUDY GOALS:To examine the prevalence of risky sexual behaviors and HIV and STD in a large sample of street-recr...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199804000-00002

    authors: Jones DL,Irwin KL,Inciardi J,Bowser B,Schilling R,Word C,Evans P,Faruque S,McCoy HV,Edlin BR

    更新日期:1998-04-01 00:00:00

  • Papillomavirus infection among abortion applicants and patients at a sexually transmitted disease clinic.

    abstract::The base-line prevalence of human papillomavirus (HPV) infection among applicants for first trimester induced abortion and among a sexually transmitted disease (STD) clinic population with macroscopically visible condyloma is investigated. Cervical cells were collected from 505 women applying for induced abortion. Cel...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Csángó PA,Skuland J,Nilsen A,Pedersen BS,Jagars G

    更新日期:1992-05-01 00:00:00

  • Chlamydia prevalence among college students: reproductive and public health implications.

    abstract:BACKGROUND:Routine chlamydia screening is not readily available at all college campuses. OBJECTIVES:: To assess the prevalence of Chlamydia trachomatis among asymptomatic college students and to compare chlamydia positivity by selected demographic variables. METHODS:Analysis of demographical data collected on 789 stu...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181676697

    authors: James AB,Simpson TY,Chamberlain WA

    更新日期:2008-06-01 00:00:00

  • A novel method to increase the viability of Trichomonas vaginalis in urine.

    abstract:OBJECTIVES:Two of the major diagnostic methods for Trichomonas vaginalis, wet mount and culture, rely on the continued viability of the organism. Methods to increase the viability of T. vaginalis in urine are needed. GOAL:The goal of this study was to develop a method that increases the time of viability of T. vaginal...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000249724.72816.a0

    authors: Shafir SC,Sorvillo FJ,Upcroft JA,Upcroft P

    更新日期:2007-07-01 00:00:00

  • HIV transmission risk behavior and its relation to antiretroviral treatment adherence.

    abstract:BACKGROUND:Rising rates of antiretroviral drug resistance among recently infected persons are evidence of high-risk behavior among persons in HIV care. GOAL:The goal was to determine HIV transmission risk behavior among persons in HIV care and evaluate its association with treatment adherence. STUDY DESIGN:The study ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200305000-00005

    authors: Flaks RC,Burman WJ,Gourley PJ,Rietmeijer CA,Cohn DL

    更新日期:2003-05-01 00:00:00

  • Can we get people to participate in a study of sexual behavior?

    abstract:BACKGROUND AND OBJECTIVES:Interpreting the results of any study requires careful analysis to determine how selective participation may have influenced the findings. Participation in a study of sexual behavior may be influenced by who is doing the study, who the participants are, what it means to participate, what the s...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00007435-199505000-00007

    authors: Peterman TA

    更新日期:1995-05-01 00:00:00

  • Sexually transmitted disease syndromes in rural South Africa. Results from health facility surveillance.

    abstract:BACKGROUND AND OBJECTIVE:Surveillance for sexually transmitted diseases (STD) is important for priority setting, service development, and evaluating interventions. GOAL:To conduct health facility-based surveillance for STDs to inform design of a control program and to provide baseline measures for evaluation of interv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199801000-00005

    authors: Wilkinson D,Connolly AM,Harrison A,Lurie M,Karim SS

    更新日期:1998-01-01 00:00:00

  • Estimated Lifetime HIV-related Medical Costs in the United States.

    abstract:BACKGROUND:Lifetime cost estimates are a useful tool in measuring the economic burden of HIV in the United States. Previous estimation methods need to be updated, given improving antiretroviral therapy regimens and updated costs. METHODS:We used an updated version of the agent-based model Progression and Transmission ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001366

    authors: Bingham A,Shrestha RK,Khurana N,Jacobson E,Farnham PG

    更新日期:2021-01-23 00:00:00

  • Identifying likely syphilis transmitters: implications for control and evaluation.

    abstract:BACKGROUND/OBJECTIVES:Persistence of syphilis in communities may be maintained by relatively small groups of high-risk persons centrally placed among a larger group with low to moderately risky behavior. We sought to determine which control strategies identified particularly high-risk, early-stage syphilis cases consid...

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    pub_type: 杂志文章

    doi:10.1097/01.olq.0000216063.75575.f8

    authors: Kahn RH,Peterman TA,Arno J,Coursey EJ,Berman SM

    更新日期:2006-10-01 00:00:00