Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

Abstract:

:Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, in the treatment of PID. A total of 108 patients with acute salpingitis were hospitalized and randomized into two treatment groups: cefotetan/doxycycline (N = 54) and cefoxitin/doxycycline (N = 54). Before antibiotic administration, Chlamydia trachomatis was identified in 17 (16%) of the patients, Neisseria gonorrhoeae from 72 (67%), and anaerobic and aerobic bacteria were identified from the endometrial cultures of 86 (80%). There were seven tubo-ovarian abscesses (TOAs) that were diagnosed in the cefotetan group, and six in the cefoxitin group. Clinical cure was achieved in 51 of 54 (94%) patients in each group. Of the six patients whose treatment failed, all had positive cultures for N. gonorrhoeae and facultative/anaerobic bacteria, whereas none had C. trachomatis. Two patients from each study arm whose treatment failed were diagnosed with TOAs and responded subsequently to clindamycin plus an aminoglycoside. Cultures that were obtained after the completion of inpatient treatment showed the eradication of C. trachomatis and N. gonorrhoeae in all patients. Also, both regimens were effective in reducing aerobic and anaerobic pathogens. Finally, both regimens were well tolerated, with few side-effects.

journal_name

Sex Transm Dis

authors

Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

doi

10.1097/00007435-199118020-00012

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

119-23

issue

2

eissn

0148-5717

issn

1537-4521

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

    doi:

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    pub_type: 杂志文章,评审

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    更新日期:1995-09-01 00:00:00

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    authors: Wylie JL,Jolly A

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

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    authors: Gerend MA,Shepherd MA,Lustria ML

    更新日期:2013-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00007435-197701000-00004

    authors: Walzer PD,Armstrong D

    更新日期:1977-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: van Klingeren B,van Wijngaarden LJ,Dessens-Kroon M

    更新日期:1984-10-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000600

    authors: Mikalová L,Grillová L,Osbak K,Strouhal M,Kenyon C,Crucitti T,Šmajs D

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    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1993-07-01 00:00:00

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    更新日期:2016-03-01 00:00:00

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    更新日期:2016-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2001-09-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2002-04-01 00:00:00

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    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2007-12-01 00:00:00

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    更新日期:1981-07-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Harrington KF,DiClemente RJ,Wingood GM,Crosby RA,Person S,Oh MK,Hook EW 3rd

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