Comparison of enoxacin and ceftriaxone in the treatment of uncomplicated gonorrhea.

Abstract:

BACKGROUND AND OBJECTIVES:The increasing prevalence of resistant strains of Neisseria gonorrhoeae has prompted investigation of new agents for the treatment of this sexually transmitted disease. GOAL OF THIS STUDY:This study compared the efficacy and safety of a single oral dose of enoxacin to intramuscular ceftriaxone in the treatment of uncomplicated anogenital infection with N. gonorrhoeae. STUDY DESIGN:A randomized open trial was conducted at a sexually transmitted diseases clinic in Brooklyn, New York. Adults with uncomplicated gonorrhea were randomly assigned to receive 400 mg of enoxacin or 250 mg of ceftriaxone. A follow-up examination was conducted 5 to 9 days later. RESULTS:59 women and 23 men were enrolled; 40 women and 19 men were evaluable. Enoxacin eradicated 18 of 19 endocervical, 10 of 10 urethral, 5 of 5 anorectal, and 3 of 3 pharyngeal gonococcal infections. Ceftriaxone eradicated 20 of 21 pharyngeal gonococcal infections. Fifty-nine pretreatment isolates of N. gonorrhoeae were available for antimicrobial susceptibility testing. The geometric mean minimal inhibitory concentration was 0.03 mg/1 for enoxacin and 0.005 mg/l for ceftriaxone. There were few sides effects in either group, and both drugs were ineffective against concomitant infection with Chlamydia trachomatis. CONCLUSION:Oral enoxacin appears to be a safe and effective method of treatment for anogenital infections caused by N. gonorrhoeae.

journal_name

Sex Transm Dis

authors

Covino JM,Smith BL,Cummings MC,Benes S,Draft K,McCormack WM

doi

10.1097/00007435-199307000-00008

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

227-9

issue

4

eissn

0148-5717

issn

1537-4521

journal_volume

20

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Jongen VW,van Rooijen MS,Schim van der Loeff MF,Newsum AM,de Vos Klootwijk L,Hoornenborg E,Hogewoning A,van der Valk M,van den Berk GEL,Prins M,Heijman T

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    pub_type: 杂志文章

    doi:

    authors: Magalhães M

    更新日期:1983-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00007435-199010000-00005

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    更新日期:1990-10-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

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    更新日期:1983-10-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2006-10-01 00:00:00

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    更新日期:2007-08-01 00:00:00

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    更新日期:2013-09-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2005-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000581

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    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

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