Abstract:
BACKGROUND AND OBJECTIVES:The increasing prevalence of resistant strains of Neisseria gonorrhoeae has prompted investigation of new agents for the treatment of this sexually transmitted disease. GOAL OF THIS STUDY:This study compared the efficacy and safety of a single oral dose of enoxacin to intramuscular ceftriaxone in the treatment of uncomplicated anogenital infection with N. gonorrhoeae. STUDY DESIGN:A randomized open trial was conducted at a sexually transmitted diseases clinic in Brooklyn, New York. Adults with uncomplicated gonorrhea were randomly assigned to receive 400 mg of enoxacin or 250 mg of ceftriaxone. A follow-up examination was conducted 5 to 9 days later. RESULTS:59 women and 23 men were enrolled; 40 women and 19 men were evaluable. Enoxacin eradicated 18 of 19 endocervical, 10 of 10 urethral, 5 of 5 anorectal, and 3 of 3 pharyngeal gonococcal infections. Ceftriaxone eradicated 20 of 21 pharyngeal gonococcal infections. Fifty-nine pretreatment isolates of N. gonorrhoeae were available for antimicrobial susceptibility testing. The geometric mean minimal inhibitory concentration was 0.03 mg/1 for enoxacin and 0.005 mg/l for ceftriaxone. There were few sides effects in either group, and both drugs were ineffective against concomitant infection with Chlamydia trachomatis. CONCLUSION:Oral enoxacin appears to be a safe and effective method of treatment for anogenital infections caused by N. gonorrhoeae.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Covino JM,Smith BL,Cummings MC,Benes S,Draft K,McCormack WMdoi
10.1097/00007435-199307000-00008subject
Has Abstractpub_date
1993-07-01 00:00:00pages
227-9issue
4eissn
0148-5717issn
1537-4521journal_volume
20pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Few men are tested for syphilis or human immunodeficiency virus (HIV) during their partner's pregnancy, a high-risk period for HIV and syphilis transmission. Offering home-based rapid testing of syphilis to couples during pregnancy can support prevention efforts to reduce transmission of sexually transmitted...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0000000000000649
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Black race is a risk marker for Chlamydia trachomatis infection. Because chlamydial serovar and race could both influence the transmission dynamics of chlamydia, studies characterizing serovars in a predominantly black population are of interest, yet remain sparse. STUDY DESIGN AND GOALS: C. trachomatis isol...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000216027.71144.74
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to measure frequency and predictors of patient-delivered partner treatment (PDPT) and the frequency of other partner management strategies among New York City healthcare providers (HCPs) as well as to determine whether use of PDPT detracts from other partner management strat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000225322.94613.c2
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:The modes of transmission of HHV-8 are still unclear. GOAL:To evaluate the distribution and transmission of HHV-8 infection. DESIGN:Serosurvey conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 years), and adults (30-40 years). Antibodies against lytic a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200003000-00008
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Methods for accessing large sexual networks are essential for investigating the mechanisms for the spread of sexually transmitted infections. GOAL:Four samples of cases were compared with the total population to determine which identified the largest networks. STUDY DESIGN:Individuals with positive test re...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200104000-00003
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:Detection of vaginal Y-chromosome sequences (YCS) may be a useful biomarker to validate sexual behavior reporting in women. We describe the effects of condom use on the detection of vaginal YCS. METHODS:Fifty-six women were asked to abstain from sexual intercourse for 14 days. On day 15, participants were as...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000258318.99606.d9
更新日期:2007-08-01 00:00:00
abstract:INTRODUCTION:As the incidence of hepatitis C virus (HCV) infections remains high among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) an HCV testing strategy was introduced at the sexually transmitted infections (STI) clinic in Amsterdam in 2017. We aimed to evaluate this HCV testing strate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001223
更新日期:2020-09-01 00:00:00
abstract::Culture of urethral specimens from a 21-year-old man with nongonococcal urethritis yielded both Chlamydia trachomatis and a minocycline-resistant strain of Ureaplasma urealyticum. In such situations, the causal agent of the urethritis is frequently considered to be C. trachomatis. However, the etiology of this case wa...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::Though ampicillin is no longer recommended as first-line therapy for infections caused by Neisseria gonorrhoeae, the cost and efficacy of this policy in low prevalence areas has not been investigated. The problem was highlighted by an outbreak of penicillin-resistant N. gonorrhoeae in an area where the proportion of r...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199010000-00005
更新日期:1990-10-01 00:00:00
abstract::We developed 4 algorithms for syphilis among HIV-positive men who have sex with men who engaged in primary care in 2016 to 2017. Clinician-based diagnosis from chart reviews was the gold standard. Sensitivities ranged from 74.2% to 93.9%. Specificities were greater than 99% with positive and negative predictive values...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000938
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Cuban Ministry of Public Health plans to implement the syndromic approach to sexually transmitted diseases in persons with urethral or vaginal syndrome in Cuba using 500 mg ciprofloxacin as therapy. Although the emergence of clinical isolates of Neisseria gonorrhoeae with decreased suscept...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200102000-00004
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:The use of new technologies, such as mobile phones and internet, has increased dramatically in recent years. Text messages offer a novel method of sexual health promotion to young people who are the greatest users of new technology and are also at high risk of sexually transmitted infections (STIs). METHODS...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181f68d7b
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Repeat syphilis is playing an increasing role in syphilis transmission in several populations. The assessment of repeat syphilis and response to treatment depends on accurately measuring intraindividual changes in non-treponemal tests. For a 0- to 6-month delta rapid plasma reagin (RPR) to be determined by r...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000684
更新日期:2018-01-01 00:00:00
abstract::The national Sexually Transmitted Diseases (STD) Clinical Consultation Network receives requests regarding complex STD cases. A total of 927 requests from Western states, 2017 to 2019, were analyzed for STD of inquiry and syphilis-specific subtopics. Syphilis requests accounted for most queries, and the number and pro...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001233
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:HIV counseling prevents sexually transmitted diseases (STDs), with most of the benefit accumulating in the first 6 months. STUDY:The authors conducted a multicenter, randomized, controlled trial of a 20-minute additional (booster) counseling session 6 months after HIV counseling compared with no additional ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.olq.0000151420.92624.c0
更新日期:2005-02-01 00:00:00
abstract::The presence of serum IgG antibody to Mycoplasma hominis was studied by enzyme immunoassay in 150 women with suspected cervicitis at a clinic for sexually transmitted diseases. Positive levels of antibody were associated with gravidity and parity but not with age, method of birth control, or sexual behavior. Women fro...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Persistence of syphilis in communities may be maintained by relatively small groups of high-risk persons centrally placed among a larger group with low to moderately risky behavior. We sought to determine which control strategies identified particularly high-risk, early-stage syphilis cases consid...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000216063.75575.f8
更新日期:2006-10-01 00:00:00
abstract::The implementation of express testing in an sexually transmitted infection (STI) clinic reduced the length of visit time compared with other visit types and increased the proportion of STIs diagnosed at clinic visits. Express testing did not impact the time to treatment for asymptomatic patients diagnosed as having an...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000363
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To investigate, among male injecting drug users (IDU), the relationships between higher risk IDU-related and sex-related behaviors. GOAL:To highlight the clustering effects of the 2 forms of risk behaviors. STUDY DESIGN:Behavioral surveillance surveys conducted in Sichuan were analyzed (n = 3105). RESULTS...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000253339.49181.f9
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) is a frequent cause of vaginal discharge that may be more common among women reporting sex with women (WSW). The objective of this study was to determine the prevalence of BV and predictors of infection among a sample of African American WSW. METHODS:African American WSW aged 18 yea...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000004
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:A sharp increase in the incidence of gonorrhea has been observed in Tel Aviv, Israel, since 1999. Almost one half of interviewed patients admitted contracting the infection from a sex worker. In two thirds of the cases, oral sex (fellatio) was the most probable route of acquiring the disease. In the current ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000204675.92459.3c
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess the risk profile for chronic pelvic pain (CPP) after pelvic inflammatory disease (PID). STUDY:Multivariate logistic regression was used to assess risk factors for CPP in a longitudinal study of 780 predominately black, urban women with clinically suspected PID: compl...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000162361.69041.a5
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus self-testing (HIVST) holds great promise for reaching high-risk key populations who do not access facility-based services. We sought to characterize unsupervised HIVST implementation among men who have sex with men in China. METHODS:We conducted a nationwide online survey in Chi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000581
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:While researchers seek to use administrative health data to examine outcomes for individuals with sexually transmitted infections, the ICD-CM-10 codes used to identify persons with chlamydia and gonorrhea have not been validated. Objectives were to determine the validity of using ICD-10-CM codes to identify ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001257
更新日期:2020-07-31 00:00:00
abstract::We described the ASiManager-AT digital flocculation reader to demonstrate concordance between visual and digital readings of the rapid plasma reagin test for detection of antibodies in the serum of patients with syphilis. A qualitative and quantitative rapid plasma reagin was performed on each serum samples giving a c...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182389ab9
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:In the United States, black men who have sex with men (BMSM) are disproportionately affected by the HIV epidemic. The elevated estimates of HIV among BMSM suggest that to slow rates of HIV infections, a range of factors that may contribute to transmission must be researched. Use of online venues for seeking ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000454
更新日期:2016-06-01 00:00:00
abstract::We conducted a simulation study to illustrate that P values can suggest but not confirm statistical significance; and they may not indicate epidemiological significance (importance). We recommend that researchers consider reporting effect sizes as P values in conjunction with confidence intervals or point estimates wi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000635
更新日期:2017-08-01 00:00:00
abstract::60 women with bacterial vaginosis were entered into a double blind, placebo-controlled treatment trial with lyophilized Lactobacillus acidophilus. The lactobacilli used were producing H2O2. Immediately after completion of treatment, 16 out of 28 women who were treated with lactobacilli had normal vaginal wet smear res...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199205000-00007
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVES:To examine changes in the sexual behavior of London gay men between 1998 and 2008. METHODS:Gay men using London gyms were surveyed annually between 1998 and 2005, and again in 2008 (n=6064; range, 482-834 per year). Information was collected on human immunodeficiency virus (HIV) status of the respondent, un...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181f2ebe1
更新日期:2011-03-01 00:00:00
abstract::Clinical observations indicate that herpes simplex virus type 1 (HSV-1) is significantly less likely than herpes simplex virus type 2 (HSV-2) to establish latency in (or reactivate from) sacral ganglionic tissue. In an effort to identify viral functions associated with latency, we analyzed HSV-1 isolates from three pa...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198607000-00005
更新日期:1986-07-01 00:00:00