Prevalence and risk factors for human herpesvirus 8 infection in northern Cameroon.

Abstract:

BACKGROUND:The modes of transmission of HHV-8 are still unclear. GOAL:To evaluate the distribution and transmission of HHV-8 infection. DESIGN:Serosurvey conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 years), and adults (30-40 years). Antibodies against lytic and latent antigens to HHV-8 were detected by immunofluorescence assay; antibodies against Epstein-Barr virus viral antigens were detected by enzyme-linked immunoabsorbent assay. RESULTS:The prevalence of HHV-8 antilytic antibodies remained stable and was 39.8% among children, 51.5% among adolescents, and 61.8% among adults. Epstein-Barr virus seroprevalence was high among children, and remained stable among adolescents and adults. A history of sexually transmitted diseases was an independent determinant of HHV-8 infection (adjusted odds ratio 2.47; 95% CI 1.09-4.91). CONCLUSION:The high prevalence of HHV-8 infection among children indicates nonsexual modes of transmission in Cameroon, with sexual transmission occurring among adolescents and adults. :The modes of transmission of HHV-8 are still unclear. To evaluate the distribution and transmission of HHV-8 infection serosurvey was conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 years), and adults (30-40 years). Antibodies against lytic and latent antigens to HHV-8 were detected by immunofluorescence assay; antibodies against Epstein-Barr virus viral antigens were detected by enzyme-linked immunoabsorbent assay. The prevalence of HHV-8 antilytic antibodies remained stable and was 39.8% among children, 51.5% among adolescents, and 61.8% among adults. Epstein-Barr virus seroprevalence was high among children, and remained stable among adolescents and adults. A history of sexually transmitted diseases was an independent determinant of HHV-8 infection (adjusted odds ratio, 2.47; 95% CI, 1.09-4.91). The high prevalence of HHV-8 infection among children indicates nonsexual modes of transmission in Cameroon, with sexual transmission occurring among adolescents and adults.

journal_name

Sex Transm Dis

authors

Rezza G,Tchangmena OB,Andreoni M,Bugarini R,Toma L,Bakary DK,Glikoutou M,Sarmati L,Monini P,Pezzotti P,Ensoli B

doi

10.1097/00007435-200003000-00008

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

159-64

issue

3

eissn

0148-5717

issn

1537-4521

journal_volume

27

pub_type

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