Lack of evidence for intertypic recombinants in the pathogenesis of recurrent genital infections with herpes simplex virus type 1.

Abstract:

:Clinical observations indicate that herpes simplex virus type 1 (HSV-1) is significantly less likely than herpes simplex virus type 2 (HSV-2) to establish latency in (or reactivate from) sacral ganglionic tissue. In an effort to identify viral functions associated with latency, we analyzed HSV-1 isolates from three patients with established recurrent genital herpes and sought evidence of DNA sequences and proteins similar to those found in HSV-2. By restriction endonuclease cleavage patterns and by DNA hybridization analysis using either whole HSV-2 DNA or several cloned segments of HSV-2 DNA as probes, we found that the three HSV-1 isolates from patients with recurrent genital herpes showed no unusual homology to HSV-2 as compared with other HSV-1 isolates. Similarly, the proteins of these isolates could not be distinguished from those of other HSV-1 isolates and were distinct from those of HSV-2. At this level of resolution, there was no evidence to suggest that these recurrent genital HSV-1 isolates were intertypic recombinants, nor did they show any other unusual similarity to HSV-2.

journal_name

Sex Transm Dis

authors

Fife KH,Boggs D

doi

10.1097/00007435-198607000-00005

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

138-44

issue

3

eissn

0148-5717

issn

1537-4521

journal_volume

13

pub_type

杂志文章
  • Telephone-administered motivational interviewing to reduce risky sexual behavior in HIV-infected rural persons: a pilot randomized clinical trial.

    abstract:BACKGROUND:Although several studies have characterized patterns and predictors of continued risky sexual behavior in HIV-infected rural persons, far less research has evaluated interventions to reduce risky sex in this group. This pilot randomized clinical trial compared 2 brief telephone-administered interventions des...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/OLQ.0b013e3181c18975

    authors: Cosio D,Heckman TG,Anderson T,Heckman BD,Garske J,McCarthy J

    更新日期:2010-03-01 00:00:00

  • Bacterial vaginosis among African American women who have sex with women.

    abstract:BACKGROUND:Bacterial vaginosis (BV) is a frequent cause of vaginal discharge that may be more common among women reporting sex with women (WSW). The objective of this study was to determine the prevalence of BV and predictors of infection among a sample of African American WSW. METHODS:African American WSW aged 18 yea...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000004

    authors: Muzny CA,Sunesara IR,Austin EL,Mena LA,Schwebke JR

    更新日期:2013-09-01 00:00:00

  • CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis.

    abstract:BACKGROUND:Asymptomatic neurosyphilis is more difficult to diagnose in human immunodeficiency virus (HIV)-infected patients because HIV itself can cause cerebrospinal fluid (CSF) pleocytosis. The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181d877a1

    authors: Marra CM,Tantalo LC,Sahi SK,Maxwell CL,Lukehart SA

    更新日期:2010-05-01 00:00:00

  • A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African women.

    abstract:BACKGROUND:Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1. METHODS:We conducted a prospective study among 151 HIV-1-seronegative Kenyan female sex workers. ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31816907fa

    authors: McClelland RS,Richardson BA,Graham SM,Masese LN,Gitau R,Lavreys L,Mandaliya K,Jaoko W,Baeten JM,Ndinya-Achola JO

    更新日期:2008-06-01 00:00:00

  • Predictors of bacterial vaginosis in adolescent women who douche.

    abstract:OBJECTIVE:Risk factors for bacterial vaginosis (BV) include douching and sexual activity, although the exact cause of BV is unknown. GOAL:The goal of this study was to determine the relative significance of douching as a risk factor for BV. STUDY DESIGN:Two hundred fifty adolescent women who regularly douched were en...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.olq.0000129948.91055.9f

    authors: Schwebke JR,Desmond RA,Oh MK

    更新日期:2004-07-01 00:00:00

  • Human immunodeficiency virus type 1 among bar and hotel workers in northern Tanzania: the role of alcohol, sexual behavior, and herpes simplex virus type 2.

    abstract:GOALS:We assessed baseline prevalence of human immunodeficiency virus type 1 (HIV-1) and other STDs, as well as behavioral and biologic risk factors for HIV-1 in a population of female bar/hotel workers in Moshi, Tanzania. STUDY DESIGN:Between 2002 and 2003, we enrolled 1042 female bar/hotel workers in an ongoing pros...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000187204.57006.b3

    authors: Ao TT,Sam NE,Masenga EJ,Seage GR 3rd,Kapiga SH

    更新日期:2006-03-01 00:00:00

  • Pregnancy, Penile-anal Sex, and Other Sexual Behaviors in the United States, 2011-2015.

    abstract::We used the US national survey data to examine sexual behavior by pregnancy status and found that, overall, pregnant women did not differ from nonpregnant women in penile-anal sex and associated condom use. Compared with nonpregnant women, pregnant women had lower or similar reports of other sexual behaviors. ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000927

    authors: Leichliter JS,Aral SO

    更新日期:2019-03-01 00:00:00

  • Risk factors for incident and recurrent condylomata acuminata among men. A population-based study.

    abstract:BACKGROUND AND OBJECTIVES:The rapid increase in the number of physician office visits for condylomata acuminata and the association of human papillomavirus and cancer has prompted renewed interest in the epidemiology of this sexually-transmitted disease. Few epidemiologic studies have examined what risk factors are ass...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199807000-00002

    authors: Van Den Eeden SK,Habel LA,Sherman KJ,McKnight B,Stergachis A,Daling JR

    更新日期:1998-07-01 00:00:00

  • High-frequency of quinolone-resistant Neisseria gonorrhoeae in Austria with a common pattern of triple mutations in GyrA and ParC genes.

    abstract:OBJECTIVE:Quinolones have a broad spectrum of antimicrobial activity and are widely used for the treatment of uncomplicated Neisseria gonorrhoeae infections. A dramatic increase in the number of reported N. gonorrhoeae infections as well as quinolone-resistant isolates in Vienna prompted us to investigate the pattern o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000140019.18390.28

    authors: Uthman A,Heller-Vitouch C,Stary A,Bilina A,Kuchinka-Koch A,Söltz-Szöts J,Tschachler E

    更新日期:2004-10-01 00:00:00

  • Sexually transmitted infections and reproductive health in Azerbaijan.

    abstract:BACKGROUND:Little is known about the prevalence of sexually transmitted infections (STIs) and about sexual and reproductive health in Central and Eastern Europe. However, it is clear that major epidemics of STIs currently exist. GOAL:To provide baseline information for the development of national guidelines on the man...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200107000-00003

    authors: Claeys P,Ismailov R,Rathe S,Jabbarova A,Claeys G,Fonck K,Temmerman M

    更新日期:2001-07-01 00:00:00

  • Biomarkers of cervicovaginal inflammation for the assessment of microbicide safety.

    abstract::The human cervicovaginal mucosa is the primary target of HIV-1 infection during male to female transmission. This tissue contains the the full spectrum of cell types and immune modulators that comprise both the innate and adaptive arms of the immune system. Mounting evidence indicates that mucosal epithelial cells are...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/OLQ.0b013e3181994191

    authors: Cummins JE Jr,Doncel GF

    更新日期:2009-03-01 00:00:00

  • Chlamydia test results were associated with sexual risk behavior change among participants of the Chlamydia screening implementation in The Netherlands.

    abstract:OBJECTIVE:To examine the effect of a laboratory-confirmed Chlamydia trachomatis (Ct) test result on subsequent sexual risk behavior in a large population-based screening program. METHODS:The study population consisted of 16- to 29-year-old participants of the Chlamydia Screening Implementation who completed Ct testing...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000234

    authors: Soetens LC,van Benthem BH,Op de Coul EL

    更新日期:2015-03-01 00:00:00

  • Observed Treatment Responses to Short-Course Doxycycline Therapy for Rectal Lymphogranuloma Venereum in Men Who Have Sex With Men.

    abstract:BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including i...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000772

    authors: Simons R,Candfield S,French P,White JA

    更新日期:2018-06-01 00:00:00

  • Concurrency, sex partner risk, and high-risk human papillomavirus infection among African American, Asian, and Hispanic women.

    abstract:BACKGROUND:Although the role of concurrent sexual partnerships (i.e., having sexual activity with another partner after a current partnership has been established) has been most strongly associated with the transmission of bacterial sexually transmitted infections, its role in the transmission of viral sexually transmi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181bcd3e7

    authors: Javanbakht M,Gorbach PM,Amani B,Walker S,Cranston RD,Datta SD,Kerndt PR

    更新日期:2010-02-01 00:00:00

  • Zenilman's anomaly reconsidered: fallible reports, ceteris paribus, and other hypotheses.

    abstract:BACKGROUND AND OBJECTIVES:In the January-February, 1995 issue of Sexually Transmitted Diseases, Zenilman and colleagues reported a null association between incident sexually transmitted diseases (STDs) and self-reported condom use. That anomalous finding generated a flurry of letters to the editor, some of which were q...

    journal_title:Sexually transmitted diseases

    pub_type: 评论,杂志文章

    doi:10.1097/00007435-199710000-00005

    authors: Turner CF,Miller HG

    更新日期:1997-10-01 00:00:00

  • Déjà vu? A Comparison of Syphilis Outbreaks in Houston, Texas.

    abstract:BACKGROUND:After reaching an all-time low in 2000, syphilis incidence in the United States has increased as the burden shifted from heterosexuals to men who have sex with men (MSM). Houston, Texas, experienced 2 outbreaks of syphilis during this transformation in trends. Further evaluation is necessary to determine if ...

    journal_title:Sexually transmitted diseases

    pub_type: 历史文章,杂志文章

    doi:10.1097/OLQ.0000000000000488

    authors: Hallmark CJ,Hill MJ,Luswata C,Watkins KL,Thornton L,McNeese M,Ross MW

    更新日期:2016-09-01 00:00:00

  • The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women.

    abstract:BACKGROUND AND OBJECTIVES:Azithromycin, an approved single-dose therapy for cervical chlamydia infections, costs four times as much as doxycycline, the standard multidose theapy. GOAL OF THIS STUDY:This study examined whether azithromycin is cost effective for treating cervical chlamydia infections. STUDY DESIGN:Two ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199509000-00002

    authors: Haddix AC,Hillis SD,Kassler WJ

    更新日期:1995-09-01 00:00:00

  • Acceptability of urine-based screening for Chlamydia trachomatis to asymptomatic young men and their providers.

    abstract:OBJECTIVE:The objective of this study was to describe acceptability of urine chlamydia testing among asymptomatic men and providers' attitudes toward testing. STUDY DESIGN:Asymptomatic men (no urethral discharge/dysuria) were offered free testing and characteristics of men who accepted were compared with those who dec...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.olq.0000230438.12636.eb

    authors: Marrazzo JM,Ellen JM,Kent C,Gaydos C,Chapin J,Dunne EF,Rietmeijer CA

    更新日期:2007-03-01 00:00:00

  • Prevalence and incidence of HPV genital infection in women.

    abstract:BACKGROUND:A prophylactic quadrivalent human papillomavirus (HPV) vaccine could benefit adult women if they are susceptible to incident genital HPV infections and are acquiring new infections with vaccine HPV types to which they were previously not exposed. This report presents baseline and prospective data from a rand...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181ad25ff

    authors: Velicer C,Zhu X,Vuocolo S,Liaw KL,Saah A

    更新日期:2009-11-01 00:00:00

  • Prevalence of sexually transmitted infections among antenatal women in Vanuatu, 1999-2000.

    abstract:BACKGROUND:The epidemiology of sexually transmitted infections (STIs) and HIV in Vanuatu is poorly defined. GOAL:The goal was to determine the prevalence of laboratory-confirmed gonorrhea, chlamydia, trichomoniasis, syphilis seroreactivity, and HIV among pregnant women in Vila, Vanuatu. STUDY DESIGN:A cross-sectional...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200304000-00017

    authors: Sullivan EA,Abel M,Tabrizi S,Garland SM,Grice A,Poumerol G,Taleo H,Chen S,Kaun K,O'Leary M,Kaldor J

    更新日期:2003-04-01 00:00:00

  • Characterization of ciprofloxacin resistance in Neisseria gonorrhoeae isolates in Canada.

    abstract:BACKGROUND:Ciprofloxacin (500 mg orally, single dose) is one of the recommended therapies for gonorrhea in Canada. In Canada, the first ciprofloxacin-resistant (CipR) Neisseria gonorrhoeae strain was isolated in 1993. Antimicrobial susceptibilities of N gonorrhoeae isolates were monitored as part of a national surveill...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00007435-200212000-00008

    authors: Ng LK,Sawatzky P,Martin IE,Booth S

    更新日期:2002-12-01 00:00:00

  • Hepatitis due to herpes simplex virus in a nonpregnant patient: treatment with acyclovir.

    abstract::A previously healthy 19-year-old nonpregnant woman had disseminated infection with herpes simplex virus. The disseminated disease was accompanied by hepatitis. The patient was treated with parenteral acyclovir (5 mg/kg) given every 8 hr. The patient's symptoms resolved after three days of therapy. A review of five sim...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198607000-00014

    authors: Baxter RP,Phillips LE,Faro S,Hoffman L

    更新日期:1986-07-01 00:00:00

  • Use of a Novel Couples' Verification Tool in a Male Partner Treatment Study of Women With Recurrent Bacterial Vaginosis.

    abstract::Verification of relationship status beyond self-report is an important aspect in sexually transmitted infection research, including partner treatment studies where primary sexual partners are targeted for enrollment. This exploratory study describes the use of a novel couples' verification tool in a male partner treat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001225

    authors: Muzny CA,Pontius A,Woznicki N,Hudak KE,Lensing SY,Sobel JD,Schwebke JR

    更新日期:2020-12-01 00:00:00

  • Patterns of chlamydia and gonorrhea infection in sexual networks in Manitoba, Canada.

    abstract:BACKGROUND:The use of sexual network analysis has the potential to further our understanding of sexually tranmitted disease (STD) epidemics and contribute to the development of more effective targeted control strategies. GOAL:To use sexual network analysis to study transmission patterns of chlamydia and gonorrhea in M...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200101000-00005

    authors: Wylie JL,Jolly A

    更新日期:2001-01-01 00:00:00

  • Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199118020-00012

    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00

  • Alcohol Use and Associations With Biological Markers and Self-Reported Indicators of Unprotected Sex in Human Immunodeficiency Virus-Positive Female Sex Workers in Mombasa, Kenya.

    abstract:BACKGROUND:Studies of alcohol use and sexual behavior in African populations have primarily been cross-sectional, used nonvalidated measures of alcohol use, or relied on self-reported sexual risk endpoints. Few have focused on human immunodeficiency virus (HIV)-positive women. METHODS:Longitudinal data were collected ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000502

    authors: White D,Wilson KS,Masese LN,Wanje G,Jaoko W,Mandaliya K,Richardson BA,Kinuthia J,Simoni JM,McClelland RS

    更新日期:2016-10-01 00:00:00

  • Measuring the in vitro susceptibility of Trichomonas vaginalis to metronidazole: a disk broth method.

    abstract::Strains of Trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. A serial twofold dilution method that measured minimal inhibitory concentrations (MICs) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trop...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198007000-00005

    authors: Smith RF,Di Domenico A

    更新日期:1980-07-01 00:00:00

  • Patterns and trends of sexual behavior, HIV testing, and HIV prevalence among all sexually transmitted disease clinic attenders in Denmark.

    abstract:BACKGROUND AND OBJECTIVES:Persons attending a sexually transmitted disease (STD) clinic have shown to be at a higher risk for HIV infection than the population in general. We evaluate the patterns of HIV prevalence and testing in relation to reported risk behavior. STUDY DESIGN:Data have been collected on all new atte...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199403000-00008

    authors: Smith E,Worm AM,Jepsen LV,Larsen J,Brandrup F,Veien N,Andersen BL

    更新日期:1994-03-01 00:00:00

  • Suppressive valacyclovir therapy: impact on the population spread of HSV-2 infection.

    abstract:OBJECTIVES:Recent trial results demonstrate that the transmission probability of HSV-2 in monogamous couples is nearly halved by the use of valacyclovir as suppressive therapy. GOAL:The goal of this study is to understand the potential impact of suppressive valacyclovir therapy on the transmission of HSV-2 within a po...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000258486.81492.a2

    authors: Williams JR,Jordan JC,Davis EA,Garnett GP

    更新日期:2007-03-01 00:00:00

  • Nationwide increase of Chlamydia trachomatis infection in Finland: highest rise among adolescent women and men.

    abstract:BACKGROUND:Since 1995, the incidence of Chlamydia trachomatis infection has been increasing in Finland, although there have been no major changes in public sexually transmitted disease (STD) services or screening practice. OBJECTIVES:The objective was to study whether the change in C. trachomatis incidence is signific...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.OLQ.0000086606.77125.66

    authors: Hiltunen-Back E,Haikala O,Kautiainen H,Ruutu P,Paavonen J,Reunala T

    更新日期:2003-10-01 00:00:00