Abstract:
BACKGROUND:Asymptomatic neurosyphilis is more difficult to diagnose in human immunodeficiency virus (HIV)-infected patients because HIV itself can cause cerebrospinal fluid (CSF) pleocytosis. The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B cell chemoattractant, chemokine (C-X-C motif) ligand 13 (CXCL13) concentration may also be elevated. METHODS:CSF and blood were collected from 199 HIV-infected patients with syphilis and neurosyphilis. Serum and CSF CXCL13 concentrations were determined. RESULTS:Patients with neurosyphilis had higher CSF and serum CXCL13 concentrations compared to patients with syphilis but not neurosyphilis. The odds of having symptomatic neurosyphilis were increased by 2.23-fold for every log increase in CSF CXCL13 concentration and were independent of CSF white blood cell and plasma HIV RNA concentrations, peripheral blood CD4+ T cell count and use of antiretroviral medications. A cut-off of 10 pg/mL CSF CXCL13 had high sensitivity and a cut-off of 250 pg/mL or evidence of intrathecal synthesis of CXCL13 had high specificity for diagnosis of both symptomatic and asymptomatic neurosyphilis. CSF concentrations of CXCL13 declined after treatment for neurosyphilis. CONCLUSIONS:CSF CXCL13 concentration may be particularly useful for diagnosis of neurosyphilis in HIV-infected patients because it is independent of CSF pleocytosis and markers of HIV disease.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Marra CM,Tantalo LC,Sahi SK,Maxwell CL,Lukehart SAdoi
10.1097/OLQ.0b013e3181d877a1subject
Has Abstractpub_date
2010-05-01 00:00:00pages
283-7issue
5eissn
0148-5717issn
1537-4521journal_volume
37pub_type
杂志文章abstract:BACKGROUND:Individuals diagnosed with gonorrhea are at elevated risk for HIV. Per US Centers for Disease Control and Prevention guideline, individuals being evaluated for gonorrhea should be screened for HIV concurrently. There is limited information on HIV screening among gonorrhea-diagnosed individuals across differe...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001252
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To investigate, among male injecting drug users (IDU), the relationships between higher risk IDU-related and sex-related behaviors. GOAL:To highlight the clustering effects of the 2 forms of risk behaviors. STUDY DESIGN:Behavioral surveillance surveys conducted in Sichuan were analyzed (n = 3105). RESULTS...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000253339.49181.f9
更新日期:2007-08-01 00:00:00
abstract::We examined the prevalence of rectal chlamydia treatment failures in men who have sex with men and women attending Alberta sexually transmitted infection clinics. Among those completing a test of cure, there was no significant difference among patients treated initially with azithromycin (treatment failure, 39/460 [8....
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000403
更新日期:2016-02-01 00:00:00
abstract::The effect of the susceptibility of Trichomonas vaginalis strains to metronidazole on response to treatment was determined from minimal inhibitory concentrations (MICs) for organisms isolated during a clinical trial in which single 1- and 2-g doses of metronidazole were compared. Fifty-seven strains were isolated from...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章
doi:10.1097/00007435-198307000-00003
更新日期:1983-07-01 00:00:00
abstract:INTRODUCTION:As the incidence of hepatitis C virus (HCV) infections remains high among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) an HCV testing strategy was introduced at the sexually transmitted infections (STI) clinic in Amsterdam in 2017. We aimed to evaluate this HCV testing strate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001223
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Cervicovaginal lavage (CVL) is often used for research and may be easier and more accurate than vaginal swabs as a specimen collection method. GOAL:The goal of this study was to compare (CVL) with vaginal swabs for the detection of bacterial vaginosis (BV) and Trichomonas vaginalis (TV). STUDY:CVL and vagi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000151416.56717.7d
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:: To estimate the effects of reproductive tract infections (RTIs) on HIV acquisition among Zimbabwean and Ugandan women. METHODS:: A multicenter prospective observational cohort study enrolled 4439 HIV-uninfected women aged 18 to 35 attending family planning clinics in Zimbabwe and Uganda. Participants were ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e3181a4f695
更新日期:2009-06-01 00:00:00
abstract::Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment pr...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199007000-00003
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Herpes simplex virus type 2 (HSV-2) is an important cause of genital ulcers and can increase the risk for human immunodeficiency virus type 1 (HIV-1) transmission. Our objective was to determine the incidence and correlates of HSV-2 infection in HIV-1-seronegative Kenyan men reporting high-risk sexual behavi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31821a6225
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:This study examined the use of HIV postexposure prophylaxis (PEP) among sexually assaulted adolescent females. METHODS:We analyzed data from the HIV PEP Project, an implementation and evaluation of a program of universal offering of PEP to sexual assault victims of all ages. Baseline and follow-up data were...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181824f3c
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Oral human papillomavirus (HPV) infection is a cause of oropharyngeal squamous cell carcinoma, yet little is known about the epidemiology and natural history of infection. METHODS:At a baseline and 3-month follow-up visit, 1000 young adults aged 18 to 30 years provided an oral rinse sample and completed a s...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31824f1c65
更新日期:2012-07-01 00:00:00
abstract::Medical record review was used to identify missed opportunities for chlamydia screening among 103 American Indian/Alaska Native women. Of these, 69% had received a pregnancy test and 74% had received a urine test in the previous 12 months. Chlamydia screening may increase if linked to the other routine clinical testin...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318222f126
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Centers for Disease Control and Prevention funds a national telephone hotline as a source of information for persons with questions about sexually transmitted diseases. Hotline callers were last surveyed in 1980. GOAL:To determine the current profile of callers to the Centers for Disease ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199603000-00008
更新日期:1996-03-01 00:00:00
abstract::We described the ASiManager-AT digital flocculation reader to demonstrate concordance between visual and digital readings of the rapid plasma reagin test for detection of antibodies in the serum of patients with syphilis. A qualitative and quantitative rapid plasma reagin was performed on each serum samples giving a c...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182389ab9
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Incorrect condom use is a common problem that can undermine their prevention impact. We assessed the prevalence of 2 condom use problems, breakage/slippage and partial use, compared problems by partnership type, and examined associations with respondent, partner, and partnership characteristics. METHODS:Dat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e31825ef325
更新日期:2012-09-01 00:00:00
abstract::60 women with bacterial vaginosis were entered into a double blind, placebo-controlled treatment trial with lyophilized Lactobacillus acidophilus. The lactobacilli used were producing H2O2. Immediately after completion of treatment, 16 out of 28 women who were treated with lactobacilli had normal vaginal wet smear res...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199205000-00007
更新日期:1992-05-01 00:00:00
abstract::The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV). Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000123
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Public health authorities want to evaluate their sexually transmitted disease (STD) surveillance systems to promote the most effective use of health resources. GOAL:The goal of this study was to estimate the sensitivity of national laboratory reports of in Switzerland (the proportion of cases detected by na...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200211000-00016
更新日期:2002-11-01 00:00:00
abstract::Increasing evidence suggests that human papillomavirus (HPV) infection of the female anogenital tract is multifocal. Less is known of the distribution of HPVs in men. To investigate this, a prospective study was conducted of 116 men consecutively attending a clinic for ablative treatment of anogenital warts. Wart tiss...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199301000-00005
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The development of topical microbicides represents a new and exciting field in the prevention of sexually transmitted diseases, and it is especially important that candidate products undergo rigorous preclinical safety and efficacy testing before advancing to clinical trials. METHODS:We have developed a sta...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31817dfdb8
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To describe demographic and geographic trends in gonorrhea incidence in the United States from 1981 through 1996. STUDY DESIGN:We analyzed aggregate gonorrhea cases reported to the Centers for Disease Control and Prevention by the 50 states, District of Columbia, and 63 large cities. Annual incidence rates (...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199808000-00011
更新日期:1998-08-01 00:00:00
abstract::We present the case of a man with a bicuspid aortic valve who presented with persistent fever. Blood cultures yielded Neisseria gonorrhoeae, and the diagnosis of infected mycotic aneurysm was confirmed by detection of the bacterial genome in the aortic wall. The patient was cured with surgery and intravenous ceftriaxo...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000079
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:A dye-based method for determining applicator usage in microbicide trials has been developed to assess whether applicators have been exposed to vaginal fluid. Our objective was to evaluate this method on polypropylene HTI applicators that are being widely used in several effectiveness trials of microbicides....
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e3181972397
更新日期:2009-06-01 00:00:00
abstract::Amniotic fluid is rarely used in the evaluation of syphilis during pregnancy but was available from a woman with positive serologic tests in the 30th week of gestation. Nonmotile intra-amniotic spirochetes were seen by dark-field microscopy 20 hr after treatment with benzathine penicillin G. The identity of the organi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198507000-00010
更新日期:1985-07-01 00:00:00
abstract::Identifying pathogen-specific signs or symptoms of nongonococcal urethritis could improve syndromic management accuracy. We evaluated nongonococcal urethritis signs and symptoms in 220 men with single-pathogen infections (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, or Ureaplasma urealyticum) o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001158
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181c9c23f
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To quantify the scope and yield of targeted syphilis screening in nonmedical settings in 7 US cities affected by recent syphilis outbreaks among men who have sex with men (MSM). METHODS:Data were collected from syphilis screening activities targeting MSM between 1999 and 2004, conducted in bathhouses or othe...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/01.olq.0000181148.80193.91
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Male circumcision (MC) decreases the risk of human immunodeficiency virus (HIV) acquisition in men. We explored associations between MC of the primary sex partner and women's risk of acquisition of chlamydial (Ct), gonococcal (GC), or trichomonal (Tv) infections. METHODS:We analyzed data from a prospective ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31816b1fcc
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differenti...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181e50671
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Adolescents are at high risk of sexually transmitted disease (STD)/HIV infection, and one vulnerable subgroup is African American females. The association between adolescents' previous experience of STD and recent sexual risk behaviors has been ill-defined. GOAL:The goal was to examine the associations betw...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200209000-00002
更新日期:2002-09-01 00:00:00