Abstract:
:The effect of the susceptibility of Trichomonas vaginalis strains to metronidazole on response to treatment was determined from minimal inhibitory concentrations (MICs) for organisms isolated during a clinical trial in which single 1- and 2-g doses of metronidazole were compared. Fifty-seven strains were isolated from patients receiving 1 g of metronidazole, and 75 from those receiving 2 g. The mean MIC for all strains was 1.50 microgram/ml (range, 0.5-4.5 microgram/ml) and was similar in both groups. The mean MICs for isolates from patients who were cured were significantly less than the mean MICs of isolates from those who were treatment failures. The cure rates, compared to the MICs for the strains isolated, varied from 84% (MIC, 0.5 microgram/ml) to 16% (MIC, greater than or equal to 3.0 microgram/ml) for the group given the single 1-g dose and from 94% (MIC, 0.5 microgram/ml) to 43% (MIC, greater than or equal to 3.0 micrograms/ml) for those given the 2-g dose. The data demonstrate a direct relationship between susceptibility of T. vaginalis isolates and response to treatment with single-dose regimens of metronidazole.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Ralph ED,Darwish R,Austin TW,Smith EA,Pattison FLdoi
10.1097/00007435-198307000-00003subject
Has Abstractpub_date
1983-07-01 00:00:00pages
119-22issue
3eissn
0148-5717issn
1537-4521journal_volume
10pub_type
临床试验,杂志文章abstract:BACKGROUND:At-risk sexual behaviors appear to have increased recently in France, possibly because of the reassuring efficacy of highly active antiretroviral treatments. The objective of this study was to assess the pattern of change. GOAL:The goal was to analyze trends in the incidence of male urethritis, a marker of ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200206000-00002
更新日期:2002-06-01 00:00:00
abstract:INTRODUCTION:As the incidence of hepatitis C virus (HCV) infections remains high among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) an HCV testing strategy was introduced at the sexually transmitted infections (STI) clinic in Amsterdam in 2017. We aimed to evaluate this HCV testing strate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001223
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Approximately 40% of patients infected with hepatitis C virus (HCV) have no history of blood transfusion or other high-risk practice. Other causes should be considered. GOAL:The goal was to describe sexual transmission of HCV from a chronic carrier to his female partner during unprotected vaginal intercours...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200305000-00015
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Studies assessing the validity attributed to self-reported measures of sexually transmitted diseases (STDs) clearly are needed, particularly those used for high-risk populations such as female adolescents, in whom STD prevention is a priority. GOAL:To determine the accuracy of self-reported STD test results...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007435-200108000-00009
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To examine the effect of a laboratory-confirmed Chlamydia trachomatis (Ct) test result on subsequent sexual risk behavior in a large population-based screening program. METHODS:The study population consisted of 16- to 29-year-old participants of the Chlamydia Screening Implementation who completed Ct testing...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000234
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Women with disabilities can and do contract sexually transmitted diseases (STDs). However, because of access barriers, attitudinal misconceptions, and lack of awareness of their risk status, these infections may go under or undiagnosed. GOAL:To address issues regarding the treatment of women ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/00007435-200005000-00007
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Crack-smoking sexually transmitted disease (STD) patients are at high-risk for contracting HIV. GOAL OF THE STUDY:To examine the effects of cocaine use and other correlates on high-risk sexual behavior among STD clinic patients. STUDY DESIGN:This was a cross-sectional study of 1,490 consecut...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199902000-00003
更新日期:1999-02-01 00:00:00
abstract::We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of th...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000036
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Centers for Disease Control and Prevention funds a national telephone hotline as a source of information for persons with questions about sexually transmitted diseases. Hotline callers were last surveyed in 1980. GOAL:To determine the current profile of callers to the Centers for Disease ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199603000-00008
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Women with cervicitis frequently have bacterial vaginosis (BV). Prior studies have suggested that BV is involved in the pathogenesis of cervicitis. GOALS:To delineate the association of BV and cervicitis and to determine whether treatment of BV results in increased resolution of cervicitis. STUDY DESIGN:Wo...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-200201000-00010
更新日期:2002-01-01 00:00:00
abstract::The human cervicovaginal mucosa is the primary target of HIV-1 infection during male to female transmission. This tissue contains the the full spectrum of cell types and immune modulators that comprise both the innate and adaptive arms of the immune system. Mounting evidence indicates that mucosal epithelial cells are...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0b013e3181994191
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Juvenile detention facilities house adolescents at high risk for sexually transmitted diseases. Collaboration between health departments and juvenile detention authorities can provide routine, cost-efficient chlamydia screening and treatment to females with limited access to care. We describe trends in scree...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000382
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To describe the reliability of reported dates of first and last sexual exposure, as elicited from sexually transmitted disease/human immunodeficiency virus cases during routine contact investigation, and determine their adequacy for assessing concurrency. METHODS:We used contact tracing data from 5 studies ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000204746.58160.c1
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND GOAL:Patients with sexually transmitted diseases (STDs) serve as a bridge population to transmit HIV from higher-risk to lower-risk populations. Our goal was to understand the level of risk behaviors and HIV/STD-related knowledge as well as attitudes among STD patients in China. STUDY DESIGN:An anonymou...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000081394.94426.7A
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Measurement of human immunodeficiency virus(HIV) incidence among female sex workers in Rwanda is a key part of preparing for HIV prevention trials. METHODS:HIV-negative, nonpregnant female sex workers (N =397) were tested for HIV-1, sexually transmitted infections, and pregnancy quarterly for 12 months, and...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/olq.0b013e31820b8eba
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) continue to exert a tremendous health burden on women in developing countries. Poor socioeconomic status, inadequate knowledge, lack of diagnostic facilities, and shortages of effective treatment all contribute to the high incidence of STIs. The use of clinical algorith...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199909000-00010
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The care of patients with first episode and recurrent genital herpes differs with respect to therapy and source partner evaluation. Of 498 persons who presented with what appeared by history and symptoms to be a first episode of genital herpes, we identified 41 who had serologic evidence of re...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199904000-00007
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000459
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity. GOALS:The objective of this analysis was to examine the association of sexual behavior, cervical HPV 16 DNA positivity at enrollment (past) and at diagnosis (current), and oth...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200203000-00009
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE/GOAL:The objective of this study was to examine sildenafil (Viagra) use and its relationship to sexual risk behavior for HIV and sexually transmitted diseases among men who have sex with men (MSM). STUDY:A population-based telephone sample of MSM in San Francisco was interviewed about sexual behavior, substa...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000175294.76494.77
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Since the early 1980s, the Bahamas has experienced sequential epidemics of freebase/crack cocaine use, genital ulcer-inguinal adenopathy disease (GUD), and heterosexual HIV infection. GOAL:To prospectively define the etiology of GUD in patients at the Princess Margaret Hospital during outbreaks of crack coc...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200205000-00001
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Routine HIV testing is recommended for all adolescents ages 13 years and older. This study aims to report the prevalence of HIV testing among black adolescents, describe characteristics of adolescents who have been tested, and identify potentially modifiable factors associated with greater likelihood of test...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181b4704c
更新日期:2009-09-01 00:00:00
abstract::To define the performance characteristics of two newer tests for Trichomonas vaginalis (TV), the authors compared direct fluorescent antibody (DFA) (mixed monoclonal antibody, Integrated Diagnostics, Inc, Berkeley, CA) and acridine orange (AO) tests to standard wet mount (WM) preparations and culture (modified Diamond...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198907000-00002
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Interpreting the results of any study requires careful analysis to determine how selective participation may have influenced the findings. Participation in a study of sexual behavior may be influenced by who is doing the study, who the participants are, what it means to participate, what the s...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/00007435-199505000-00007
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV), a prevalent infection in women of reproductive age, is associated with increased risk of upper genital tract and sexually transmitted infections, and complications in pregnancy. Currently approved treatments include metronidazole, which requires once or twice daily intravaginal admi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/OLQ.0000000000000300
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Chronic nongonococcal urethritis (NGU) is a well-recognized clinical problem in genitourinary medicine clinics, but its etiology and optimal management are poorly understood. GOAL:The authors showed previously that antibody to chlamydial hsp60 is associated with urethritis 30 to 92 days after treatment of a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200302000-00007
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Little is known about the prevalence and determinants of human papillomavirus (HPV) infection in women from West India, although incidence of and mortality from cervical cancer is high. METHODS:Cervical specimens were collected, and questionnaires on lifestyle and reproductive factors were administered to 2...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318223be5f
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To describe the impact of surveillance for antimicrobial resistance (AMR) in Neisseria gonorrhoeae over a 7-year period on treatment guidelines in Alberta, Canada. METHODS:AMR testing data from gonorrhea cases were combined with demographic and risk behavior information collected through surveillance to des...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181aad9df
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In the January-February, 1995 issue of Sexually Transmitted Diseases, Zenilman and colleagues reported a null association between incident sexually transmitted diseases (STDs) and self-reported condom use. That anomalous finding generated a flurry of letters to the editor, some of which were q...
journal_title:Sexually transmitted diseases
pub_type: 评论,杂志文章
doi:10.1097/00007435-199710000-00005
更新日期:1997-10-01 00:00:00
abstract::Among 413 Nigerian men who have sex with men and transgender women, retrospective testing for Mycoplasma genitalium revealed mostly asymptomatic infections of the anorectum (prevalence, 36.8%; incidence, 18.4 cases/100 person-years) and urogenital tract (12.4%, 4.0 cases/100 person-years). Risk factors included HIV an...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001105
更新日期:2020-03-01 00:00:00