当前位置： SCI文献检索 > SEXUALLY TRANSMITTED DISEASES期刊下所有文献 > Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity.

Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity.

Abstract：

BACKGROUND:Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity. GOALS:The objective of this analysis was to examine the association of sexual behavior, cervical HPV 16 DNA positivity at enrollment (past) and at diagnosis (current), and other potential determinants with the likelihood and magnitude of HPV 16 seropositivity at diagnosis. STUDY DESIGN:With use of stored specimens from an incidence case-control study at Kaiser Permanente (Portland, OR), women were tested for seroreactivity to HPV 16 by enzyme-linked immunosorbent assay with virus-like particles at diagnosis and were tested for past and concurrent cervical HPV 16 DNA positivity with MY09/MY11 L1 consensus primer PCR. Questionnaire data were used to ascertain past sexual behavior. RESULTS:Increased lifetime number of sex partners (P(Trend) < 0.001), past HPV 16 DNA positivity (odds ratio = 6.9; 95% confidence interval = 1.5-31), and a current cytologic diagnosis (P(Trend) < 0.03) were independently associated with HPV 16 seropositivity. Among the seropositive, only lifetime number of sex partners (P(Trend) < 0.001) and past HPV 16 DNA positivity (P = 0.003) were independently associated with mean signal strength (optical density) in an age-adjusted analysis. Women negative for past and concurrent HPV 16 DNA had a significant trend of increasing optical densities associated with greater numbers of lifetime partners (P(Trend) < 0.001). Conversely, the mean signal strength for those women who were ever HPV 16 DNA-positive during the study did not depend on lifetime numbers of sex partners (P(Trend) = 0.36). CONCLUSIONS:HPV 16 seropositivity is a surrogate for past HPV 16 infection. Circulating levels of antibodies to HPV 16 may reflect recent HPV 16 infection or the frequency of past HPV 16 infection.

journal_name

Sex Transm Dis

journal_title

Sexually transmitted diseases

authors

Castle PE,Shields T,Kirnbauer R,Manos MM,Burk RD,Glass AG,Scott DR,Sherman ME,Schiffman M

doi

10.1097/00007435-200203000-00009

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

182-7

issue

eissn

0148-5717

issn

1537-4521

pii

00007435-200203000-00009

journal_volume

pub_type

杂志文章

在线工具

Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity.