Sexual bridging socially and over time: a simulation model exploring the relative effects of mixing and concurrency on viral sexually transmitted infection transmission.


BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic model, the authors investigated the impact of mixing and concurrency on the spread of a persistent viral STI. STUDY DESIGN:A total of 1,050 populations were simulated of 1,000 subjects over 400 weeks with varied concurrency levels and mixing patterns. STI prevalence and the average number of secondary transmissions per subject were analyzed with regression. RESULTS:Mixing had a greater impact on prevalence for all groups, whereas concurrency was significant for only the lowest activity group. Mixing patterns moderated the magnitude of concurrency's impact on secondary transmissions. CONCLUSIONS:Through connecting subgroups of differential risk, sexual mixing facilitates dissemination of STIs throughout a population. Concurrency expedites transmission by shortening the time between sexual contacts among infected and susceptible persons, particularly during the highly infectious period.


Sex Transm Dis


Doherty IA,Shiboski S,Ellen JM,Adimora AA,Padian NS




Has Abstract


2006-06-01 00:00:00














  • Treatment of gonorrhea with single-dose thiamphenicol.

    abstract::This study was undertaken to determine the effectiveness of a single 2.5-g dose of thiamphenicol as therapy for gonococcal infection and to compare the results obtained in a limited group of male and female patients to those reported by other investigators. Diagnosis was determined by direct microscopy and culture. Cu...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Murat A,Oran M,Altinok T,Giz H

    更新日期:1984-10-01 00:00:00

  • Gonococcal aneurysm of the ascending aorta: case report and review of Neisseria gonorrhoeae endovascular infections.

    abstract::We present the case of a man with a bicuspid aortic valve who presented with persistent fever. Blood cultures yielded Neisseria gonorrhoeae, and the diagnosis of infected mycotic aneurysm was confirmed by detection of the bacterial genome in the aortic wall. The patient was cured with surgery and intravenous ceftriaxo...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审


    authors: Markowicz S,Anstey JR,Hites M,Montesinos I,Roisin S,Keyzer C,Jacobs F

    更新日期:2014-02-01 00:00:00

  • Combination of laser-therapy with 0.5% idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.

    abstract::Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment pr...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Happonen HP,Lassus A,Santalahti J,Forsstrom S,Lassus J

    更新日期:1990-07-01 00:00:00

  • Chlamydia test results were associated with sexual risk behavior change among participants of the Chlamydia screening implementation in The Netherlands.

    abstract:OBJECTIVE:To examine the effect of a laboratory-confirmed Chlamydia trachomatis (Ct) test result on subsequent sexual risk behavior in a large population-based screening program. METHODS:The study population consisted of 16- to 29-year-old participants of the Chlamydia Screening Implementation who completed Ct testing...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Soetens LC,van Benthem BH,Op de Coul EL

    更新日期:2015-03-01 00:00:00

  • Online Sex Partner Meeting Venues as a Risk Factor for Testing HIV Positive Among a Community-Based Sample of Black Men Who Have Sex With Men.

    abstract:OBJECTIVES:In the United States, black men who have sex with men (BMSM) are disproportionately affected by the HIV epidemic. The elevated estimates of HIV among BMSM suggest that to slow rates of HIV infections, a range of factors that may contribute to transmission must be researched. Use of online venues for seeking ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Eaton LA,Maksut JL,Gamarel KE,Siembida EJ,Driffin DD,Baldwin R

    更新日期:2016-06-01 00:00:00

  • Trends in sexual behavior, testing, and knowledge in young people; 2006-2011.

    abstract::Cross-sectional surveys were conducted annually from 2006 to 2011 at a music festival. Eight thousand one hundred sixty-five young people completed surveys. STI testing rates increased over time, but there was an increase in the prevalence of some sexual risk behaviors and little improvement in STI knowledge between 2...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Lim MS,Bowring AL,Gold J,Aitken CK,Hellard ME

    更新日期:2012-11-01 00:00:00

  • Identifying likely syphilis transmitters: implications for control and evaluation.

    abstract:BACKGROUND/OBJECTIVES:Persistence of syphilis in communities may be maintained by relatively small groups of high-risk persons centrally placed among a larger group with low to moderately risky behavior. We sought to determine which control strategies identified particularly high-risk, early-stage syphilis cases consid...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Kahn RH,Peterman TA,Arno J,Coursey EJ,Berman SM

    更新日期:2006-10-01 00:00:00

  • HIV/AIDS behavioral surveillance surveys of the cross-border sex-networker population in Hong Kong from 1997 to 2001.

    abstract:BACKGROUND:Mobility is an important risk factor in the spread of HIV. GOAL:The goal was to conduct behavioral surveillance surveys on Hong Kong males crossing the border to mainland China to have sex with female sex workers (FSW) or nonregular female sex partners who were not FSW (NRP). STUDY DESIGN:Four surveys (199...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Lau JT,Tsui HY

    更新日期:2003-11-01 00:00:00

  • Estimating the basic reproductive rates of Neisseria gonorrhoeae and Chlamydia trachomatis: the implications of acquired immunity.

    abstract:BACKGROUND AND OBJECTIVES:The basic reproductive rate of and STD is an important parameter from which the success of intervention strategies can be predicted. GOAL OF THE STUDY:To evaluate different methods to estimate the basic reproductive rate. RESULTS:Two different methods of estimating the basic reproductive rat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Brunham RC,Nagelkerke NJ,Plummer FA,Moses S

    更新日期:1994-11-01 00:00:00

  • Prevalence and incidence of HPV genital infection in women.

    abstract:BACKGROUND:A prophylactic quadrivalent human papillomavirus (HPV) vaccine could benefit adult women if they are susceptible to incident genital HPV infections and are acquiring new infections with vaccine HPV types to which they were previously not exposed. This report presents baseline and prospective data from a rand...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Velicer C,Zhu X,Vuocolo S,Liaw KL,Saah A

    更新日期:2009-11-01 00:00:00

  • Treatment of bacterial vaginosis with lactobacilli.

    abstract::60 women with bacterial vaginosis were entered into a double blind, placebo-controlled treatment trial with lyophilized Lactobacillus acidophilus. The lactobacilli used were producing H2O2. Immediately after completion of treatment, 16 out of 28 women who were treated with lactobacilli had normal vaginal wet smear res...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hallén A,Jarstrand C,Påhlson C

    更新日期:1992-05-01 00:00:00

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    abstract::Strains of Trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. A serial twofold dilution method that measured minimal inhibitory concentrations (MICs) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trop...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Smith RF,Di Domenico A

    更新日期:1980-07-01 00:00:00

  • Neighborhoods at risk: estimating risk of higher Neisseria gonorrhoeae incidence among women at the census tract level.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究


    authors: Stenger MR,Samuel MC,Anschuetz GL,Pugsley R,Eaglin M,Klingler E,Reed M,Schumacher CM,Simon J,Weinstock H

    更新日期:2014-11-01 00:00:00

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    abstract:BACKGROUND:Asymptomatic neurosyphilis is more difficult to diagnose in human immunodeficiency virus (HIV)-infected patients because HIV itself can cause cerebrospinal fluid (CSF) pleocytosis. The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Marra CM,Tantalo LC,Sahi SK,Maxwell CL,Lukehart SA

    更新日期:2010-05-01 00:00:00

  • Solid-hase hemadsorption: a method for rapid detection of Treponema pallidum-specific IgM.

    abstract::A solid-phase hemadsorption (SPHA) technique for the rapid detection of Treponema pallidum-specific IgM antibodies is described. The demonstration of these immunoglobulins permits differentiation between a recent and a long-lasting infection and facilitates the decision as to whether or not a patient should receive th...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Schmidt BL

    更新日期:1980-04-01 00:00:00

  • Characterization of ciprofloxacin resistance in Neisseria gonorrhoeae isolates in Canada.

    abstract:BACKGROUND:Ciprofloxacin (500 mg orally, single dose) is one of the recommended therapies for gonorrhea in Canada. In Canada, the first ciprofloxacin-resistant (CipR) Neisseria gonorrhoeae strain was isolated in 1993. Antimicrobial susceptibilities of N gonorrhoeae isolates were monitored as part of a national surveill...

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    pub_type: 杂志文章,多中心研究


    authors: Ng LK,Sawatzky P,Martin IE,Booth S

    更新日期:2002-12-01 00:00:00

  • Low prevalence of ciprofloxacin-resistant Neisseria gonorrhoeae in Nuuk, Greenland.

    abstract::During a 35-day period, 32 isolates of Neisseria gonorrhoeae strains were collected by culture from patients with positive nucleic acid amplification test results in Nuuk, Greenland, where ciprofloxacin is the preferred treatment. All isolates were quinolone susceptible, suggesting that resistance is rare. Sampling pa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Pedersen ML,Clausen-Dichow P,Poulsen P,Nyborg H,Jensen JS

    更新日期:2013-08-01 00:00:00

  • Genital ulcer disease treatment policies and access to acyclovir in eight sub-Saharan African countries.

    abstract:BACKGROUND:Herpes simplex virus-2, the most common cause of genital ulcer disease (GUD) globally, is a cofactor in human immunodeficiency virus type-1 (HIV-1) acquisition and transmission. Current World Health Organization guidelines for sexually transmitted infections recommend acyclovir as first-line syndromic treatm...

    journal_title:Sexually transmitted diseases

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    authors: Corbell C,Stergachis A,Ndowa F,Ndase P,Barnes L,Celum C

    更新日期:2010-08-01 00:00:00

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    abstract:BACKGROUND:In October 2009, a quadrivalent vaccine for human papillomavirus (HPV) was licensed in the United States for males aged 9 to 26 years. The attitudes and beliefs of parents play a critical role in uptake of this vaccine because parental consent is typically required for adolescent HPV vaccination. This study ...

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    pub_type: 杂志文章,随机对照试验


    authors: Dempsey AF,Butchart A,Singer D,Clark S,Davis M

    更新日期:2011-08-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Freeman AH,Bernstein KT,Kohn RP,Philip S,Rauch LM,Klausner JD

    更新日期:2011-11-01 00:00:00

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    abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...

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    pub_type: 杂志文章


    authors: Cañadas MP,Darwich L,Sirera G,Bofill M,Piñol M,Garcia-Cuyas F,Llatjos M,Corbasi P,Clotet B,Videla S,HIV-HPV Can Ruti Study Group.

    更新日期:2010-05-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Goh BT,Varia KB,Ayliffe PF,Lim FK

    更新日期:1985-07-01 00:00:00

  • Rate and predictors of new genital warts claims and genital warts-related healthcare utilization among privately insured patients in the United States.

    abstract:BACKGROUND:Little non-clinic-based data are available on incident genital warts rates and related healthcare use. GOAL:: The goal of this study was to describe the incidence and predictors of genital warts and associated healthcare utilization patterns among a group of privately insured patients in the United States. ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Koshiol JE,Laurent SA,Pimenta JM

    更新日期:2004-12-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Copen CE,Leichliter JS,Spicknall IH,Aral SO

    更新日期:2019-11-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Fiumara NJ,Schmidt-Ulrick B,Comite H

    更新日期:1980-07-01 00:00:00

  • Iron and virulence of Haemophilus ducreyi in a primate model.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Sturm AW

    更新日期:1997-02-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Swenson CE,Schachter J

    更新日期:1984-04-01 00:00:00

  • Laboratory Capacity for Antimicrobial Susceptibility Surveillance of Neisseria gonorrhoeae-District of Columbia, 2007-2012.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Garrett TA,Davies-Cole J,Furness B

    更新日期:2015-08-01 00:00:00

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Bollerup S,Baldur-Felskov B,Blomberg M,Baandrup L,Dehlendorff C,Kjaer SK

    更新日期:2016-04-01 00:00:00

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    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00