Sexual bridging socially and over time: a simulation model exploring the relative effects of mixing and concurrency on viral sexually transmitted infection transmission.


BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic model, the authors investigated the impact of mixing and concurrency on the spread of a persistent viral STI. STUDY DESIGN:A total of 1,050 populations were simulated of 1,000 subjects over 400 weeks with varied concurrency levels and mixing patterns. STI prevalence and the average number of secondary transmissions per subject were analyzed with regression. RESULTS:Mixing had a greater impact on prevalence for all groups, whereas concurrency was significant for only the lowest activity group. Mixing patterns moderated the magnitude of concurrency's impact on secondary transmissions. CONCLUSIONS:Through connecting subgroups of differential risk, sexual mixing facilitates dissemination of STIs throughout a population. Concurrency expedites transmission by shortening the time between sexual contacts among infected and susceptible persons, particularly during the highly infectious period.


Sex Transm Dis


Doherty IA,Shiboski S,Ellen JM,Adimora AA,Padian NS




Has Abstract


2006-06-01 00:00:00














  • Observed Treatment Responses to Short-Course Doxycycline Therapy for Rectal Lymphogranuloma Venereum in Men Who Have Sex With Men.

    abstract:BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including i...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Simons R,Candfield S,French P,White JA

    更新日期:2018-06-01 00:00:00

  • Oral Human Papillomavirus in Youth From the Pediatric HIV/AIDS Cohort Study.

    abstract::In contrast to high rates of oral human papillomavirus (HPV) found in human immunodeficiency virus (HIV)-infected adults, only 2% of 209 perinatally HIV-infected youth had oral HPV. This rate was similar in HIV-exposed but uninfected youth. No association was found with sexual activity; however, low CD4 counts were as...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Moscicki AB,Farhat S,Yao TJ,Ryder MI,Russell JS,Van Dyke RB,Hazra R,Shiboski CH,Pediatric HIVAIDS Cohort Study.

    更新日期:2016-08-01 00:00:00

  • Anorectal and Urogenital Mycoplasma genitalium in Nigerian Men Who Have Sex With Men and Transgender Women: Prevalence, Incidence, and Association With HIV.

    abstract::Among 413 Nigerian men who have sex with men and transgender women, retrospective testing for Mycoplasma genitalium revealed mostly asymptomatic infections of the anorectum (prevalence, 36.8%; incidence, 18.4 cases/100 person-years) and urogenital tract (12.4%, 4.0 cases/100 person-years). Risk factors included HIV an...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Crowell TA,Lawlor J,Lombardi K,Nowak RG,Hardick J,Odeyemi S,Kokogho A,Malia J,Stewart C,Robb ML,Baral SD,Adebajo S,Charurat ME,Ake JA,Peel SA,Gaydos CA,TRUST\/RV368 Study Group.

    更新日期:2020-03-01 00:00:00

  • Confirmation of the Syva MicroTrak enzyme immunoassay for chlamydia trachomatis by Syva Direct Fluorescent Antibody Test.

    abstract:BACKGROUND AND OBJECTIVES:The Syva Micro Trak enzyme immunoassay (EIA) is used widely for screening women infected with Chlamydia trachomatis. Confirmatory tests used in conjunction with EIA screening have shown that false-positive results are common. GOALS:To evaluate the specificity of the Syva MicroTrak EIA by conf...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beebe JL,Masters H,Jungkind D,Heltzel DM,Weinberg A

    更新日期:1996-11-01 00:00:00

  • Sexually transmitted diseases and risk behaviors among pregnant women attending inner city public sexually transmitted diseases clinics in Baltimore, MD, 1996-2002.

    abstract:OBJECTIVE:To determine the prevalence of sexually transmitted diseases (STDs) and characterize behavioral correlates among pregnant women attending inner city public STD clinics. STUDY DESIGN:A retrospective study of 2303 pregnant women frequency matched by clinic and year of visit to 2303 nonpregnant women seeking se...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Johnson HL,Erbelding EJ,Zenilman JM,Ghanem KG

    更新日期:2007-12-01 00:00:00

  • Spontaneous HIV-1 seroreversion in an adult male.

    abstract::A man developed HIV-1 antibodies, which disappeared spontaneously. He had negative HIV viral load and p24 antigen tests and did not develop immunosuppression. Further investigations suggest the HIV-positive result was a nonspecific reaction. An alternative explanation is that he was exposed to HIV and had a "near-miss...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Coyne KM,Parry JV,Atkins M,Pozniak A,McOwan A

    更新日期:2007-09-01 00:00:00

  • Epidemiology of human immunodeficiency virus, viral hepatitis (B and C), treponema pallidum, and human T-cell lymphotropic I/II virus among men who have sex with men in Buenos Aires, Argentina.

    abstract:BACKGROUND:Human immunodeficiency virus (HIV) and sexually transmitted infections (STI) are prevalent among men who have sex with men (MSM). GOAL:To estimate the prevalence of HIV and STIs in this group. STUDY:A total of 694 MSM were tested for HIV, hepatitis B (HBV), hepatitis C (HCV), human T-cell lymphotropic (HTL...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Pando MA,Bautista CT,Maulen S,Duranti R,Marone R,Rey J,Vignoles M,Eirin ME,Biglione MM,Griemberg G,Montano SM,Carr JK,Sanchez JL,Avila MM

    更新日期:2006-05-01 00:00:00

  • Effect of a Rapid Test Algorithm on Linkage to Medical Care and Viral Suppression Among New Jersey Residents, 2007 to 2015.

    abstract:BACKGROUND:Efforts to identify and link human immunodeficiency virus-infected persons to medical care are the first steps to achieving viral suppression. In the United States, the goals are to link 85% of newly diagnosed persons to medical care in 30 days or less and for 80% to become virally suppressed by 2020. Among ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Mohammed DY,Davidow A,Martin E,Ibrahim A,Paul S,Ryan J,Bolden B

    更新日期:2018-07-01 00:00:00

  • Serologic groups of Neisseria gonorrhoeae recovered from patients in Nashville, Tennessee, 1971--1976.

    abstract::The objective of this study was to develop and apply a serologic method for identification of different strains of Neisseria gonorrhoeae. Several procedures for preparation of cell-free extracts were tried; the most satisfactory was that with phosphate-buffered saline solution. Both capillary tube and immunodiffusion ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Quinn RW,Lowry PN,Hellerqvist CG

    更新日期:1980-04-01 00:00:00

  • Chlamydial infections in Italy.

    abstract::Chlamydia trachomatis was present in cell cultures of specimens from 96 (32%) of 300 men with nongonococcal urethritis, but this organism was not isolated from 100 healthy volunteers matched for sex and age. The prevalence of serum antibodies to C. trachomatis was investigated with the use of a single-antigen, indirec...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Cevenini R,La Placa M

    更新日期:1981-10-01 00:00:00

  • Hepatitis C seroprevalence and risk behaviors in patients attending sexually transmitted disease clinics.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is a major global problem, transmitted primarily by percutaneous exposure to contaminated blood. GOAL:The goal of the study was to determine the seroprevalence of and risk factors for HCV among patients attending two urban STD clinics in Alberta. STUDY DESIGN:Anonymous unlinked sero...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Romanowski B,Preiksaitis J,Campbell P,Fenton J

    更新日期:2003-01-01 00:00:00

  • Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00

  • Identifying syphilis risk networks through venue attendance in San Francisco.

    abstract:BACKGROUND:Prioritizing interventions for patients with syphilis who are part of large or interconnected sexual networks may be high yield for partner services, and identifying venues named by patients with syphilis who report high numbers of partners may help identify such networks. In this analysis, we explore differ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Stephens SC,Fann CK,Strona FV,Wolf W,Cohen SE,Philip SS,Bernstein KT

    更新日期:2014-05-01 00:00:00

  • Primary herpes simplex and primary syphilis: a description of seven cases.

    abstract::This report describes the cases of seven patients who had primary genital infection with herpes simplex virus and whose initial nontreponemal and treponemal tests for syphilis were nonreactive. On routine posttreatment examination, a change in the consistency of the ulcers was noticed, and the inguinal nodes, which ha...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Fiumara NJ,Schmidt-Ulrick B,Comite H

    更新日期:1980-07-01 00:00:00

  • Risk factors for incident and recurrent condylomata acuminata among men. A population-based study.

    abstract:BACKGROUND AND OBJECTIVES:The rapid increase in the number of physician office visits for condylomata acuminata and the association of human papillomavirus and cancer has prompted renewed interest in the epidemiology of this sexually-transmitted disease. Few epidemiologic studies have examined what risk factors are ass...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Van Den Eeden SK,Habel LA,Sherman KJ,McKnight B,Stergachis A,Daling JR

    更新日期:1998-07-01 00:00:00

  • Needs assessment for STD/HIV prevention among patients with sexually transmitted diseases in southern China.

    abstract:BACKGROUND AND GOAL:Patients with sexually transmitted diseases (STDs) serve as a bridge population to transmit HIV from higher-risk to lower-risk populations. Our goal was to understand the level of risk behaviors and HIV/STD-related knowledge as well as attitudes among STD patients in China. STUDY DESIGN:An anonymou...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Lau JT,Chen R,Wang Q,Diao J,Tsui H,Yuan W

    更新日期:2003-08-01 00:00:00

  • Estimating the direct costs of pelvic inflammatory disease in adolescents: a within-system analysis.

    abstract::We used 2008-2009 physician and hospital charges to estimate the direct cost of medical care per case of pelvic inflammatory disease. The estimated average total charge per episode was $3,025 (SD: $4155). The estimated average charge for patients treated in ambulatory (outpatient clinic and emergency department) setti...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Trent M,Ellen JM,Frick KD

    更新日期:2011-04-01 00:00:00

  • High prevalence of sexual concurrency and concurrent unprotected anal intercourse across racial/ethnic groups among a national, Web-based study of men who have sex with men in the United States.

    abstract:BACKGROUND:Men who have sex with men (MSM) are the largest human immunodeficiency virus (HIV) risk group in the United States. Sexual concurrency may contribute to high HIV incidence or to racial/ethnic HIV disparities among MSM. Limited information is available on concurrency and racial/ethnic differences among MSM or...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Rosenberg ES,Khosropour CM,Sullivan PS

    更新日期:2012-10-01 00:00:00

  • Patients attending STD clinics in an evolving health care environment. Demographics, insurance coverage, preferences for STD services, and STD morbidity.

    abstract:OBJECTIVES:To characterize client demographics, sexually transmitted diseases (STD) morbidity, insurance status, reasons for attending public STD clinics, and future preferences for source of STD services. DESIGN:Cross-sectional study of 2,490 clients attending five urban STD clinics for new problems with interviewer-...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Celum CL,Bolan G,Krone M,Code K,Leone P,Spaulding C,Henry K,Clarke P,Smith M,Hook EW 3rd

    更新日期:1997-11-01 00:00:00

  • Sexually transmitted disease clinic clients at risk for subsequent gonorrhea and chlamydia infections: possible 'core' transmitters.

    abstract:BACKGROUND:From an sexually transmitted disease (STD) intervention perspective, developing a practical way to identify persons in core transmitter groups has been difficult. However, persons who have repeated STD infections may be in such groups. GOAL:To evaluate a self-administered risk assessment approach that would...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Gunn RA,Fitzgerald S,Aral SO

    更新日期:2000-07-01 00:00:00

  • Neurocognitive impairment in human immunodeficiency virus infection is correlated with sexually transmitted disease history.

    abstract:BACKGROUND AND OBJECTIVES:Neurocognitive impairment is common in human immunodeficiency virus (HIV)-infected subjects. The relationship of sexually transmitted diseases to neurocognitive changes is unknown. GOAL:To establish whether HIV-infected patients with a history of syphilis or gonorrhea have a higher rate of ne...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Wallace MR,Heaton RK,McCutchan JA,Malone JL,Velin R,Nelson J,Miller LK,Weiss PJ,Oldfield EC 3rd,Grant I

    更新日期:1997-08-01 00:00:00

  • Association of coexisting vaginal infections and multiple abusers in female children with genital warts.

    abstract::All 11 girls less than 12 years of age presenting to the pediatric clinic between 1980 and 1986 with genital warts were evaluated by the Child Protection Team for possible sexual abuse. Nine of the 11 girls had condylomata acuminata, and two had verruca vulgaris. Ten of the 11 had historical and/or physical evidence o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Herman-Giddens ME,Gutman LT,Berson NL

    更新日期:1988-01-01 00:00:00

  • Control of syphilis outbreaks in men who have sex with men: the role of screening in nonmedical settings.

    abstract:OBJECTIVE:To quantify the scope and yield of targeted syphilis screening in nonmedical settings in 7 US cities affected by recent syphilis outbreaks among men who have sex with men (MSM). METHODS:Data were collected from syphilis screening activities targeting MSM between 1999 and 2004, conducted in bathhouses or othe...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审


    authors: Ciesielski C,Kahn RH,Taylor M,Gallagher K,Prescott LJ,Arrowsmith S

    更新日期:2005-10-01 00:00:00

  • Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial.

    abstract::In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验


    authors: Baeten JM,Reid SE,Delany-Moretlwe S,Hughes JP,Wang RS,Wilcox E,Limbada M,Akpomiemie G,Corey L,Wald A,Celum C

    更新日期:2012-01-01 00:00:00

  • Outbreak of Neisseria gonorrhoeae in Northern Alberta, Canada.

    abstract:BACKGROUND:In January 2001 we investigated an outbreak of Neisseria gonorrhoeae in a northern region of Alberta, Canada, and here we report on the epidemiology of the outbreak. GOAL:The goal was to examine the outbreak etiology and make recommendations for strengthening regional STD programs. STUDY DESIGN:Provincial ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: De P,Singh AE,Wong T,Yacoub W

    更新日期:2003-06-01 00:00:00

  • Urethritis caused by Neisseria meningitidis group B: a case report.

    abstract::We describe a case of acute urethritis caused by Neisseria meningitidis group B in a heterosexual man. The symptoms started five days after intercourse that included fellatio with a casual female partner. No other urethral pathogens could be isolated. After intramuscular administration of penicillin G, clinical signs ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Hartmann AA,Elsner P

    更新日期:1988-07-01 00:00:00

  • Failure of serosorting to protect African American men who have sex with men from HIV infection.

    abstract:BACKGROUND:Serosorting is the practice of choosing sex partners or selectively using condoms based on a sex partner's perceived HIV status. The extent to which serosorting protects African American (AA) and Hispanic men who have sex with men (MSM) is unknown. METHODS:We analyzed data collected from MSM sexually transm...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Golden MR,Dombrowski JC,Kerani RP,Stekler JD

    更新日期:2012-09-01 00:00:00

  • Sexual behavior and sexually transmitted diseases among male adolescents in detention.

    abstract:BACKGROUND:Youth in detention represent a medically underserved population at risk for a variety of medical and emotional disorders. GOAL OF THE STUDY:To determine prevalence of STDs and high-risk sexual behaviors for HIV/STD among adolescent males admitted to a juvenile detention facility. STUDY DESIGN:Cross-section...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Oh MK,Cloud GA,Wallace LS,Reynolds J,Sturdevant M,Feinstein RA

    更新日期:1994-05-01 00:00:00

  • Patient-delivered partner treatment and other partner management strategies for sexually transmitted diseases used by New York City healthcare providers.

    abstract:OBJECTIVES:The objectives of this study were to measure frequency and predictors of patient-delivered partner treatment (PDPT) and the frequency of other partner management strategies among New York City healthcare providers (HCPs) as well as to determine whether use of PDPT detracts from other partner management strat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: Rogers ME,Opdyke KM,Blank S,Schillinger JA

    更新日期:2007-02-01 00:00:00

  • High rates of enteric protozoal infections in selected homosexual men attending a venereal disease clinic.

    abstract::Stool specimens from 89 high-risk, sexually active homosexual men were screened for enteric protozoal cysts. Patients whose specimens contained nonpathogenic cysts were investigated further by examination of fresh purged specimens. A total of 27 of the initial specimens (30%) contained protozoal cysts. Twenty-three pa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章


    authors: William DC,Shookhoff HB,Felman YM,DeRamos SW

    更新日期:1978-10-01 00:00:00