Comparison of cefpimizole with cefotaxime and penicillin G for treatment of uncomplicated gonorrhea.

Abstract:

:One hundred sixteen patients (92 men and 24 women) with suspected uncomplicated gonorrhea were randomized in a double-blind manner to receive intramuscular treatment with 1.0 g of cefpimizole, 1.0 g of cefotaxime, or 4.8 x 10(6) units of aqueous procaine penicillin G (APPG) with 1 g of oral probenecid. Seventeen percent were nonassessable (cultures negative, co-existing syphilis, etc.). Infection sites in 96 assessable patients were urethra (78), cervix (17), pharynx (two), and rectum (two). Of 52 patients treated with cefpimizole, 46 (88%) were bacteriologically cured, as compared with 100% (24 of 24) treated with APPG (P = 0.18) and 90% (18 of 20) treated with cefotaxime (P greater than 0.20). On a weight basis the in-vitro activity of cefpimizole against Neisseria gonorrhoeae was similar to that of APPG. Pain at the injection site was reported by 52% of patients treated with cefpimizole as compared with 27% of those given cefotaxime (P = 0.008) and 17% of those given APPG (P = 0.002). No major organ toxicity was found with cefpimizole, cefotaxime, or APPG. Thus, for acute uncomplicated gonorrhea cefpimizole is similar in efficacy to cefotaxime and APPG but has a higher frequency of pain at the injection site.

journal_name

Sex Transm Dis

authors

Raad II,Sherertz RJ,Loveless MO,Carillo C,O'Connor RP,Miller M,Mostow SR

doi

10.1097/00007435-198804000-00001

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

73-7

issue

2

eissn

0148-5717

issn

1537-4521

journal_volume

15

pub_type

临床试验,杂志文章,随机对照试验
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