Abstract:
:One hundred sixteen patients (92 men and 24 women) with suspected uncomplicated gonorrhea were randomized in a double-blind manner to receive intramuscular treatment with 1.0 g of cefpimizole, 1.0 g of cefotaxime, or 4.8 x 10(6) units of aqueous procaine penicillin G (APPG) with 1 g of oral probenecid. Seventeen percent were nonassessable (cultures negative, co-existing syphilis, etc.). Infection sites in 96 assessable patients were urethra (78), cervix (17), pharynx (two), and rectum (two). Of 52 patients treated with cefpimizole, 46 (88%) were bacteriologically cured, as compared with 100% (24 of 24) treated with APPG (P = 0.18) and 90% (18 of 20) treated with cefotaxime (P greater than 0.20). On a weight basis the in-vitro activity of cefpimizole against Neisseria gonorrhoeae was similar to that of APPG. Pain at the injection site was reported by 52% of patients treated with cefpimizole as compared with 27% of those given cefotaxime (P = 0.008) and 17% of those given APPG (P = 0.002). No major organ toxicity was found with cefpimizole, cefotaxime, or APPG. Thus, for acute uncomplicated gonorrhea cefpimizole is similar in efficacy to cefotaxime and APPG but has a higher frequency of pain at the injection site.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Raad II,Sherertz RJ,Loveless MO,Carillo C,O'Connor RP,Miller M,Mostow SRdoi
10.1097/00007435-198804000-00001subject
Has Abstractpub_date
1988-04-01 00:00:00pages
73-7issue
2eissn
0148-5717issn
1537-4521journal_volume
15pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND AND GOAL:Patients with sexually transmitted diseases (STDs) serve as a bridge population to transmit HIV from higher-risk to lower-risk populations. Our goal was to understand the level of risk behaviors and HIV/STD-related knowledge as well as attitudes among STD patients in China. STUDY DESIGN:An anonymou...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000081394.94426.7A
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:The cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory (VDRL) test is only 27% sensitive for diagnosing neurosyphilis. Discriminant analysis, used on 124 patients, shows that other commonly used laboratory tests can, in combination, identify 87% of patients with neurosyphilis with 94% specificity...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199609000-00008
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Efforts to identify and link human immunodeficiency virus-infected persons to medical care are the first steps to achieving viral suppression. In the United States, the goals are to link 85% of newly diagnosed persons to medical care in 30 days or less and for 80% to become virally suppressed by 2020. Among ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000776
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Few men are tested for syphilis or human immunodeficiency virus (HIV) during their partner's pregnancy, a high-risk period for HIV and syphilis transmission. Offering home-based rapid testing of syphilis to couples during pregnancy can support prevention efforts to reduce transmission of sexually transmitted...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0000000000000649
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Women with disabilities can and do contract sexually transmitted diseases (STDs). However, because of access barriers, attitudinal misconceptions, and lack of awareness of their risk status, these infections may go under or undiagnosed. GOAL:To address issues regarding the treatment of women ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/00007435-200005000-00007
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:HIV counseling prevents sexually transmitted diseases (STDs), with most of the benefit accumulating in the first 6 months. STUDY:The authors conducted a multicenter, randomized, controlled trial of a 20-minute additional (booster) counseling session 6 months after HIV counseling compared with no additional ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.olq.0000151420.92624.c0
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to determine the rate of new infections and reinfections or persistent infections with Chlamydia trachomatis to define appropriate screening intervals and to identify risk factors for reinfection. DESIGN:This was a cross-sectional study among a subsample of participants in ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000179887.01141.c3
更新日期:2005-10-01 00:00:00
abstract::In a large health insurance database in Germany, incidence of anogenital warts among 15- to 19-year-old females decreased from 316/100,000 person-years in 2007 to 242 in 2008 (23% reduction, P = 0.0001). The decrease started between the first and second quarter of 2007 (human papillomavirus vaccination was introduced ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182756efd
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:There is a high level of coinfection with human immunodeficiency virus (HIV) among persons diagnosed with syphilis in the United States. Public health workers at state and local health departments help inform exposed partners to sexually transmitted disease (STD)/HIV infections to facilitate early testing an...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001201
更新日期:2020-08-01 00:00:00
abstract::We developed 4 algorithms for syphilis among HIV-positive men who have sex with men who engaged in primary care in 2016 to 2017. Clinician-based diagnosis from chart reviews was the gold standard. Sensitivities ranged from 74.2% to 93.9%. Specificities were greater than 99% with positive and negative predictive values...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000938
更新日期:2019-04-01 00:00:00
abstract::The objective of this study was to develop and apply a serologic method for identification of different strains of Neisseria gonorrhoeae. Several procedures for preparation of cell-free extracts were tried; the most satisfactory was that with phosphate-buffered saline solution. Both capillary tube and immunodiffusion ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198004000-00002
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Patients with sexually transmitted diseases (STDs) are at an increased risk of HIV infection and they must be targeted for increased condom use. GOAL:To identify predictors of condom use among patients with STDs. STUDY DESIGN:In a cross-sectional survey, an interview-administered questionnair...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199910000-00001
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) vaccination is a safe and effective primary prevention strategy for cervical cancer. Despite the need for effective HPV vaccination interventions, relatively few have been tested. Moreover, existing interventions have tended to use a one-size-fits-all educational approach. We inves...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0b013e318283c8a8
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Denmark introduced the quadrivalent human papillomavirus vaccine into the vaccination program for 12- to 15-year-old girls in 2008 to 2009. In 2012, the program was supplemented with a catch-up program for women aged up to 27 years. We evaluated the effectiveness of the Danish vaccination program on the nati...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000418
更新日期:2016-04-01 00:00:00
abstract::Fifty-five men were treated for culture-positive chancroid with two 2.5-g doses of thiamphenicol given on each of two consecutive days. Forty-nine patients (89.1%) were cured on this regimen. No adverse effects were noted. Cultured strains of Haemophilus ducreyi were found to be sensitive to thiamphenicol. ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198410001-00040
更新日期:1984-10-01 00:00:00
abstract::Both neurosyphilis and diplopia are widely known medical terms. Nevertheless, low clinical awareness by the physician and the often-overlooked presentation of diplopia, make the combination of neurosyphilis and diplopia rarely observed. In this article, we report 2 neurosyphilitic patients presenting with diplopia and...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000703
更新日期:2018-02-01 00:00:00
abstract::This review of the treatment of patients exposed to gonorrhea uses decision analysis techniques to estimate and compare the probabilities of disease and treatment risks for epidemiologic treatment, for treatment contingent on results of gram stains and culture, and for treatment contingent on culture results alone. E...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-197904000-00022
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Rising rates of antiretroviral drug resistance among recently infected persons are evidence of high-risk behavior among persons in HIV care. GOAL:The goal was to determine HIV transmission risk behavior among persons in HIV care and evaluate its association with treatment adherence. STUDY DESIGN:The study ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200305000-00005
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:This study examined condom use and sexually transmitted infection (STI) testing among unmarried, non-cohabiting women and men who had multiple past-year partnerships or perceived their partner's involvement in another sexual relationship. METHODS:We identified 5868 and 5330 unmarried, non-cohabiting sexuall...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001067
更新日期:2019-11-01 00:00:00
abstract::Twenty of 37 gonorrhea cases identified during an outbreak were diagnosed at one health care organization that used an out-of-state laboratory. The results were transmitted into electronic medical records without provider notification. Delays in treatment and reporting were identified. Systems should be implemented to...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182927c8c
更新日期:2013-07-01 00:00:00
abstract::We believe this to be the first report of coexisting polymerase chain reaction (PCR)-confirmed primary genital and ocular syphilis in a patient with penicillin allergy treated with doxycycline. The case examines the use of nonpenicillin and corticosteroid treatment of ocular syphilis and highlights the risk of eye inv...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000900
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:After reaching an all-time low in 2000, syphilis incidence in the United States has increased as the burden shifted from heterosexuals to men who have sex with men (MSM). Houston, Texas, experienced 2 outbreaks of syphilis during this transformation in trends. Further evaluation is necessary to determine if ...
journal_title:Sexually transmitted diseases
pub_type: 历史文章,杂志文章
doi:10.1097/OLQ.0000000000000488
更新日期:2016-09-01 00:00:00
abstract::All 11 girls less than 12 years of age presenting to the pediatric clinic between 1980 and 1986 with genital warts were evaluated by the Child Protection Team for possible sexual abuse. Nine of the 11 girls had condylomata acuminata, and two had verruca vulgaris. Ten of the 11 had historical and/or physical evidence o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198801000-00014
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Serosorting is the practice of choosing sex partners or selectively using condoms based on a sex partner's perceived HIV status. The extent to which serosorting protects African American (AA) and Hispanic men who have sex with men (MSM) is unknown. METHODS:We analyzed data collected from MSM sexually transm...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31825727cb
更新日期:2012-09-01 00:00:00
abstract::Medical record review was used to identify missed opportunities for chlamydia screening among 103 American Indian/Alaska Native women. Of these, 69% had received a pregnancy test and 74% had received a urine test in the previous 12 months. Chlamydia screening may increase if linked to the other routine clinical testin...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318222f126
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Transgender women and transgender men are disproportionately affected by human immunodeficiency virus (HIV) infection and may be vulnerable to other sexually transmitted diseases (STDs), but the lack of surveillance data inclusive of gender identity hinders prevention and intervention strategies. METHODS:We...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000917
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Incorrect condom use is a common problem that can undermine their prevention impact. We assessed the prevalence of 2 condom use problems, breakage/slippage and partial use, compared problems by partnership type, and examined associations with respondent, partner, and partnership characteristics. METHODS:Dat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e31825ef325
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Millions of cases of sexually transmitted infections (STIs) occur in the United States each year, resulting in substantial medical costs to the nation. Previous estimates of the total direct cost of STIs are quite dated. We present updated direct medical cost estimates of STIs in the United States. METHODS:...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318285c6d2
更新日期:2013-03-01 00:00:00
abstract::The QuadFERM+ (Analytab Products, Plainview, NY) rapid identification system was evaluated for its ability to identify correctly Neisseria gonorhoeae isolates from specimens obtained at a sexually transmitted disease clinic. One hundred eighty-five isolates (115 N. gonorrhoeae, 45 Neisseria meningitidis, 16 Neisseria ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198904000-00002
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVES:In the Russian Federation, large sectors of the population regularly undergo mandatory occupational screening for sexually transmitted infections (STIs). Objectives of our study were to determine the prevalence of syphilis and gonorrhea in the screened occupational groups in Moscow and to conduct a cost-effe...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31816f1c65
更新日期:2008-05-01 00:00:00