Abstract:
OBJECTIVES:To assess the efficacy of topical 80% trichloroacetic acid (TCA) to treat internal anal high-grade squamous intraepithelial lesions (HSILs) in HIV-positive individuals. METHODS:All patients who attended the University of Pittsburgh Anal Dysplasia Clinic for treatment of biopsy-proven internal anal HSIL with topical TCA between July 1, 2009, and June 30, 2012, and who had 1 or more follow-up visits to assess treatment efficacy were included in the analysis. Recurrence of HSIL was assessed in July 1, 2013. RESULTS:A total of 98 HSILs from 72 patients were treated, and 77 (78.6%) resolved to normal epithelium or low-grade SIL during follow-up. Forty-eight (49.0%) and 27 (27.6%) of lesions resolved with 1 and 2 TCA treatments, respectively, whereas 1 lesion (1%) each resolved with 3 and 4 TCA treatments. Twenty-one (21.4%) lesions in 20 patients remained without resolution after TCA treatments. These patients were offered an alternative treatment. During follow-up, 8 (15.1%) of 53 patients had a lesion that recurred at the index site (11/53 [20.8%], inclusive of adjacent lesions) and 17 patients had new lesions diagnosed. CONCLUSIONS:Topical TCA is an efficacious treatment of internal anal HSIL in an anal dysplasia clinic setting with high-resolution anoscopy capacity. Advantages of TCA for this recurrent disease process include the following: low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure. A larger prospective comparative study would better define efficacy and patient acceptability between treatment methods.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Cranston RD,Baker JR,Liu Y,Wang L,Elishaev E,Ho KSdoi
10.1097/OLQ.0000000000000145subject
Has Abstractpub_date
2014-07-01 00:00:00pages
420-6issue
7eissn
0148-5717issn
1537-4521pii
00007435-201407000-00002journal_volume
41pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:A quick and highly sensitive diagnostic test would be valuable in the diagnosis of Chlamydia trachomatis. GOAL OF THIS STUDY:We compared a new polymerase chain reaction (PCR) technique to Chlamydiazyme (Abbott, North Chicago, IL) in the detection of male chlamydial urethritis, and evaluated t...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章
doi:10.1097/00007435-199409000-00004
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Cisgender female sex workers (CFSWs) have elevated rates of sexually transmitted infections (STI) yet are underrepresented in targeted programming and research in the United States. We examined the prevalence, incidence and predictors of chlamydia, gonorrhea, and trichomonas infection among CFSW. METHODS:Tw...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001085
更新日期:2019-12-01 00:00:00
abstract::We present the case of a man with a bicuspid aortic valve who presented with persistent fever. Blood cultures yielded Neisseria gonorrhoeae, and the diagnosis of infected mycotic aneurysm was confirmed by detection of the bacterial genome in the aortic wall. The patient was cured with surgery and intravenous ceftriaxo...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000079
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To investigate in a cross-sectional study the determinants of oral human papillomavirus infection in 287 individuals who are sexually active. GOAL:To assess prevalence as well as risk factors for oral human papillomavirus infection. STUDY DESIGN:One hundred seventy-eight human immunodeficien...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199701000-00006
更新日期:1997-01-01 00:00:00
abstract::We believe this to be the first report of coexisting polymerase chain reaction (PCR)-confirmed primary genital and ocular syphilis in a patient with penicillin allergy treated with doxycycline. The case examines the use of nonpenicillin and corticosteroid treatment of ocular syphilis and highlights the risk of eye inv...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000900
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Youth in detention represent a medically underserved population at risk for a variety of medical and emotional disorders. GOAL OF THE STUDY:To determine prevalence of STDs and high-risk sexual behaviors for HIV/STD among adolescent males admitted to a juvenile detention facility. STUDY DESIGN:Cross-section...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199405000-00001
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVES/GOAL:We compared risk behaviors and HIV testing between recent (in the U.S. <5 years) and established (in the U.S. >5 years) Hispanic immigrant men (N = 410). STUDY:This study was a population-based, cross-sectional survey of HIV/sexually transmitted disease markers and risk behaviors in men age 18 to 35 ye...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000161185.06387.94
更新日期:2005-08-01 00:00:00
abstract::The objective of this study was to develop and apply a serologic method for identification of different strains of Neisseria gonorrhoeae. Several procedures for preparation of cell-free extracts were tried; the most satisfactory was that with phosphate-buffered saline solution. Both capillary tube and immunodiffusion ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198004000-00002
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:Douching may interfere with determination of microbicide safety and effectiveness. This practice has not been adequately studied among women at risk of HIV infection. GOAL:This study assessed douching practices among women at risk of HIV infection in the United States. STUDY DESIGN:Data were collected on d...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200207000-00008
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Routine chlamydia screening is not readily available at all college campuses. OBJECTIVES:: To assess the prevalence of Chlamydia trachomatis among asymptomatic college students and to compare chlamydia positivity by selected demographic variables. METHODS:Analysis of demographical data collected on 789 stu...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181676697
更新日期:2008-06-01 00:00:00
abstract::Despite over a century of clinical experience in diagnosing and managing patients with syphilis, many thorny clinical questions remain unanswered. We focus on several areas of uncertainty for the clinician: the role of serologic tests in diagnosing syphilis and assessing syphilis treatment responses, and the risk of n...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000851
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Serosorting is the practice of choosing sex partners or selectively using condoms based on a sex partner's perceived HIV status. The extent to which serosorting protects African American (AA) and Hispanic men who have sex with men (MSM) is unknown. METHODS:We analyzed data collected from MSM sexually transm...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31825727cb
更新日期:2012-09-01 00:00:00
abstract::All 11 girls less than 12 years of age presenting to the pediatric clinic between 1980 and 1986 with genital warts were evaluated by the Child Protection Team for possible sexual abuse. Nine of the 11 girls had condylomata acuminata, and two had verruca vulgaris. Ten of the 11 had historical and/or physical evidence o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198801000-00014
更新日期:1988-01-01 00:00:00
abstract::The case of a young man with condylomata lata in the toewebs of both feet is presented. Treponema pallidum was identified in these lesions. Examination two weeks after intramuscular injection of 2.4 X 10(6) units of benzathine penicillin showed resolution of the lesions on the toewebs. ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198407000-00010
更新日期:1984-07-01 00:00:00
abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199118020-00012
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence > or =1 year after HIV-1 diagnosis. METHODS:HSV type-specific antibodies were detected by enzyme immunoassay. RESULTS:The cohort comprised 850 adults diagnosed HIV-positive in...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000187211.61052.c7
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND GOAL:Patients with sexually transmitted diseases (STDs) serve as a bridge population to transmit HIV from higher-risk to lower-risk populations. Our goal was to understand the level of risk behaviors and HIV/STD-related knowledge as well as attitudes among STD patients in China. STUDY DESIGN:An anonymou...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000081394.94426.7A
更新日期:2003-08-01 00:00:00
abstract::The effect of the susceptibility of Trichomonas vaginalis strains to metronidazole on response to treatment was determined from minimal inhibitory concentrations (MICs) for organisms isolated during a clinical trial in which single 1- and 2-g doses of metronidazole were compared. Fifty-seven strains were isolated from...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章
doi:10.1097/00007435-198307000-00003
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) are associated with an increased risk of human immunodeficiency virus (HIV) acquisition and transmission. We estimated the proportion of HIV incidence among men who have sex with men attributable to infection with the 2 most common bacterial STIs, Neisseria gonorrhoeae ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000980
更新日期:2019-06-01 00:00:00
abstract::We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of th...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000036
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Syva Micro Trak enzyme immunoassay (EIA) is used widely for screening women infected with Chlamydia trachomatis. Confirmatory tests used in conjunction with EIA screening have shown that false-positive results are common. GOALS:To evaluate the specificity of the Syva MicroTrak EIA by conf...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199611000-00005
更新日期:1996-11-01 00:00:00
abstract::In a large health insurance database in Germany, incidence of anogenital warts among 15- to 19-year-old females decreased from 316/100,000 person-years in 2007 to 242 in 2008 (23% reduction, P = 0.0001). The decrease started between the first and second quarter of 2007 (human papillomavirus vaccination was introduced ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182756efd
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Use of the stimulant methamphetamine (METH) is increasingly common, with >35 million users worldwide. There is a known association between stimulant use and an increased incidence of HIV and other sexually transmitted infections (STIs). METH is known to have immune modulatory properties. However, the impact ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31825af129
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:This study examined the use of HIV postexposure prophylaxis (PEP) among sexually assaulted adolescent females. METHODS:We analyzed data from the HIV PEP Project, an implementation and evaluation of a program of universal offering of PEP to sexual assault victims of all ages. Baseline and follow-up data were...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181824f3c
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Errors in the classification of male circumcision status could bias studies linking infection to lack of circumcision. GOAL:To determine the frequency and factors associated with the reproducibility of reporting circumcision status. STUDY DESIGN:Secondary analysis of data using logistic regression modeling...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200106000-00005
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:The modes of transmission of HHV-8 are still unclear. GOAL:To evaluate the distribution and transmission of HHV-8 infection. DESIGN:Serosurvey conducted in a Cameroon hospital among 292 persons, including children (5-10 years), adolescents (15-20 years), and adults (30-40 years). Antibodies against lytic a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200003000-00008
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION:As the incidence of hepatitis C virus (HCV) infections remains high among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) an HCV testing strategy was introduced at the sexually transmitted infections (STI) clinic in Amsterdam in 2017. We aimed to evaluate this HCV testing strate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001223
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:There have been few recent population-based herpes simplex virus type 2 (HSV-2) seroprevalence studies in England, but reports from the United States have indicated a 30% rise in HSV-2 seroprevalence between 1976 and 1994. This study aimed to ascertain trends in HSV-2 infection in England between 1991 and 20...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/01.olq.0000118081.54177.95
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Evaluating chlamydia prevalence trends from sentinel surveillance is important for understanding population disease burden over time. However, prevalence trend estimates from surveillance data may be misleading if they do not account for changes in risk profiles of individuals who are screened (case mix) and...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000798
更新日期:2018-08-01 00:00:00
abstract::The base-line prevalence of human papillomavirus (HPV) infection among applicants for first trimester induced abortion and among a sexually transmitted disease (STD) clinic population with macroscopically visible condyloma is investigated. Cervical cells were collected from 505 women applying for induced abortion. Cel...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00