Abstract:
:The Gonozyme test (Abbott Laboratories; North Chicago, IL), a solid-phase enzyme immunoassay (EIA), was evaluated for direct detection of antigens from Neisseria gonorrhoeae in clinical specimens. Results of the EIA were compared with those of culture and gram stain. Separate swab specimens for each procedure were collected from cervical secretions of 119 females and urethral exudate of 198 males (total, 324 specimens) seen in a sexually transmitted disease clinic. Cultures from 132 specimens were positive for gonococci (27 women and 105 men), and gram stains of 119 specimens were positive (14 women and 105 men). The EIA test was positive for 145 specimens (34 women and 111 men). The sensitivities of EIA for females and males were 88.5% and 99.0%, respectively, as compared with 29.6% and 98.1% for gram stain. Specificities of EIA were 89.2% and 92.5%, while those of gram stain were 93.5% and 86.0%, respectively. Overall accuracy of the EIA was 89.1% for females and 95.9% for males. In veiw of the speed and independence from viable organisms of the EIA test, the lack of good gram stain sensitivity for females, and the inherent drawbacks of culture, the Gonozyme test, if used in conjunction with culture, can detect a higher percentage of patients with genital gonorrhea than can culture alone. However, EIA in its present form cannot be used as the sole criterion for a laboratory diagnosis of gonococcal disease because of the ethical and medicolegal consequences of an EIA-positive, culture-negative result.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Nasello MA,Callihan DR,Menegus MA,Steigbigel RTdoi
10.1097/00007435-198510000-00006subject
Has Abstractpub_date
1985-10-01 00:00:00pages
198-202issue
4eissn
0148-5717issn
1537-4521journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Natural history data on human papillomavirus (HPV) incidence and its risk factors have not been reported on from young women in Norway. We report on incidence and predictors of HPV-6, 11, 16, and 18; 6 or 11; 16 or 18; or all 4. METHODS:A 48-month prospective study enrolled 898 women aged 16 to 24 between 1...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31820a9324
更新日期:2011-07-01 00:00:00
abstract::In developed nations, Chlamydia trachomatis is the most common sexually transmitted pathogen. To determine whether prior disease affects the probability of subsequent chlamydial infection, we took culture specimens from 2,546 men and 1,998 women attending a sexually transmitted diseases clinic. The men had nongonococc...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198707000-00008
更新日期:1987-07-01 00:00:00
abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199118020-00012
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Little is known about the prevalence and determinants of human papillomavirus (HPV) infection in women from West India, although incidence of and mortality from cervical cancer is high. METHODS:Cervical specimens were collected, and questionnaires on lifestyle and reproductive factors were administered to 2...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318223be5f
更新日期:2011-10-01 00:00:00
abstract::Specimens of urethral exudate from 200 men with uncomplicated urethritis were tested for Neisseria gonorrhoeae by the limulus amebocyte lysate assay, culture on modified Thayer-Martin medium, and gram-stained smear. As compared with cultures, the sensitivity and specificity of the limulus assay were 94.8% and 89.3%, r...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198107000-00001
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVES:This study examined serologic markers of hepatitis B virus (HBV) infection and immunity among young Asian/Pacific Islander men who have sex with men (API MSM) in San Francisco. METHODS:Participants were 496 API MSM, aged 18 to 29 years, recruited to participate in a cross-sectional survey using a random, ve...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000148296.93945.53
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Millions of cases of sexually transmitted infections (STIs) occur in the United States each year, resulting in substantial medical costs to the nation. Previous estimates of the total direct cost of STIs are quite dated. We present updated direct medical cost estimates of STIs in the United States. METHODS:...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318285c6d2
更新日期:2013-03-01 00:00:00
abstract::Various experimental monkey models have been used for the study of mycoplasmal infections of the urogenital tract. Direct inoculation of Mycoplasma hominis and Ureaplasma urealyticum into the urethra of male monkeys resulted in successful reisolation of the organisms from the urethra without giving rise to signs of ur...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to measure frequency and predictors of patient-delivered partner treatment (PDPT) and the frequency of other partner management strategies among New York City healthcare providers (HCPs) as well as to determine whether use of PDPT detracts from other partner management strat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000225322.94613.c2
更新日期:2007-02-01 00:00:00
abstract::We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of th...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000036
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV)/sexually transmitted disease (STD)-related interventions rely on self-reported risk behavioral data, which are biased toward social desirability. It is warranted to develop methods for data triangulation. METHODS:Some questions on HIV/STD-related behaviors that were asked ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318218cc66
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Neurocognitive impairment is common in human immunodeficiency virus (HIV)-infected subjects. The relationship of sexually transmitted diseases to neurocognitive changes is unknown. GOAL:To establish whether HIV-infected patients with a history of syphilis or gonorrhea have a higher rate of ne...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199708000-00003
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:While researchers seek to use administrative health data to examine outcomes for individuals with sexually transmitted infections, the ICD-CM-10 codes used to identify persons with chlamydia and gonorrhea have not been validated. Objectives were to determine the validity of using ICD-10-CM codes to identify ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001257
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Asymptomatic neurosyphilis is more difficult to diagnose in human immunodeficiency virus (HIV)-infected patients because HIV itself can cause cerebrospinal fluid (CSF) pleocytosis. The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181d877a1
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1. METHODS:We conducted a prospective study among 151 HIV-1-seronegative Kenyan female sex workers. ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31816907fa
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Measurement of human immunodeficiency virus(HIV) incidence among female sex workers in Rwanda is a key part of preparing for HIV prevention trials. METHODS:HIV-negative, nonpregnant female sex workers (N =397) were tested for HIV-1, sexually transmitted infections, and pregnancy quarterly for 12 months, and...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/olq.0b013e31820b8eba
更新日期:2011-05-01 00:00:00
abstract::Three cases of endocarditis caused by Neisseria gonorrhoeae involving the aortic, mitral an tricuspid valves are reported. Two cases in young women, following syndromes suggestive of gonococcal arthritis, presented as acute endocarditis and were fatal. The male patient experienced a subacute course, and the diagnosis ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-197707000-00002
更新日期:1977-07-01 00:00:00
abstract::Susceptibility to thiamphenicol was tested, and plasmids were characterized for 1925 strains of penicillinase-producing Neisseria gonorrhoeae (PPNG) isolated in The Netherlands in 1981 and 1982. Of the 1925 isolates, 771 harbored the so-called "Asia" (4.5-megadalton) resistance plasmid and 1154 had the so called "Afri...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198410001-00011
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVES:To evaluate factors associated with recurrent chlamydial infection and failure to return for retesting in socioeconomically disadvantaged women (aged 16-24 years) entering the National Job Training Program, 1998--2005. GOAL:To evaluate sociodemographic characteristics of young women associated with recurren...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31815ea2bb
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Limited prospective data are available on sexually transmitted infections (STIs) among HIV-infected patients. The incidence and predictors of STIs were assessed among HIV-infected women enrolled in a clinical trial. STUDY DESIGN:Prospective cohort of 323 women. RESULTS:Sixty-five percent had...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199809000-00012
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:To study the incidence, persistence, and determinants of human papillomavirus (HPV) infection in a population of Inuit women from Nunavik, Quebec, by overall HPV infection, Alphapapillomavirus (α) species, and oncogenic risk grouping. METHODS:We recruited a cohort of Inuit women living in communities in Nun...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000272
更新日期:2015-05-01 00:00:00
abstract::A retrospective study of the diagnosis of gonorrhea by gram-stained smear and culture was made. Of 1,681 men with gonococcal urethritis, 1,437 (85.5%) were positive by both smear and culture; 151 (9%), by smear alone; and 93 (5.5%), by culture alone. Of 1,148 women with gonorrhea, 742 (64.6%) had infection in both the...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198507000-00008
更新日期:1985-07-01 00:00:00
abstract::High-performance liquid chromatography was used for quantitative determination of podophyllotoxin in serum subsequent to repeated applications of a 0.5% ethanolic preparation on condylomata acuminata. The drug was not detectable in the serum of ten men treated with < or = 50 microliters. In serum of seven patients rec...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to measure the progress since 1997 of implementing sexually transmitted disease (STD) clinic-based recommendations for hepatitis B prevention. GOAL:The goal of this study was to assess improvements since 1997 in hepatitis B prevention integration in STD services. STUDY:Repeat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000154503.41684.5d
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Little is known about cytokine responses to syphilis infection in HIV-1-infected individuals. METHODS:We retrospectively identified patients with HIV-1 and Treponema pallidum coinfection. Plasma samples from before, during, and after coinfection were analyzed for interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10,...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318193ca26
更新日期:2009-05-01 00:00:00
abstract::Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment pr...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199007000-00003
更新日期:1990-07-01 00:00:00
abstract::Despite over a century of clinical experience in diagnosing and managing patients with syphilis, many thorny clinical questions remain unanswered. We focus on several areas of uncertainty for the clinician: the role of serologic tests in diagnosing syphilis and assessing syphilis treatment responses, and the risk of n...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000851
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To determine whether women who collect self-collected vaginal swabs at home demonstrated a higher positivity of Chlamydia trachomatis than women in family planning clinics. METHODS:Collection kits for vaginal swabs were internet requested, collected at home, and mailed to a laboratory for testing; questionn...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182039d7f
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Public health authorities want to evaluate their sexually transmitted disease (STD) surveillance systems to promote the most effective use of health resources. GOAL:The goal of this study was to estimate the sensitivity of national laboratory reports of in Switzerland (the proportion of cases detected by na...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200211000-00016
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Approximately 40% of patients infected with hepatitis C virus (HCV) have no history of blood transfusion or other high-risk practice. Other causes should be considered. GOAL:The goal was to describe sexual transmission of HCV from a chronic carrier to his female partner during unprotected vaginal intercours...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200305000-00015
更新日期:2003-05-01 00:00:00