Incidence, persistence, and determinants of human papillomavirus infection in a population of Inuit women in northern Quebec.

Abstract:

BACKGROUND:To study the incidence, persistence, and determinants of human papillomavirus (HPV) infection in a population of Inuit women from Nunavik, Quebec, by overall HPV infection, Alphapapillomavirus (α) species, and oncogenic risk grouping. METHODS:We recruited a cohort of Inuit women living in communities in Nunavik when they presented for routine care. Baseline sociodemographic and lifestyle characteristics were collected and cervical specimens collected throughout the follow-up period were tested for HPV-DNA using the PGMY Line-blot assay. RESULTS:A total of 416 women were eligible for this analysis. Almost 40% of women acquired a new any-type HPV infection, at a rate of 14.44 infections per 1000 women-months. High-risk HPV infections were acquired at a higher rate than low-risk infections and persisted for longer durations. Multivariate logistic regression found age and marital status to be the most important predictors of overall HPV infection acquisition. Over the study period, 36.1% of women cleared their incident infections. The cumulative incidence of any HPV type at 12 months was 10.3% (95% confidence interval, 7.9-13.1). No predictors of clearance were found. CONCLUSIONS:The high incidence and persistence of HPV infections found demonstrate that this population is at high risk for HPV infection. These data provide a deeper understanding of the HPV infection experience of Inuit women, but they may also help evaluate vaccination strategies currently used for this high-risk population.

journal_name

Sex Transm Dis

authors

Bennett R,Cerigo H,Coutlée F,Roger M,Franco EL,Brassard P

doi

10.1097/OLQ.0000000000000272

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

272-8

issue

5

eissn

0148-5717

issn

1537-4521

pii

00007435-201505000-00008

journal_volume

42

pub_type

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