Effect of highly active antiretroviral therapy on incidence of early syphilis in HIV-infected patients.

Abstract:

OBJECTIVES:To evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. STUDY DESIGN:Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (primary or secondary) syphilis. Incidence rate trends according to time from HAART initiation were evaluated by Poisson regression after adjustment for calendar year. RESULTS:With median follow-up of 2.9 years, 56 (10.4%) patients experienced early syphilis, 17 (3.2%) with primary syphilis, and 39 (7.2%) with secondary syphilis. The overall incidence rate of early syphilis for 4 years after the start of HAART was 4.57 per 100 person-years (95% confidence interval, 3.45-5.93). The incidence rate of early syphilis significantly increased in proportion to the years after the start of HAART (3.4-6.1 per 100 person-year, P for trend <0.001). CONCLUSIONS:Early syphilis incidence in HIV-infected patients increased in proportion to HAART duration. The finding suggests that screening for syphilis in HIV-infected patients who initiate HAART should be encouraged with attention to the time passed since HAART initiation.

journal_name

Sex Transm Dis

authors

Park WB,Jang HC,Kim SH,Kim HB,Kim NJ,Oh MD,Choe KW

doi

10.1097/OLQ.0b013e31815b0148

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

304-6

issue

3

eissn

0148-5717

issn

1537-4521

journal_volume

35

pub_type

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