Abstract:
BACKGROUND:Up to 50% of women with nonoptimal vaginal microbial community state type (CST) have bacterial vaginosis (BV). Little is known about what distinguishes women with and without BV diagnosis within nonoptimal CST. We identified features of women and their male sex partners associated with BV among women with nonoptimal vaginal CST. METHODS:In this prospective study, 252 heterosexual couples were observed at 1, 6, and 12 months after baseline. Microbiomes were characterized in cervicovaginal lavage and penile meatal swabs through high-throughput 16s ribosomal RNA gene amplicon sequencing. Nonoptimal CST was defined as CST-IV. Bacterial vaginosis was defined as a Nugent score of 7 to 10. Generalized estimating equation analysis estimated adjusted odds ratios (aORs) for BV among women with nonoptimal CST. RESULTS:At baseline, women with nonoptimal CST were a median age of 22 years, 44% had BV, 16% had HIV, and 66% had herpes simplex virus (HSV) type 2. Male partners were a median age of 27 years, 12% had HIV, 48% had HSV-2, and 55% were circumcised. Within nonoptimal CST, Sneathia sanguinegens, Prevotella species, Prevotella amnii, and Clostridiales, BV-associated bacteria-2 were statistically significantly enriched in observations with BV. In multivariable generalized estimating equation controlling for CST, HIV, and HSV-2, BV was increased among women with CST-IVA (aOR, 1.91; P = 0.087), HIV (aOR, 2.30; P = 0.051), HSV-2 (aOR, 1.75; P = 0.065), and enrichment of male partner penile taxa: Dialister (aOR, 1.16; P = 0.034), Megasphaera (aOR, 1.22; P = 0.001), and Brevibacterium (aOR, 1.13; P = 0.019).These results provide insights into factors differentiating women with BV among those with nonoptimal vaginal CST. Interrupting the sexual exchange of penile and vaginal taxa may be beneficial for preventing pathologic state of vaginal microbiome.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Mehta SD,Agingu W,Nordgren RK,Green SJ,Bhaumik DK,Bailey RC,Otieno Fdoi
10.1097/OLQ.0000000000001259subject
Has Abstractpub_date
2020-12-01 00:00:00pages
840-850issue
12eissn
0148-5717issn
1537-4521journal_volume
47pub_type
杂志文章abstract:OBJECTIVES:To describe the reliability of reported dates of first and last sexual exposure, as elicited from sexually transmitted disease/human immunodeficiency virus cases during routine contact investigation, and determine their adequacy for assessing concurrency. METHODS:We used contact tracing data from 5 studies ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000204746.58160.c1
更新日期:2006-05-01 00:00:00
abstract::Eighty-nine women prostitutes who underwent clinical and microbiologic examination were found to have gonococcal infection. The median age was 22; 92.1% were from urban areas. Nearly all the women prostitutes refrained from barrier methods (92.1%) and had contact with several partners (91.0%). The most frequent clinic...
journal_title:Sexually transmitted diseases
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abstract::A 46-year-old woman developed a febrile illness characterized by supraclavicular and inguinal lymphadopathy. The diagnosis of lymphogranuloma venereum was made by a fourfold rise in complement fixing antibody titer. Treatment with tetracycline was successful. Lymphogranuloma venereum can yield protean manifestations, ...
journal_title:Sexually transmitted diseases
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318214bb70
更新日期:2011-08-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318255aeef
更新日期:2012-08-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000161185.06387.94
更新日期:2005-08-01 00:00:00
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journal_title:Sexually transmitted diseases
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pub_type: 杂志文章
doi:10.1097/01.olq.0000187204.57006.b3
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To examine factors associated with heterosexual anal intercourse (AI). METHODS:Between 2001 and 2004, 1084 heterosexual adults aged 18 to 26 attending public sexually transmitted disease clinics in Seattle, New Orleans, and St Louis were interviewed using computer-assisted self interview and tested for STIs;...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181901ccf
更新日期:2009-04-01 00:00:00
abstract::We conducted a simulation study to illustrate that P values can suggest but not confirm statistical significance; and they may not indicate epidemiological significance (importance). We recommend that researchers consider reporting effect sizes as P values in conjunction with confidence intervals or point estimates wi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000635
更新日期:2017-08-01 00:00:00
abstract::We present the case of a man with a bicuspid aortic valve who presented with persistent fever. Blood cultures yielded Neisseria gonorrhoeae, and the diagnosis of infected mycotic aneurysm was confirmed by detection of the bacterial genome in the aortic wall. The patient was cured with surgery and intravenous ceftriaxo...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000079
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Since 1995, the incidence of Chlamydia trachomatis infection has been increasing in Finland, although there have been no major changes in public sexually transmitted disease (STD) services or screening practice. OBJECTIVES:The objective was to study whether the change in C. trachomatis incidence is signific...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000086606.77125.66
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis infections are prevalent among young sexually active females, have serious sequelae, and are mostly asymptomatic. Screening and treatment of infected females has been demonstrated to prevent sequelae such as pelvic inflammatory disease. GOAL:To assess prevalence and risk factors for ch...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200307000-00002
更新日期:2003-07-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199709000-00005
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Cuban Ministry of Public Health plans to implement the syndromic approach to sexually transmitted diseases in persons with urethral or vaginal syndrome in Cuba using 500 mg ciprofloxacin as therapy. Although the emergence of clinical isolates of Neisseria gonorrhoeae with decreased suscept...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200102000-00004
更新日期:2001-02-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0000000000001037
更新日期:2019-09-01 00:00:00
abstract::60 women with bacterial vaginosis were entered into a double blind, placebo-controlled treatment trial with lyophilized Lactobacillus acidophilus. The lactobacilli used were producing H2O2. Immediately after completion of treatment, 16 out of 28 women who were treated with lactobacilli had normal vaginal wet smear res...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001257
更新日期:2020-07-31 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000338
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Limited prospective data are available on sexually transmitted infections (STIs) among HIV-infected patients. The incidence and predictors of STIs were assessed among HIV-infected women enrolled in a clinical trial. STUDY DESIGN:Prospective cohort of 323 women. RESULTS:Sixty-five percent had...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199809000-00012
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Rising rates of antiretroviral drug resistance among recently infected persons are evidence of high-risk behavior among persons in HIV care. GOAL:The goal was to determine HIV transmission risk behavior among persons in HIV care and evaluate its association with treatment adherence. STUDY DESIGN:The study ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200305000-00005
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVES:To characterize client demographics, sexually transmitted diseases (STD) morbidity, insurance status, reasons for attending public STD clinics, and future preferences for source of STD services. DESIGN:Cross-sectional study of 2,490 clients attending five urban STD clinics for new problems with interviewer-...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199711000-00009
更新日期:1997-11-01 00:00:00
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journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000036
更新日期:2013-11-01 00:00:00
abstract::Survey data from a university in the southeast United States were used to estimate the relation between sexual risk factors, perceived susceptibility, and human immunodeficiency virus testing intention among sexually active college students who had never been tested. Sexual risk factors, but not knowledge, were indire...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001000
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Incorrect condom use is a common problem that can undermine their prevention impact. We assessed the prevalence of 2 condom use problems, breakage/slippage and partial use, compared problems by partnership type, and examined associations with respondent, partner, and partnership characteristics. METHODS:Dat...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e31825ef325
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:In April of 2011, the Cook County Jail initiated opt-out screening of all women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) at the time of intake. In this retrospective review, we assess the impact of opt-out protocol on rates of testing, diagnoses, and successful treatment. METHODS:We col...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000106
更新日期:2014-03-01 00:00:00