Observed Treatment Responses to Short-Course Doxycycline Therapy for Rectal Lymphogranuloma Venereum in Men Who Have Sex With Men.

Abstract:

BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including its duration is very limited. METHODS:We conducted a retrospective review in 2 central London genitourinary medicine clinics of men who have sex with men (MSM) with LGV in whom less than 21 days of doxycycline was used initially. RESULTS:Sixty MSM were treated initially with less than 21 days of doxycycline, of whom 50 (83%) were prescribed a 7-day course. Fifty percent of patients were asymptomatic, with the rest having rectal or other symptoms. Fifty-nine (97%) of 60 had a negative test of cure for LGV at a median of 31 days (7-200 days). Reinfection as opposed to treatment failure was considered likely in the patient testing positive. A second test of cure at a median of 139 days later (37-638 days) was completed in 30 patients, of whom 28 (93%) were negative for LGV. CONCLUSIONS:Seven to 14 days of doxycycline is effective in most cases of LGV with negative TOCs in 59 of 60 patients. These data suggest that 7 days of doxycycline is effective in achieving cure of rectal LGV in most MSM. There is a case for a randomized controlled trial of LGV treatment including a 7-day regimen of doxycycline.

journal_name

Sex Transm Dis

authors

Simons R,Candfield S,French P,White JA

doi

10.1097/OLQ.0000000000000772

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

406-408

issue

6

eissn

0148-5717

issn

1537-4521

journal_volume

45

pub_type

杂志文章
  • Partner referral by patients with gonorrhea and chlamydial infection. Case-finding observations.

    abstract:OBJECTIVE:To evaluate the outcomes of a partner referral program at the sexually transmitted disease (STD) clinic in Amsterdam that encourages gonorrhea and chlamydia patients to refer their own partners to medical examination. STUDY DESIGN:355 patients with a confirmed infection cooperated in partner referral and gav...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199707000-00005

    authors: van de Laar MJ,Termorshuizen F,van den Hoek A

    更新日期:1997-07-01 00:00:00

  • Finding neurosyphilis without the Venereal Disease Research Laboratory test.

    abstract:BACKGROUND:The cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory (VDRL) test is only 27% sensitive for diagnosing neurosyphilis. Discriminant analysis, used on 124 patients, shows that other commonly used laboratory tests can, in combination, identify 87% of patients with neurosyphilis with 94% specificity...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199609000-00008

    authors: MacLean S,Luger A

    更新日期:1996-09-01 00:00:00

  • Trends in Chlamydia Screening, Test Positivity, and Treatment Among Females in California Juvenile Detention Facilities, 2003-2014.

    abstract:BACKGROUND:Juvenile detention facilities house adolescents at high risk for sexually transmitted diseases. Collaboration between health departments and juvenile detention authorities can provide routine, cost-efficient chlamydia screening and treatment to females with limited access to care. We describe trends in scree...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000382

    authors: Burghardt NO,Chow JM,Steiner A,Bauer HM

    更新日期:2016-01-01 00:00:00

  • Seroprevalence and risk factors for herpes simplex virus infection in a population of HIV-infected patients in Canada.

    abstract:OBJECTIVE:To determine the seroprevalence of herpes simplex virus infection in a population of HIV-infected individuals in Canada. METHODS:HIV-infected patients attending 5 infectious disease clinics for follow-up care were approached to participate in the study. After informed consent was obtained, subjects completed...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31818d3fb6

    authors: Romanowski B,Myziuk LN,Walmsley SL,Trottier S,Singh AE,Houston S,Joffe M,Chiu I

    更新日期:2009-03-01 00:00:00

  • Comparison of enoxacin and ceftriaxone in the treatment of uncomplicated gonorrhea.

    abstract:BACKGROUND AND OBJECTIVES:The increasing prevalence of resistant strains of Neisseria gonorrhoeae has prompted investigation of new agents for the treatment of this sexually transmitted disease. GOAL OF THIS STUDY:This study compared the efficacy and safety of a single oral dose of enoxacin to intramuscular ceftriaxon...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199307000-00008

    authors: Covino JM,Smith BL,Cummings MC,Benes S,Draft K,McCormack WM

    更新日期:1993-07-01 00:00:00

  • Type-specific prevalence of genital human papillomaviruses in benign, premalignant, and malignant biopsies in patients from Greece.

    abstract:BACKGROUND AND OBJECTIVES:More than 30 different human papillomavirus (HPV) types infect the anogenital mucosa and are responsible for a variety of benign, premalignant, and malignant lesions including cervical cancer. The goal of this study was to determine the distribution of individual HPV types in various grads of ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199709000-00005

    authors: Labropoulou V,Diakomanolis E,Dailianas S,Kalpaktsoglou K,Balamotis A,Mavromara P

    更新日期:1997-09-01 00:00:00

  • Syphilis epidemiology and clinical outcomes in HIV-infected and HIV-uninfected patients in Kaiser Permanente Northern California.

    abstract:BACKGROUND:Syphilis rates are rising in California, but the impact of HIV infection on syphilis infection remains uncertain. We describe differences between HIV-infected and HIV-uninfected patients diagnosed with syphilis within Kaiser Permanente Northern California. METHODS:We performed retrospective analyses of pati...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181b6f0cc

    authors: Horberg MA,Ranatunga DK,Quesenberry CP,Klein DB,Silverberg MJ

    更新日期:2010-01-01 00:00:00

  • Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai.

    abstract:BACKGROUND:Azithromycin has been used to treat primary and secondary syphilis and as prophylaxis for sexual partners. We evaluated syphilis treatment failure in patients who received azithromycin therapy. METHODS:Patients who did not respond to azithromycin therapy were referred to Shanghai Skin Disease and sexually t...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181e2c753

    authors: Zhou P,Li K,Lu H,Qian Y,Gu X,Gong W,Tucker JD,Cohen MS

    更新日期:2010-11-01 00:00:00

  • Declining prevalence rates of syphilis among police officers in Guinea-Bissau, West Africa, 1990-2010.

    abstract::We analyzed prevalence rates of syphilis (positive Treponema pallidum hemagglutinin antigen/T. pallidum particle antigen and venereal disease research laboratory test) among police officers in Guinea-Bissau from 1990 to 2010 and found a significant decline from 4.5% to 0.4% (P = 0.0065). Our results are in line with o...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000012

    authors: Lindman JL,Månsson F,Biague A,Da Silva ZJ,Andersson S,Norrgren H

    更新日期:2013-10-01 00:00:00

  • Sex in a lifetime: Sexual behaviors in the United States by lifetime number of sex partners, 2006-2010.

    abstract::Using data from the 2006-2010 National Survey of Family Growth, we found that lifetime number of vaginal sex partners is positively associated with the number of sex partners in the past 12 months and negatively associated with age at first vaginal intercourse among 15- to 44-year-old male and female respondents. ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000132

    authors: Haderxhanaj LT,Leichliter JS,Aral SO,Chesson HW

    更新日期:2014-06-01 00:00:00

  • Bacterial vaginosis among African American women who have sex with women.

    abstract:BACKGROUND:Bacterial vaginosis (BV) is a frequent cause of vaginal discharge that may be more common among women reporting sex with women (WSW). The objective of this study was to determine the prevalence of BV and predictors of infection among a sample of African American WSW. METHODS:African American WSW aged 18 yea...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000004

    authors: Muzny CA,Sunesara IR,Austin EL,Mena LA,Schwebke JR

    更新日期:2013-09-01 00:00:00

  • Predictors of condom use among patients with sexually transmitted diseases in Uganda.

    abstract:BACKGROUND AND OBJECTIVE:Patients with sexually transmitted diseases (STDs) are at an increased risk of HIV infection and they must be targeted for increased condom use. GOAL:To identify predictors of condom use among patients with STDs. STUDY DESIGN:In a cross-sectional survey, an interview-administered questionnair...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199910000-00001

    authors: Nuwaha F,Faxelid E,Höjer B

    更新日期:1999-10-01 00:00:00

  • What Is the Role of Paired Rapid Plasma Reagin Testing (Simultaneous Testing of Acute and Convalescent Samples) in the Diagnosis of Repeat Syphilis and the Follow-up of Syphilis?

    abstract:BACKGROUND:Repeat syphilis is playing an increasing role in syphilis transmission in several populations. The assessment of repeat syphilis and response to treatment depends on accurately measuring intraindividual changes in non-treponemal tests. For a 0- to 6-month delta rapid plasma reagin (RPR) to be determined by r...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000684

    authors: Kenyon CR,Osbak KK,Van Esbroek M,Lynen L,Crucitti T

    更新日期:2018-01-01 00:00:00

  • Factors associated with recurrent chlamydial infection and failure to return for retesting in young women entering national job training program, 1998--2005.

    abstract:OBJECTIVES:To evaluate factors associated with recurrent chlamydial infection and failure to return for retesting in socioeconomically disadvantaged women (aged 16-24 years) entering the National Job Training Program, 1998--2005. GOAL:To evaluate sociodemographic characteristics of young women associated with recurren...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31815ea2bb

    authors: Joesoef MR,Weinstock HS,Johnson RE

    更新日期:2008-04-01 00:00:00

  • Diagnostic considerations in intra-amniotic syphilis.

    abstract::Amniotic fluid is rarely used in the evaluation of syphilis during pregnancy but was available from a woman with positive serologic tests in the 30th week of gestation. Nonmotile intra-amniotic spirochetes were seen by dark-field microscopy 20 hr after treatment with benzathine penicillin G. The identity of the organi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198507000-00010

    authors: Glover DD,Winter CA,Charles D,Larsen B

    更新日期:1985-07-01 00:00:00

  • Incidence and Predictors of Chlamydia, Gonorrhea and Trichomonas Among a Prospective Cohort of Cisgender Female Sex Workers in Baltimore, Maryland.

    abstract:BACKGROUND:Cisgender female sex workers (CFSWs) have elevated rates of sexually transmitted infections (STI) yet are underrepresented in targeted programming and research in the United States. We examined the prevalence, incidence and predictors of chlamydia, gonorrhea, and trichomonas infection among CFSW. METHODS:Tw...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001085

    authors: Park JN,Gaydos CA,White RH,Decker MR,Footer KHA,Galai N,Silberzahn BE,Riegger K,Morris M,Huettner SS,Allen ST,Sherman SG

    更新日期:2019-12-01 00:00:00

  • Reinfections, persistent infections, and new infections after general population screening for Chlamydia trachomatis infection in the Netherlands.

    abstract:OBJECTIVES:The objectives of this study were to determine the rate of new infections and reinfections or persistent infections with Chlamydia trachomatis to define appropriate screening intervals and to identify risk factors for reinfection. DESIGN:This was a cross-sectional study among a subsample of participants in ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000179887.01141.c3

    authors: Veldhuijzen IK,Van Bergen JE,Götz HM,Hoebe CJ,Morré SA,Richardus JH,PILOT CT Study Group.

    更新日期:2005-10-01 00:00:00

  • Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy.

    abstract::Metronidazole-resistant trichomoniasis is an uncommon condition that presents significant therapeutic challenges. Combination therapy with high-dose oral tinidazole and vaginal paromomycin cream has been uniformly successful. We present a case report of a patient who responded to combination therapy with high-dose ora...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000903

    authors: Henien M,Nyirjesy P,Smith K

    更新日期:2019-01-01 00:00:00

  • Condom use to prevent incident STDs: the validity of self-reported condom use.

    abstract:BACKGROUND:Studies of sexual behavior and of interventions designed to reduce human immunodeficiency virus risk usually depend on self-report. Validation of self-reported condom use measures has not been previously reported in an urban population at high risk for sexually transmitted diseases and human immunodeficiency...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199501000-00003

    authors: Zenilman JM,Weisman CS,Rompalo AM,Ellish N,Upchurch DM,Hook EW 3rd,Celentano D

    更新日期:1995-01-01 00:00:00

  • Sexual behavior and smoking: risk factor for urethritis in men.

    abstract::Two hundred men who had symptoms of urethritis and 207 controls were interviewed. Because 60% of the men were of foreign nationality, the analysis of risk factors for urethritis was undertaken separately for the French and foreign subpopulations. The risk factors for urethritis were different for the French and foreig...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198804000-00012

    authors: Pessione F,Dolivo M,Casin I,Morel P,Perol Y,Laporte A,Ducot B,Spira A

    更新日期:1988-04-01 00:00:00

  • Concurrency, sex partner risk, and high-risk human papillomavirus infection among African American, Asian, and Hispanic women.

    abstract:BACKGROUND:Although the role of concurrent sexual partnerships (i.e., having sexual activity with another partner after a current partnership has been established) has been most strongly associated with the transmission of bacterial sexually transmitted infections, its role in the transmission of viral sexually transmi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181bcd3e7

    authors: Javanbakht M,Gorbach PM,Amani B,Walker S,Cranston RD,Datta SD,Kerndt PR

    更新日期:2010-02-01 00:00:00

  • Comparison of the QuadFERM+ 2-hr identification system with conventional carbohydrate degradation tests for confirmatory identification of Neisseria gonorrhoeae.

    abstract::The QuadFERM+ (Analytab Products, Plainview, NY) rapid identification system was evaluated for its ability to identify correctly Neisseria gonorhoeae isolates from specimens obtained at a sexually transmitted disease clinic. One hundred eighty-five isolates (115 N. gonorrhoeae, 45 Neisseria meningitidis, 16 Neisseria ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198904000-00002

    authors: Gradus MS,Ng CM,Silver KJ

    更新日期:1989-04-01 00:00:00

  • Sexual partner concurrency and sexual risk among gay, lesbian, bisexual, and transgender American Indian/Alaska natives.

    abstract:BACKGROUND:American Indian and Alaska Natives suffer pervasive health disparities, including disproportionately high rates of HIV. Sexual network dynamics, including concurrency and sexual mixing patterns, are key determinants of HIV disparities. METHODS:We analyzed data from the first national study of gay, lesbian, ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181c37e3e

    authors: Cassels S,Pearson CR,Walters K,Simoni JM,Morris M

    更新日期:2010-04-01 00:00:00

  • Reduction in sexual risk behaviors and infection rates among African Americans and Mexican Americans.

    abstract:BACKGROUND:Project SAFE, a gender- and culture-specific cognitive-behavioral intervention, was one of the few interventions to have demonstrated a significant reduction in sexually transmitted infections in a randomized, controlled trial. GOAL:We evaluated intervention efficacy in 379 Mexican Americans and 170 African...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000115461.50698.55

    authors: Korte JE,Shain RN,Holden AE,Piper JM,Perdue ST,Champion JD,Sterneckert K

    更新日期:2004-03-01 00:00:00

  • Susceptibility to vaccine-preventable diseases in a sexually transmitted disease clinic population.

    abstract:BACKGROUND AND OBJECTIVE:Sexually transmitted disease (STD) clinics often serve a population that has low medical care utilization. The objective of this study was to determine the susceptibility of an STD clinic population to vaccine-preventable diseases. STUDY DESIGN:A cross-sectional study of immunization practices...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199808000-00001

    authors: Staat MA,Tang YL,Fresia AE,Halsey N,Kacergis J,Zenilman J

    更新日期:1998-08-01 00:00:00

  • Changes in incidence of anogenital warts diagnoses after the introduction of human papillomavirus vaccination in Germany-an ecologic study.

    abstract::In a large health insurance database in Germany, incidence of anogenital warts among 15- to 19-year-old females decreased from 316/100,000 person-years in 2007 to 242 in 2008 (23% reduction, P = 0.0001). The decrease started between the first and second quarter of 2007 (human papillomavirus vaccination was introduced ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3182756efd

    authors: Mikolajczyk RT,Kraut AA,Horn J,Schulze-Rath R,Garbe E

    更新日期:2013-01-01 00:00:00

  • Sexually transmitted infections in women infected with the human immunodeficiency virus. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA).

    abstract:BACKGROUND AND OBJECTIVES:Limited prospective data are available on sexually transmitted infections (STIs) among HIV-infected patients. The incidence and predictors of STIs were assessed among HIV-infected women enrolled in a clinical trial. STUDY DESIGN:Prospective cohort of 323 women. RESULTS:Sixty-five percent had...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199809000-00012

    authors: Capps L,Peng G,Doyle M,El-Sadr W,Neaton JD

    更新日期:1998-09-01 00:00:00

  • Fleeting foreskins: the misclassification of male circumcision status.

    abstract:BACKGROUND:Errors in the classification of male circumcision status could bias studies linking infection to lack of circumcision. GOAL:To determine the frequency and factors associated with the reproducibility of reporting circumcision status. STUDY DESIGN:Secondary analysis of data using logistic regression modeling...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200106000-00005

    authors: Diseker RA 3rd,Lin LS,Kamb ML,Peterman TA,Kent C,Zenilman J,Lentz A,Douglas JM Jr,Rhodes F,Malotte KC,Iatesta M

    更新日期:2001-06-01 00:00:00

  • Prevalence of nonspecific vaginitis and other cervicovaginal infections during the third trimester of pregnancy.

    abstract::Nonspecific vaginitis (NSV) is a clinical syndrome characterized by a decreased concentration of normal acidophilic Döderlein flora in the vagina and increased concentration of nonacidophilic microorganisms, such as Gardnerella vaginalis, anaerobic bacteria, and mycoplasmas. Since several NSV-associated organisms are ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198601000-00002

    authors: Paavonen J,Heinonen PK,Aine R,Laine S,Grönroos P

    更新日期:1986-01-01 00:00:00

  • Sexually transmitted infections in women with disabilities: diagnosis, treatment, and prevention: a review.

    abstract:BACKGROUND AND OBJECTIVES:Women with disabilities can and do contract sexually transmitted diseases (STDs). However, because of access barriers, attitudinal misconceptions, and lack of awareness of their risk status, these infections may go under or undiagnosed. GOAL:To address issues regarding the treatment of women ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00007435-200005000-00007

    authors: Welner SL

    更新日期:2000-05-01 00:00:00