An Illustration of Errors in Using the P Value to Indicate Clinical Significance or Epidemiological Importance of a Study Finding.

Abstract:

:We conducted a simulation study to illustrate that P values can suggest but not confirm statistical significance; and they may not indicate epidemiological significance (importance). We recommend that researchers consider reporting effect sizes as P values in conjunction with confidence intervals or point estimates with standard errors to indicate precision (uncertainty).

journal_name

Sex Transm Dis

authors

Kang J,Hong J,Esie P,Bernstein KT,Aral S

doi

10.1097/OLQ.0000000000000635

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

495-497

issue

8

eissn

0148-5717

issn

1537-4521

pii

00007435-201708000-00009

journal_volume

44

pub_type

杂志文章
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    abstract:BACKGROUND AND OBJECTIVES:In the January-February, 1995 issue of Sexually Transmitted Diseases, Zenilman and colleagues reported a null association between incident sexually transmitted diseases (STDs) and self-reported condom use. That anomalous finding generated a flurry of letters to the editor, some of which were q...

    journal_title:Sexually transmitted diseases

    pub_type: 评论,杂志文章

    doi:10.1097/00007435-199710000-00005

    authors: Turner CF,Miller HG

    更新日期:1997-10-01 00:00:00

  • Can experiential-didactic training improve clinical STD practices?

    abstract:BACKGROUND:High rates of sexually transmitted diseases (STDs) present an ongoing costly public health challenge. One approach to reduce STD transmission is to increase the number of clinicians adopting the Centers for Disease Control and Prevention's STD Treatment Guidelines. This evaluation assesses the effectiveness ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3182045306

    authors: Dreisbach S,Devine S,Fitch J,Anderson T,Lee T,Rietmeijer C,Corbett KK

    更新日期:2011-06-01 00:00:00

  • Patterns and trends of sexual behavior, HIV testing, and HIV prevalence among all sexually transmitted disease clinic attenders in Denmark.

    abstract:BACKGROUND AND OBJECTIVES:Persons attending a sexually transmitted disease (STD) clinic have shown to be at a higher risk for HIV infection than the population in general. We evaluate the patterns of HIV prevalence and testing in relation to reported risk behavior. STUDY DESIGN:Data have been collected on all new atte...

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    doi:10.1097/00007435-199403000-00008

    authors: Smith E,Worm AM,Jepsen LV,Larsen J,Brandrup F,Veien N,Andersen BL

    更新日期:1994-03-01 00:00:00

  • HIV-related risk behavior among Hispanic immigrant men in a population-based household survey in low-income neighborhoods of northern California.

    abstract:OBJECTIVES/GOAL:We compared risk behaviors and HIV testing between recent (in the U.S. <5 years) and established (in the U.S. >5 years) Hispanic immigrant men (N = 410). STUDY:This study was a population-based, cross-sectional survey of HIV/sexually transmitted disease markers and risk behaviors in men age 18 to 35 ye...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000161185.06387.94

    authors: Levy V,Page-Shafer K,Evans J,Ruiz J,Morrow S,Reardon J,Lynch M,Raymond HF,Klausner JD,Facer M,Molitor F,Allen B,Ajufo BG,Ferrero D,Sanford GB,McFarland W,HeyMan Study Team.

    更新日期:2005-08-01 00:00:00

  • A randomized controlled trial of partner notification methods for prevention of trichomoniasis in women.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/OLQ.0b013e3181dd1691

    authors: Schwebke JR,Desmond RA

    更新日期:2010-06-01 00:00:00

  • Sexually transmitted infections in women infected with the human immunodeficiency virus. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA).

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

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    authors: Capps L,Peng G,Doyle M,El-Sadr W,Neaton JD

    更新日期:1998-09-01 00:00:00

  • Acceptability of formulations and application methods for vaginal microbicides among drug-involved women: results of product trials in three cities.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200002000-00011

    authors: Hammett TM,Mason TH,Joanis CL,Foster SE,Harmon P,Robles RR,Finlinson HA,Feudo R,Vining-Bethea S,Jeter G,Mayer KH,Doherty-Iddings P,Seage GR 3rd

    更新日期:2000-02-01 00:00:00

  • Prevalence of human papillomavirus infection in Guangdong Province, China: a population-based survey of 78,355 women.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000201

    authors: Jing L,Zhong X,Zhong Z,Huang W,Liu Y,Yang G,Zhang X,Zou J,Jing C,Wei X

    更新日期:2014-12-01 00:00:00

  • Trends in sexual behavior, testing, and knowledge in young people; 2006-2011.

    abstract::Cross-sectional surveys were conducted annually from 2006 to 2011 at a music festival. Eight thousand one hundred sixty-five young people completed surveys. STI testing rates increased over time, but there was an increase in the prevalence of some sexual risk behaviors and little improvement in STI knowledge between 2...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3182663f27

    authors: Lim MS,Bowring AL,Gold J,Aitken CK,Hellard ME

    更新日期:2012-11-01 00:00:00

  • Sexual behavior and sexually transmitted diseases among male adolescents in detention.

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    pub_type: 杂志文章

    doi:10.1097/00007435-199405000-00001

    authors: Oh MK,Cloud GA,Wallace LS,Reynolds J,Sturdevant M,Feinstein RA

    更新日期:1994-05-01 00:00:00

  • Epidemiology of genital herpes simplex virus type 1 and 2 infections in southwestern Finland during a 10-year period (2003-2012).

    abstract:BACKGROUND:The objective of this study was to analyze the proportion of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in genital infections during a 10-year period (2003-2012) among outpatients of a clinic of sexually transmitted disease in Southwestern Finland. METHODS:We analyzed prospectively the proportion ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000101

    authors: Kortekangas-Savolainen O,Orhanen E,Puodinketo T,Vuorinen T

    更新日期:2014-04-01 00:00:00

  • High human immunodeficiency virus incidence in a cohort of Rwandan female sex workers.

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    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/olq.0b013e31820b8eba

    authors: Braunstein SL,Ingabire CM,Kestelyn E,Uwizera AU,Mwamarangwe L,Ntirushwa J,Nash D,Veldhuijzen NJ,Nel A,Vyankandondera J,van de Wijgert JH

    更新日期:2011-05-01 00:00:00

  • Reliable identification of herpes simplex viruses by DNA restriction endonuclease analysis with EcoRI.

    abstract::A simple procedure that permits the rapid identification of clinical isolates of herpes simplex virus (HSV, type 1 or type 2) on the basis of stable and type-specific differences in the EcoRI restriction endonuclease patterns of the HSV-1 and HSV-2 genomes was tested for reliability. Complete concordance was first obt...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198404000-00007

    authors: Gerson M,Portnoy J,Hamelin C

    更新日期:1984-04-01 00:00:00

  • Neisseria gonorrhoeae resistant to ciprofloxacin: first report in Cuba.

    abstract:BACKGROUND AND OBJECTIVES:The Cuban Ministry of Public Health plans to implement the syndromic approach to sexually transmitted diseases in persons with urethral or vaginal syndrome in Cuba using 500 mg ciprofloxacin as therapy. Although the emergence of clinical isolates of Neisseria gonorrhoeae with decreased suscept...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200102000-00004

    authors: Llanes R,Sosa J,Guzmán D,Gutiérrez Y,Llop A,Ricardo O

    更新日期:2001-02-01 00:00:00

  • Trends in sexual behavior. Analyse des Comportements Sexuels en France Investigators.

    abstract::The definition of strategies for preventing STD and AIDS requires a better knowledge of sexual behavior in the general population and in specific subgroups of the population. Surveys have been undertaken in different countries to provide such information, and they allow to draw some general conclusions. Even if there ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:

    authors: Spira A,Bajos N,Ducot B

    更新日期:1994-03-01 00:00:00

  • Evaluation of an advertising program on sexually transmitted diseases.

    abstract::The Division of Venereal Disease Control in British Columbia undertook a three-year, $235,000 advertising campaign to increase demand for information on sexually transmitted disease, increase clinic attendance, and decrease the incidence of gonorrhea. As a result of the campaign, demand for information increased, and ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198207000-00002

    authors: Labonte RN

    更新日期:1982-07-01 00:00:00

  • Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199118020-00012

    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00

  • Syphilitic hepatitis treated with doxycycline in an HIV-infected patient and review of the literature.

    abstract::An HIV-infected male patient who had sex with men and with a penicillin allergy presented with liver dysfunction due to secondary syphilis and was successfully treated with doxycycline. This case highlights that syphilitic hepatitis may be overlooked in this particular population, and health care providers should be a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/OLQ.0000000000000143

    authors: Bork JT,Macharia T,Choi J,Gilliam BL,Buchwald UK

    更新日期:2014-08-01 00:00:00

  • Alcohol Use and Associations With Biological Markers and Self-Reported Indicators of Unprotected Sex in Human Immunodeficiency Virus-Positive Female Sex Workers in Mombasa, Kenya.

    abstract:BACKGROUND:Studies of alcohol use and sexual behavior in African populations have primarily been cross-sectional, used nonvalidated measures of alcohol use, or relied on self-reported sexual risk endpoints. Few have focused on human immunodeficiency virus (HIV)-positive women. METHODS:Longitudinal data were collected ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000502

    authors: White D,Wilson KS,Masese LN,Wanje G,Jaoko W,Mandaliya K,Richardson BA,Kinuthia J,Simoni JM,McClelland RS

    更新日期:2016-10-01 00:00:00

  • Cytokine expression during syphilis infection in HIV-1-infected individuals.

    abstract:BACKGROUND:Little is known about cytokine responses to syphilis infection in HIV-1-infected individuals. METHODS:We retrospectively identified patients with HIV-1 and Treponema pallidum coinfection. Plasma samples from before, during, and after coinfection were analyzed for interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10,...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318193ca26

    authors: Knudsen A,Benfield T,Kofoed K

    更新日期:2009-05-01 00:00:00

  • Misclassification of the stages of syphilis: implications for surveillance.

    abstract:SHORT SUMMARY:Syphilis cases were reviewed to see if reported stages met the Centers for Disease Control and Prevention case definition. Classification was excellent for primary and secondary and good for late latent, but half of early latent and unknown duration were misclassified. New surveillance definitions are sug...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.olq.0000156552.91788.25

    authors: Peterman TA,Kahn RH,Ciesielski CA,Ortiz-Rios E,Furness BW,Blank S,Schillinger JA,Gunn RA,Taylor M,Berman SM

    更新日期:2005-03-01 00:00:00

  • Human papillomavirus 16 integration and risk factors associated in anal samples of HIV-1 infected men.

    abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181c9c23f

    authors: Cañadas MP,Darwich L,Sirera G,Bofill M,Piñol M,Garcia-Cuyas F,Llatjos M,Corbasi P,Clotet B,Videla S,HIV-HPV Can Ruti Study Group.

    更新日期:2010-05-01 00:00:00

  • Reliability and criterion-related validity of self-report of syphilis.

    abstract:OBJECTIVE:To determine the test-retest reliability, sensitivity and specificity, and criterion-related validity of the Risk Behavior Assessment (RBA) syphilis questions. The RBA is a standardized instrument that has been used in several studies of STDs in drug users. METHODS:For the test-retest reliability study, 219 ...

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    pub_type: 杂志文章,多中心研究

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    authors: Fisher DG,Reynolds GL,Creekmur B,Johnson ME,Deaugustine N

    更新日期:2007-06-01 00:00:00

  • Laboratory diagnosis of gonorrhea by a simple transformation test with a temperature-sensitive mutant of Neisseria gonorrhoeae.

    abstract::A temperature-sensitive mutant of Neisseria gonorrhoeae strain tsA-1 was used in a transformation test for the laboratory diagnosis of gonorrhea. This transformation test (C test) is based on a spotting of a DNA lysate, obtained through simple base-acid extraction of a cervical-swab specimen, onto a lawn of tsA-1, whi...

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    pub_type: 杂志文章

    doi:10.1097/00007435-198010000-00008

    authors: Zubrzycki L,Weinberger SS

    更新日期:1980-10-01 00:00:00

  • Concurrent Primary Chancre and Ocular Syphilis in an Human Immunodeficiency Virus-Negative Man.

    abstract::We believe this to be the first report of coexisting polymerase chain reaction (PCR)-confirmed primary genital and ocular syphilis in a patient with penicillin allergy treated with doxycycline. The case examines the use of nonpenicillin and corticosteroid treatment of ocular syphilis and highlights the risk of eye inv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000900

    authors: Hamill MM,Seppings L,Kit V,Antao S

    更新日期:2018-12-01 00:00:00

  • Gonorrhea in the United States, 1981-1996. Demographic and geographic trends.

    abstract:OBJECTIVE:To describe demographic and geographic trends in gonorrhea incidence in the United States from 1981 through 1996. STUDY DESIGN:We analyzed aggregate gonorrhea cases reported to the Centers for Disease Control and Prevention by the 50 states, District of Columbia, and 63 large cities. Annual incidence rates (...

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    pub_type: 杂志文章

    doi:10.1097/00007435-199808000-00011

    authors: Fox KK,Whittington WL,Levine WC,Moran JS,Zaidi AA,Nakashima AK

    更新日期:1998-08-01 00:00:00

  • Human papillomavirus seropositivity and subsequent risk of HIV acquisition in rural South African women.

    abstract:OBJECTIVE:This study aimed to provide a population-based estimate of human papillomavirus (HPV) seropositivity for women in a rural African context and to evaluate the impact of HPV serostatus on subsequent acquisition of HIV outside a clinical setting. DESIGN:A random sample of women participating in a longitudinal, ...

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    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3182918578

    authors: Tanser F,Jones KG,Viljoen J,Imrie J,Grapsa E,Newell ML

    更新日期:2013-07-01 00:00:00

  • Sexual bridging socially and over time: a simulation model exploring the relative effects of mixing and concurrency on viral sexually transmitted infection transmission.

    abstract:BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic mo...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000194586.66409.7a

    authors: Doherty IA,Shiboski S,Ellen JM,Adimora AA,Padian NS

    更新日期:2006-06-01 00:00:00

  • The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment.

    abstract:BACKGROUND:Studies of the natural history of genital chlamydial infections in humans are sparse and have had study design limitations. An improved understanding of chlamydial natural history may influence recommendations for elements of control efforts such as chlamydia screening frequency or time parameters for partne...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318151497d

    authors: Geisler WM,Wang C,Morrison SG,Black CM,Bandea CI,Hook EW 3rd

    更新日期:2008-02-01 00:00:00

  • A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African women.

    abstract:BACKGROUND:Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1. METHODS:We conducted a prospective study among 151 HIV-1-seronegative Kenyan female sex workers. ...

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    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31816907fa

    authors: McClelland RS,Richardson BA,Graham SM,Masese LN,Gitau R,Lavreys L,Mandaliya K,Jaoko W,Baeten JM,Ndinya-Achola JO

    更新日期:2008-06-01 00:00:00