Misclassification of the stages of syphilis: implications for surveillance.

Abstract:

SHORT SUMMARY:Syphilis cases were reviewed to see if reported stages met the Centers for Disease Control and Prevention case definition. Classification was excellent for primary and secondary and good for late latent, but half of early latent and unknown duration were misclassified. New surveillance definitions are suggested, comments requested. BACKGROUND:Uncertainty when staging latent syphilis should lead clinicians to call it late latent (requires more treatment) and disease investigators to call it early latent (priority for partner investigation). Accurate surveillance requires consistent case definitions. OBJECTIVE:Assess validity of reported syphilis stages. METHODS:Record reviews in 6 jurisdictions to determine if reported cases met the Centers for Disease Control and Prevention case definitions. RESULTS:Nine hundred seventy-three records from 6 jurisdictions in 2002 showed excellent agreement for reported primary (94.0%) and secondary (95.4%), good agreement for late latent (80.2%), and poor agreement for early latent (48.4%) and unknown duration (49.7%). Unknown duration (age < or =35 and nontreponemal test titer > or =32) was often misinterpreted to mean "not known." Early latent (within the past year, documented: seroconversion, fourfold titer increase, symptoms, or contact with an independently documented early syphilis case) was often misinterpreted to include patients with risky behavior, young age, or high nontreponemal test titers. CONCLUSIONS:The unknown duration stage should be dropped. Surveillance of latent syphilis would be more consistent if cases were reported as having high or low titers on nontreponemal test. Alternative approaches are solicited from readers.

journal_name

Sex Transm Dis

authors

Peterman TA,Kahn RH,Ciesielski CA,Ortiz-Rios E,Furness BW,Blank S,Schillinger JA,Gunn RA,Taylor M,Berman SM

doi

10.1097/01.olq.0000156552.91788.25

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

144-9

issue

3

eissn

0148-5717

issn

1537-4521

pii

00007435-200503000-00002

journal_volume

32

pub_type

杂志文章,多中心研究
  • Primary herpes simplex and primary syphilis: a description of seven cases.

    abstract::This report describes the cases of seven patients who had primary genital infection with herpes simplex virus and whose initial nontreponemal and treponemal tests for syphilis were nonreactive. On routine posttreatment examination, a change in the consistency of the ulcers was noticed, and the inguinal nodes, which ha...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198007000-00008

    authors: Fiumara NJ,Schmidt-Ulrick B,Comite H

    更新日期:1980-07-01 00:00:00

  • Use of spermicide and impact of prophylactic condom use among sex workers in Santa Fe de Bogota, Colombia.

    abstract:BACKGROUND AND OBJECTIVES:Condom use is one of the most important preventive measures sex workers can take to reduce the risk of becoming infected with a sexually transmitted disease. However, a client may refuse to use a condom when requested. Some sexually transmitted disease prevention programs are recommending that...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199605000-00008

    authors: Farr G,Acosta Castro LA,DiSantostefano R,Claassen E,Olguin F

    更新日期:1996-05-01 00:00:00

  • Anorectal Lymphogranuloma Venereum in Madrid: A Persistent Emerging Problem in Men Who Have Sex With Men.

    abstract:BACKGROUND:Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000459

    authors: Cabello Úbeda A,Fernández Roblas R,García Delgado R,Martínez García L,Sterlin F,Fernández Guerrero ML,Górgolas M

    更新日期:2016-07-01 00:00:00

  • Critical Elements of Community Engagement to Address Disparities and Related Social Determinants of Health: The Centers of Disease Control and Prevention Community Approaches to Reducing Sexually Transmitted Disease Initiative.

    abstract:BACKGROUND:Community Approaches to Reducing Sexually Transmitted Disease (CARS), a unique initiative of the US Centers for Disease Control and Prevention, promotes the use of community engagement to increase sexually transmitted disease (STD) prevention, screening, and treatment and to address locally prioritized STD-r...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001267

    authors: Rhodes SD,Daniel-Ulloa J,Wright SS,Mann-Jackson L,Johnson DB,Hayes NA,Valentine JA

    更新日期:2021-01-01 00:00:00

  • Antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in 2004-2006 in Bangui, Central African Republic; Yaoundé, Cameroon; Antananarivo, Madagascar; and Ho Chi Minh Ville and Nha Trang, Vietnam.

    abstract:GOAL:To investigate the in vitro antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in 2004 and 2005 in Bangui, Central African Republic; Yaoundé, Cameroon; Antananarivo, Madagascar; and Ho Chi Minh Ville and Nha Trang, Vietnam. STUDY DESIGN:Antimicrobial susceptibility testing was performed by bot...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31818318d8

    authors: Cao V,Ratsima E,Van Tri D,Bercion R,Fonkoua MC,Richard V,Talarmin A

    更新日期:2008-11-01 00:00:00

  • Diagnosis of male Chlamydia trachomatis urethritis by polymerase chain reaction.

    abstract:BACKGROUND AND OBJECTIVES:A quick and highly sensitive diagnostic test would be valuable in the diagnosis of Chlamydia trachomatis. GOAL OF THIS STUDY:We compared a new polymerase chain reaction (PCR) technique to Chlamydiazyme (Abbott, North Chicago, IL) in the detection of male chlamydial urethritis, and evaluated t...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007435-199409000-00004

    authors: Wiesenfeld HC,Uhrin M,Dixon BW,Sweet RL

    更新日期:1994-09-01 00:00:00

  • Human immunodeficiency virus type 1 among bar and hotel workers in northern Tanzania: the role of alcohol, sexual behavior, and herpes simplex virus type 2.

    abstract:GOALS:We assessed baseline prevalence of human immunodeficiency virus type 1 (HIV-1) and other STDs, as well as behavioral and biologic risk factors for HIV-1 in a population of female bar/hotel workers in Moshi, Tanzania. STUDY DESIGN:Between 2002 and 2003, we enrolled 1042 female bar/hotel workers in an ongoing pros...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000187204.57006.b3

    authors: Ao TT,Sam NE,Masenga EJ,Seage GR 3rd,Kapiga SH

    更新日期:2006-03-01 00:00:00

  • Ending the HIV Epidemic: Contributions Resulting From Syphilis Partner Services.

    abstract:BACKGROUND:There is a high level of coinfection with human immunodeficiency virus (HIV) among persons diagnosed with syphilis in the United States. Public health workers at state and local health departments help inform exposed partners to sexually transmitted disease (STD)/HIV infections to facilitate early testing an...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001201

    authors: DiOrio D,Collins D,Hanley S

    更新日期:2020-08-01 00:00:00

  • Limitations of the dye-based method for determining vaginal applicator use in microbicide trials.

    abstract:BACKGROUND:A dye-based method for determining applicator usage in microbicide trials has been developed to assess whether applicators have been exposed to vaginal fluid. Our objective was to evaluate this method on polypropylene HTI applicators that are being widely used in several effectiveness trials of microbicides....

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/OLQ.0b013e3181972397

    authors: Austin MN,Rabe LK,Hillier SL

    更新日期:2009-06-01 00:00:00

  • An opportunity for prevention: prevalence, incidence, and sexual risk for HIV among young Asian and Pacific Islander men who have sex with men, San Francisco.

    abstract:OBJECTIVES:We investigated HIV prevalence and incidence and related risk factors among young Asian and Pacific Islander (API) men who have sex with men (MSM). DESIGN:We conducted a cross-sectional survey. METHODS:A venue-based sample of 496 young API MSM in San Francisco completed face-to-face questionnaires and rece...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000135988.19969.62

    authors: Choi KH,McFarland W,Neilands TB,Nguyen S,Louie B,Secura GM,Behel S,Mackellar D,Valleroy L

    更新日期:2004-08-01 00:00:00

  • Do participant characteristics influence the effectiveness of behavioral interventions? Promoting condom use to women.

    abstract:OBJECTIVES:This study assessed whether participant baseline characteristics modified the effects of a skill-based intervention promoting condom use. STUDY:The randomized, controlled trial enrolled 427 women from a sexually transmitted disease clinic in Birmingham, Alabama. The main outcome measures: consistent (100%) ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.olq.0000175392.84989.ec

    authors: Legardy JK,Macaluso M,Artz L,Brill I

    更新日期:2005-11-01 00:00:00

  • Access to health services and sexually transmitted infections in a cohort of relocating African American public housing residents: an association between travel time and infection.

    abstract:BACKGROUND:High incidence and prevalence of sexually transmitted infection (STI) in blacks have been attributed to multiple factors. However, few articles have discussed spatial access to healthcare as a driver of disparities. The objective of this analysis was to evaluate the relationship between travel time to a heal...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318235b673

    authors: Bonney LE,Cooper HL,Caliendo AM,Del Rio C,Hunter-Jones J,Swan DF,Rothenberg R,Druss B

    更新日期:2012-02-01 00:00:00

  • Clinical course of patients with serologic evidence of recurrent genital herpes presenting with signs and symptoms of first episode disease.

    abstract:BACKGROUND AND OBJECTIVES:The care of patients with first episode and recurrent genital herpes differs with respect to therapy and source partner evaluation. Of 498 persons who presented with what appeared by history and symptoms to be a first episode of genital herpes, we identified 41 who had serologic evidence of re...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199904000-00007

    authors: Diamond C,Selke S,Ashley R,Benedetti J,Corey L

    更新日期:1999-04-01 00:00:00

  • Metronidazole: utilization in the obstetric and gynecologic patient.

    abstract:BACKGROUND:Obstetric and gynecologic complications associated with bacterial vaginosis and trichomoniasis have heightened awareness of these conditions, and thus metronidazole's role in obstetric and gynecologic practice continues to increase. GOAL OF THIS STUDY:To review the clinical indications for metronidazole in ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:

    authors: Schwebke JR

    更新日期:1995-11-01 00:00:00

  • Sex and disease. Playing the odds in the 1990s.

    abstract::Selected results from a recent study on sexual behavior in the United States are presented, focusing on the association between sexual behavior, disease prevention, and STD outcome. The data are from national household samples of adult men and women. The results show that a sizeable proportion of the U.S. adult popula...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Tanfer K

    更新日期:1994-03-01 00:00:00

  • Oral human papillomavirus and human herpesvirus-8 infections among human immunodeficiency virus type 1-infected men and women in Italy.

    abstract:BACKGROUND:Oral human papillomavirus (HPV) and human herpesvirus-8 (HHV8) infections are sexually transmitted and respectively associated with the development of oropharyngeal carcinoma and Kaposi sarcoma. The aim of the study was to evaluate HPV prevalence and its possible correlation with HHV8 oral shedding, in relat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31826ef2da

    authors: Del Mistro A,Baboci L,Frayle-Salamanca H,Trevisan R,Bergamo E,Lignitto L,Sasset L,Cecchetto MG,Cattelan AM,Calabró ML

    更新日期:2012-11-01 00:00:00

  • Prevalence Estimates of Complicated Syphilis.

    abstract::We reviewed 68 cases of possible neurosyphilis among 573 syphilis cases in King County, WA, from 3rd January 2012 to 30th September 2013; 7.9% (95% confidence interval, 5.8%-10.5%) had vision or hearing changes, and 3.5% (95% confidence interval, 2.2%-5.4%) had both symptoms and objective confirmation of complicated s...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/OLQ.0000000000000368

    authors: Dombrowski JC,Pedersen R,Marra CM,Kerani RP,Golden MR

    更新日期:2015-12-01 00:00:00

  • Can Young Adults Accurately Report Sexual Partnership Dates? Factors Associated With Interpartner and Dyad Agreement.

    abstract:BACKGROUND:Sexual partnership dates are critical to sexually transmitted infection/HIV research and control programs, although validity is limited by inaccurate recall and reporting. METHODS:We examined data from 302 heterosexual adults (151 index-partner dyads) to assess reliability of reporting. Dates of first sex a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000428

    authors: Sanchez DM,Schoenbach VJ,Harvey SM,Warren JT,Poole C,Leone PA,Adimora AA,Agnew CR

    更新日期:2016-05-01 00:00:00

  • Can experiential-didactic training improve clinical STD practices?

    abstract:BACKGROUND:High rates of sexually transmitted diseases (STDs) present an ongoing costly public health challenge. One approach to reduce STD transmission is to increase the number of clinicians adopting the Centers for Disease Control and Prevention's STD Treatment Guidelines. This evaluation assesses the effectiveness ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3182045306

    authors: Dreisbach S,Devine S,Fitch J,Anderson T,Lee T,Rietmeijer C,Corbett KK

    更新日期:2011-06-01 00:00:00

  • Coital bleeding and HIV risks among men and women in Cape Town, South Africa.

    abstract:BACKGROUND:South Africa has one of the world's fastest growing HIV epidemics. Genital bleeding during sexual intercourse may play a role in facilitating HIV transmission in South Africa. PURPOSE:The purpose of this study was to examine the prevalence and sources of coital bleeding among men and women living in a Cape ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000218868.76820.7f

    authors: Kalichman SC,Simbayi LC,Cain D,Cherry C,Jooste S

    更新日期:2006-09-01 00:00:00

  • Extragenital Testing for Neisseria gonorrhoeae and Chlamydia trachomatis in a Large HIV Clinic in the US South: Implementation and Epidemiology.

    abstract:BACKGROUND:Rectal and oral Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) infections are common among people with HIV, especially men who have sex with men (MSM); however, GC/CT testing rates remain low in many HIV clinics. We evaluated the real-world implementation and results of extragenital nucleic acid a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001349

    authors: Pottorff A,Duarte P,Chow J,Luque A,Nijhawan AE

    更新日期:2021-02-01 00:00:00

  • Alternative approaches to partner notification, diagnosis, and treatment: perspectives of New York County Health Departments, 2007.

    abstract:OBJECTIVES:The Centers for Disease Control and Prevention is encouraging states to consider patient-delivered partner therapy (PDPT) as a treatment option for Chlamydia and gonorrhea. We sought to assess current sexually transmitted disease (STD) control practices in New York State county health departments, and gather...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31818eb8f8

    authors: Davis CF,Cummings M,Coles BF,McNutt LA

    更新日期:2009-03-01 00:00:00

  • The differing views of male and female patients toward chaperones for genital examinations in a sexual health setting.

    abstract:OBJECTIVES:To determine the attitudes of male and female patients to the use of chaperones during genital examination within a sexually transmitted diseases clinic. STUDY DESIGN:An anonymous, self-completed questionnaire was administered to patients attending the Melbourne Sexual Health Centre, Australia, between Sept...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3180ca8f3a

    authors: Teague R,Newton D,Fairley CK,Hocking J,Pitts M,Bradshaw C,Chen M

    更新日期:2007-12-01 00:00:00

  • Concurrent Primary Chancre and Ocular Syphilis in an Human Immunodeficiency Virus-Negative Man.

    abstract::We believe this to be the first report of coexisting polymerase chain reaction (PCR)-confirmed primary genital and ocular syphilis in a patient with penicillin allergy treated with doxycycline. The case examines the use of nonpenicillin and corticosteroid treatment of ocular syphilis and highlights the risk of eye inv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000900

    authors: Hamill MM,Seppings L,Kit V,Antao S

    更新日期:2018-12-01 00:00:00

  • Association of Chlamydia trachomatis Serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, Alabama.

    abstract:BACKGROUND:Black race is a risk marker for Chlamydia trachomatis infection. Because chlamydial serovar and race could both influence the transmission dynamics of chlamydia, studies characterizing serovars in a predominantly black population are of interest, yet remain sparse. STUDY DESIGN AND GOALS: C. trachomatis isol...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000216027.71144.74

    authors: Geisler WM,Suchland RJ,Stamm WE

    更新日期:2006-10-01 00:00:00

  • Can we get people to participate in a study of sexual behavior?

    abstract:BACKGROUND AND OBJECTIVES:Interpreting the results of any study requires careful analysis to determine how selective participation may have influenced the findings. Participation in a study of sexual behavior may be influenced by who is doing the study, who the participants are, what it means to participate, what the s...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/00007435-199505000-00007

    authors: Peterman TA

    更新日期:1995-05-01 00:00:00

  • Reduction in sexual risk behaviors and infection rates among African Americans and Mexican Americans.

    abstract:BACKGROUND:Project SAFE, a gender- and culture-specific cognitive-behavioral intervention, was one of the few interventions to have demonstrated a significant reduction in sexually transmitted infections in a randomized, controlled trial. GOAL:We evaluated intervention efficacy in 379 Mexican Americans and 170 African...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000115461.50698.55

    authors: Korte JE,Shain RN,Holden AE,Piper JM,Perdue ST,Champion JD,Sterneckert K

    更新日期:2004-03-01 00:00:00

  • A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men.

    abstract::We examined the prevalence of rectal chlamydia treatment failures in men who have sex with men and women attending Alberta sexually transmitted infection clinics. Among those completing a test of cure, there was no significant difference among patients treated initially with azithromycin (treatment failure, 39/460 [8....

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000403

    authors: Gratrix J,Brandley J,Dane M,Plitt SS,Smyczek P,Read R,Singh AE

    更新日期:2016-02-01 00:00:00

  • Confirmation of the Syva MicroTrak enzyme immunoassay for chlamydia trachomatis by Syva Direct Fluorescent Antibody Test.

    abstract:BACKGROUND AND OBJECTIVES:The Syva Micro Trak enzyme immunoassay (EIA) is used widely for screening women infected with Chlamydia trachomatis. Confirmatory tests used in conjunction with EIA screening have shown that false-positive results are common. GOALS:To evaluate the specificity of the Syva MicroTrak EIA by conf...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199611000-00005

    authors: Beebe JL,Masters H,Jungkind D,Heltzel DM,Weinberg A

    更新日期:1996-11-01 00:00:00

  • Trends in sexual behavior. Analyse des Comportements Sexuels en France Investigators.

    abstract::The definition of strategies for preventing STD and AIDS requires a better knowledge of sexual behavior in the general population and in specific subgroups of the population. Surveys have been undertaken in different countries to provide such information, and they allow to draw some general conclusions. Even if there ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:

    authors: Spira A,Bajos N,Ducot B

    更新日期:1994-03-01 00:00:00