Abstract:
BACKGROUND:Herpes simplex virus-2, the most common cause of genital ulcer disease (GUD) globally, is a cofactor in human immunodeficiency virus type-1 (HIV-1) acquisition and transmission. Current World Health Organization guidelines for sexually transmitted infections recommend acyclovir as first-line syndromic treatment of GUD in countries with high herpes simplex virus-2 prevalence (> or =30%). OBJECTIVE:To assess the extent of adoption of acyclovir as syndromic treatment for GUD, and describe procurement, distribution, and cost of acyclovir in the public and private sectors of 8 sub-Saharan African countries. METHODS:We conducted standardized interviews with Ministry of Health (MoH) officials, pharmacists, and other pharmacy workers based in the public and private sectors. Interviews were conducted in Botswana, Kenya, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. Price comparisons were conducted using the 2007 median international reference price (IRP) for acyclovir. RESULTS:Of the 8 African countries, 4 surveyed had adopted acyclovir as first-line syndromic GUD treatment in both their essential medical lists and sexually transmitted infection guidelines. Country-specific acquisition prices for acyclovir 200 mg were comparable to the median IRP and ranged from 0.74 to 1.95 times the median IRP. The median retail cost of acyclovir in the private sector ranged from 5.85 to 9.76 times the median IRP. Public health facilities faced cost and regulatory barriers that impeded the requisitioning of acyclovir from the central medical stores. CONCLUSIONS:Systems for drug procurement, distribution, and access in sub-Saharan African countries need strengthening for a GUD treatment policy using acyclovir to be effective.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Corbell C,Stergachis A,Ndowa F,Ndase P,Barnes L,Celum Cdoi
10.1097/OLQ.0b013e3181e212e5subject
Has Abstractpub_date
2010-08-01 00:00:00pages
488-93issue
8eissn
0148-5717issn
1537-4521journal_volume
37pub_type
杂志文章abstract::Neisseria gonorrhoeae and Chlamydia trachomatis screening was performed in a cohort of 100 men who have sex with men. A nucleic acid amplification test on a pooled sample of first-pass urine, pharyngeal, and anorectal specimens was compared with results on nonpooled samples. Despite an excellent agreement (Cohen κ, 0....
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000722
更新日期:2018-03-01 00:00:00
abstract::In the cases of two patients and in a rabbit with experimental syphilis, treatment of primary syphilis lesions with 5% acyclovir ointment did not affect detection of Treponema pallidum by dark-field microscopy. These results indicate that the dark-field examination need not be delayed in patients whose genital ulcers ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198311000-00008
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Higher gender equality is associated with many human immunodeficiency virus (HIV) preventive behaviors, including HIV testing. HIV self-testing is a relatively new testing technology that could assist with HIV prevention. However, there are no studies examining gender equality and HIV self-testing. We examin...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0000000000001037
更新日期:2019-09-01 00:00:00
abstract::The base-line prevalence of human papillomavirus (HPV) infection among applicants for first trimester induced abortion and among a sexually transmitted disease (STD) clinic population with macroscopically visible condyloma is investigated. Cervical cells were collected from 505 women applying for induced abortion. Cel...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Routine chlamydia screening is not readily available at all college campuses. OBJECTIVES:: To assess the prevalence of Chlamydia trachomatis among asymptomatic college students and to compare chlamydia positivity by selected demographic variables. METHODS:Analysis of demographical data collected on 789 stu...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181676697
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Few studies have examined the association between self-reported sexual risk behaviors and biologic outcomes in human immunodeficiency virus (HIV)-1-seropositive African adults. METHODS:We conducted a prospective cohort study in 898 HIV-1-seropositive women who reported engaging in transactional sex in Momba...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31820369f6
更新日期:2011-05-01 00:00:00
abstract::Lymphogranuloma venereum was diagnosed postpartum in a young black woman, who was a drug abuser. Chlamydia trachomatis was isolated from aspirate of a left inguinal mass, and the patient was also seropositive for human immunodeficiency virus. During hospitalization she was treated with ampicillin, gentamicin, and doxy...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198807000-00006
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Standard counseling at nongonococcal urethritis (NGU) diagnosis includes advice to abstain from sex for at least 7 days and until symptoms resolve. METHODS:From December 2014 to July 2018, we enrolled men who have sex with men and received azithromycin (1 g) for NGU at the Public Health-Seattle and King Cou...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001040
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:Detection of Neisseria gonorrhoeae by commercial and in-house-based assays has been hampered by false-positive and false-negative results. The current study describes a sensitive and specific real-time 5'-nuclease PCR assay targeting a 90-bp region of the multicopy opa gene. GOAL:To evaluate the sensitivity...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000154495.24519.bf
更新日期:2005-03-01 00:00:00
abstract::Chlamydia trachomatis was present in cell cultures of specimens from 96 (32%) of 300 men with nongonococcal urethritis, but this organism was not isolated from 100 healthy volunteers matched for sex and age. The prevalence of serum antibodies to C. trachomatis was investigated with the use of a single-antigen, indirec...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Approximately 40% of patients infected with hepatitis C virus (HCV) have no history of blood transfusion or other high-risk practice. Other causes should be considered. GOAL:The goal was to describe sexual transmission of HCV from a chronic carrier to his female partner during unprotected vaginal intercours...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200305000-00015
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic mo...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000194586.66409.7a
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to understand client and provider attitudes, experiences, and practices regarding HIV partner notification in the United States and to help identify future research and program needs. GOALS:The goals of this study were to synthesize the literature reporting client and provi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,meta分析
doi:10.1097/01.olq.0000194597.16236.48
更新日期:2006-05-01 00:00:00
abstract::Two hundred men who had symptoms of urethritis and 207 controls were interviewed. Because 60% of the men were of foreign nationality, the analysis of risk factors for urethritis was undertaken separately for the French and foreign subpopulations. The risk factors for urethritis were different for the French and foreig...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198804000-00012
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including i...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000772
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:In April of 2011, the Cook County Jail initiated opt-out screening of all women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) at the time of intake. In this retrospective review, we assess the impact of opt-out protocol on rates of testing, diagnoses, and successful treatment. METHODS:We col...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000106
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Little is known about cross-border sex-networking behaviors among men who have sex with men (MSM) GOAL: The goal of this study was to determine the prevalence of cross-border sex-networking in mainland China among MSM in Hong Kong and the associated risk behaviors STUDY:A telephone survey was conducted. A t...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000137905.94154.0a
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Quinolones have a broad spectrum of antimicrobial activity and are widely used for the treatment of uncomplicated Neisseria gonorrhoeae infections. A dramatic increase in the number of reported N. gonorrhoeae infections as well as quinolone-resistant isolates in Vienna prompted us to investigate the pattern o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000140019.18390.28
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:As the incidence of hepatitis C virus (HCV) infections remains high among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) an HCV testing strategy was introduced at the sexually transmitted infections (STI) clinic in Amsterdam in 2017. We aimed to evaluate this HCV testing strate...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001223
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Studies assessing the validity attributed to self-reported measures of sexually transmitted diseases (STDs) clearly are needed, particularly those used for high-risk populations such as female adolescents, in whom STD prevention is a priority. GOAL:To determine the accuracy of self-reported STD test results...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007435-200108000-00009
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To examine the effect of a laboratory-confirmed Chlamydia trachomatis (Ct) test result on subsequent sexual risk behavior in a large population-based screening program. METHODS:The study population consisted of 16- to 29-year-old participants of the Chlamydia Screening Implementation who completed Ct testing...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000234
更新日期:2015-03-01 00:00:00
abstract::We reviewed 68 cases of possible neurosyphilis among 573 syphilis cases in King County, WA, from 3rd January 2012 to 30th September 2013; 7.9% (95% confidence interval, 5.8%-10.5%) had vision or hearing changes, and 3.5% (95% confidence interval, 2.2%-5.4%) had both symptoms and objective confirmation of complicated s...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/OLQ.0000000000000368
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Women with cervicitis frequently have bacterial vaginosis (BV). Prior studies have suggested that BV is involved in the pathogenesis of cervicitis. GOALS:To delineate the association of BV and cervicitis and to determine whether treatment of BV results in increased resolution of cervicitis. STUDY DESIGN:Wo...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-200201000-00010
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:We investigated HIV prevalence and incidence and related risk factors among young Asian and Pacific Islander (API) men who have sex with men (MSM). DESIGN:We conducted a cross-sectional survey. METHODS:A venue-based sample of 496 young API MSM in San Francisco completed face-to-face questionnaires and rece...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000135988.19969.62
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Interpreting the results of any study requires careful analysis to determine how selective participation may have influenced the findings. Participation in a study of sexual behavior may be influenced by who is doing the study, who the participants are, what it means to participate, what the s...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/00007435-199505000-00007
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The prevalence of human papillomavirus (HPV) infection and the distribution of different HPV genotypes vary greatly within different geographical and ethnic populations, especially in Asia. The HPV infection data based on regional population are extremely important for researchers to develop new efficient HP...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000201
更新日期:2014-12-01 00:00:00
abstract::Heretofore most people affected by warts of the oral cavity were children, but during the past decade adults have become the most frequently seen patients with warts in the mouth. The popularity of fellatio among heterosexuals, teenagers, and adults has contributed to the spread of oral warts. Of epidemiologic interes...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198410000-00001
更新日期:1984-10-01 00:00:00
abstract::The Division of Venereal Disease Control in British Columbia undertook a three-year, $235,000 advertising campaign to increase demand for information on sexually transmitted disease, increase clinic attendance, and decrease the incidence of gonorrhea. As a result of the campaign, demand for information increased, and ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198207000-00002
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:In response to increasing sexually transmitted diseases (STDs), diminishing resources, and delays in prompt treatment, the Florida STD Program began providing test results through text message in 2011. The aims of the evaluation of the first year of the project were to assess (1) client uptake and completion...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000242
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Lifetime cost estimates are a useful tool in measuring the economic burden of HIV in the United States. Previous estimation methods need to be updated, given improving antiretroviral therapy regimens and updated costs. METHODS:We used an updated version of the agent-based model Progression and Transmission ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001366
更新日期:2021-01-23 00:00:00