Comparative studies on influenza B virus. I. Biological properties and polypeptide composition of strains isolated in different years.

Abstract:

:Influenza B viruses isolated in 1940, 1950 and 1970 belonged to antigenically remote subgroups according to the antigenic composition of haemagglutinin (HA). Antigenically related strains isolated in 1972-1976 differed by their reproduction capability, by their sensitivity to inhibitors in mammalian sera and by affinity to specific antibodies in human sera. Certain correlation between these properties was observed by strains of the Hong Kong variant. Polyacrylamide gel electrophoresis (PAGE) showed that the viruses under study differed in the mobility of the major HA chain (HA1). Molecular weights (MW) of HA1 of antigenically similar influenza B viruses isolated in 1972-1976 revealing different biological properties varied from 52.5 K to 58 K. Neuraminidase (NA) of influenza B/Leningrad/369/75 virus purified by electrophoresis in acetate cellulose consisted of 2 polypeptides with apparent MW of 62 K and 57 K. All viruses examined showed similar mobility of the NA polypeptide MW 57 K; the mobility of the former polypeptide was similar to that of nucleoprotein (NP).

journal_name

Acta Virol

journal_title

Acta virologica

authors

Korchanova NL,Simanovskaya VK,Sominina AA,Gordon MA,Goloveshkina TN,Kuznetsova EV

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

377-84

issue

5

eissn

0001-723X

issn

1336-2305

journal_volume

27

pub_type

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